WO2000047776A3 - Insulin-family homolog localized to chromosome 1 - Google Patents

Insulin-family homolog localized to chromosome 1 Download PDF

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Publication number
WO2000047776A3
WO2000047776A3 PCT/US2000/003515 US0003515W WO0047776A3 WO 2000047776 A3 WO2000047776 A3 WO 2000047776A3 US 0003515 W US0003515 W US 0003515W WO 0047776 A3 WO0047776 A3 WO 0047776A3
Authority
WO
WIPO (PCT)
Prior art keywords
chromosome
insulin
localized
zins3
provides methods
Prior art date
Application number
PCT/US2000/003515
Other languages
French (fr)
Other versions
WO2000047776A2 (en
Inventor
Stephen R Jaspers
Theodore E Whitmore
Darrell C Conklin
Catherine E Lofton-Day
Si Lok
Original Assignee
Zymogenetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zymogenetics Inc filed Critical Zymogenetics Inc
Priority to AU32285/00A priority Critical patent/AU3228500A/en
Publication of WO2000047776A2 publication Critical patent/WO2000047776A2/en
Publication of WO2000047776A3 publication Critical patent/WO2000047776A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Abstract

The present invention provides methods for identifying mutations in human chromosome 1p using an insulin/relaxin family member, designated zins3. The invention also provides methods for determining mutations in the zins3 gene are linked to defects in glucose metabolism, such as diabetes. The present invention also provides methods for identifying polymorphisms that result from mutations in the zins3 gene on chromosome 1p, a loci linked with a heritable form of NIDDM.
PCT/US2000/003515 1999-02-12 2000-02-10 Insulin-family homolog localized to chromosome 1 WO2000047776A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU32285/00A AU3228500A (en) 1999-02-12 2000-02-10 Insulin-family homolog localized to chromosome 1

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US25012599A 1999-02-12 1999-02-12
US19824899P 1999-02-12 1999-02-12
US09/250,125 1999-02-12
US60/198,248 1999-02-12

Publications (2)

Publication Number Publication Date
WO2000047776A2 WO2000047776A2 (en) 2000-08-17
WO2000047776A3 true WO2000047776A3 (en) 2000-12-21

Family

ID=26893609

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/003515 WO2000047776A2 (en) 1999-02-12 2000-02-10 Insulin-family homolog localized to chromosome 1

Country Status (2)

Country Link
AU (1) AU3228500A (en)
WO (1) WO2000047776A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20020093053A (en) * 2000-04-21 2002-12-12 다케다 야쿠힌 고교 가부시키가이샤 Novel insulin/igf/relaxin family polypeptides and dnas thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998016635A1 (en) * 1996-10-15 1998-04-23 Zymogenetics, Inc. Insulin homologs
WO1999015664A1 (en) * 1997-09-24 1999-04-01 Genentech, Inc. Insulin-like polypeptide and uses therefor

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998016635A1 (en) * 1996-10-15 1998-04-23 Zymogenetics, Inc. Insulin homologs
WO1999015664A1 (en) * 1997-09-24 1999-04-01 Genentech, Inc. Insulin-like polypeptide and uses therefor

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
CONKLIN ET AL.: "IDENTIFICATION OF INSL5, A NEW MEMBER OF THE INSULIN SUPERFAMILY", GENOMICS, vol. 60, August 1999 (1999-08-01), pages 50 - 56, XP000929741 *
DATABASE INTERNET "GENEBRIDGE 4 HUMAN/HAMSTER RH PANEL/RADIATION HYBRID MAPPING SERVICE", XP002144309 *
GYAPAY ET AL.: "A radiation hybrid map of the human genome", HUM.MOL.GEN., vol. 5, 1996, pages 339 - 346, XP002126261, DOI: doi:10.1093/hmg/5.3.339 *
SAKUL ET AL.: "FAMILIALITY OF PHYSICAL AND METABOLIC CHARACTERISTICS THAT PREDICT THE DEVELPOMENT OF NON-INSULIN-DEPENDENT DIABETES MELLITUS IN PIMA INDIANS", AM.SOC.HUM.GENET., vol. 60, 1997, pages 651 - 656, XP000929743 *
THOMPSON ET AL.: "EVIDENCE OF LINKAGE BETWEEN A REGION ON CHROMOSOME 1p AND THE ACUTE INSULIN RESPONSE IN PIMA INDIANS", DIABETES, vol. 44, 1995, pages 478 - 481, XP000929742 *

Also Published As

Publication number Publication date
AU3228500A (en) 2000-08-29
WO2000047776A2 (en) 2000-08-17

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