WO2001042511A3 - Ibd-related polymorphisms - Google Patents

Ibd-related polymorphisms Download PDF

Info

Publication number
WO2001042511A3
WO2001042511A3 PCT/US2000/033632 US0033632W WO0142511A3 WO 2001042511 A3 WO2001042511 A3 WO 2001042511A3 US 0033632 W US0033632 W US 0033632W WO 0142511 A3 WO0142511 A3 WO 0142511A3
Authority
WO
WIPO (PCT)
Prior art keywords
nucleic acid
ibd
acid segments
probes
sites
Prior art date
Application number
PCT/US2000/033632
Other languages
French (fr)
Other versions
WO2001042511A2 (en
Inventor
Mark Daly
Thomas J Hudson
Eric S Lander
John Rioux
Kathy Siminovitch
Original Assignee
Whitehead Biomedical Inst
Ellipsis Biotherapeutics Corp
Mark Daly
Thomas J Hudson
Eric S Lander
John Rioux
Kathy Siminovitch
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Whitehead Biomedical Inst, Ellipsis Biotherapeutics Corp, Mark Daly, Thomas J Hudson, Eric S Lander, John Rioux, Kathy Siminovitch filed Critical Whitehead Biomedical Inst
Priority to EP00986325A priority Critical patent/EP1276899A2/en
Priority to CA002394033A priority patent/CA2394033A1/en
Priority to AU22586/01A priority patent/AU2258601A/en
Publication of WO2001042511A2 publication Critical patent/WO2001042511A2/en
Publication of WO2001042511A3 publication Critical patent/WO2001042511A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes

Abstract

The invention provides nucleic acid segments of the human genome, particularly nucleic acid segments from a gene, including polymorphic sites. Allele-specific primers and probes hybridizing to regions flanking or containing these sites are also provided. The nucleic acids, primers and probes are used in applications such as phenotype correlations, forensics, paternity testing, medicine and genetic analysis.
PCT/US2000/033632 1999-12-10 2000-12-11 Ibd-related polymorphisms WO2001042511A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP00986325A EP1276899A2 (en) 1999-12-10 2000-12-11 Ibd-related polymorphisms
CA002394033A CA2394033A1 (en) 1999-12-10 2000-12-11 Ibd-related polymorphisms
AU22586/01A AU2258601A (en) 1999-12-10 2000-12-11 Ibd-related polymorphisms

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US17025799P 1999-12-10 1999-12-10
US60/170,257 1999-12-10
US19604600P 2000-04-10 2000-04-10
US60/196,046 2000-04-10

Publications (2)

Publication Number Publication Date
WO2001042511A2 WO2001042511A2 (en) 2001-06-14
WO2001042511A3 true WO2001042511A3 (en) 2002-11-14

Family

ID=26865891

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/033632 WO2001042511A2 (en) 1999-12-10 2000-12-11 Ibd-related polymorphisms

Country Status (4)

Country Link
EP (1) EP1276899A2 (en)
AU (1) AU2258601A (en)
CA (1) CA2394033A1 (en)
WO (1) WO2001042511A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004506402A (en) * 1999-03-23 2004-03-04 ヒューマン　ジノーム　サイエンシーズ，　インコーポレイテッド 48 human secretory proteins
CA2470325A1 (en) * 2001-12-21 2003-07-03 Ellipsis Biotherapeutics Corporation Polymorphisms of the octn1 and octn2 cation transporters associated with inflammatory bowel disease
WO2010062960A2 (en) 2008-11-26 2010-06-03 Cedars-Sinai Medical Center METHODS OF DETERMINING RESPONSIVENESS TO ANTI-TNFα THERAPY IN INFLAMMATORY BOWEL DISEASE
EP4285988A3 (en) 2013-03-27 2024-03-06 Cedars-Sinai Medical Center Treating fibrosis by inhibiting tl1a
EP4105236A1 (en) 2013-07-19 2022-12-21 Cedars-Sinai Medical Center Anti-tl1a (tnfsf15) antibody for treatment of inflammatory bowel disease
KR20220153109A (en) 2016-03-17 2022-11-17 세다르스-신나이 메디칼 센터 Methods of diagnosing inflammatory bowel disease through rnaset2
CN108359736B (en) * 2018-05-23 2020-12-29 华中农业大学 SNP genetic marker for sow limb hoof bone density character

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1986000639A1 (en) * 1984-07-06 1986-01-30 Sandoz Ag Lymphokine production and purification
WO1994004196A1 (en) * 1992-08-14 1994-03-03 Imperial Cancer Research Technology Limited Tumour therapy
WO1995021941A1 (en) * 1994-02-11 1995-08-17 Cedars-Sinai Medical Center Methods of diagnosing ulcerative colitis and crohn's disease
WO1998020165A2 (en) * 1996-11-06 1998-05-14 Whitehead Institute For Biomedical Research Biallelic markers
WO1998038846A2 (en) * 1997-03-07 1998-09-11 Affymetrix, Inc. Genetic compositions and methods
US5916748A (en) * 1996-04-12 1999-06-29 Cedars-Sinai Medical Center Method of diagnosing a clinical subtype of crohn's disease with features of ulcerative colitis

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1986000639A1 (en) * 1984-07-06 1986-01-30 Sandoz Ag Lymphokine production and purification
WO1994004196A1 (en) * 1992-08-14 1994-03-03 Imperial Cancer Research Technology Limited Tumour therapy
WO1995021941A1 (en) * 1994-02-11 1995-08-17 Cedars-Sinai Medical Center Methods of diagnosing ulcerative colitis and crohn's disease
US5916748A (en) * 1996-04-12 1999-06-29 Cedars-Sinai Medical Center Method of diagnosing a clinical subtype of crohn's disease with features of ulcerative colitis
WO1998020165A2 (en) * 1996-11-06 1998-05-14 Whitehead Institute For Biomedical Research Biallelic markers
WO1998038846A2 (en) * 1997-03-07 1998-09-11 Affymetrix, Inc. Genetic compositions and methods

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CARGILL M ET AL.: "Characterization of single-nucleotide polymorphisms in coding regions of human genes", NATURE GENETICS, vol. 22, July 1999 (1999-07-01), pages 231 - 238, XP002121300 *
FAN J ET AL: "Genetic mapping: Finding and analyzing single-nucleotide polymorphisms with high-density DNA arrays", AMERICAN JOURNAL OF HUMAN GENETICS, UNIVERSITY OF CHICAGO PRESS, CHICAGO,, US, vol. 61, no. 4, SUPPL, 1 October 1997 (1997-10-01), pages 1601, XP002089397, ISSN: 0002-9297 *
NAKAJIMA A ET AL.: "HLA-linked susceptibility and resistance genes in Crohn's disease", GASTROENTEROLOGY, vol. 109, 1995, pages 1462 - 1467, XP001025593 *
RIOUX J D ET AL.: "Genomewide search in Canadian families with inflammatory bowel disease reveals two novel susceptibility loci", AMERICAN JOURNAL OF HUMAN GENETICS, vol. 66, June 2000 (2000-06-01), pages 1863 - 1870, XP001016365 *

Also Published As

Publication number Publication date
WO2001042511A2 (en) 2001-06-14
CA2394033A1 (en) 2001-06-14
AU2258601A (en) 2001-06-18
EP1276899A2 (en) 2003-01-22

Similar Documents

Publication Publication Date Title
WO1998020165A3 (en) Biallelic markers
Wagner et al. Denaturing high-performance liquid chromatography detects reliably BRCA1 and BRCA2 mutations
CA2289872A1 (en) Target-dependent reactions using structure-bridging oligonucleotides
WO2001066800A3 (en) Human single nucleotide polymorphisms
WO2001090419A3 (en) Methods for genetic analysis of dna to detect sequence variances
CA2190588A1 (en) Pteridine nucleotide analogs as fluorescent dna probes
WO2001077384A3 (en) Detection of single nucleotide polymorphisms (snp's) and cytosine-methylations
WO2001013086A3 (en) Detection of nucleic acids
EP1212449A4 (en) Method for amplifying signal-flanking sequences from unknown genomic dna
WO2000047771A3 (en) Biallelic markers derived from genomic regions carrying genes involved in arachidonic acid metabolism
WO1999050454A3 (en) Coding sequence polymorphisms in vascular pathology genes
WO2001042511A3 (en) Ibd-related polymorphisms
DE69816467D1 (en) ROBO: A FAMILY OF POLYPEPTIDES AND NUCLEIC ACIDS EFFECTIVELY IN NERVOUS LINE
WO2000058519A3 (en) Charaterization of single nucleotide polymorphisms in coding regions of human genes
WO2001018250A3 (en) Single nucleotide polymorphisms in genes
WO2000047772A3 (en) Polymorphic markers of the lsr gene
WO2001038576A3 (en) Human single nucleotide polymorphisms
AU4766000A (en) Method for analysing a patient's genetic predisposition to at least a disease and amplification adapted to such a method
WO1999053095A3 (en) Biallelic markers
WO1999054500A3 (en) Biallelic markers for use in constructing a high density disequilibrium map of the human genome
WO2003054167A3 (en) Identification of novel polymorphic sites in the human mglur8 gene and uses thereof
CA2348828A1 (en) Genomic and complete cdna sequences of apm1 and biallelic markers thereof
WO2001051659A3 (en) Biallelic markers derived from genomic regions carrying genes involved in central nervous system disorders
EP1262565A3 (en) Genetic polymorphisms in the human neurokinin 1 receptor gene and their uses in diagnosis and treatment of diseases
GUSMĀO et al. Characterization of four short tandem repeat loci (TH01, VWA31/A, CD4, and TP53) in northern Portugal

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
WWE Wipo information: entry into national phase

Ref document number: 2394033

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2000986325

Country of ref document: EP

AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWP Wipo information: published in national office

Ref document number: 2000986325

Country of ref document: EP

NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Ref document number: 2000986325

Country of ref document: EP