AU2002364437B2 - Gel comprising at least a retinoid and benzoyl peroxide - Google Patents
Gel comprising at least a retinoid and benzoyl peroxide Download PDFInfo
- Publication number
- AU2002364437B2 AU2002364437B2 AU2002364437A AU2002364437A AU2002364437B2 AU 2002364437 B2 AU2002364437 B2 AU 2002364437B2 AU 2002364437 A AU2002364437 A AU 2002364437A AU 2002364437 A AU2002364437 A AU 2002364437A AU 2002364437 B2 AU2002364437 B2 AU 2002364437B2
- Authority
- AU
- Australia
- Prior art keywords
- composition according
- benzoyl peroxide
- retinoid
- stirring
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical compound C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 title claims description 87
- 239000004342 Benzoyl peroxide Substances 0.000 title claims description 86
- 235000019400 benzoyl peroxide Nutrition 0.000 title claims description 86
- 150000004492 retinoid derivatives Chemical class 0.000 title claims description 34
- 239000000203 mixture Substances 0.000 claims description 126
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical group CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 93
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 64
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 39
- 238000003756 stirring Methods 0.000 claims description 33
- 239000012071 phase Substances 0.000 claims description 23
- 239000003349 gelling agent Substances 0.000 claims description 22
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 21
- 206010000496 acne Diseases 0.000 claims description 18
- 238000002360 preparation method Methods 0.000 claims description 18
- 208000002874 Acne Vulgaris Diseases 0.000 claims description 17
- 239000003795 chemical substances by application Substances 0.000 claims description 17
- 229960002916 adapalene Drugs 0.000 claims description 16
- LZCDAPDGXCYOEH-UHFFFAOYSA-N adapalene Chemical compound C1=C(C(O)=O)C=CC2=CC(C3=CC=C(C(=C3)C34CC5CC(CC(C5)C3)C4)OC)=CC=C21 LZCDAPDGXCYOEH-UHFFFAOYSA-N 0.000 claims description 16
- 238000011282 treatment Methods 0.000 claims description 16
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- 230000000149 penetrating effect Effects 0.000 claims description 13
- BANXPJUEBPWEOT-UHFFFAOYSA-N 2-methyl-Pentadecane Chemical compound CCCCCCCCCCCCCC(C)C BANXPJUEBPWEOT-UHFFFAOYSA-N 0.000 claims description 12
- APSBXTVYXVQYAB-UHFFFAOYSA-M sodium docusate Chemical compound [Na+].CCCCC(CC)COC(=O)CC(S([O-])(=O)=O)C(=O)OCC(CC)CCCC APSBXTVYXVQYAB-UHFFFAOYSA-M 0.000 claims description 12
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- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 claims description 10
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- KUVMKLCGXIYSNH-UHFFFAOYSA-N isopentadecane Natural products CCCCCCCCCCCCC(C)C KUVMKLCGXIYSNH-UHFFFAOYSA-N 0.000 claims description 6
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- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 8
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- WMGSQTMJHBYJMQ-UHFFFAOYSA-N aluminum;magnesium;silicate Chemical compound [Mg+2].[Al+3].[O-][Si]([O-])([O-])[O-] WMGSQTMJHBYJMQ-UHFFFAOYSA-N 0.000 description 3
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- FWFUWXVFYKCSQA-UHFFFAOYSA-M sodium;2-methyl-2-(prop-2-enoylamino)propane-1-sulfonate Chemical compound [Na+].[O-]S(=O)(=O)CC(C)(C)NC(=O)C=C FWFUWXVFYKCSQA-UHFFFAOYSA-M 0.000 description 3
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- DWHIUNMOTRUVPG-UHFFFAOYSA-N 2-[2-[2-[2-[2-[2-(2-dodecoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol Chemical compound CCCCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCO DWHIUNMOTRUVPG-UHFFFAOYSA-N 0.000 description 2
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- 150000003408 sphingolipids Chemical class 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 230000000475 sunscreen effect Effects 0.000 description 1
- 239000000516 sunscreening agent Substances 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 201000004647 tinea pedis Diseases 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 150000003852 triazoles Chemical class 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/07—Retinol compounds, e.g. vitamin A
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/12—Keratolytics, e.g. wart or anti-corn preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Birds (AREA)
- Toxicology (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2008246274A AU2008246274B2 (en) | 2001-12-21 | 2008-11-21 | Gel comprising at least a retinoid and benzoyl peroxide |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0116747A FR2833841B1 (fr) | 2001-12-21 | 2001-12-21 | Gel comprenant au moins un retinoide et du peroxyde de benzoyle |
| FR0116747 | 2001-12-21 | ||
| PCT/FR2002/004233 WO2003055472A1 (fr) | 2001-12-21 | 2002-12-09 | Gel comprenant au moins un retinoide et du peroxyde de benzoyle |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2008246274A Division AU2008246274B2 (en) | 2001-12-21 | 2008-11-21 | Gel comprising at least a retinoid and benzoyl peroxide |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2002364437A1 AU2002364437A1 (en) | 2003-07-15 |
| AU2002364437B2 true AU2002364437B2 (en) | 2008-08-21 |
Family
ID=8870899
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2002364437A Expired AU2002364437B2 (en) | 2001-12-21 | 2002-12-09 | Gel comprising at least a retinoid and benzoyl peroxide |
| AU2008246274A Expired AU2008246274B2 (en) | 2001-12-21 | 2008-11-21 | Gel comprising at least a retinoid and benzoyl peroxide |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2008246274A Expired AU2008246274B2 (en) | 2001-12-21 | 2008-11-21 | Gel comprising at least a retinoid and benzoyl peroxide |
Country Status (22)
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20240299335A1 (en) * | 2022-03-14 | 2024-09-12 | Blue Hill Technologies Llc | Shelf-stable formulations of benzoyl peroxide and methods of producing same |
| US12357602B2 (en) | 2017-07-12 | 2025-07-15 | Mayne Pharma Llc | Compositions comprising encapsulated tretinoin |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7820186B2 (en) | 2001-12-21 | 2010-10-26 | Galderma Research & Development | Gel composition for once-daily treatment of common acne comprising a combination of benzoyl peroxide and adapalene and/or adapalene salt |
| FR2833841B1 (fr) * | 2001-12-21 | 2005-07-22 | Galderma Res & Dev | Gel comprenant au moins un retinoide et du peroxyde de benzoyle |
| EP1813312A3 (en) * | 2002-09-05 | 2010-03-24 | Galderma Research & Development | Depigmenting composition for the skin comprising adapalene and at least one depigmenting agent |
| US7544674B2 (en) | 2002-10-25 | 2009-06-09 | Galderma S.A. | Topical skin care composition |
| ATE467411T1 (de) * | 2004-11-09 | 2010-05-15 | Imaginative Res Associates Inc | Retinoidlösungen und formulierungen daraus |
| CA2617681C (en) | 2005-08-02 | 2015-02-03 | Sol-Gel Technologies Ltd. | Metal oxide coating of water insoluble ingredients |
| FR2889662B1 (fr) * | 2005-08-11 | 2011-01-14 | Galderma Res & Dev | Emulsion de type huile-dans-eau pour application topique en dermatologie |
| CA2616915A1 (en) * | 2005-09-02 | 2007-05-10 | Isabelle Pelisson | Depigmenting composition for the skin, comprising adapalene, at least one depigmenting agent and at least one anti-inflammatory agent |
| FR2890314B1 (fr) * | 2005-09-02 | 2009-03-20 | Galderma Res & Dev | Compositiondepigmentante de la peau comprenant de l'adapalene au moins un agent depigmentant et au moins un agent anti-inflammatoire |
| US8158109B2 (en) | 2006-03-31 | 2012-04-17 | Stiefel Research Australia Pty Ltd | Foamable suspension gel |
| FR2901139B1 (fr) * | 2006-05-17 | 2009-03-20 | Galderma Res & Dev S N C Snc | Compositions comprenant au moins un derive de l'acide naphtoique et du peroxyde de benzoyle, leurs procedes de preparation, et leurs utilisations |
| FR2903603B1 (fr) * | 2006-07-13 | 2009-03-20 | Galderma Res & Dev S N C Snc | Combinaison d'adapalene et de peroxyde de benzole dans le traitement de l'acne |
| US8080537B2 (en) | 2006-07-13 | 2011-12-20 | Galderma Research & Development | Combinations of adapalene and benzoyl peroxide for treating acne lesions |
| FR2903604B1 (fr) | 2006-07-13 | 2008-09-05 | Galderma Res & Dev S N C Snc | Composition comprenant un retinoide et du peroxyde de benzoyle |
| CA2656451C (en) * | 2006-07-13 | 2015-01-27 | Galderma Research & Development | Composition comprising a retinoid and benzoyl peroxide |
| FR2909000B1 (fr) * | 2006-11-28 | 2009-02-06 | Galderma Res & Dev S N C Snc | Compositions comprenant du peroxyde de benzoyle, au moins un derive de l'acide naphtoique et au moins un compose de type polymeres de polyurethane ou des derives de celui-ci, et leurs utilisations. |
| FR2910320B1 (fr) * | 2006-12-21 | 2009-02-13 | Galderma Res & Dev S N C Snc | Emulsion comprenant au moins un retinoide et du peroxyde de benzole |
| FR2910321B1 (fr) * | 2006-12-21 | 2009-07-10 | Galderma Res & Dev S N C Snc | Gel creme comprenant au moins un retinoide et du peroxyde de benzole |
| ES2546029T3 (es) * | 2007-01-30 | 2015-09-17 | Galderma Research & Development | Uso de adapaleno y peróxido de benzoilo para el tratamiento a largo plazo del acné vulgar |
| EP2109445B1 (en) * | 2007-02-01 | 2022-04-20 | Sol-Gel Technologies Ltd. | Compositions for topical application comprising a peroxide and retinoid |
| US12350382B2 (en) | 2007-02-01 | 2025-07-08 | Mayne Pharma Llc | Method for preparing particles comprising metal oxide coating and particles with metal oxide coating |
| EP1967180A1 (de) * | 2007-03-06 | 2008-09-10 | Almirall Hermal GmbH | Topische Zusammensetzung enthaltend einen Retinoid-Rezeptor-Agonist |
| FR2916966B1 (fr) * | 2007-06-11 | 2011-01-14 | Galderma Res & Dev | Compositions comprenant au moins un compose retinoide, un compose anti-irritant et du peroxyde de benzoyle, et leurs utilisations |
| FR2916975B1 (fr) * | 2007-06-11 | 2009-09-04 | Galderma Res & Dev | Compositions comprenant au moins un compose retinoide, un compose anti-irritant et du peroxyde de benzoyle, et leurs utilisations |
| EP2065032A1 (en) * | 2007-11-27 | 2009-06-03 | Galderma Research & Development | A method for producing adapalene gels |
| CA2706655A1 (fr) * | 2007-11-30 | 2009-06-25 | Galderma Research & Development | Compositions comprenant au moins un derive de l'acide naphtoique, du peroxyde de benzoyle et au moins un agent filmogene, leurs procedes de preparation, et leurs ulitisations |
| MX2010013152A (es) * | 2008-06-05 | 2011-05-02 | Dow Pharmaceutical Sciences | Formulaciones farmaceuticas topicas que contienen una baja concentracion de peroxido de benzoilo en suspension en agua y un solvente organico miscibe en agua. |
| WO2010051641A1 (en) | 2008-11-07 | 2010-05-14 | Klox Technologies Inc. | Oxidatitive photoactivated skin rejeuvenation composition comprising hyaluronic acid, glucosamine, or allantoin |
| WO2011042902A2 (en) * | 2009-10-07 | 2011-04-14 | Tagra Biotechnologies Ltd | Microcapsules comprising benzoyl peroxide and topical compositions comprising them |
| MX350488B (es) * | 2009-10-21 | 2017-09-07 | Dow Pharmaceutical Sciences | Metodo para humectar un polvo que contiene peroxido de benzoilo. |
| JP2013518920A (ja) | 2010-02-09 | 2013-05-23 | ガルデルマ・リサーチ・アンド・デヴェロップメント | 非白人系人種における炎症後色素沈着の減少と共にざ瘡の処置を目的とする、アダパレンと過酸化ベンゾイルとの組合せを含む皮膚科学的組成物 |
| FR2969492B1 (fr) * | 2010-12-23 | 2013-07-05 | Galderma Res & Dev | Mousses dermatologiques obtenues a partir d'un gel ou d'une suspension contenant de l'adapalene |
| FR2969491B1 (fr) * | 2010-12-23 | 2013-07-12 | Galderma Res & Dev | Mousses dermatologiques obtenues a partir d'un gel ou d'une suspension contenant une combinaison d'adapalene et de bpo |
| US8563535B2 (en) | 2011-03-29 | 2013-10-22 | Kamal Mehta | Combination composition comprising benzoyl peroxide and adapalene |
| WO2013175011A1 (en) | 2012-05-25 | 2013-11-28 | Galderma Research & Development | Treatment of preadolescent moderate acne vulgaris |
| CN104918598B (zh) * | 2012-11-13 | 2018-12-04 | 盖尔德玛公司 | Bpo清洗凝胶组合物 |
| US9687465B2 (en) | 2012-11-27 | 2017-06-27 | Sol-Gel Technologies Ltd. | Compositions for the treatment of rosacea |
| JP2017500328A (ja) | 2013-12-19 | 2017-01-05 | ガルデルマ・リサーチ・アンド・デヴェロップメント | 重度のざ瘡に関連した疾患を処置する治療レジメン |
| RU2016142678A (ru) | 2014-04-01 | 2018-05-07 | Галдерма Ресерч Энд Девелопмент | Способ лечения и/или предотвращения постугревых рубцов с помощью фиксированной комбинации адапалена или его солей и пероксида бензоила |
| PT3171857T (pt) | 2014-07-25 | 2020-11-19 | Galderma Res & Dev | Combinação de adapaleno e peróxido de benzoil para o tratamento de acne grave |
| JP6526322B2 (ja) * | 2015-08-20 | 2019-06-05 | ソル − ゲル テクノロジーズ リミテッド | 過酸化ベンゾイルおよびアダパレンを含む局所投与用組成物 |
| WO2018080284A1 (ko) * | 2016-10-31 | 2018-05-03 | (주)동구바이오제약 | 여드름 치료용 약물의 생체이용률을 증진시키는 약학적 조성물 |
| CN106729722B (zh) * | 2016-11-21 | 2020-05-12 | 成都山信药业有限公司 | 一种制备稳定复方制剂的方法及复方制剂 |
| BR112021019904A2 (pt) * | 2019-04-04 | 2021-12-07 | Galderma Holding SA | Composições de isopropillcarbonato benzoil peróxido e métodos de uso |
| JPWO2023112664A1 (enrdf_load_stackoverflow) * | 2021-12-14 | 2023-06-22 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4189501A (en) * | 1977-10-07 | 1980-02-19 | A. H. C. Pharmacal, Inc. | Composition and method for the treatment of acne |
| WO1993007856A1 (en) * | 1991-10-16 | 1993-04-29 | Richardson-Vicks, Inc. | LOW pH AQUEOUS COSMETIC GEL CONTAINING NON-IONIC POLYACRYLAMIDE DERIVATIVES |
| USRE34805E (en) * | 1985-04-11 | 1994-12-06 | Centre International De Recherches Dermatologiques (Cird) | Benzonaphthalene derivatives and their use in therapeutic and cosmetic compositions |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2378523A1 (fr) * | 1977-01-26 | 1978-08-25 | Grupper Charles | Medicament pour le traitement de l'acne |
| US4792452A (en) * | 1987-07-28 | 1988-12-20 | E. R. Squibb & Sons, Inc. | Controlled release formulation |
| FR2628319B1 (fr) * | 1988-03-09 | 1990-12-07 | Oreal | Compositions pharmaceutiques et cosmetiques a base de peroxyde de benzoyle et de sels d'ammonium quaternaires |
| US5470884A (en) * | 1994-05-19 | 1995-11-28 | Procter & Gamble | Anti-acne compositions |
| FR2785284B1 (fr) * | 1998-11-02 | 2000-12-01 | Galderma Res & Dev | Analogues de la vitamine d |
| FR2787322B1 (fr) * | 1998-12-18 | 2002-10-18 | Galderma Res & Dev | Emulsion huile-dans-eau comprenant un agent actif micronise et un systeme emulsionnant approprie |
| CN100387225C (zh) * | 1999-12-20 | 2008-05-14 | 汉高两合股份公司 | 稠化体系的制片方法 |
| FR2833841B1 (fr) * | 2001-12-21 | 2005-07-22 | Galderma Res & Dev | Gel comprenant au moins un retinoide et du peroxyde de benzoyle |
-
2001
- 2001-12-21 FR FR0116747A patent/FR2833841B1/fr not_active Expired - Fee Related
-
2002
- 2002-12-09 DE DE122008000041C patent/DE122008000041I1/de active Pending
- 2002-12-09 HU HU0500006A patent/HU230439B1/hu unknown
- 2002-12-09 KR KR1020047008461A patent/KR101014586B1/ko not_active Expired - Lifetime
- 2002-12-09 RU RU2004122429/15A patent/RU2320327C2/ru active
- 2002-12-09 DK DK02799797T patent/DK1458369T3/da active
- 2002-12-09 PT PT02799797T patent/PT1458369E/pt unknown
- 2002-12-09 BR BRPI0214264A patent/BRPI0214264B8/pt not_active IP Right Cessation
- 2002-12-09 WO PCT/FR2002/004233 patent/WO2003055472A1/fr active IP Right Grant
- 2002-12-09 PL PL372270A patent/PL220838B1/pl unknown
- 2002-12-09 EP EP02799797A patent/EP1458369B1/fr not_active Expired - Lifetime
- 2002-12-09 SI SI200230454T patent/SI1458369T1/sl unknown
- 2002-12-09 ES ES02799797T patent/ES2275948T3/es not_active Expired - Lifetime
- 2002-12-09 AU AU2002364437A patent/AU2002364437B2/en not_active Expired
- 2002-12-09 DE DE60216634T patent/DE60216634T2/de not_active Expired - Lifetime
- 2002-12-09 CA CA2466321A patent/CA2466321C/fr not_active Expired - Fee Related
- 2002-12-09 CN CNB028258460A patent/CN1329025C/zh not_active Expired - Lifetime
- 2002-12-09 JP JP2003556050A patent/JP4889922B2/ja not_active Expired - Lifetime
- 2002-12-09 MX MXPA04005918A patent/MXPA04005918A/es active IP Right Grant
- 2002-12-09 AT AT02799797T patent/ATE347354T1/de active
- 2002-12-18 AR ARP020104930A patent/AR038026A1/es not_active Application Discontinuation
-
2004
- 2004-05-17 ZA ZA2004/03759A patent/ZA200403759B/en unknown
-
2007
- 2007-01-29 CY CY20071100120T patent/CY1107583T1/el unknown
-
2008
- 2008-06-05 FR FR08C0024C patent/FR08C0024I2/fr active Active
- 2008-11-21 AU AU2008246274A patent/AU2008246274B2/en not_active Expired
-
2010
- 2010-11-26 JP JP2010264093A patent/JP5478468B2/ja not_active Expired - Lifetime
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4189501A (en) * | 1977-10-07 | 1980-02-19 | A. H. C. Pharmacal, Inc. | Composition and method for the treatment of acne |
| USRE34805E (en) * | 1985-04-11 | 1994-12-06 | Centre International De Recherches Dermatologiques (Cird) | Benzonaphthalene derivatives and their use in therapeutic and cosmetic compositions |
| WO1993007856A1 (en) * | 1991-10-16 | 1993-04-29 | Richardson-Vicks, Inc. | LOW pH AQUEOUS COSMETIC GEL CONTAINING NON-IONIC POLYACRYLAMIDE DERIVATIVES |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12357602B2 (en) | 2017-07-12 | 2025-07-15 | Mayne Pharma Llc | Compositions comprising encapsulated tretinoin |
| US20240299335A1 (en) * | 2022-03-14 | 2024-09-12 | Blue Hill Technologies Llc | Shelf-stable formulations of benzoyl peroxide and methods of producing same |
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Legal Events
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| DA3 | Amendments made section 104 |
Free format text: THE NATURE OF THE AMENDMENT IS: AMEND THE NAME OF THE APPLICANT FROM GALDERMA RESEARCH & DEVELOPMENT, SNC TO GALDERMA RESEARCH & DEVELOPMENT, S.N.C. |
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| TC | Change of applicant's name (sec. 104) |
Owner name: GALDERMA RESEARCH & DEVELOPMENT Free format text: FORMER NAME: GALDERMA RESEARCH & DEVELOPMENT, S.N.C. |
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| FGA | Letters patent sealed or granted (standard patent) | ||
| NC | Extension of term for standard patent requested (sect. 70) | ||
| GD | Licence registered |
Name of requester: S |
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| NDA | Extension of term for standard patent accepted (sect.70) |
Free format text: PRODUCT NAME: EPIDUO ADAPALENE/BENZOYL PEROXIDE GEL TUBE; THE EARLIEST FIRST REGULATORY APPROVAL DATE PROVIDED BY THE PATENTEE 20090122 Extension date: 20240122 |
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| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |