SI1565451T1 - Derivati halotienoil-ciklopropan-1-karboksilne kisline - Google Patents
Derivati halotienoil-ciklopropan-1-karboksilne kislineInfo
- Publication number
- SI1565451T1 SI1565451T1 SI200330828T SI200330828T SI1565451T1 SI 1565451 T1 SI1565451 T1 SI 1565451T1 SI 200330828 T SI200330828 T SI 200330828T SI 200330828 T SI200330828 T SI 200330828T SI 1565451 T1 SI1565451 T1 SI 1565451T1
- Authority
- SI
- Slovenia
- Prior art keywords
- branched
- linear
- alkyl
- halothienoyl
- cyclopropane
- Prior art date
Links
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 abstract 2
- 102100037652 Kynurenine 3-monooxygenase Human genes 0.000 abstract 2
- 108010033242 Kynurenine 3-monooxygenase Proteins 0.000 abstract 2
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 abstract 2
- 229930195712 glutamate Natural products 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 239000003112 inhibitor Substances 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 229960005070 ascorbic acid Drugs 0.000 abstract 1
- 235000010323 ascorbic acid Nutrition 0.000 abstract 1
- 239000011668 ascorbic acid Substances 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000003563 glycoside group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 230000005923 long-lasting effect Effects 0.000 abstract 1
- -1 phenoxy, benzyloxy Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/28—Halogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02026597A EP1424333A1 (en) | 2002-11-28 | 2002-11-28 | Halothenoyl-cyclopropane-1-carboxylic acid derivatives |
| EP03811772A EP1565451B1 (en) | 2002-11-28 | 2003-11-25 | Halothienoyl-cyclopropane-1-carboxylic acid derivatives |
| PCT/EP2003/013244 WO2004048361A1 (en) | 2002-11-28 | 2003-11-25 | Halothenoyl-cyclopropane-1-carboxylic acid derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI1565451T1 true SI1565451T1 (sl) | 2007-08-31 |
Family
ID=32241303
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI200330828T SI1565451T1 (sl) | 2002-11-28 | 2003-11-25 | Derivati halotienoil-ciklopropan-1-karboksilne kisline |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20060116329A1 (enExample) |
| EP (2) | EP1424333A1 (enExample) |
| JP (1) | JP4522864B2 (enExample) |
| AT (1) | ATE361921T1 (enExample) |
| AU (1) | AU2003296596B2 (enExample) |
| CA (1) | CA2507597A1 (enExample) |
| CY (1) | CY1106692T1 (enExample) |
| DE (1) | DE60313798T2 (enExample) |
| DK (1) | DK1565451T3 (enExample) |
| ES (1) | ES2286509T3 (enExample) |
| PT (1) | PT1565451E (enExample) |
| SI (1) | SI1565451T1 (enExample) |
| WO (1) | WO2004048361A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1475088A1 (en) * | 2003-05-05 | 2004-11-10 | Newron Pharmaceuticals S.p.A. | Use of kynurenine-3-hydroxylase inhibitors for the preparation of medicaments for the treatment of l-dopa induced movement disorders, dyskinesias, drug addiction, pain and cataract |
| GB2402940A (en) * | 2004-08-19 | 2004-12-22 | Pfizer Ltd | Biomarkers of inflammation and/or macrophage activation |
| JP2008535892A (ja) * | 2005-04-11 | 2008-09-04 | プロビオドルグ エージー | プロリルエンドペプチダーゼの阻害剤 |
| AR086992A1 (es) | 2011-06-20 | 2014-02-05 | Bayer Ip Gmbh | Tienilpiri(mi)dinilpirazoles |
| JP6275690B2 (ja) * | 2012-04-05 | 2018-02-07 | シーエイチディーアイ ファウンデーション，インコーポレーテッド | キヌレニン−３−モノオキシゲナーゼインヒビターおよびその医薬組成物ならびにこれらの使用方法 |
| JP6449893B2 (ja) * | 2013-09-26 | 2019-01-09 | シーエイチディーアイ ファウンデーション，インコーポレーテッド | キヌレニン−３−モノオキシゲナーゼ阻害薬、医薬組成物、及びこれらの使用方法 |
| JP2016536350A (ja) | 2013-09-26 | 2016-11-24 | シーエイチディーアイ ファウンデーション，インコーポレーテッド | キヌレニン−３−モノオキシゲナーゼ阻害薬、医薬組成物、及びこれらの使用方法 |
| GB201322512D0 (en) | 2013-12-19 | 2014-02-05 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
| GB201508857D0 (en) | 2015-05-22 | 2015-07-01 | Glaxosmithkline Ip Dev Ltd | Compounds |
| GB201508864D0 (en) | 2015-05-22 | 2015-07-01 | Glaxosmithkline Ip Dev Ltd | Compounds |
| PL450605A1 (pl) | 2024-12-16 | 2026-06-22 | Uniwersytet Łódzki | Zastosowanie inhibitorów enzymów szlaku kynureninowego jako regulatora wzrostu Trichophyton rubrum do zapobiegania lub leczenia grzybic, zwłaszcza wywołanych Trichophyton rubrum |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1278435B (de) * | 1965-01-19 | 1968-09-26 | Merck Ag E | Verfahren zur Herstellung von 1, 2-disubstituierten Cyclopropanderivaten |
| US4022903A (en) * | 1975-06-05 | 1977-05-10 | Abbott Laboratories | α-Thienyl and α-substituted thienyl, phenyl and substituted phenyl cyclopropylomethanols useful as biodegradable insecticides and mollusicides |
| US6274590B1 (en) * | 1993-01-15 | 2001-08-14 | G. D. Searle & Co. | Method of treating skin related conditions |
| JP4176150B2 (ja) * | 1996-10-30 | 2008-11-05 | 塩野義製薬株式会社 | グルタミン酸放出阻害剤および新規化合物 |
| GB9705031D0 (en) * | 1997-03-11 | 1997-04-30 | Pharmacia & Upjohn Spa | 2-substituted benzoyl-cycloalkyl-1-carboxylic acid derivatives |
-
2002
- 2002-11-28 EP EP02026597A patent/EP1424333A1/en not_active Withdrawn
-
2003
- 2003-11-25 CA CA002507597A patent/CA2507597A1/en not_active Abandoned
- 2003-11-25 JP JP2004554463A patent/JP4522864B2/ja not_active Expired - Fee Related
- 2003-11-25 DE DE60313798T patent/DE60313798T2/de not_active Expired - Lifetime
- 2003-11-25 WO PCT/EP2003/013244 patent/WO2004048361A1/en not_active Ceased
- 2003-11-25 AT AT03811772T patent/ATE361921T1/de not_active IP Right Cessation
- 2003-11-25 AU AU2003296596A patent/AU2003296596B2/en not_active Ceased
- 2003-11-25 SI SI200330828T patent/SI1565451T1/sl unknown
- 2003-11-25 US US10/536,307 patent/US20060116329A1/en not_active Abandoned
- 2003-11-25 PT PT03811772T patent/PT1565451E/pt unknown
- 2003-11-25 ES ES03811772T patent/ES2286509T3/es not_active Expired - Lifetime
- 2003-11-25 DK DK03811772T patent/DK1565451T3/da active
- 2003-11-25 EP EP03811772A patent/EP1565451B1/en not_active Expired - Lifetime
-
2007
- 2007-07-02 CY CY20071100873T patent/CY1106692T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP4522864B2 (ja) | 2010-08-11 |
| WO2004048361A1 (en) | 2004-06-10 |
| CY1106692T1 (el) | 2012-05-23 |
| AU2003296596B2 (en) | 2010-03-04 |
| DK1565451T3 (da) | 2007-09-10 |
| JP2006509753A (ja) | 2006-03-23 |
| DE60313798D1 (en) | 2007-06-21 |
| US20060116329A1 (en) | 2006-06-01 |
| PT1565451E (pt) | 2007-08-03 |
| CA2507597A1 (en) | 2004-06-10 |
| ES2286509T3 (es) | 2007-12-01 |
| EP1565451B1 (en) | 2007-05-09 |
| DE60313798T2 (de) | 2008-01-24 |
| ATE361921T1 (de) | 2007-06-15 |
| AU2003296596A1 (en) | 2004-06-18 |
| EP1565451A1 (en) | 2005-08-24 |
| EP1424333A1 (en) | 2004-06-02 |
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