AU2002340224B2 - Oligoamine compounds and derivatives thereof for cancer therapy - Google Patents

Oligoamine compounds and derivatives thereof for cancer therapy Download PDF

Info

Publication number
AU2002340224B2
AU2002340224B2 AU2002340224A AU2002340224A AU2002340224B2 AU 2002340224 B2 AU2002340224 B2 AU 2002340224B2 AU 2002340224 A AU2002340224 A AU 2002340224A AU 2002340224 A AU2002340224 A AU 2002340224A AU 2002340224 B2 AU2002340224 B2 AU 2002340224B2
Authority
AU
Australia
Prior art keywords
chohch
group
compound
ethyl
compound according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2002340224A
Other languages
English (en)
Other versions
AU2002340224A1 (en
Inventor
Hirak S. Basu
Andrei V. Blokhin
Benjamin Frydman
Laurence J. Marton
Venodhar K. Reddy
Aldonia L. Valasinas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PROGEN PHARMACEUTICALS Inc
Original Assignee
PROGEN PHARMACEUTICALS Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PROGEN PHARMACEUTICALS Inc filed Critical PROGEN PHARMACEUTICALS Inc
Publication of AU2002340224A1 publication Critical patent/AU2002340224A1/en
Assigned to CELLGATE, INC. reassignment CELLGATE, INC. Request for Assignment Assignors: SLIL BIOMEDICAL CORPORATION
Application granted granted Critical
Publication of AU2002340224B2 publication Critical patent/AU2002340224B2/en
Assigned to PROGEN PHARMACEUTICALS, INC reassignment PROGEN PHARMACEUTICALS, INC Alteration of Name(s) of Applicant(s) under S113 Assignors: CELLGATE, INC.
Priority to AU2009200639A priority Critical patent/AU2009200639A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
    • C07C215/06—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic
    • C07C215/18—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic with hydroxy groups and at least two amino groups bound to the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C211/14—Amines containing amino groups bound to at least two aminoalkyl groups, e.g. diethylenetriamines

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
AU2002340224A 2001-10-16 2002-10-16 Oligoamine compounds and derivatives thereof for cancer therapy Ceased AU2002340224B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2009200639A AU2009200639A1 (en) 2001-10-16 2009-02-18 Oligoamine compounds and derivatives thereof for cancer therapy

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US32998201P 2001-10-16 2001-10-16
US60/329,982 2001-10-16
PCT/US2002/032932 WO2003033455A1 (en) 2001-10-16 2002-10-16 Oligoamine compounds and derivatives thereof for cancer therapy

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2009200639A Division AU2009200639A1 (en) 2001-10-16 2009-02-18 Oligoamine compounds and derivatives thereof for cancer therapy

Publications (2)

Publication Number Publication Date
AU2002340224A1 AU2002340224A1 (en) 2003-07-03
AU2002340224B2 true AU2002340224B2 (en) 2008-11-27

Family

ID=23287844

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2002340224A Ceased AU2002340224B2 (en) 2001-10-16 2002-10-16 Oligoamine compounds and derivatives thereof for cancer therapy
AU2009200639A Abandoned AU2009200639A1 (en) 2001-10-16 2009-02-18 Oligoamine compounds and derivatives thereof for cancer therapy

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2009200639A Abandoned AU2009200639A1 (en) 2001-10-16 2009-02-18 Oligoamine compounds and derivatives thereof for cancer therapy

Country Status (7)

Country Link
US (3) US20030130356A1 (https=)
EP (1) EP1436246A1 (https=)
JP (1) JP2005506354A (https=)
AU (2) AU2002340224B2 (https=)
CA (1) CA2463771A1 (https=)
IL (1) IL161428A0 (https=)
WO (1) WO2003033455A1 (https=)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4743673B2 (ja) * 1999-04-30 2011-08-10 プロゲン ファーマシューティカルズ， インコーポレイテッド ポリアミンおよび治療におけるそれらの使用
AU4678300A (en) 1999-04-30 2000-11-17 Slil Biomedical Corporation Novel polyamine analog conjugates and quinone conjugates as therapies for cancers and prostate diseases
AU2001297817A1 (en) 2000-11-08 2002-11-25 Eli Lilly And Company Antiviral therapies using polyamine or polyamine analog-amino acid conjugates
IL161428A0 (en) * 2001-10-16 2004-09-27 Slil Biomedical Corp Oligoamine derivatives, methods for the production thereof and pharmaceutical compositions containing the same
MXPA04005509A (es) 2001-12-07 2004-12-06 Slil Biomedical Corp Poliaminas sustituidas con cicloalquilo para terapia de cancer y metodos de sintesis de las mismas.
WO2004002991A1 (en) * 2002-06-26 2004-01-08 Cellgate, Inc. Porphyrin-polyamine conjugates for cancer therapy
US7095075B2 (en) * 2003-07-01 2006-08-22 Micron Technology, Inc. Apparatus and method for split transistor memory having improved endurance
US7241654B2 (en) * 2003-12-17 2007-07-10 Micron Technology, Inc. Vertical NROM NAND flash memory array
US7075146B2 (en) * 2004-02-24 2006-07-11 Micron Technology, Inc. 4F2 EEPROM NROM memory arrays with vertical devices
MX2007004030A (es) * 2004-10-04 2008-01-14 Cellgate Inc Analogos de poliamina como agentes terapeuticos para enfermedades oculares.
WO2006086773A2 (en) * 2005-02-11 2006-08-17 Cellgate, Inc. Polyamine analogs as modulators of cell migration and cell motility
WO2007106554A2 (en) * 2006-03-14 2007-09-20 Progen Pharmaceuticals, Inc. Treatment and prevention of vascular hyperplasia using polyamine and polyamine analog compounds
IL187247A0 (en) * 2007-11-08 2008-12-29 Hadasit Med Res Service Novel synthetic analogs of sphingolipids
FR2932088B1 (fr) * 2008-06-06 2013-04-05 Lvmh Rech Utilisation d'un extrait de lepechinia caulescens comme agent cosmetique, et composition cosmetique le contenant
EP3613426A1 (en) 2014-05-21 2020-02-26 Entrada Therapeutics, Inc. Cell penetrating peptides and methods of making and using thereof
US10815276B2 (en) 2014-05-21 2020-10-27 Entrada Therapeutics, Inc. Cell penetrating peptides and methods of making and using thereof
EP3185880B1 (en) 2014-08-27 2020-02-12 Ohio State Innovation Foundation Improved peptidyl calcineurin inhibitors
WO2019070962A1 (en) 2017-10-04 2019-04-11 Ohio State Innovation Foundation BICYCLIC PEPTIDE INHIBITORS
EP3746105A4 (en) 2018-01-29 2022-05-18 Ohio State Innovation Foundation CYCLIC PEPTIDYLIN HIBITORS OF THE CAL-PDZ-BINDING DOMAIN
EP3749365A4 (en) 2018-01-29 2022-01-12 Ohio State Innovation Foundation PEPTIDY INHIBITORS OF THE CALCINEURIN-NFAT INTERACTION
TW201945014A (zh) 2018-02-22 2019-12-01 美商安卓達治療股份有限公司 用於治療粒線體性神經胃腸腦病變之組合物及方法

Family Cites Families (97)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2440724A (en) 1944-10-27 1948-05-04 Commercial Solvents Corp Nu-substituted, 2-butene-1, 4-diamines, and process for preparing
US4013507A (en) 1973-09-18 1977-03-22 California Institute Of Technology Ionene polymers for selectively inhibiting the vitro growth of malignant cells
US3956502A (en) 1974-09-04 1976-05-11 Nalco Chemical Company Polyamine alcohols as microbiocides
PL109855B1 (en) 1977-12-12 1980-06-30 Bath for electro-galvanizing and polishing
US4661509A (en) 1982-09-28 1987-04-28 Gordon Arnold Z Methods for treating leukopenia
US4551550A (en) 1983-12-06 1985-11-05 Merrell Dow Pharmaceuticals Inc. N-2,3-Butadienyl-1,4-butanediamine derivatives
CA1247598A (en) * 1984-12-27 1988-12-28 Harry J. Andress, Jr. Compounds containing amide linkages from mono-and polycarboxylic acids in the same molecule and lubricants and fuels containing same
CS252771B1 (cs) * 1986-01-20 1987-10-15 Josef Urbanek Reakční produkty vyšších nasycených a/nebo nenasycených karboxylových kyselin s polytopickými aminy
US4889851A (en) 1986-11-21 1989-12-26 Fujisawa Pharmaceutical Co, Ltd. Benzothiadiazine compounds, and pharmaceutical composition comprising the same
US5342945A (en) 1986-12-02 1994-08-30 University Of Florida Research Foundation, Inc. Anti-neoplastic, anti-viral or anti-retroviral spermine derivatives
US6184232B1 (en) 1986-12-02 2001-02-06 University Of Florida Analogs of biologically active, naturally occurring polyamines, pharmaceutical compositions and methods of treatment
US5677351A (en) 1986-12-02 1997-10-14 University Of Florida Research Foundation, Inc. Sterically hindered tetraamines and method for their production
USRE38417E1 (en) 1986-12-02 2004-02-03 University Of Florida Research Foundation, Inc. Anti-neoplastic, anti-viral or anti-retroviral spermine derivatives
US5091576A (en) 1986-12-02 1992-02-25 University Of Florida Anti-neoplastic, anti-viral or anti-retroviral spermine derivatives
US5393757A (en) 1986-12-02 1995-02-28 University Of Florida Polyamines and anti-diarrheal and gastrointestinal anti-spasmodic pharmaceutical compositions and methods of treatment
US5654484A (en) 1987-10-08 1997-08-05 Merrell Pharmaceuticals Inc. Polyamine derivatives as antineoplastic agents
US4868219A (en) 1988-04-07 1989-09-19 Thornfeldt Carl R Treatment of skin diseases with aliphatic amines
CA2011367C (en) 1988-08-30 1997-07-08 Henry Ashjian Reaction products of alkenyl succinimides with ethylenediamine carboxy acids as fuel detergents
US5719193A (en) 1989-05-23 1998-02-17 Merrell Pharmaceuticals, Inc. Method of potentiating cell-mediated immunity utilizing polyamine derivatives
US5283367A (en) 1989-08-30 1994-02-01 Ciba-Geigy Corporation Substituted 1,4-diamino-2-butene stabilizers
JP3007391B2 (ja) 1990-08-13 2000-02-07 花王株式会社 新規第４級アンモニウム化合物
GB9111794D0 (en) 1991-05-31 1991-07-24 Robins David J Antifungal compounds
US5185369A (en) 1991-08-23 1993-02-09 Pfizer Inc. Synthetic heteroaryl polyamines as excitatory amino acid neurotransmitter antagonists
CZ39994A3 (en) 1991-08-23 1994-11-16 Pfizer Synthetic aryl polyamines representing antagonists of excitation amino acid neurotransmitters, process of their preparation and use
US5242684A (en) 1991-10-25 1993-09-07 Isp Investments Inc. Antimicrobial, low toxicity, non-irritating composition comprising a blend of bis-quaternary ammonium compounds coprecipitated with a copolymer of vinylpyrrolidone and an acrylamido or vinyl quaternary ammonium monomer
US6051611A (en) 1991-11-08 2000-04-18 Alcon Laboratories, Inc. Polymeric quaternary ammonium compounds and their use as ophthalmic antimicrobias
US5512597A (en) 1991-11-08 1996-04-30 Alcon Laboratories, Inc. Polymeric quaternary ammonium compounds and their use as ophthalmic antimicrobials
US5530092A (en) 1992-01-13 1996-06-25 Dsm N.V. Dendritic macromolecule and the preparation thereof
GB9220921D0 (en) 1992-10-05 1992-11-18 Merrell Dow Pharma Polyamine derivatives as anticytomegaloviral agents
DE4306152A1 (de) 1993-02-27 1994-09-01 Hoechst Ag Positiv arbeitendes strahlungsempfindliches Gemisch und damit hergestelltes Aufzeichnungsmaterial
US5451347A (en) 1993-06-24 1995-09-19 Lumigen, Inc. Methods and compositions providing enhanced chemiluminescence from chemiluminescent compounds using dicationic surfactants
US5541230A (en) 1993-11-05 1996-07-30 Us Health Therapeutic polyamines
DK0686143T3 (da) 1993-12-27 1999-05-17 Novartis Ag Umættede aminoforbindelser som middel mod cancer og mod protozoer
DE4403039A1 (de) 1994-01-28 1995-08-03 Schering Ag Oktaazamakrocyclen, deren Metallkomplexe, Verfahren zu deren Herstellung, diese Komplexe enthaltende Mittel sowie deren Verwendung in Diagnostik und Therapie
DK0741756T3 (da) 1994-01-28 1999-02-22 Dsm Nv Dendritisk makromolekyle og fremgangsmåde til fremstilling heraf
JPH07228589A (ja) 1994-02-16 1995-08-29 Fuji Photo Film Co Ltd リン酸エステル誘導体およびそれを含有するハロゲン化銀写真感光材料
JPH07277964A (ja) 1994-04-08 1995-10-24 Nippon Kayaku Co Ltd 抗腫瘍剤
JP3805364B2 (ja) 1994-11-12 2006-08-02 ビーエーエスエフ アクチェンゲゼルシャフト 少なくとも３個のシアノ基を有する化合物からのアミンの製造法
FR2729852A1 (fr) 1995-01-30 1996-08-02 Oreal Composition reductrice comprenant un acide amine basique et un polymere cationique
US6060604A (en) 1995-03-31 2000-05-09 Florida State University Pharmaceutical compounds comprising polyamines substituted with electron-affinic groups
EP0752465A1 (en) 1995-06-01 1997-01-08 The Procter & Gamble Company Betaine esters for delivery of alcohols
US6114108A (en) 1995-08-29 2000-09-05 V.I. Technologies, Inc. Methods and compositions for the selective modification of viral nucleic acids
US6136586A (en) 1995-08-29 2000-10-24 Vi Technologies, Inc. Methods for the selective modification of viral nucleic acids
EP0761680A3 (en) 1995-09-12 1999-05-06 Ono Pharmaceutical Co., Ltd. Tetrazole compounds having Interleukin-1beta converting enzyme inhibitory activity
US5869715A (en) 1995-09-27 1999-02-09 The Reagents Of The University Of California Polyfunctional cationic cytofectins
US5886051A (en) 1995-11-08 1999-03-23 University Of Florida Research Foundation, Inc. Methods and compositions for the treatment of neurodegeneration
US6126964A (en) 1996-01-04 2000-10-03 Mirus Corporation Process of making a compound by forming a polymer from a template drug
US5962533A (en) * 1996-02-06 1999-10-05 University Of Florida Research Foundation, Inc. Hydroxy polyamines
CN1105496C (zh) 1996-02-07 2003-04-16 巴科曼实验室国际公司 含一种紫罗烯聚合物及十二烷胺盐的协同抗微生物组合物及其使用方法
DE19621510A1 (de) 1996-05-29 1997-12-04 Basf Ag Dendritische stickstoffhaltige organische Verbindungen mit planar-chiralen oder axial-chiralen Endgruppen, ihre Herstellung und Verwendung
US6034129A (en) 1996-06-24 2000-03-07 Geltex Pharmaceuticals, Inc. Ionic polymers as anti-infective agents
DE19625982A1 (de) 1996-06-28 1998-01-02 Wella Ag Kosmetisches Mittel zur Haarbehandlung mit Dendrimeren
US5866016A (en) 1997-07-01 1999-02-02 Buckman Laboratories International, Inc. Methods and compositions for controlling biofouling using combinations of an ionene polymer and a salt of dodecylamine
US5958397A (en) 1996-07-22 1999-09-28 Schering-Plough Healthcare Products, Inc. Method and composition for protecting against jellyfish stings
US5906996A (en) 1996-08-21 1999-05-25 Murphy; Michael A. Tetramine treatment of neurological disorders
DE69733207T2 (de) 1996-09-13 2006-02-02 University of Florida Research Foundation, Inc., Gainesville Verfahren zur hemmung von elf5a-biosynthese
ES2171911T3 (es) 1996-10-18 2002-09-16 Wisconsin Alumni Res Found Poliaminas conformacionalmente restringidas y su uso como agentes antineoplasicos.
EP0889112A1 (en) 1996-10-22 1999-01-07 Tonen Corporation Lubricating oil composition for automatic transmissions
US6235794B1 (en) 1997-04-03 2001-05-22 University Of Florida Biologically active spermidine analogues, pharmaceutical compositions and methods of treatment
US6093564A (en) 1997-10-03 2000-07-25 V.I. Technologies, Inc. Methods and compositions for the selective modification of nucleic acids
US6307102B1 (en) 1997-10-15 2001-10-23 Tosoh Corporation Amine catalyst for producing polyurethane and polyisocyanurate
US6046282A (en) 1998-01-06 2000-04-04 Air Products And Chemicals, Inc. Reactive diluents for polyamidoamine epoxy curatives
WO1999043752A1 (fr) * 1998-02-27 1999-09-02 Dnavec Research Inc. Compositions pour transporter des substances chargees negativement
CA2304557C (en) 1998-04-21 2008-12-30 Universite Laval Polyamine transport inhibitors
JP3996274B2 (ja) 1998-07-07 2007-10-24 電気化学工業株式会社 モノビニルアセチレンの製造方法
AU5241499A (en) 1998-07-31 2000-02-21 Health Research, Inc., The Method of treating cancer in patients having a deficiency in p53 tumor suppressor gene
GB9817383D0 (en) 1998-08-10 1998-10-07 Ass Octel Diesel fuel compositions
JP2002525131A (ja) 1998-09-25 2002-08-13 ブイ．アイ． テクノロジーズ インク． 生物学的組成物においてウイルスを選択的に不活化する方法
AU1180300A (en) 1998-11-16 2000-06-05 Rohto Pharmaceutical Co., Ltd. Liquid ophthalmic preparations
JP3747355B2 (ja) 1998-12-21 2006-02-22 独立行政法人理化学研究所 鎖状ポリアミン系化合物及びポリアミン系抗ガン剤
AU4678300A (en) 1999-04-30 2000-11-17 Slil Biomedical Corporation Novel polyamine analog conjugates and quinone conjugates as therapies for cancers and prostate diseases
US6649587B1 (en) 1999-04-30 2003-11-18 Slil Biomedical Corporation Polyamine analog conjugates and quinone conjugates as therapies for cancers and prostate diseases
US6673890B1 (en) 1999-07-16 2004-01-06 Basf Aktiengesellschaft Zwitterionic polyamines and process for their production
GB9920107D0 (en) 1999-08-26 1999-10-27 Avecia Ltd Fluidising agents
JP2001131449A (ja) 1999-11-01 2001-05-15 Matsushita Electric Ind Co Ltd インクジェット記録用インク
FR2802817B1 (fr) 1999-12-23 2002-10-11 Centre Nat Rech Scient Nouveaux inhibiteurs de glycosidases et leurs applications pharmacologiques, notamment pour traiter le diabete
DE60128407T2 (de) 2000-01-10 2008-01-10 Zetetic Research, Inc., Coconut Creek Verwendung einer pharmazeutischen zusammensetzung enthaltend zwei quaternäre ammoniumverbindungen und eine organometal-verbindung zur behandlung von viralen und fungalen infekten und krankheiten
US6494944B1 (en) 2000-03-02 2002-12-17 Akzo Nobel N.V. Amine oxides as asphalt emulsifiers
FI112796B (fi) 2000-04-14 2004-01-15 Valtion Teknillinen Menetelmä oligo-/polymeripihkahappoaimididendrimeerien valmistamiseksi ja niiden käyttö
US6444707B1 (en) 2000-08-22 2002-09-03 West Agro Topically applied hoof treatment composition and concentrate
AU2001294557A1 (en) 2000-09-11 2002-03-26 Merck And Co., Inc. Thrombin inhibitors
EP1318801B1 (en) 2000-09-19 2009-03-11 Dermal Therapy (Barbados) Inc. Topical analgesic compositions containing aliphatic polyamines and methods of using same
US6545181B1 (en) 2000-10-24 2003-04-08 Pilot Chemical Holdings, Inc. Demulsifying compound and a method of breaking or inhibiting emulsions
AU2001297817A1 (en) 2000-11-08 2002-11-25 Eli Lilly And Company Antiviral therapies using polyamine or polyamine analog-amino acid conjugates
CA2429982C (en) 2000-12-01 2010-07-13 Ning Li Copper chelators for treating ocular inflammation
US7754765B2 (en) 2000-12-01 2010-07-13 Radical Vision Therapeutics Inc Copper chelators for treating ocular inflammation
US6399662B1 (en) 2000-12-13 2002-06-04 University Of Florida Method and composition for the treatment of diarrhea and gastrointestinal spasms
WO2002062341A1 (en) 2001-02-07 2002-08-15 University Of Florida Method and composition for the control of hair growth
US6635679B2 (en) 2001-05-14 2003-10-21 Akzo Nobel N.V. Methods and compositions for inactivating viruses
US6713653B2 (en) 2001-08-24 2004-03-30 E. I. Du Pont De Nemours And Company Polyamines and polymers made therewith
IL161428A0 (en) 2001-10-16 2004-09-27 Slil Biomedical Corp Oligoamine derivatives, methods for the production thereof and pharmaceutical compositions containing the same
US6458795B1 (en) 2001-11-15 2002-10-01 University Of Florida Method and composition for treatment of irritable bowel disease
US7030126B2 (en) 2001-11-16 2006-04-18 Als Therapy Development Foundation, Inc. Use of polyamine analogs for amyotrophic lateral sclerosis
US20050027016A1 (en) 2002-02-07 2005-02-03 Fahl Kathleen L Polyamine compounds and compositions for use in conjection with cancer therapy
US6881732B2 (en) 2002-06-13 2005-04-19 Chelator Llc Neuroprotection and cardioprotection afforded by chelators with high affinity and specificity for cations of first transition series elements
US20040019043A1 (en) 2002-07-23 2004-01-29 Dimitri Coucouvanis Thiomolybdate analogues and uses thereof
US7189865B2 (en) 2002-07-23 2007-03-13 Attenuon, Llc Thiomolybdate analogues and uses thereof

Also Published As

Publication number Publication date
EP1436246A1 (en) 2004-07-14
US7491849B2 (en) 2009-02-17
JP2005506354A (ja) 2005-03-03
WO2003033455A1 (en) 2003-04-24
AU2009200639A1 (en) 2009-03-12
CA2463771A1 (en) 2003-04-24
US20050080144A1 (en) 2005-04-14
US20090124832A1 (en) 2009-05-14
IL161428A0 (en) 2004-09-27
US20030130356A1 (en) 2003-07-10

Similar Documents

Publication Publication Date Title
AU2002340224B2 (en) Oligoamine compounds and derivatives thereof for cancer therapy
AU2002340224A1 (en) Oligoamine compounds and derivatives thereof for cancer therapy
US7312244B2 (en) Polyamine analog-amino acid conjugates useful as anticancer agents
US7453011B2 (en) Cycloalkyl substituted polyamines for cancer therapy and methods of synthesis therefor
US7186825B2 (en) Conformationally restricted polyamine analogs as disease therapies
US5889061A (en) Conformationally restricted polyamines
US5109024A (en) Polyamine derivatives as antineoplastic agents
US7026347B2 (en) Porphyrin-polyamine conjugates for cancer therapy
AU2009276744A1 (en) Anti-malarial compounds
WO1998017624A1 (en) Conformationally restricted polyamines and their use as antineoplastic agents
US5654484A (en) Polyamine derivatives as antineoplastic agents
JP4181636B2 (ja) 抗腫瘍剤としてのポリアミン配位子を有する新規ビス―プラチナ錯体
EP0311068A2 (en) Polyamine derivatives as antineoplastic agents
EP0662829A1 (en) Polyamine derivatives as anti-cytomegaloviral agents

Legal Events

Date Code Title Description
PC1 Assignment before grant (sect. 113)

Owner name: CELLGATE, INC.

Free format text: FORMER APPLICANT(S): SLIL BIOMEDICAL CORPORATION

FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired