AU2002356860A1 - Preparation of amphetamines from phenylpropanolamines - Google Patents
Preparation of amphetamines from phenylpropanolaminesInfo
- Publication number
- AU2002356860A1 AU2002356860A1 AU2002356860A AU2002356860A AU2002356860A1 AU 2002356860 A1 AU2002356860 A1 AU 2002356860A1 AU 2002356860 A AU2002356860 A AU 2002356860A AU 2002356860 A AU2002356860 A AU 2002356860A AU 2002356860 A1 AU2002356860 A1 AU 2002356860A1
- Authority
- AU
- Australia
- Prior art keywords
- formula
- alkyl group
- group
- lower alkyl
- phenylpropanolamine salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- 150000002367 halogens Chemical group 0.000 abstract 4
- DLNKOYKMWOXYQA-APPZFPTMSA-N phenylpropanolamine Chemical class C[C@@H](N)[C@H](O)C1=CC=CC=C1 DLNKOYKMWOXYQA-APPZFPTMSA-N 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000002425 crystallisation Methods 0.000 abstract 1
- 230000008025 crystallization Effects 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/68—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/020,488 | 2001-10-29 | ||
| US10/020,488 US6399828B1 (en) | 2001-10-29 | 2001-10-29 | Preparation of amphetamines from phenylpropanolamines |
| PCT/US2002/034400 WO2003037843A2 (en) | 2001-10-29 | 2002-10-28 | Preparation of amphetamines from phenylpropanolamines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2002356860A1 true AU2002356860A1 (en) | 2003-05-12 |
Family
ID=21798883
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2002356860A Abandoned AU2002356860A1 (en) | 2001-10-29 | 2002-10-28 | Preparation of amphetamines from phenylpropanolamines |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6399828B1 (enExample) |
| EP (1) | EP1442006B1 (enExample) |
| JP (1) | JP2005507936A (enExample) |
| AT (1) | ATE302747T1 (enExample) |
| AU (1) | AU2002356860A1 (enExample) |
| CA (1) | CA2462916A1 (enExample) |
| DE (1) | DE60205769T2 (enExample) |
| DK (1) | DK1442006T3 (enExample) |
| ES (1) | ES2248640T3 (enExample) |
| PT (1) | PT1442006E (enExample) |
| WO (1) | WO2003037843A2 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4898445B2 (ja) * | 2003-05-29 | 2012-03-14 | シャイア エルエルシー | 乱用抵抗性アンフェタミン化合物類 |
| DE602004016401D1 (de) * | 2004-12-22 | 2008-10-16 | Emmellen Biotech Pharmaceutica | Verfahren zur herstellung von r-(-)-n, alpha-dimethylphenethylamin (levmetamphetamin) oder s-(+)-n, alpha-dimethylphenethylamin (metamphetamin) aus d-ephedrin bzw. l-ephedrin |
| JP2008526850A (ja) * | 2005-01-06 | 2008-07-24 | マリンクロッド・インコーポレイテッド | ベンジル化アミン類の製造方法 |
| TWI401237B (zh) * | 2006-07-24 | 2013-07-11 | ３-〔（１ｒ，２ｒ）-３-（二甲基氨基）-１-乙基-２-甲基丙基〕酚之製備 | |
| US7705184B2 (en) * | 2008-05-20 | 2010-04-27 | Cambrex Charles City, Inc. | Method of making amphetamine |
| US20100125146A1 (en) * | 2008-11-19 | 2010-05-20 | Johnson Matthey Public Limited Company | Method for making pharmaceutical compounds |
| US8614346B2 (en) | 2009-06-19 | 2013-12-24 | Cambrex Charles City, Inc. | Methods and compositions for preparation of amphetamine conjugates and salts thereof |
| JP5094832B2 (ja) * | 2009-12-25 | 2012-12-12 | 日東電工株式会社 | 粘着剤組成物および粘着シート |
| JP5657913B2 (ja) * | 2010-05-10 | 2015-01-21 | 中部電力株式会社 | ナノコンポジット半導体光触媒材料とメタノール水溶液を用いた水素製造手法 |
| US8779191B2 (en) | 2010-12-20 | 2014-07-15 | Cambrex Charles City, Inc. | Methods and compositions for preparing lisdexamfetamine and salts thereof |
| US11123310B2 (en) | 2017-02-24 | 2021-09-21 | Pharmapotheca, Llc | Amphetamine controlled release, prodrug, and abuse-deterrent dosage forms |
| US12208068B2 (en) | 2013-12-31 | 2025-01-28 | Pharmapotheca A Inc. | Amphetamine controlled release, prodrug, and abuse-deterrent dosage forms |
| US9321794B2 (en) | 2013-12-31 | 2016-04-26 | Chemapotheca, Llc | Synthesis of racemic amphetamine derivatives by cuprate addition reaction with aziridine phosphoramidate compounds |
| US9278904B2 (en) | 2013-12-31 | 2016-03-08 | Chemapotheca, Llc | Synthesis of chiral amphetamine derivatives by stereospecific, regioselective cuprate addition reaction with aziridine phosphoramidate compounds |
| US10544434B2 (en) | 2015-06-29 | 2020-01-28 | Noramco, Inc. | Process for the preparation of lisdexamfetamine and related derivatives |
| IL288554B2 (en) | 2016-02-24 | 2024-02-01 | Chemapotheca LLC | Controlled release of amphetamine, drug meters and dosage forms with abuse deterrence |
| US11590081B1 (en) | 2017-09-24 | 2023-02-28 | Tris Pharma, Inc | Extended release amphetamine tablets |
| US12458592B1 (en) | 2017-09-24 | 2025-11-04 | Tris Pharma, Inc. | Extended release amphetamine tablets |
| WO2020180825A1 (en) | 2019-03-02 | 2020-09-10 | Chemapotheca, Llc | Application for letters patent |
| US12534428B2 (en) | 2023-02-22 | 2026-01-27 | Pharmapotheca A, Inc. | Non-distillative process for manufacturing high purity amphetamines |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2802828A (en) * | 1957-08-13 | New derivatives of hydroxylated | ||
| DE2817494A1 (de) * | 1977-05-03 | 1978-11-09 | Continental Pharma | Aminoalkohol-derivat |
| DE19859684A1 (de) * | 1998-12-23 | 2000-06-29 | Bayer Ag | Verfahren zur Herstellung von Fluor enthaltenden Phenethylaminen sowie neue, Fluor enthalende beta-Iminovinyl- und beta-Iminoethylbenzole |
-
2001
- 2001-10-29 US US10/020,488 patent/US6399828B1/en not_active Expired - Lifetime
-
2002
- 2002-10-28 PT PT02802245T patent/PT1442006E/pt unknown
- 2002-10-28 AT AT02802245T patent/ATE302747T1/de not_active IP Right Cessation
- 2002-10-28 CA CA002462916A patent/CA2462916A1/en not_active Abandoned
- 2002-10-28 WO PCT/US2002/034400 patent/WO2003037843A2/en not_active Ceased
- 2002-10-28 EP EP02802245A patent/EP1442006B1/en not_active Expired - Lifetime
- 2002-10-28 JP JP2003540126A patent/JP2005507936A/ja active Pending
- 2002-10-28 AU AU2002356860A patent/AU2002356860A1/en not_active Abandoned
- 2002-10-28 ES ES02802245T patent/ES2248640T3/es not_active Expired - Lifetime
- 2002-10-28 DK DK02802245T patent/DK1442006T3/da active
- 2002-10-28 DE DE60205769T patent/DE60205769T2/de not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP2005507936A (ja) | 2005-03-24 |
| US6399828B1 (en) | 2002-06-04 |
| PT1442006E (pt) | 2005-11-30 |
| ES2248640T3 (es) | 2006-03-16 |
| EP1442006B1 (en) | 2005-08-24 |
| EP1442006A2 (en) | 2004-08-04 |
| WO2003037843A3 (en) | 2003-10-30 |
| DE60205769D1 (de) | 2005-09-29 |
| WO2003037843A2 (en) | 2003-05-08 |
| DK1442006T3 (da) | 2005-12-12 |
| CA2462916A1 (en) | 2003-05-08 |
| ATE302747T1 (de) | 2005-09-15 |
| DE60205769T2 (de) | 2006-06-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK6 | Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase |