WO2002053579A3 - Haplotypes of the fmo2 gene - Google Patents

Haplotypes of the fmo2 gene Download PDF

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Publication number
WO2002053579A3
WO2002053579A3 PCT/US2001/049059 US0149059W WO02053579A3 WO 2002053579 A3 WO2002053579 A3 WO 2002053579A3 US 0149059 W US0149059 W US 0149059W WO 02053579 A3 WO02053579 A3 WO 02053579A3
Authority
WO
WIPO (PCT)
Prior art keywords
haplotypes
fmo2
gene
disclosed
fmo2 gene
Prior art date
Application number
PCT/US2001/049059
Other languages
French (fr)
Other versions
WO2002053579A2 (en
Inventor
Steven C Bentivegna
Amy Duda
Amir Kazemi
Helen H Lee
Chad Messer
Katie E Parks
Original Assignee
Genaissance Pharmaceuticals
Steven C Bentivegna
Amy Duda
Amir Kazemi
Helen H Lee
Chad Messer
Katie E Parks
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genaissance Pharmaceuticals, Steven C Bentivegna, Amy Duda, Amir Kazemi, Helen H Lee, Chad Messer, Katie E Parks filed Critical Genaissance Pharmaceuticals
Priority to AU2002229103A priority Critical patent/AU2002229103A1/en
Publication of WO2002053579A2 publication Critical patent/WO2002053579A2/en
Publication of WO2002053579A3 publication Critical patent/WO2002053579A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C12Y114/13—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with NADH or NADPH as one donor, and incorporation of one atom of oxygen (1.14.13)
    • C12Y114/13008—Flavin-containing monooxygenase (1.14.13.8), i.e. dimethylaniline-monooxygenase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Novel genetic variants of the Flavin Containing Monooxygenase 2 (FMO2) gene are described. Various genotypes, haplotypes, and haplotype pairs that exist in the general United States population are disclosed for the FMO2 gene. Compositions and methods for haplotyping and/or genotyping the FMO2 gene in an individual are also disclosed. Polynucleotides defined by the haplotypes disclosed herein are also described.
PCT/US2001/049059 2000-12-29 2001-12-18 Haplotypes of the fmo2 gene WO2002053579A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002229103A AU2002229103A1 (en) 2000-12-29 2001-12-18 Haplotypes of the fmo2 gene

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25906200P 2000-12-29 2000-12-29
US60/259,062 2000-12-29

Publications (2)

Publication Number Publication Date
WO2002053579A2 WO2002053579A2 (en) 2002-07-11
WO2002053579A3 true WO2002053579A3 (en) 2003-03-06

Family

ID=22983341

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/049059 WO2002053579A2 (en) 2000-12-29 2001-12-18 Haplotypes of the fmo2 gene

Country Status (2)

Country Link
AU (1) AU2002229103A1 (en)
WO (1) WO2002053579A2 (en)

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DOLPHIN ET AL.: "Cloning, primary sequence and chromosomal localization of human FMO2, a new member of the flavin-containing mono-oxygenase family", BIOCHEMICAL JOURNAL, vol. 287, 1992, pages 261 - 267, XP002956812 *
DOLPHIN ET AL.: "The flavin-containing monooxygenase 2 gene (FMO2) of humans, but not of other primates, encodes a truncated nonfunctional protein", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 273, no. 46, 13 November 1998 (1998-11-13), pages 30599 - 30607, XP002956813 *
WHETSTINE ET AL.: "Ethnic differences in human flavin-containing monooxygenase 2 (FMO2) polymorphisms: detection of expressed protein in African-Americans", TOXICOLOGY AND APPLIED PHARMACOLOGY, vol. 168, 1 November 2000 (2000-11-01), pages 216 - 224, XP002956814 *

Also Published As

Publication number Publication date
AU2002229103A1 (en) 2002-07-16
WO2002053579A2 (en) 2002-07-11

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