AU2002221112A1 - Method of estimating risk of the expression of side effect caused by the administration of compound metabolized, either per se or as its metabolic intermediate,by ugt1a1 enzyme - Google Patents
Method of estimating risk of the expression of side effect caused by the administration of compound metabolized, either per se or as its metabolic intermediate,by ugt1a1 enzymeInfo
- Publication number
- AU2002221112A1 AU2002221112A1 AU2002221112A AU2111202A AU2002221112A1 AU 2002221112 A1 AU2002221112 A1 AU 2002221112A1 AU 2002221112 A AU2002221112 A AU 2002221112A AU 2111202 A AU2111202 A AU 2111202A AU 2002221112 A1 AU2002221112 A1 AU 2002221112A1
- Authority
- AU
- Australia
- Prior art keywords
- administration
- expression
- irinotecan
- adverse drug
- drug reaction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2000-376756 | 2000-12-12 | ||
JP2000376756 | 2000-12-12 | ||
PCT/JP2001/010813 WO2002048400A1 (fr) | 2000-12-12 | 2001-12-10 | Procede d'estimation du risque de l'expression d'effets secondaires causes par l'administration de compose metabolise, soit automatiquement, soit comme intermediaire metabolique, par l'enzyme ugt1a1 |
Publications (1)
Publication Number | Publication Date |
---|---|
AU2002221112A1 true AU2002221112A1 (en) | 2002-06-24 |
Family
ID=18845576
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2002221112A Abandoned AU2002221112A1 (en) | 2000-12-12 | 2001-12-10 | Method of estimating risk of the expression of side effect caused by the administration of compound metabolized, either per se or as its metabolic intermediate,by ugt1a1 enzyme |
Country Status (10)
Country | Link |
---|---|
US (4) | US20040058363A1 (ja) |
EP (1) | EP1352970B1 (ja) |
JP (2) | JP4447835B2 (ja) |
KR (2) | KR101651391B1 (ja) |
CN (1) | CN100374575C (ja) |
AT (1) | ATE469966T1 (ja) |
AU (1) | AU2002221112A1 (ja) |
DE (1) | DE60142309D1 (ja) |
ES (1) | ES2346848T3 (ja) |
WO (1) | WO2002048400A1 (ja) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6395481B1 (en) * | 1999-02-16 | 2002-05-28 | Arch Development Corp. | Methods for detection of promoter polymorphism in a UGT gene promoter |
WO2002059375A2 (en) * | 2001-01-26 | 2002-08-01 | University Of Chicago | Determination of ugt2b7 gene polymorphisms for predicting ugt2b7 substrate toxicity and for optimising drug dosage |
AU2003257344A1 (en) * | 2002-09-20 | 2004-04-08 | Universite Laval | Method for determining the predisposition of patients to toxicity or lack of efficacy of a drug |
US20040203034A1 (en) * | 2003-01-03 | 2004-10-14 | The University Of Chicago | Optimization of cancer treatment with irinotecan |
JP2006526412A (ja) | 2003-05-30 | 2006-11-24 | ユニバーシティ オブ シカゴ | イリノテカン毒性を推定する方法および組成物 |
CA2541097A1 (en) * | 2003-10-06 | 2005-05-06 | Novartis Ag | Biomarkers for the prediction of drug-induced diarrhoea |
US20090247475A1 (en) * | 2004-03-05 | 2009-10-01 | The Regents Of The University Of California | Methods and compositions relating to pharmacogenetics of different gene variants in the context of irinotecan-based therapies |
WO2007055261A1 (ja) * | 2005-11-10 | 2007-05-18 | The New Industry Research Organization | Ugt1a1遺伝子多型の検査法 |
EP1790343A1 (en) * | 2005-11-11 | 2007-05-30 | Emotional Brain B.V. | Pharmaceuticals formulations and uses thereof in the treatment of female sexual dysfunction |
GB2432365A (en) * | 2005-11-18 | 2007-05-23 | Dxs Ltd | A nucleic acid molecule for detecting polymorphisms in the UGT1A1 promoter |
JP4884899B2 (ja) * | 2006-09-19 | 2012-02-29 | 東洋鋼鈑株式会社 | イリノテカンの副作用の発生危険度を判定する方法およびそのためのキット |
CN102168140B (zh) * | 2006-11-30 | 2013-10-23 | 爱科来株式会社 | Ugt1a1基因扩增用引物对、含有其的ugt1a1基因扩增用试剂及其用途 |
KR200452078Y1 (ko) * | 2009-03-10 | 2011-01-28 | 주식회사 디아이디 | 벽지샘플북의 손잡이 |
JP2011250726A (ja) * | 2010-06-01 | 2011-12-15 | Toyo Kohan Co Ltd | イリノテカンの副作用の発生危険度を判定する方法及びそのためのキット |
CN102816858B (zh) * | 2012-09-06 | 2014-02-19 | 上海源奇生物医药科技有限公司 | 一种检测ugt1a1基因型的引物和探针、及其试剂盒 |
JP6324828B2 (ja) * | 2014-07-07 | 2018-05-16 | 株式会社日立製作所 | 薬効分析システム及び薬効分析方法 |
WO2016132736A1 (ja) | 2015-02-17 | 2016-08-25 | 国立大学法人山口大学 | イリノテカンによる副作用の発生リスクの予測を補助する方法 |
CN107043808A (zh) * | 2017-01-19 | 2017-08-15 | 上海赛安生物医药科技有限公司 | Ugt1a1基因多态性检测引物肽核酸及其试剂盒 |
CN109371127A (zh) * | 2018-10-22 | 2019-02-22 | 江苏美因康生物科技有限公司 | 一种同时快速检测ugt1a1*6型与ugt1a1*28型基因多态性的试剂盒及方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5786344A (en) * | 1994-07-05 | 1998-07-28 | Arch Development Corporation | Camptothecin drug combinations and methods with reduced side effects |
WO1997032042A2 (en) * | 1996-03-01 | 1997-09-04 | The University Court Of The University Of Dundee | Drug trial assay system |
DK1071710T4 (da) * | 1998-04-15 | 2011-12-12 | Merck Serono Biodevelopment | Genomisk sekvens for 5-lipoxygenase-aktiveringsproteinet (FLAP), polymorfe markører deri og fremgangsmåder til påvisning af astma |
WO1999057322A2 (en) * | 1998-05-07 | 1999-11-11 | Axys Pharmaceuticals, Inc. | Genotyping the human udp-glucuronosyltransferase 1 (ugt1) gene |
US6395481B1 (en) * | 1999-02-16 | 2002-05-28 | Arch Development Corp. | Methods for detection of promoter polymorphism in a UGT gene promoter |
-
2001
- 2001-12-10 KR KR1020167005073A patent/KR101651391B1/ko active IP Right Grant
- 2001-12-10 KR KR1020037007790A patent/KR101651287B1/ko active IP Right Grant
- 2001-12-10 ES ES01270625T patent/ES2346848T3/es not_active Expired - Lifetime
- 2001-12-10 DE DE60142309T patent/DE60142309D1/de not_active Expired - Lifetime
- 2001-12-10 JP JP2002550114A patent/JP4447835B2/ja not_active Expired - Lifetime
- 2001-12-10 WO PCT/JP2001/010813 patent/WO2002048400A1/ja active Application Filing
- 2001-12-10 AU AU2002221112A patent/AU2002221112A1/en not_active Abandoned
- 2001-12-10 AT AT01270625T patent/ATE469966T1/de not_active IP Right Cessation
- 2001-12-10 EP EP01270625A patent/EP1352970B1/en not_active Expired - Lifetime
- 2001-12-10 CN CNB01822542XA patent/CN100374575C/zh not_active Expired - Lifetime
-
2003
- 2003-06-12 US US10/459,729 patent/US20040058363A1/en not_active Abandoned
-
2006
- 2006-10-05 US US11/543,055 patent/US20070082357A1/en not_active Abandoned
-
2009
- 2009-05-06 US US12/453,291 patent/US20090263818A1/en not_active Abandoned
- 2009-05-29 JP JP2009129753A patent/JP4616919B2/ja not_active Expired - Fee Related
-
2011
- 2011-02-14 US US13/026,719 patent/US20110151474A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO2002048400A1 (fr) | 2002-06-20 |
JPWO2002048400A1 (ja) | 2004-04-15 |
ES2346848T3 (es) | 2010-10-21 |
CN100374575C (zh) | 2008-03-12 |
KR20160031023A (ko) | 2016-03-21 |
JP2009195247A (ja) | 2009-09-03 |
EP1352970A1 (en) | 2003-10-15 |
KR101651391B1 (ko) | 2016-08-25 |
US20070082357A1 (en) | 2007-04-12 |
DE60142309D1 (de) | 2010-07-15 |
US20040058363A1 (en) | 2004-03-25 |
KR101651287B1 (ko) | 2016-08-26 |
CN1547613A (zh) | 2004-11-17 |
US20110151474A1 (en) | 2011-06-23 |
JP4616919B2 (ja) | 2011-01-19 |
EP1352970B1 (en) | 2010-06-02 |
ATE469966T1 (de) | 2010-06-15 |
JP4447835B2 (ja) | 2010-04-07 |
US20090263818A1 (en) | 2009-10-22 |
KR20030053064A (ko) | 2003-06-27 |
EP1352970A4 (en) | 2004-08-25 |
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