AU2003299683B2 - Biocompatible dialysis fluids containing icodextrins - Google Patents
Biocompatible dialysis fluids containing icodextrins Download PDFInfo
- Publication number
- AU2003299683B2 AU2003299683B2 AU2003299683A AU2003299683A AU2003299683B2 AU 2003299683 B2 AU2003299683 B2 AU 2003299683B2 AU 2003299683 A AU2003299683 A AU 2003299683A AU 2003299683 A AU2003299683 A AU 2003299683A AU 2003299683 B2 AU2003299683 B2 AU 2003299683B2
- Authority
- AU
- Australia
- Prior art keywords
- solution
- ranging
- icodextrin
- peritoneal dialysis
- lactate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229920002177 Icodextrin Polymers 0.000 title claims description 49
- 238000000502 dialysis Methods 0.000 title description 38
- 239000012530 fluid Substances 0.000 title description 9
- 239000000243 solution Substances 0.000 claims description 91
- 229940016836 icodextrin Drugs 0.000 claims description 47
- 239000000385 dialysis solution Substances 0.000 claims description 23
- 239000007853 buffer solution Substances 0.000 claims description 22
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims description 15
- 238000001802 infusion Methods 0.000 claims description 14
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 claims description 9
- 150000001413 amino acids Chemical class 0.000 claims description 5
- 239000000872 buffer Substances 0.000 claims description 4
- 150000007522 mineralic acids Chemical class 0.000 claims description 3
- 150000007524 organic acids Chemical class 0.000 claims description 3
- 238000010979 pH adjustment Methods 0.000 claims description 3
- 239000003795 chemical substances by application Substances 0.000 claims 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 38
- 239000008103 glucose Substances 0.000 description 33
- 229920000642 polymer Polymers 0.000 description 29
- 238000002560 therapeutic procedure Methods 0.000 description 18
- 210000004369 blood Anatomy 0.000 description 16
- 239000008280 blood Substances 0.000 description 16
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 14
- 238000000034 method Methods 0.000 description 13
- 239000011259 mixed solution Substances 0.000 description 12
- 238000004659 sterilization and disinfection Methods 0.000 description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 11
- 230000008901 benefit Effects 0.000 description 10
- 238000001631 haemodialysis Methods 0.000 description 10
- 230000000322 hemodialysis Effects 0.000 description 10
- 239000000203 mixture Substances 0.000 description 10
- 230000001954 sterilising effect Effects 0.000 description 9
- 238000002156 mixing Methods 0.000 description 8
- CYDQOEWLBCCFJZ-UHFFFAOYSA-N 4-(4-fluorophenyl)oxane-4-carboxylic acid Chemical compound C=1C=C(F)C=CC=1C1(C(=O)O)CCOCC1 CYDQOEWLBCCFJZ-UHFFFAOYSA-N 0.000 description 7
- 238000002474 experimental method Methods 0.000 description 7
- 239000007789 gas Substances 0.000 description 7
- 210000004379 membrane Anatomy 0.000 description 7
- 239000012528 membrane Substances 0.000 description 7
- 239000011780 sodium chloride Substances 0.000 description 7
- 239000001540 sodium lactate Substances 0.000 description 7
- 229940005581 sodium lactate Drugs 0.000 description 7
- 235000011088 sodium lactate Nutrition 0.000 description 7
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 6
- 239000002253 acid Substances 0.000 description 6
- 230000004888 barrier function Effects 0.000 description 6
- 239000011575 calcium Substances 0.000 description 6
- 229910052791 calcium Inorganic materials 0.000 description 6
- 238000002615 hemofiltration Methods 0.000 description 6
- 239000000463 material Substances 0.000 description 6
- 239000002357 osmotic agent Substances 0.000 description 6
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 5
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 5
- 229960005069 calcium Drugs 0.000 description 5
- 239000008121 dextrose Substances 0.000 description 5
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 5
- 229940001447 lactate Drugs 0.000 description 5
- 239000011777 magnesium Substances 0.000 description 5
- 229910052749 magnesium Inorganic materials 0.000 description 5
- 229940050906 magnesium chloride hexahydrate Drugs 0.000 description 5
- DHRRIBDTHFBPNG-UHFFFAOYSA-L magnesium dichloride hexahydrate Chemical compound O.O.O.O.O.O.[Mg+2].[Cl-].[Cl-] DHRRIBDTHFBPNG-UHFFFAOYSA-L 0.000 description 5
- 229940091250 magnesium supplement Drugs 0.000 description 5
- 239000011734 sodium Substances 0.000 description 5
- 229910052708 sodium Inorganic materials 0.000 description 5
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 4
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 4
- 208000001647 Renal Insufficiency Diseases 0.000 description 4
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 4
- LLSDKQJKOVVTOJ-UHFFFAOYSA-L calcium chloride dihydrate Chemical compound O.O.[Cl-].[Cl-].[Ca+2] LLSDKQJKOVVTOJ-UHFFFAOYSA-L 0.000 description 4
- 229940052299 calcium chloride dihydrate Drugs 0.000 description 4
- 230000015556 catabolic process Effects 0.000 description 4
- 239000007857 degradation product Substances 0.000 description 4
- 238000006731 degradation reaction Methods 0.000 description 4
- -1 for example Polymers 0.000 description 4
- 201000006370 kidney failure Diseases 0.000 description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 4
- 238000013160 medical therapy Methods 0.000 description 4
- 210000004303 peritoneum Anatomy 0.000 description 4
- 238000000108 ultra-filtration Methods 0.000 description 4
- 239000002699 waste material Substances 0.000 description 4
- 108010005094 Advanced Glycation End Products Proteins 0.000 description 3
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 3
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 3
- 235000001014 amino acid Nutrition 0.000 description 3
- 208000020832 chronic kidney disease Diseases 0.000 description 3
- 239000000470 constituent Substances 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 238000012959 renal replacement therapy Methods 0.000 description 3
- 235000017557 sodium bicarbonate Nutrition 0.000 description 3
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 3
- 239000003053 toxin Substances 0.000 description 3
- 231100000765 toxin Toxicity 0.000 description 3
- 108700012359 toxins Proteins 0.000 description 3
- 238000011282 treatment Methods 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 2
- 239000004471 Glycine Substances 0.000 description 2
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 2
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 2
- 229920001328 Polyvinylidene chloride Polymers 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- 235000004279 alanine Nutrition 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 229960002713 calcium chloride Drugs 0.000 description 2
- 239000001110 calcium chloride Substances 0.000 description 2
- 229910001628 calcium chloride Inorganic materials 0.000 description 2
- 239000012141 concentrate Substances 0.000 description 2
- 238000011340 continuous therapy Methods 0.000 description 2
- 238000011975 continuous veno-venous hemodiafiltration Methods 0.000 description 2
- 238000011974 continuous veno-venous hemodialysis Methods 0.000 description 2
- 238000011973 continuous veno-venous hemofiltration Methods 0.000 description 2
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- BFMKFCLXZSUVPI-UHFFFAOYSA-N ethyl but-3-enoate Chemical compound CCOC(=O)CC=C BFMKFCLXZSUVPI-UHFFFAOYSA-N 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 230000007062 hydrolysis Effects 0.000 description 2
- 238000006460 hydrolysis reaction Methods 0.000 description 2
- 239000003978 infusion fluid Substances 0.000 description 2
- 239000000543 intermediate Substances 0.000 description 2
- 239000004310 lactic acid Substances 0.000 description 2
- 235000014655 lactic acid Nutrition 0.000 description 2
- 230000002503 metabolic effect Effects 0.000 description 2
- 230000003204 osmotic effect Effects 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 235000002639 sodium chloride Nutrition 0.000 description 2
- 239000003381 stabilizer Substances 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 description 1
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 210000000476 body water Anatomy 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 208000022831 chronic renal failure syndrome Diseases 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 239000012611 container material Substances 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 229940109239 creatinine Drugs 0.000 description 1
- 231100000433 cytotoxic Toxicity 0.000 description 1
- 230000001472 cytotoxic effect Effects 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 230000003467 diminishing effect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 229940021013 electrolyte solution Drugs 0.000 description 1
- 239000008151 electrolyte solution Substances 0.000 description 1
- 208000028208 end stage renal disease Diseases 0.000 description 1
- 201000000523 end stage renal failure Diseases 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 229910001385 heavy metal Inorganic materials 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 208000017169 kidney disease Diseases 0.000 description 1
- 150000003893 lactate salts Chemical group 0.000 description 1
- 150000002605 large molecules Chemical class 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 229960002337 magnesium chloride Drugs 0.000 description 1
- 229910001629 magnesium chloride Inorganic materials 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000008155 medical solution Substances 0.000 description 1
- 210000005033 mesothelial cell Anatomy 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 210000003200 peritoneal cavity Anatomy 0.000 description 1
- 239000003330 peritoneal dialysis fluid Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 210000005227 renal system Anatomy 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000004102 tricarboxylic acid cycle Effects 0.000 description 1
- 150000004043 trisaccharides Chemical class 0.000 description 1
- 229940045136 urea Drugs 0.000 description 1
- 229940116269 uric acid Drugs 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/724—Cyclodextrins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/718—Starch or degraded starch, e.g. amylose, amylopectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/28—Peritoneal dialysis ; Other peritoneal treatment, e.g. oxygenation
- A61M1/287—Dialysates therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Vascular Medicine (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Medicinal Preparation (AREA)
- External Artificial Organs (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/327,264 | 2002-12-20 | ||
| US10/327,264 US20040121982A1 (en) | 2002-12-20 | 2002-12-20 | Biocompatible dialysis fluids containing icodextrins |
| PCT/US2003/040336 WO2004058277A1 (en) | 2002-12-20 | 2003-12-18 | Biocompatible dialysis fluids containing icodextrins |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2003299683A1 AU2003299683A1 (en) | 2004-07-22 |
| AU2003299683B2 true AU2003299683B2 (en) | 2008-10-02 |
Family
ID=32594208
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2003299683A Expired AU2003299683B2 (en) | 2002-12-20 | 2003-12-18 | Biocompatible dialysis fluids containing icodextrins |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US20040121982A1 (https=) |
| EP (1) | EP1585531B1 (https=) |
| JP (5) | JP4719470B2 (https=) |
| KR (1) | KR101130017B1 (https=) |
| CN (2) | CN101843634B (https=) |
| AR (1) | AR042795A1 (https=) |
| AU (1) | AU2003299683B2 (https=) |
| BR (1) | BR0317450A (https=) |
| CA (1) | CA2510788A1 (https=) |
| ES (1) | ES2755946T3 (https=) |
| MX (1) | MXPA05006634A (https=) |
| SG (1) | SG169228A1 (https=) |
| TW (1) | TWI309569B (https=) |
| WO (1) | WO2004058277A1 (https=) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050245612A1 (en) | 2004-05-03 | 2005-11-03 | Blass John P | Pharmaceutical compositions for metabolic insufficiencies |
| US20040121982A1 (en) * | 2002-12-20 | 2004-06-24 | Leo Martis | Biocompatible dialysis fluids containing icodextrins |
| GB0325292D0 (en) * | 2003-10-29 | 2003-12-03 | Wivenhoe Technology Ltd | Treatment of sugar solutions |
| US7118857B2 (en) | 2004-02-27 | 2006-10-10 | Baxter International Inc. | Methods and compositions for detection of microbial contaminants in peritoneal dialysis solutions |
| US20050276868A1 (en) * | 2004-06-10 | 2005-12-15 | Bart Degreve | Bicarbonate-based peritoneal dialysis solutions |
| US8202248B2 (en) | 2004-08-18 | 2012-06-19 | Sequana Medical Ag | Dialysis implant and methods of use |
| US7935070B2 (en) | 2005-01-28 | 2011-05-03 | Fresenius Medical Care North America | Systems and methods for dextrose containing peritoneal dialysis (PD) solutions with neutral pH and reduced glucose degradation product |
| ES2338257T3 (es) * | 2005-09-29 | 2010-05-05 | Alcon, Inc. | Sistema de envasado de solucion de doble camara. |
| US8740034B2 (en) | 2010-09-30 | 2014-06-03 | Ethicon Endo-Surgery, Inc. | Surgical stapling instrument with interchangeable staple cartridge arrangements |
| US9585810B2 (en) | 2010-10-14 | 2017-03-07 | Fresenius Medical Care Holdings, Inc. | Systems and methods for delivery of peritoneal dialysis (PD) solutions with integrated inter-chamber diffuser |
| CN103732233B (zh) | 2011-03-18 | 2016-08-10 | 贝克斯特国际公司 | 包含葡萄糖聚合物的腹膜透析溶液 |
| USD699343S1 (en) | 2011-12-20 | 2014-02-11 | Alcon Research, Ltd. | Irrigation solution bag |
| EP2609918A1 (en) * | 2011-12-27 | 2013-07-03 | Zytoprotec GmbH | Peritoneal dialysis fluid comprising a GSK-3 inhibitor |
| US8585635B2 (en) | 2012-02-15 | 2013-11-19 | Sequana Medical Ag | Systems and methods for treating chronic liver failure based on peritoneal dialysis |
| EP2926835B1 (en) * | 2012-11-27 | 2019-03-20 | Terumo Kabushiki Kaisha | Peritoneal dialysis fluid |
| WO2014083613A1 (ja) | 2012-11-27 | 2014-06-05 | テルモ株式会社 | 腹膜透析液 |
| JP6216777B2 (ja) * | 2013-04-02 | 2017-10-18 | テルモ株式会社 | 腹膜透析液 |
| JP6313653B2 (ja) * | 2014-05-19 | 2018-04-18 | テルモ株式会社 | 腹膜透析液 |
| JP6419615B2 (ja) * | 2015-03-19 | 2018-11-07 | テルモ株式会社 | 腹膜透析液 |
| JP2018519031A (ja) * | 2015-05-28 | 2018-07-19 | クック・メディカル・テクノロジーズ・リミテッド・ライアビリティ・カンパニーＣｏｏｋ Ｍｅｄｉｃａｌ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｌｌｃ | 腹膜透析システムおよび方法 |
| US12491301B2 (en) * | 2016-04-04 | 2025-12-09 | Mozarc Medical Us Llc | Peritoneal dialysate preparation and sensor system |
| US10994064B2 (en) | 2016-08-10 | 2021-05-04 | Medtronic, Inc. | Peritoneal dialysate flow path sensing |
| EP3439710A1 (en) * | 2016-04-04 | 2019-02-13 | Medtronic Inc. | Regenerative peritoneal dialysis system |
| US20170281846A1 (en) * | 2016-04-04 | 2017-10-05 | Medtronic, Inc. | Peritoneal dialysate fluid generation system with integrated cycler |
| JP6925362B2 (ja) * | 2016-04-04 | 2021-08-25 | メドトロニック，インコーポレイテッド | 腹膜透析液流体生成システム |
| US12329892B2 (en) | 2016-04-04 | 2025-06-17 | Mozarc Medical Us Llc | Dextrose concentration sensor for a peritoneal dialysis system |
| JP6944932B2 (ja) * | 2016-06-09 | 2021-10-06 | テルモ株式会社 | 生体適合性腹膜透析液 |
| CN107550928A (zh) * | 2016-06-30 | 2018-01-09 | 华仁药业股份有限公司 | 一种葡萄糖聚合物腹膜透析液及其制备工艺 |
| AU2017316520A1 (en) | 2016-08-26 | 2019-03-14 | Sequana Medical Nv | Systems and methods for managing and analyzing data generated by an implantable device |
| FR3055898B1 (fr) * | 2016-09-15 | 2018-11-02 | Roquette Freres | Nouveaux polymeres de glucose pour dialyse peritoneale |
| EP3381484A1 (en) | 2017-03-31 | 2018-10-03 | Opterion Health AG | Carbohydrate composition for dialysis |
| EP3603675A4 (en) * | 2017-03-31 | 2020-09-02 | Terumo Kabushiki Kaisha | SOLUTION FOR PERITONEAL DIALYSIS |
| JP7562410B2 (ja) * | 2017-05-24 | 2024-10-07 | セクアナ メディカル エヌブイ | 心不全患者の体液過剰を軽減するための直接ナトリウム除去方法、溶液、及び装置 |
| US11559618B2 (en) | 2017-05-24 | 2023-01-24 | Sequana Medical Nv | Formulations and methods for direct sodium removal in patients having severe renal dysfunction |
| CN109528760A (zh) * | 2018-11-13 | 2019-03-29 | 华仁药业股份有限公司 | 一种艾考糊精腹膜透析液及其制备方法 |
| US11965763B2 (en) | 2021-11-12 | 2024-04-23 | Mozarc Medical Us Llc | Determining fluid flow across rotary pump |
| CN120053479A (zh) * | 2025-02-18 | 2025-05-30 | 石家庄四药有限公司 | 一种中性腹膜透析液及其制备方法 |
| CN120661750B (zh) * | 2025-07-01 | 2026-01-02 | 青岛力腾医药科技有限公司 | 一种含艾考糊精的腹腔手术或腹腔镜手术用防粘连液及其制备方法 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5092838A (en) * | 1989-11-30 | 1992-03-03 | Baxter International Inc. | Histidine buffered peritoneal dialysis solution |
| US5536469A (en) * | 1991-11-18 | 1996-07-16 | Gambro Ab | System employing a sterile medical solution containing glucose or glucose-like compounds and a solution intended for said system |
| US5827820A (en) * | 1992-04-06 | 1998-10-27 | Baxter International Inc. | Aqueous peritoneal dialysis solution |
Family Cites Families (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3878664A (en) * | 1972-11-27 | 1975-04-22 | Cybersol | Process for producing a therapeutic composition |
| US3993751A (en) * | 1972-11-27 | 1976-11-23 | Cybersol, Inc. | Process for stabilizing therapeutic compositions and article |
| CA1017249A (en) * | 1973-12-19 | 1977-09-13 | Chemo Drug Company | Injectable electrolyte solutions |
| US3974034A (en) * | 1975-09-12 | 1976-08-10 | Cpc International Inc. | Malto-dextrins of improved stability prepared by enzymatic hydrolysis of oxidized starch |
| US4182756A (en) * | 1977-11-21 | 1980-01-08 | Abbott Laboratories | High calorie solutions of low molecular weight glucose polymer mixtures useful for intravenous administration |
| US4326955A (en) * | 1979-06-14 | 1982-04-27 | Diachem, Inc. | Hemodialysis with sodium bicarbonate dialysate prepared in plural stages |
| US4756838A (en) * | 1980-02-21 | 1988-07-12 | Veltman Preston Leonard | Preparation of dry dialysate products |
| US4489535A (en) * | 1980-10-02 | 1984-12-25 | Veltman Preston Leonard | Materials and method for preparing dialysis solutions containing bicarbonate ions |
| US4339433A (en) * | 1981-01-09 | 1982-07-13 | Baxter Travenol Laboratories, Inc. | Additives for peritoneal dialysis solutions |
| US4761237A (en) * | 1981-07-10 | 1988-08-02 | Baxter Travenol Laboratories, Inc. | Peritoneal dialysis solution containing carbohydrate polymers |
| US4879280A (en) * | 1981-09-24 | 1989-11-07 | Fresenius Ag | Dialysis solution for use in intraperitoneal dialysis |
| US6077836A (en) * | 1983-01-12 | 2000-06-20 | Ml Laboratotries, Plc | Peritoneal dialysis and compositions for use therein |
| US4886789A (en) * | 1983-01-12 | 1989-12-12 | M. L. Laboratories Plc | Peritoneal dialysis and compositions for use therein |
| US4604379A (en) * | 1984-06-18 | 1986-08-05 | Curators Of The University Of Missouri | Dialysis solutions containing cross-linked gelatin |
| US4668400A (en) * | 1984-06-22 | 1987-05-26 | Veech Richard L | Hemodialysis processes and hemodialysis solutions |
| US6020007A (en) * | 1984-06-22 | 2000-02-01 | Btg International Limited | Fluid therapy with l-lactate and/or pyruvate anions |
| JPS61502943A (ja) * | 1984-06-22 | 1986-12-18 | ビ−チ、リチャ−ド・エル | 電解質溶液およびその生体内における使用 |
| JPS61247466A (ja) * | 1985-04-25 | 1986-11-04 | テルモ株式会社 | 腹膜透析用透析液 |
| US6248726B1 (en) * | 1985-06-22 | 2001-06-19 | M L Laboratories Plc | Method of peritoneal dialysis using glucose polymer solutions |
| US5091094A (en) * | 1985-06-24 | 1992-02-25 | Veech Richard L | Hemodialysis processes & hemodialysis solutions |
| GB8521712D0 (en) * | 1985-08-31 | 1985-10-02 | Giltech Ltd | Solution for peritoneal dialysis |
| DE3683583D1 (de) * | 1985-09-10 | 1992-03-05 | Res Corp Technologies Inc | Osmotische mittel fuer peritonealdialyse. |
| JPS63502274A (ja) * | 1985-12-18 | 1988-09-01 | ビ−チ，リチヤ−ド エル | Ｌ↓−乳酸および／またはピルビン酸アニオンを用いた流体式治療法 |
| US4976683A (en) * | 1986-06-20 | 1990-12-11 | Abbott Laboratories | Peritoneal dialysis method |
| GR870129B (en) * | 1987-01-27 | 1987-02-04 | Giatzidis Ippokratis | Stable bicarbonate - glycylglycine dialysate for hemodialysis and peritoneal dialysis |
| DE3812525C1 (https=) * | 1988-04-15 | 1989-06-22 | Fresenius Ag, 6380 Bad Homburg, De | |
| DE3917251A1 (de) * | 1989-05-26 | 1990-11-29 | Fresenius Ag | Natriumbicarbonat enthaltendes konzentrat sowie verfahren zur herstellung einer dialysierfluessigkeit |
| AU627309B2 (en) * | 1989-05-26 | 1992-08-20 | Terumo Kabushiki Kaisha | Preparation for blood dialysis and method for production thereof |
| US5071558A (en) * | 1989-08-11 | 1991-12-10 | Nikkiso Co., Ltd. | Sodium bicarbonate dialysate |
| SE505967C2 (sv) * | 1990-10-15 | 1997-10-27 | Gambro Ab | Förfarande respektive anläggning för beredning av en medicinsk lösning, t ex en dialyslösning |
| DE4125819A1 (de) * | 1991-08-03 | 1993-02-04 | Rolf Prof Dr Med Zander | Waessrige loesung und deren verwendung |
| DE69320078T2 (de) * | 1992-02-04 | 1999-03-25 | Baxter International Inc., Deerfield, Ill. 60015 | Peritonealdialyselösungen die mindestens ein Dipeptid enthalten |
| EP0564672B2 (de) * | 1992-04-06 | 1999-05-06 | Baxter International Inc. | Wässrige Peritonealdialyse-Lösung |
| US5616248A (en) * | 1992-04-06 | 1997-04-01 | Schal; Wilfried | Method for the preparation of hemodialysis fluids containing bicarbonate |
| DE4242926C2 (de) * | 1992-12-18 | 1994-12-15 | Fresenius Ag | Dialyselösung für die Peritonealdialyse |
| SG48090A1 (en) * | 1993-01-19 | 1998-04-17 | Baxter Int | Multiple chamber container |
| US5436232A (en) * | 1994-01-07 | 1995-07-25 | Laevosan-Gesellschaft Mbh | Pharmaceutical composition for peritoneal dialysis |
| US6306836B1 (en) * | 1994-01-21 | 2001-10-23 | Baxter International Inc. | Peritoneal dialysis solutions containing maltodextrins and amino acids |
| GB9411009D0 (en) * | 1994-06-02 | 1994-07-20 | Giltech Ltd | Dialysis fluid |
| SE510030C2 (sv) * | 1995-08-08 | 1999-04-12 | Gambro Ab | Förfarande för blandning av steril medicinsk lösning samt behållare för utförande av förfarandet |
| CA2155910C (en) * | 1995-08-11 | 1999-12-14 | George Wu | Biocompatible aqueous solution for use in continuous ambulatory peritoneal dialysis |
| JP3623294B2 (ja) * | 1995-11-28 | 2005-02-23 | 株式会社新素材総合研究所 | 電解質液が収容された医療用容器及びその製造方法 |
| SE9600631D0 (sv) * | 1996-02-20 | 1996-02-20 | Gambro Ab | Use of a solution comprising glucose for peritonial dialysis having reduced formation of AGE products |
| AR006049A1 (es) * | 1996-03-01 | 1999-07-21 | Johnson & Johnson Consumer | Una emulsion de aceite en agua |
| DE19631124A1 (de) * | 1996-08-01 | 1998-02-05 | Fresenius Medical Care De Gmbh | Verfahren zur Herstellung einer Bicarbonat enthaltenden Infusions- oder Dialysierlösung |
| GB9714218D0 (en) * | 1997-07-04 | 1997-09-10 | Allied Therapeutics Ltd | Peritoneal dialysis fluid |
| WO1999009953A1 (fr) * | 1997-08-22 | 1999-03-04 | Shimizu Pharmaceutical Co., Ltd. | Preparation contenant du glucose |
| SE510587C2 (sv) * | 1997-10-07 | 1999-06-07 | Gambro Lundia Ab | Koncentrat för dialyslösning och användning därav |
| DE19748290B8 (de) * | 1997-10-31 | 2009-09-03 | Fresenius Medical Care Deutschland Gmbh | Lösung für die Peritonealdialyse |
| DE69929550T8 (de) * | 1998-05-21 | 2006-12-28 | Nipro Corp. | Albumin enthaltende Lösung für die Peritonealdialyse |
| DE69929555T8 (de) * | 1998-06-17 | 2007-05-31 | Nipro Corp. | Verwendung einer Flüssigkeit zur Herstellung einer Dialyselösung für die kontinuierliche rezirkulierende Peritonealdialyse |
| SE521219C2 (sv) * | 1998-10-23 | 2003-10-14 | Gambro Ab | Metod och anordning för att reducera nedbrytning av värmekänsliga komponenter i medicinska substanser under värmesterilisering |
| DE69815113T2 (de) * | 1998-12-04 | 2004-04-08 | Lucent Technologies Inc. | Fehlerverschleierung und -korrektur für Sprach-, Bild- und Videosignale |
| US6770148B1 (en) * | 1998-12-04 | 2004-08-03 | Baxter International Inc. | Peritoneal dialysis solution containing modified icodextrins |
| JP4284737B2 (ja) * | 1999-02-26 | 2009-06-24 | 株式会社ジェイ・エム・エス | 中性腹膜透析液 |
| DE19912850B4 (de) * | 1999-03-22 | 2005-04-07 | Fresenius Medical Care Deutschland Gmbh | Lösung, insbesondere für Hämo- oder Peritonealdialyse, sowie Verfahren zu deren Herstellung |
| EP1165148A1 (en) * | 1999-03-30 | 2002-01-02 | Gambro Lundia AB | Method and apparatus for sterilising a heat sensitive fluid |
| US6251437B1 (en) * | 1999-07-13 | 2001-06-26 | Minntech Corporation | Liquid/powder acid concentrate for dialysate and a method of making the same |
| US6309673B1 (en) * | 1999-09-10 | 2001-10-30 | Baxter International Inc. | Bicarbonate-based solution in two parts for peritoneal dialysis or substitution in continuous renal replacement therapy |
| US20030202958A1 (en) * | 1999-10-15 | 2003-10-30 | Strickland Alan D. | Dialysis solution including polyglycol osmotic agent |
| DE19955578C1 (de) * | 1999-11-18 | 2001-09-06 | Fresenius Medical Care De Gmbh | Mehrkammerbehälter, mit Glucosekonzentratkompartiment und Salzsäurekonzentratkompartiment |
| US6582734B1 (en) * | 2000-07-20 | 2003-06-24 | Ecolab Inc. | Antimicrobial composition useful for the treatment of bovine mastitis |
| US20020077579A1 (en) * | 2000-12-20 | 2002-06-20 | Sheldon Tobe | Sterile bicarbonate-free dialysis concentrate solutions |
| US6787039B2 (en) * | 2001-01-26 | 2004-09-07 | Degussa Ag | Amino acid composition for hemodialysis |
| EP1377594A4 (en) * | 2001-04-10 | 2004-06-30 | Danisco Usa Inc | POLYMERIZATION OF MONO- AND DISACCHARIDES WITH MONOCARBOXYLIC ACIDS AND LACTONES |
| ITMI20020516A1 (it) * | 2002-03-12 | 2003-09-12 | Gambro Lundia Ab | Liquidi per dialisi peritoneale emodialisi e reintegrazione |
| DE10217356B4 (de) * | 2002-04-18 | 2012-03-29 | Fresenius Medical Care Deutschland Gmbh | Lösung für die Peritonealdialyse |
| US20040121982A1 (en) * | 2002-12-20 | 2004-06-24 | Leo Martis | Biocompatible dialysis fluids containing icodextrins |
-
2002
- 2002-12-20 US US10/327,264 patent/US20040121982A1/en not_active Abandoned
-
2003
- 2003-12-18 EP EP03799967.9A patent/EP1585531B1/en not_active Expired - Lifetime
- 2003-12-18 AU AU2003299683A patent/AU2003299683B2/en not_active Expired
- 2003-12-18 KR KR1020057011217A patent/KR101130017B1/ko not_active Expired - Lifetime
- 2003-12-18 CN CN2010101569399A patent/CN101843634B/zh not_active Expired - Lifetime
- 2003-12-18 SG SG200607298-7A patent/SG169228A1/en unknown
- 2003-12-18 JP JP2004563745A patent/JP4719470B2/ja not_active Expired - Lifetime
- 2003-12-18 BR BR0317450-6A patent/BR0317450A/pt not_active Application Discontinuation
- 2003-12-18 CA CA002510788A patent/CA2510788A1/en not_active Abandoned
- 2003-12-18 ES ES03799967T patent/ES2755946T3/es not_active Expired - Lifetime
- 2003-12-18 MX MXPA05006634A patent/MXPA05006634A/es active IP Right Grant
- 2003-12-18 CN CN2003801066186A patent/CN1767838B/zh not_active Expired - Lifetime
- 2003-12-18 WO PCT/US2003/040336 patent/WO2004058277A1/en not_active Ceased
- 2003-12-19 TW TW092136126A patent/TWI309569B/zh not_active IP Right Cessation
- 2003-12-22 AR ARP030104789A patent/AR042795A1/es not_active Application Discontinuation
-
2006
- 2006-02-10 US US11/351,922 patent/US20060128658A1/en not_active Abandoned
-
2010
- 2010-03-12 JP JP2010056524A patent/JP2010150281A/ja not_active Withdrawn
-
2013
- 2013-03-04 JP JP2013041474A patent/JP5815581B2/ja not_active Expired - Lifetime
-
2014
- 2014-05-29 JP JP2014111346A patent/JP5947334B2/ja not_active Expired - Lifetime
-
2016
- 2016-04-18 JP JP2016082908A patent/JP2016166229A/ja not_active Withdrawn
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5092838A (en) * | 1989-11-30 | 1992-03-03 | Baxter International Inc. | Histidine buffered peritoneal dialysis solution |
| US5536469A (en) * | 1991-11-18 | 1996-07-16 | Gambro Ab | System employing a sterile medical solution containing glucose or glucose-like compounds and a solution intended for said system |
| US5827820A (en) * | 1992-04-06 | 1998-10-27 | Baxter International Inc. | Aqueous peritoneal dialysis solution |
Non-Patent Citations (1)
| Title |
|---|
| Peers E et al., Artificial Organs, 1998, Vol 22, No1, pp8-12 * |
Also Published As
| Publication number | Publication date |
|---|---|
| US20060128658A1 (en) | 2006-06-15 |
| JP2006513211A (ja) | 2006-04-20 |
| EP1585531B1 (en) | 2019-09-11 |
| CN1767838B (zh) | 2010-05-26 |
| AR042795A1 (es) | 2005-07-06 |
| SG169228A1 (en) | 2011-03-30 |
| EP1585531A1 (en) | 2005-10-19 |
| JP2014210780A (ja) | 2014-11-13 |
| JP4719470B2 (ja) | 2011-07-06 |
| WO2004058277A1 (en) | 2004-07-15 |
| CN101843634B (zh) | 2012-07-18 |
| JP2010150281A (ja) | 2010-07-08 |
| TWI309569B (en) | 2009-05-11 |
| CN1767838A (zh) | 2006-05-03 |
| JP2016166229A (ja) | 2016-09-15 |
| US20040121982A1 (en) | 2004-06-24 |
| JP5815581B2 (ja) | 2015-11-17 |
| JP2013116352A (ja) | 2013-06-13 |
| BR0317450A (pt) | 2005-11-16 |
| KR20050089833A (ko) | 2005-09-08 |
| CN101843634A (zh) | 2010-09-29 |
| KR101130017B1 (ko) | 2012-04-20 |
| JP5947334B2 (ja) | 2016-07-06 |
| ES2755946T3 (es) | 2020-04-24 |
| TW200422045A (en) | 2004-11-01 |
| CA2510788A1 (en) | 2004-07-15 |
| HK1088535A1 (en) | 2006-11-10 |
| AU2003299683A1 (en) | 2004-07-22 |
| MXPA05006634A (es) | 2005-09-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2003299683B2 (en) | Biocompatible dialysis fluids containing icodextrins | |
| JP5690040B2 (ja) | 重炭酸塩ベースの腹膜透析溶液 | |
| US5906978A (en) | Method for iron delivery to a patient by transfer from dialysate | |
| US7053059B2 (en) | Dialysis solutions with reduced levels of glucose degradation products | |
| JP2009131669A (ja) | 単一容器中にある重炭酸塩ベースの溶液 | |
| HK1088535B (en) | Biocompatible dialysis fluids containing icodextrins | |
| JP2002165875A (ja) | 透析用補充製剤 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FGA | Letters patent sealed or granted (standard patent) | ||
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |