AU2003296596B2 - Halothenoyl-cyclopropane-1-carboxylic acid derivatives - Google Patents
Halothenoyl-cyclopropane-1-carboxylic acid derivatives Download PDFInfo
- Publication number
- AU2003296596B2 AU2003296596B2 AU2003296596A AU2003296596A AU2003296596B2 AU 2003296596 B2 AU2003296596 B2 AU 2003296596B2 AU 2003296596 A AU2003296596 A AU 2003296596A AU 2003296596 A AU2003296596 A AU 2003296596A AU 2003296596 B2 AU2003296596 B2 AU 2003296596B2
- Authority
- AU
- Australia
- Prior art keywords
- cyclopropane
- thenoyl
- chloro
- carboxylate
- residue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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- 125000002252 acyl group Chemical group 0.000 claims abstract description 3
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- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 229920001592 potato starch Polymers 0.000 description 1
- 210000000063 presynaptic terminal Anatomy 0.000 description 1
- 210000004129 prosencephalon Anatomy 0.000 description 1
- 125000006239 protecting group Chemical group 0.000 description 1
- 208000020016 psychiatric disease Diseases 0.000 description 1
- XHKUDCCTVQUHJQ-LCYSNFERSA-N quinidine D-gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.C([C@H]([C@H](C1)C=C)C2)C[N@@]1[C@H]2[C@@H](O)C1=CC=NC2=CC=C(OC)C=C21 XHKUDCCTVQUHJQ-LCYSNFERSA-N 0.000 description 1
- 150000004060 quinone imines Chemical class 0.000 description 1
- 230000006340 racemization Effects 0.000 description 1
- 201000000980 schizophrenia Diseases 0.000 description 1
- 230000036280 sedation Effects 0.000 description 1
- 230000036303 septic shock Effects 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 229920003109 sodium starch glycolate Polymers 0.000 description 1
- 229940079832 sodium starch glycolate Drugs 0.000 description 1
- 239000008109 sodium starch glycolate Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 210000000278 spinal cord Anatomy 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 229940032147 starch Drugs 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000004575 stone Substances 0.000 description 1
- 238000000859 sublimation Methods 0.000 description 1
- 230000008022 sublimation Effects 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 238000009495 sugar coating Methods 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 230000024587 synaptic transmission, glutamatergic Effects 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 108091008646 testicular receptors Proteins 0.000 description 1
- CZDYPVPMEAXLPK-UHFFFAOYSA-N tetramethylsilane Chemical compound C[Si](C)(C)C CZDYPVPMEAXLPK-UHFFFAOYSA-N 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 230000000472 traumatic effect Effects 0.000 description 1
- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1
- 241001430294 unidentified retrovirus Species 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 238000010626 work up procedure Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/28—Halogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02026597A EP1424333A1 (en) | 2002-11-28 | 2002-11-28 | Halothenoyl-cyclopropane-1-carboxylic acid derivatives |
| EP02026597.1 | 2002-11-28 | ||
| PCT/EP2003/013244 WO2004048361A1 (en) | 2002-11-28 | 2003-11-25 | Halothenoyl-cyclopropane-1-carboxylic acid derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2003296596A1 AU2003296596A1 (en) | 2004-06-18 |
| AU2003296596B2 true AU2003296596B2 (en) | 2010-03-04 |
Family
ID=32241303
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2003296596A Ceased AU2003296596B2 (en) | 2002-11-28 | 2003-11-25 | Halothenoyl-cyclopropane-1-carboxylic acid derivatives |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20060116329A1 (enExample) |
| EP (2) | EP1424333A1 (enExample) |
| JP (1) | JP4522864B2 (enExample) |
| AT (1) | ATE361921T1 (enExample) |
| AU (1) | AU2003296596B2 (enExample) |
| CA (1) | CA2507597A1 (enExample) |
| CY (1) | CY1106692T1 (enExample) |
| DE (1) | DE60313798T2 (enExample) |
| DK (1) | DK1565451T3 (enExample) |
| ES (1) | ES2286509T3 (enExample) |
| PT (1) | PT1565451E (enExample) |
| SI (1) | SI1565451T1 (enExample) |
| WO (1) | WO2004048361A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1475088A1 (en) * | 2003-05-05 | 2004-11-10 | Newron Pharmaceuticals S.p.A. | Use of kynurenine-3-hydroxylase inhibitors for the preparation of medicaments for the treatment of l-dopa induced movement disorders, dyskinesias, drug addiction, pain and cataract |
| GB2402940A (en) * | 2004-08-19 | 2004-12-22 | Pfizer Ltd | Biomarkers of inflammation and/or macrophage activation |
| JP2008535892A (ja) * | 2005-04-11 | 2008-09-04 | プロビオドルグ エージー | プロリルエンドペプチダーゼの阻害剤 |
| AR086992A1 (es) | 2011-06-20 | 2014-02-05 | Bayer Ip Gmbh | Tienilpiri(mi)dinilpirazoles |
| EP2833879A4 (en) | 2012-04-05 | 2016-03-02 | Chdi Foundation Inc | CYNURENINE-3-MONOOXYGENASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND METHOD OF USE THEREOF |
| EP3049389B1 (en) | 2013-09-26 | 2019-08-07 | CHDI Foundation, Inc. | Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof |
| JP2016536350A (ja) | 2013-09-26 | 2016-11-24 | シーエイチディーアイ ファウンデーション，インコーポレーテッド | キヌレニン−３−モノオキシゲナーゼ阻害薬、医薬組成物、及びこれらの使用方法 |
| GB201322512D0 (en) | 2013-12-19 | 2014-02-05 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
| GB201508864D0 (en) | 2015-05-22 | 2015-07-01 | Glaxosmithkline Ip Dev Ltd | Compounds |
| GB201508857D0 (en) | 2015-05-22 | 2015-07-01 | Glaxosmithkline Ip Dev Ltd | Compounds |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1278435B (de) * | 1965-01-19 | 1968-09-26 | Merck Ag E | Verfahren zur Herstellung von 1, 2-disubstituierten Cyclopropanderivaten |
| US4022903A (en) * | 1975-06-05 | 1977-05-10 | Abbott Laboratories | α-Thienyl and α-substituted thienyl, phenyl and substituted phenyl cyclopropylomethanols useful as biodegradable insecticides and mollusicides |
| US6274590B1 (en) * | 1993-01-15 | 2001-08-14 | G. D. Searle & Co. | Method of treating skin related conditions |
| JP4176150B2 (ja) * | 1996-10-30 | 2008-11-05 | 塩野義製薬株式会社 | グルタミン酸放出阻害剤および新規化合物 |
| GB9705031D0 (en) * | 1997-03-11 | 1997-04-30 | Pharmacia & Upjohn Spa | 2-substituted benzoyl-cycloalkyl-1-carboxylic acid derivatives |
-
2002
- 2002-11-28 EP EP02026597A patent/EP1424333A1/en not_active Withdrawn
-
2003
- 2003-11-25 US US10/536,307 patent/US20060116329A1/en not_active Abandoned
- 2003-11-25 CA CA002507597A patent/CA2507597A1/en not_active Abandoned
- 2003-11-25 ES ES03811772T patent/ES2286509T3/es not_active Expired - Lifetime
- 2003-11-25 PT PT03811772T patent/PT1565451E/pt unknown
- 2003-11-25 DK DK03811772T patent/DK1565451T3/da active
- 2003-11-25 JP JP2004554463A patent/JP4522864B2/ja not_active Expired - Fee Related
- 2003-11-25 AU AU2003296596A patent/AU2003296596B2/en not_active Ceased
- 2003-11-25 SI SI200330828T patent/SI1565451T1/sl unknown
- 2003-11-25 WO PCT/EP2003/013244 patent/WO2004048361A1/en not_active Ceased
- 2003-11-25 EP EP03811772A patent/EP1565451B1/en not_active Expired - Lifetime
- 2003-11-25 DE DE60313798T patent/DE60313798T2/de not_active Expired - Lifetime
- 2003-11-25 AT AT03811772T patent/ATE361921T1/de not_active IP Right Cessation
-
2007
- 2007-07-02 CY CY20071100873T patent/CY1106692T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE60313798D1 (en) | 2007-06-21 |
| DE60313798T2 (de) | 2008-01-24 |
| JP2006509753A (ja) | 2006-03-23 |
| EP1565451A1 (en) | 2005-08-24 |
| EP1424333A1 (en) | 2004-06-02 |
| WO2004048361A1 (en) | 2004-06-10 |
| ES2286509T3 (es) | 2007-12-01 |
| SI1565451T1 (sl) | 2007-08-31 |
| CA2507597A1 (en) | 2004-06-10 |
| US20060116329A1 (en) | 2006-06-01 |
| DK1565451T3 (da) | 2007-09-10 |
| EP1565451B1 (en) | 2007-05-09 |
| AU2003296596A1 (en) | 2004-06-18 |
| JP4522864B2 (ja) | 2010-08-11 |
| ATE361921T1 (de) | 2007-06-15 |
| CY1106692T1 (el) | 2012-05-23 |
| PT1565451E (pt) | 2007-08-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FGA | Letters patent sealed or granted (standard patent) | ||
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |