DE60205769D1 - Verfahren zur herstellung von amphetaminen aus phenylpropanolaminen - Google Patents

Verfahren zur herstellung von amphetaminen aus phenylpropanolaminen

Info

Publication number
DE60205769D1
DE60205769D1 DE60205769T DE60205769T DE60205769D1 DE 60205769 D1 DE60205769 D1 DE 60205769D1 DE 60205769 T DE60205769 T DE 60205769T DE 60205769 T DE60205769 T DE 60205769T DE 60205769 D1 DE60205769 D1 DE 60205769D1
Authority
DE
Germany
Prior art keywords
formula
alkyl group
group
lower alkyl
phenylpropanolamine salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60205769T
Other languages
English (en)
Other versions
DE60205769T2 (de
Inventor
Robert F Boswell
S Lo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharmaceuticals Inc
Original Assignee
Boehringer Ingelheim Chemicals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Chemicals Inc filed Critical Boehringer Ingelheim Chemicals Inc
Publication of DE60205769D1 publication Critical patent/DE60205769D1/de
Application granted granted Critical
Publication of DE60205769T2 publication Critical patent/DE60205769T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/68—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton
DE60205769T 2001-10-29 2002-10-28 Verfahren zur herstellung von amphetaminen aus phenylpropanolaminen Expired - Fee Related DE60205769T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/020,488 US6399828B1 (en) 2001-10-29 2001-10-29 Preparation of amphetamines from phenylpropanolamines
US20488 2001-10-29
PCT/US2002/034400 WO2003037843A2 (en) 2001-10-29 2002-10-28 Preparation of amphetamines from phenylpropanolamines

Publications (2)

Publication Number Publication Date
DE60205769D1 true DE60205769D1 (de) 2005-09-29
DE60205769T2 DE60205769T2 (de) 2006-06-08

Family

ID=21798883

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60205769T Expired - Fee Related DE60205769T2 (de) 2001-10-29 2002-10-28 Verfahren zur herstellung von amphetaminen aus phenylpropanolaminen

Country Status (11)

Country Link
US (1) US6399828B1 (de)
EP (1) EP1442006B1 (de)
JP (1) JP2005507936A (de)
AT (1) ATE302747T1 (de)
AU (1) AU2002356860A1 (de)
CA (1) CA2462916A1 (de)
DE (1) DE60205769T2 (de)
DK (1) DK1442006T3 (de)
ES (1) ES2248640T3 (de)
PT (1) PT1442006E (de)
WO (1) WO2003037843A2 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1644019E (pt) * 2003-05-29 2012-05-23 Shire Llc Compostos de anfetamina resistentes ao abuso
EP1828105B1 (de) * 2004-12-22 2008-09-03 Emmellen Biotech Pharmaceuticals Limited Verfahren zur herstellung von r-(-)-n, alpha-dimethylphenethylamin (levmetamphetamin) oder s-(+)-n, alpha-dimethylphenethylamin (metamphetamin) aus d-ephedrin bzw. l-ephedrin
JP2008526850A (ja) * 2005-01-06 2008-07-24 マリンクロッド・インコーポレイテッド ベンジル化アミン類の製造方法
TWI401237B (zh) * 2006-07-24 2013-07-11 ３-〔（１ｒ，２ｒ）-３-（二甲基氨基）-１-乙基-２-甲基丙基〕酚之製備
US7705184B2 (en) * 2008-05-20 2010-04-27 Cambrex Charles City, Inc. Method of making amphetamine
US20100125146A1 (en) * 2008-11-19 2010-05-20 Johnson Matthey Public Limited Company Method for making pharmaceutical compounds
US8614346B2 (en) 2009-06-19 2013-12-24 Cambrex Charles City, Inc. Methods and compositions for preparation of amphetamine conjugates and salts thereof
JP5094832B2 (ja) * 2009-12-25 2012-12-12 日東電工株式会社 粘着剤組成物および粘着シート
JP5657913B2 (ja) * 2010-05-10 2015-01-21 中部電力株式会社 ナノコンポジット半導体光触媒材料とメタノール水溶液を用いた水素製造手法
US8779191B2 (en) 2010-12-20 2014-07-15 Cambrex Charles City, Inc. Methods and compositions for preparing lisdexamfetamine and salts thereof
US9321794B2 (en) 2013-12-31 2016-04-26 Chemapotheca, Llc Synthesis of racemic amphetamine derivatives by cuprate addition reaction with aziridine phosphoramidate compounds
US9278904B2 (en) 2013-12-31 2016-03-08 Chemapotheca, Llc Synthesis of chiral amphetamine derivatives by stereospecific, regioselective cuprate addition reaction with aziridine phosphoramidate compounds
US11123310B2 (en) 2017-02-24 2021-09-21 Pharmapotheca, Llc Amphetamine controlled release, prodrug, and abuse-deterrent dosage forms
US10544434B2 (en) 2015-06-29 2020-01-28 Noramco, Inc. Process for the preparation of lisdexamfetamine and related derivatives
CA3207586A1 (en) 2016-02-24 2017-08-31 Chemapotheca, Llc Amphetamine controlled release, prodrug, and abuse-deterrent dosage forms
US11590081B1 (en) 2017-09-24 2023-02-28 Tris Pharma, Inc Extended release amphetamine tablets
US20220162153A1 (en) 2019-03-02 2022-05-26 Chemapotheca, Llc Process for Making Levoamphetamine

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2802828A (en) * 1957-08-13 New derivatives of hydroxylated
DE2817494A1 (de) * 1977-05-03 1978-11-09 Continental Pharma Aminoalkohol-derivat
DE19859684A1 (de) * 1998-12-23 2000-06-29 Bayer Ag Verfahren zur Herstellung von Fluor enthaltenden Phenethylaminen sowie neue, Fluor enthalende beta-Iminovinyl- und beta-Iminoethylbenzole

Also Published As

Publication number Publication date
ATE302747T1 (de) 2005-09-15
EP1442006B1 (de) 2005-08-24
US6399828B1 (en) 2002-06-04
DK1442006T3 (da) 2005-12-12
CA2462916A1 (en) 2003-05-08
JP2005507936A (ja) 2005-03-24
WO2003037843A3 (en) 2003-10-30
PT1442006E (pt) 2005-11-30
AU2002356860A1 (en) 2003-05-12
WO2003037843A2 (en) 2003-05-08
ES2248640T3 (es) 2006-03-16
EP1442006A2 (de) 2004-08-04
DE60205769T2 (de) 2006-06-08

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Legal Events

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8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee