AU2003300434A1 - Process for the production of 3'-nucleoside prodrugs - Google Patents

Process for the production of 3'-nucleoside prodrugs Download PDF

Info

Publication number
AU2003300434A1
AU2003300434A1 AU2003300434A AU2003300434A AU2003300434A1 AU 2003300434 A1 AU2003300434 A1 AU 2003300434A1 AU 2003300434 A AU2003300434 A AU 2003300434A AU 2003300434 A AU2003300434 A AU 2003300434A AU 2003300434 A1 AU2003300434 A1 AU 2003300434A1
Authority
AU
Australia
Prior art keywords
nucleoside
free
protection
reaction
methyl branched
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2003300434A
Other languages
English (en)
Inventor
Steven Mathieu
Adel Moussa
Richard Storer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Idenix Cayman Ltd
Original Assignee
Idenix Cayman Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Idenix Cayman Ltd filed Critical Idenix Cayman Ltd
Publication of AU2003300434A1 publication Critical patent/AU2003300434A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AU2003300434A 2002-12-23 2003-12-23 Process for the production of 3'-nucleoside prodrugs Abandoned AU2003300434A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US43615002P 2002-12-23 2002-12-23
US60/436,150 2002-12-23
PCT/US2003/041603 WO2004058792A1 (en) 2002-12-23 2003-12-23 Process for the production of 3'-nucleoside prodrugs

Publications (1)

Publication Number Publication Date
AU2003300434A1 true AU2003300434A1 (en) 2004-07-22

Family

ID=32682350

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003300434A Abandoned AU2003300434A1 (en) 2002-12-23 2003-12-23 Process for the production of 3'-nucleoside prodrugs

Country Status (16)

Country Link
US (1) US20040181051A1 (enExample)
EP (1) EP1575971A4 (enExample)
JP (1) JP2006514038A (enExample)
KR (1) KR20050110611A (enExample)
CN (1) CN100335492C (enExample)
AU (1) AU2003300434A1 (enExample)
BR (1) BR0316868A (enExample)
CA (1) CA2511616A1 (enExample)
IL (1) IL169314A0 (enExample)
MX (1) MXPA05006865A (enExample)
NO (1) NO20053557L (enExample)
NZ (1) NZ540913A (enExample)
PL (1) PL377608A1 (enExample)
RU (1) RU2005123395A (enExample)
WO (1) WO2004058792A1 (enExample)
ZA (1) ZA200505040B (enExample)

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JP2009532411A (ja) 2006-04-04 2009-09-10 エフ．ホフマン−ラ ロシュ アーゲー Ｈｃｖ治療のための３’，５’−ジ−ｏ−アシル化ヌクレオシド
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US8716263B2 (en) 2008-12-23 2014-05-06 Gilead Pharmasset Llc Synthesis of purine nucleosides
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US8551973B2 (en) 2008-12-23 2013-10-08 Gilead Pharmasset Llc Nucleoside analogs
CA2749394A1 (en) 2009-01-09 2010-07-15 University College Of Cardiff Consultants Limited Phosphoramidate derivatives of guanosine nucleoside compounds for treatment of viral infections
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Also Published As

Publication number Publication date
WO2004058792A1 (en) 2004-07-15
PL377608A1 (pl) 2006-02-06
NZ540913A (en) 2008-02-29
IL169314A0 (en) 2007-07-04
KR20050110611A (ko) 2005-11-23
BR0316868A (pt) 2005-10-25
CN100335492C (zh) 2007-09-05
CN1751058A (zh) 2006-03-22
NO20053557L (no) 2005-09-08
ZA200505040B (en) 2006-04-26
MXPA05006865A (es) 2005-12-12
EP1575971A1 (en) 2005-09-21
CA2511616A1 (en) 2004-07-15
US20040181051A1 (en) 2004-09-16
RU2005123395A (ru) 2006-01-27
EP1575971A4 (en) 2008-03-05
JP2006514038A (ja) 2006-04-27

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Legal Events

Date Code Title Description
MK4 Application lapsed section 142(2)(d) - no continuation fee paid for the application