WO2002062820A3 - Haplotypes of the cyp27b1 gene - Google Patents

Haplotypes of the cyp27b1 gene Download PDF

Info

Publication number
WO2002062820A3
WO2002062820A3 PCT/US2001/047438 US0147438W WO02062820A3 WO 2002062820 A3 WO2002062820 A3 WO 2002062820A3 US 0147438 W US0147438 W US 0147438W WO 02062820 A3 WO02062820 A3 WO 02062820A3
Authority
WO
WIPO (PCT)
Prior art keywords
haplotypes
cyp27b1
gene
disclosed
cyp27b1 gene
Prior art date
Application number
PCT/US2001/047438
Other languages
French (fr)
Other versions
WO2002062820A2 (en
Inventor
Karyn M Bieglecki
Glen Monroe
Amir Kazemi
Nisha Shah
Original Assignee
Genaissance Pharmaceuticals
Karyn M Bieglecki
Glen Monroe
Amir Kazemi
Nisha Shah
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genaissance Pharmaceuticals, Karyn M Bieglecki, Glen Monroe, Amir Kazemi, Nisha Shah filed Critical Genaissance Pharmaceuticals
Priority to AU2002251686A priority Critical patent/AU2002251686A1/en
Publication of WO2002062820A2 publication Critical patent/WO2002062820A2/en
Publication of WO2002062820A3 publication Critical patent/WO2002062820A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0077—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with a reduced iron-sulfur protein as one donor (1.14.15)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C12Y114/13—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with NADH or NADPH as one donor, and incorporation of one atom of oxygen (1.14.13)
    • C12Y114/13013—Calcidiol 1-monooxygenase (1.14.13.13), i.e. 25-hydroxyvitamin D-1-alpha-hydroxylase
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Novel genetic variants of the Cytochrome P450, Subfamily XXVIIB (25-Hydroxyvitamin D-1-Alpha-Hydroxylase), Polypeptide 1 (CYP27B1) gene are described. Various genotypes, haplotypes, and haplotype pairs that exist in the general United States population are disclosed for the CYP27B1 gene. Compositions and methods for haplotyping and/or genotyping the CYP27B1 gene in an individual are also disclosed. Polynucleotides defined by the haplotypes disclosed herein are also described.
PCT/US2001/047438 2000-11-03 2001-11-05 Haplotypes of the cyp27b1 gene WO2002062820A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002251686A AU2002251686A1 (en) 2000-11-03 2001-11-05 Haplotypes of the CYP27B1 gene

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24579700P 2000-11-03 2000-11-03
US60/245,797 2000-11-03

Publications (2)

Publication Number Publication Date
WO2002062820A2 WO2002062820A2 (en) 2002-08-15
WO2002062820A3 true WO2002062820A3 (en) 2003-03-13

Family

ID=22928116

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/047438 WO2002062820A2 (en) 2000-11-03 2001-11-05 Haplotypes of the cyp27b1 gene

Country Status (2)

Country Link
AU (1) AU2002251686A1 (en)
WO (1) WO2002062820A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10577669B2 (en) 2015-02-11 2020-03-03 Loma Linda University Method for utilizing engineered dendritic cells to induce gut-homing regulatory T cells and treat gut inflammation
CN111363805B (en) * 2020-04-30 2022-06-17 北京和合医学诊断技术股份有限公司 Primer group, kit and method for detecting mutation of vitamin D metabolic gene

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
FU G.K. ET AL.: "Complete structure of the human gene for the vitamin D 1a-hydroxylase, P450c1a", DNA AND CELL BIOLOGY, vol. 16, 1997, pages 1499 - 1507, XP002092696 *

Also Published As

Publication number Publication date
AU2002251686A1 (en) 2002-08-19
WO2002062820A2 (en) 2002-08-15

Similar Documents

Publication Publication Date Title
WO2002026768A3 (en) Haplotypes of the por gene
WO2002038589A3 (en) Haplotypes of the cyp2d6 gene
WO2001090122A3 (en) Haplotypes of the ctla4 gene
WO2002062820A3 (en) Haplotypes of the cyp27b1 gene
WO2002006294A3 (en) Haplotypes of the mmp13 gene
WO2001079234A3 (en) Haplotypes of the apoe gene
WO2002030951A3 (en) Haplotypes of the cyp1b1 gene
WO2002008425A3 (en) Haplotypes of the adrb3 gene
WO2001079224A3 (en) Haplotypes of the cyp8b1 gene
WO2002046209A3 (en) Haplotypes of the cyp3a5 gene
WO2002026764A3 (en) Haplotypes of the ccr6 gene
WO2002036608A3 (en) Haplotypes of the cyp1a2 gene
WO2002050098A3 (en) Haplotypes of the prlr gene
WO2002016399A3 (en) Haplotypes of the tacr1 gene
WO2001087909A3 (en) Haplotypes of the aanat gene
WO2002030952A3 (en) Haplotypes of the cyp27a1 gene
WO2002032930A3 (en) Haplotypes of the scya21 gene
WO2002040503A3 (en) Haplotypes of the plau gene
WO2002002580A3 (en) Haplotypes of the etfb gene
WO2002053579A3 (en) Haplotypes of the fmo2 gene
WO2002090378A3 (en) Haplotypes of the ces2 gene
WO2002026766A3 (en) Haplotypes of the sstr4 gene
WO2002012499A3 (en) Haplotypes of the ntf3 gene
WO2002055534A3 (en) Haplotypes of the f2rli gene
WO2002063044A3 (en) Haplotypes of the il15 gene

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PH PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PH PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

WPC Withdrawal of priority claims after completion of the technical preparations for international publication

Ref country code: WO

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP