WO2000058510A3 - Schizophrenia associated genes, proteins and biallelic markers - Google Patents

Schizophrenia associated genes, proteins and biallelic markers Download PDF

Info

Publication number
WO2000058510A3
WO2000058510A3 PCT/IB2000/000435 IB0000435W WO0058510A3 WO 2000058510 A3 WO2000058510 A3 WO 2000058510A3 IB 0000435 W IB0000435 W IB 0000435W WO 0058510 A3 WO0058510 A3 WO 0058510A3
Authority
WO
WIPO (PCT)
Prior art keywords
biallelic markers
schizophrenia
proteins
associated genes
genes
Prior art date
Application number
PCT/IB2000/000435
Other languages
French (fr)
Other versions
WO2000058510A2 (en
Inventor
Daniel Cohen
Marta Blumenfeld
Ilya Chumakov
Lydie Bougueleret
Bernard Bihain
Laurent Essioux
Original Assignee
Genset Sa
Daniel Cohen
Marta Blumenfeld
Ilya Chumakov
Lydie Bougueleret
Bernard Bihain
Laurent Essioux
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genset Sa, Daniel Cohen, Marta Blumenfeld, Ilya Chumakov, Lydie Bougueleret, Bernard Bihain, Laurent Essioux filed Critical Genset Sa
Priority to AU35719/00A priority Critical patent/AU778868B2/en
Priority to EP00914325A priority patent/EP1165836A2/en
Priority to CA002361408A priority patent/CA2361408A1/en
Priority to JP2000608788A priority patent/JP2002539845A/en
Publication of WO2000058510A2 publication Critical patent/WO2000058510A2/en
Publication of WO2000058510A3 publication Critical patent/WO2000058510A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Abstract

The invention concerns the human sbg1, g34665, sbg2, g35017 and g35018 genes, polynucleotides, polypeptides biallelic markers, and human chromosome 13q31-q33 biallelic markers. The invention also concerns the association established between schizophrenia and bipolar disorder and the biallelic markers and the sbg1, g34665, sbg2, g35017 and g35018 genes and nucleotide sequences. The invention provides means to identify compounds useful in the treatment of schizophrenia, bipolar disorder and related diseases, means to determine the predisposition of individuals to said disease as well as means for the disease diagnosis and prognosis.
PCT/IB2000/000435 1999-03-30 2000-03-30 Schizophrenia associated genes, proteins and biallelic markers WO2000058510A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU35719/00A AU778868B2 (en) 1999-03-30 2000-03-30 Schizophrenia associated genes, proteins and biallelic markers
EP00914325A EP1165836A2 (en) 1999-03-30 2000-03-30 Schizophrenia associated genes, proteins and biallelic markers
CA002361408A CA2361408A1 (en) 1999-03-30 2000-03-30 Schizophrenia associated genes, proteins and biallelic markers
JP2000608788A JP2002539845A (en) 1999-03-30 2000-03-30 Schizophrenia-related genes, proteins and biallelic markers

Applications Claiming Priority (16)

Application Number Priority Date Filing Date Title
US12690399P 1999-03-30 1999-03-30
US13197199P 1999-04-30 1999-04-30
US13206599P 1999-04-30 1999-04-30
US14392899P 1999-07-14 1999-07-14
US14591599P 1999-07-27 1999-07-27
US14645299P 1999-07-29 1999-07-29
US14645399P 1999-07-29 1999-07-29
US16228899P 1999-10-28 1999-10-28
US60/162,288 1999-10-28
US60/143,928 1999-10-28
US60/145,915 1999-10-28
US60/146,452 1999-10-28
US60/146,453 1999-10-28
US60/126,903 1999-10-28
US60/131,971 1999-10-28
US60/132,065 1999-10-28

Publications (2)

Publication Number Publication Date
WO2000058510A2 WO2000058510A2 (en) 2000-10-05
WO2000058510A3 true WO2000058510A3 (en) 2001-08-09

Family

ID=27574884

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2000/000435 WO2000058510A2 (en) 1999-03-30 2000-03-30 Schizophrenia associated genes, proteins and biallelic markers

Country Status (5)

Country Link
EP (1) EP1165836A2 (en)
JP (1) JP2002539845A (en)
AU (1) AU778868B2 (en)
CA (1) CA2361408A1 (en)
WO (1) WO2000058510A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA79927C2 (en) * 2000-12-05 2007-08-10 Serono Genetics Inst Sa Polynucleotide, coding a polypeptide of potential-depending portal ionic human channel (canion), polypeptyde, antibody, method for identification of candidate modulator of canion-polypeptyde, method for treatment of bipolar disorder or schizophrenia and use of an antibody for production of drugs for treatment of schizophrenia or bipolar disorder
CN1568370A (en) * 2001-01-16 2005-01-19 根瑟特公司 Treatment of CNS disorders using D-amino acid oxidase and D-aspartate oxidase antagonists
EP1470245A4 (en) * 2001-04-24 2005-08-31 Pharmacia & Upjohn Co Llc Single nucleotide polymorphisms diagnostic for schizophrenia
JP2003038198A (en) * 2001-07-27 2003-02-12 Univ Niigata Method for analyzing nucleic acid specifying gene having expression level changeable with schizophrenia
US20060234221A1 (en) * 2001-12-12 2006-10-19 Genset S.A. Biallelic markers of d-amino acid oxidase and uses thereof
EP1495041A4 (en) * 2002-02-20 2006-02-01 Sirna Therapeutics Inc RNA INTERFERENCE MEDIATED INHIBITION OF G72 AND D-AMINO ACID OXIDASE (DAAO) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
US20060088835A1 (en) * 2002-04-05 2006-04-27 Pickard Benjamin S Schizophrenia associated genes
WO2004047727A2 (en) * 2002-11-01 2004-06-10 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for diagnosing and treating mood disorders
EP2453024B1 (en) 2004-06-21 2017-12-06 The Board of Trustees of The Leland Stanford Junior University Genes and pathways differentially expressed in bipolar disorder and/or major depressive disorder

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997027284A2 (en) * 1996-01-26 1997-07-31 Genelabs Technologies, Inc. Human rad50 and septin-2 genes and methods of use
WO1998020165A2 (en) * 1996-11-06 1998-05-14 Whitehead Institute For Biomedical Research Biallelic markers
WO2000022122A2 (en) * 1998-10-13 2000-04-20 Genset Genes, proteins and biallelic markers related to central nervous system disease

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997027284A2 (en) * 1996-01-26 1997-07-31 Genelabs Technologies, Inc. Human rad50 and septin-2 genes and methods of use
WO1998020165A2 (en) * 1996-11-06 1998-05-14 Whitehead Institute For Biomedical Research Biallelic markers
WO2000022122A2 (en) * 1998-10-13 2000-04-20 Genset Genes, proteins and biallelic markers related to central nervous system disease

Non-Patent Citations (11)

* Cited by examiner, † Cited by third party
Title
CHEE M ET AL: "ACCESSING GENETIC INFORMATION WITH HIGH-DENSITY DNA ARRAYS", SCIENCE,US,AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, vol. 274, 25 October 1996 (1996-10-25), pages 610 - 614, XP002022508, ISSN: 0036-8075 *
DATABASE EMEST EMBL,Heidelberg; 25 June 1997 (1997-06-25), MARRA M. ET AL.: "The WashU-HHMI mouse EST project", XP002155360 *
DATABASE GENESEQ Derwent,UK; 16 March 1999 (1999-03-16), BARASH S.C. ET AL.: "Polynucleotides and proteins derived from S. aureus", XP002155359 *
DATABASE SWISSPROT 1 October 1989 (1989-10-01), MCCARN D.F. ET AL.: "Genes encoding the alpha,gamma delta and four FO subunits of ATP synthase constitute an operon in the cyanobacterium Anabaena sp.", XP002155358 *
DATABASE TREMBL EMBL,Heidelberg; 1 July 1997 (1997-07-01), D.W. LIU ET AL.: "Molecular cloning and expression of the gene encoding a cysteine proteinase of Spirometra erinacei", XP002155357 *
J.-L. BLOUIN ET AL.: "Schizophrenia susceptibility loci on chromosomes 13q32 and 8p21", NATURE GENETICS, vol. 20, 20 September 1998 (1998-09-20), UK, pages 70 - 73, XP000944108 *
M.-W. LIN ET AL.: "Suggestive evidence for linkage of schizophrenia to markers on chromosome 13q14.1-q32", PSYCHIATRIC GENETICS, vol. 5, no. 3, 1995, pages 117 - 126, XP000944456 *
MING-WEI LIN ET AL: "SUGGESTIVE EVIDENCE FOR LINKAGE OF SCHIZOPHRENIA TO MARKERS ON CHROMOSOME 13 IN CAUCASIAN BUT NOT ORIENTAL POPULATIONS", HUMAN GENETICS,DE,BERLIN, vol. 99, no. 3, March 1997 (1997-03-01), pages 417 - 420, XP000876937 *
S.E. ANTONARAKIS ET AL.: "LInkage and sib-pair analysis reveal a potential schizophrenia susceptibility gene on chromosome 13q32", AMERICAN JOURNAL OF HUMAN GENETICS, vol. 59, 1996, US, pages a210, XP000944209 *
Y. INAYAMA ET AL.: "Positive association betwen a DNA sequence variant in the serotonin 2A receptor gene and schizophrenia", AMERICAN JOURNAL OF MEDICAL GENETICS, vol. 67, 1996, US, pages 103 - 105, XP000944353 *
ZHANG M.Q.: "identification of protein coding regions in the human genome by quadratic discriminant analysis", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 94, January 1997 (1997-01-01), US, pages 565 - 568, XP002155356 *

Also Published As

Publication number Publication date
EP1165836A2 (en) 2002-01-02
CA2361408A1 (en) 2000-10-05
WO2000058510A2 (en) 2000-10-05
AU3571900A (en) 2000-10-16
AU778868B2 (en) 2004-12-23
JP2002539845A (en) 2002-11-26

Similar Documents

Publication Publication Date Title
WO2004066941A3 (en) Expression profiles for colon cancer and methods of use
WO2003029421A3 (en) Regulated breast cancer genes
WO2000050639A3 (en) Gene sequence variations with utility in determining the treatment of disease
WO1999047669A3 (en) Human nucleic acid sequences from tissue of breast tumors
WO1998007850A3 (en) Agents for pre-symptomatic detection and therapeutic targeting of alzheimer's disease and down syndrome in humans
WO2005059108A3 (en) Gene expression profiles and methods of use
WO2002074992A3 (en) Phosphodiesterase 4d genes related to human stroke
WO2004098377A3 (en) Methods and compositions for diagnosis and therapy of parkin-associated disorders
WO2004047514A3 (en) Methods for identifying risk of breast cancer and treatments thereof
WO2004078035A3 (en) Expression profiles for breast cancer and methods of use
WO2000058510A3 (en) Schizophrenia associated genes, proteins and biallelic markers
WO2005014846A3 (en) Methods for identifying risk of breast cancer and treatments thereof
WO2000022122A3 (en) Genes, proteins and biallelic markers related to central nervous system disease
WO2004044163A3 (en) Methods for identifying risk of melanoma and treatments thereof
WO2003063773A3 (en) Differentially-regulated prostate cancer genes
WO2003040331A3 (en) Prostate cancer genes
WO2001040493A3 (en) Schizophrenia associated gene, proteins and biallelic markers
WO2003054167A3 (en) Identification of novel polymorphic sites in the human mglur8 gene and uses thereof
WO2003054143A3 (en) Genes and polymorphisms on chromosome 10 associated with alzheimer's disease and other neurodegenerative diseases
WO2003050303A3 (en) Biallelic markers of d-amino acid oxidase and uses thereof
DE60123109D1 (en) GENUS CONNECTING SCHIZOPHRENIA GENERATING A POTENTIAL DEPENDENT ION CHANNEL
WO2004048546A3 (en) Methods for identifying risk of breast cancer and treatments thereof
AU2002358580A1 (en) Methods of identifying genetic risk for and evaluating treatment of alzheimer's disease by determing single nucleotide polymorphisms
WO2000058509A3 (en) Prostate cancer associated human fibronectin gene and biallelic markers
WO2005037204A3 (en) Ntrk1 genetic markers associated with age of onset of alzheimer's disease

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
WWE Wipo information: entry into national phase

Ref document number: 35719/00

Country of ref document: AU

ENP Entry into the national phase

Ref document number: 2361408

Country of ref document: CA

Ref document number: 2361408

Country of ref document: CA

Kind code of ref document: A

AK Designated states

Kind code of ref document: A3

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

ENP Entry into the national phase

Ref document number: 2000 608788

Country of ref document: JP

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 2000914325

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2000914325

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWG Wipo information: grant in national office

Ref document number: 35719/00

Country of ref document: AU

DPE2 Request for preliminary examination filed before expiration of 19th month from priority date (pct application filed from 20040101)