WO1999053095A3 - Biallelic markers - Google Patents

Biallelic markers Download PDF

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Publication number
WO1999053095A3
WO1999053095A3 PCT/US1999/006893 US9906893W WO9953095A3 WO 1999053095 A3 WO1999053095 A3 WO 1999053095A3 US 9906893 W US9906893 W US 9906893W WO 9953095 A3 WO9953095 A3 WO 9953095A3
Authority
WO
WIPO (PCT)
Prior art keywords
biallelic markers
probes
sites
primers
forensics
Prior art date
Application number
PCT/US1999/006893
Other languages
French (fr)
Other versions
WO1999053095A2 (en
Inventor
Eric S Lander
David Wang
Thomas Hudson
Original Assignee
Whitehead Biomedical Inst
Eric S Lander
David Wang
Thomas Hudson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Whitehead Biomedical Inst, Eric S Lander, David Wang, Thomas Hudson filed Critical Whitehead Biomedical Inst
Priority to CA002324869A priority Critical patent/CA2324869A1/en
Priority to EP99915117A priority patent/EP1068354A2/en
Priority to AU33711/99A priority patent/AU3371199A/en
Publication of WO1999053095A2 publication Critical patent/WO1999053095A2/en
Publication of WO1999053095A3 publication Critical patent/WO1999053095A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Abstract

The invention provides nucleic acid segments of the human genome including polymorphic sites. Allele-specific primers and probes hybridizing to regions flanking these sites are also provided. The nucleic acids, primers and probes are used in applications such as forensics, paternity testing, medicine and genetic analysis.
PCT/US1999/006893 1998-04-09 1999-03-30 Biallelic markers WO1999053095A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA002324869A CA2324869A1 (en) 1998-04-09 1999-03-30 Biallelic markers
EP99915117A EP1068354A2 (en) 1998-04-09 1999-03-30 Biallelic markers
AU33711/99A AU3371199A (en) 1998-04-09 1999-03-30 Biallelic markers

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5787198A 1998-04-09 1998-04-09
US09/057,871 1998-04-09

Publications (2)

Publication Number Publication Date
WO1999053095A2 WO1999053095A2 (en) 1999-10-21
WO1999053095A3 true WO1999053095A3 (en) 2000-03-16

Family

ID=22013239

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/006893 WO1999053095A2 (en) 1998-04-09 1999-03-30 Biallelic markers

Country Status (4)

Country Link
EP (1) EP1068354A2 (en)
AU (1) AU3371199A (en)
CA (1) CA2324869A1 (en)
WO (1) WO1999053095A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2255248T3 (en) 1998-02-05 2006-06-16 Glaxosmithkline Biologicals S.A. DERIVATIVES OF ANTIGENS ASSOCIATED TO TUMOR OF THE MAGE FAMILY, AND SEQUENCES OF NUCLEIC ACIDS THAT CODIFY THEM, USED FOR THE PREPARATION OF FUSION PROTEINS AND COMPOSITIONS FOR VACCINES.
CA2371752A1 (en) * 1999-01-19 2000-07-20 Zymogenetics, Inc. Tumor marker zsig62
AU1477601A (en) * 1999-11-10 2001-06-06 Affymetrix, Inc. Genetic compositions and methods
US6756214B2 (en) 2000-11-09 2004-06-29 Zymogenetics, Inc. Protein zlmda33
EP1383922A4 (en) 2001-04-10 2005-03-30 Agensys Inc Nucleid acid and corresponding protein entitled 158p3d2 useful in treatment and detection of cancer
WO2012097474A1 (en) * 2011-01-20 2012-07-26 深圳华大基因科技有限公司 Method and system for detecting the insertion sites of transgenic foreign fragments

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995012607A1 (en) * 1993-11-03 1995-05-11 Molecular Tool, Inc. Single nucleotide polymorphisms and their use in genetic analysis
FR2722295A1 (en) * 1994-07-07 1996-01-12 Roussy Inst Gustave Single strand conformation polymorphism analysis of DNA
EP0785280A2 (en) * 1995-11-29 1997-07-23 Affymetrix, Inc. (a California Corporation) Polymorphism detection
WO1998020165A2 (en) * 1996-11-06 1998-05-14 Whitehead Institute For Biomedical Research Biallelic markers
WO1999004038A2 (en) * 1997-07-18 1999-01-28 Genset Biallelic markers for use in constructing a high density disequilibrium map of the human genome
WO1999032644A2 (en) * 1997-12-22 1999-07-01 Genset Prostate cancer gene

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995012607A1 (en) * 1993-11-03 1995-05-11 Molecular Tool, Inc. Single nucleotide polymorphisms and their use in genetic analysis
FR2722295A1 (en) * 1994-07-07 1996-01-12 Roussy Inst Gustave Single strand conformation polymorphism analysis of DNA
EP0785280A2 (en) * 1995-11-29 1997-07-23 Affymetrix, Inc. (a California Corporation) Polymorphism detection
WO1998020165A2 (en) * 1996-11-06 1998-05-14 Whitehead Institute For Biomedical Research Biallelic markers
WO1999004038A2 (en) * 1997-07-18 1999-01-28 Genset Biallelic markers for use in constructing a high density disequilibrium map of the human genome
WO1999032644A2 (en) * 1997-12-22 1999-07-01 Genset Prostate cancer gene

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
FAN J ET AL: "Genetic mapping: Finding and analyzing single-nucleotide polymorphisms with high-density DNA arrays", AMERICAN JOURNAL OF HUMAN GENETICS, vol. 61, no. 4, SUPPL, 1 October 1997 (1997-10-01), pages 1601, XP002089397 *
GROMPE M: "THE RAPID DETECTION OF UNKNOWN MUTATIONS IN NUCLEIC ACIDS", NATURE GENETICS, vol. 5, no. 2, 1 October 1993 (1993-10-01), pages 111 - 117, XP000615290 *
HRUBAN R H ET AL: "K-RAS ONCOGENE ACTIVATION IN ADENOCARCINOMA OF THE HUMAN PANCREAS A STUDY OF 82 CARCINOMAS USING A COMBINATION OF MUTANT-ENRICHED POLYMERASE CHAIN RACTION ANALYSIS AND ALLELE-SPECIFIC OLIGONUCLEOTIDE HYBRIDIZATION", AMERICAN JOURNAL OF PATHOLOGY, vol. 143, no. 2, 1 August 1993 (1993-08-01), pages 545 - 554, XP000572114 *
NIKIFOROV T T ET AL: "GENETIC BIT ANALYSIS: A SOLID PHASE METHOD FOR TYPING SINGLE NUCLEOTIDE POLYMORPHISMS", NUCLEIC ACIDS RESEARCH, vol. 22, no. 20, 1 October 1994 (1994-10-01), pages 4167 - 4175, XP002015765 *
SYVANEN A -CH ET AL: "IDENTIFICATION OF INDIVIDUALS BY ANALYSIS OF BIALLELIC DNA MARKERS, USING PCR AND SOLID-PHASE MINISEQUENCING", AMERICAN JOURNAL OF HUMAN GENETICS, vol. 52, no. 1, 1 January 1993 (1993-01-01), pages 46 - 59, XP002050638 *
WANG D ET AL: "TOWARD A THIRD GENERATION GENETIC MAP OF THE HUMAN GENOME BASED ON BI-ALLELIC POLYMORPHISMS", AMERICAN JOURNAL OF HUMAN GENETICS, vol. 59, no. 4, 1 October 1996 (1996-10-01), pages A03, XP002050641 *
WANG D G ET AL: "Large-scale identification, mapping, and genotyping of single -nucleotide polymorphisms in the human genome", SCIENCE, vol. 280, 1 January 1998 (1998-01-01), pages 1077 - 1082, XP002089398 *

Also Published As

Publication number Publication date
EP1068354A2 (en) 2001-01-17
CA2324869A1 (en) 1999-10-21
AU3371199A (en) 1999-11-01
WO1999053095A2 (en) 1999-10-21

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