WO2001077363A3 - Haplotypes of the impdh2 gene - Google Patents

Haplotypes of the impdh2 gene Download PDF

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Publication number
WO2001077363A3
WO2001077363A3 PCT/US2001/011851 US0111851W WO0177363A3 WO 2001077363 A3 WO2001077363 A3 WO 2001077363A3 US 0111851 W US0111851 W US 0111851W WO 0177363 A3 WO0177363 A3 WO 0177363A3
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WO
WIPO (PCT)
Prior art keywords
impdh2
gene
haplotypes
disclosed
impdh2 gene
Prior art date
Application number
PCT/US2001/011851
Other languages
French (fr)
Other versions
WO2001077363A2 (en
Inventor
Anne Chew
Julie Y Choi
Beena Koshy
Helen H Lee
J Claiborne Stephens
Original Assignee
Genaissance Pharmaceuticals
Anne Chew
Julie Y Choi
Beena Koshy
Helen H Lee
J Claiborne Stephens
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genaissance Pharmaceuticals, Anne Chew, Julie Y Choi, Beena Koshy, Helen H Lee, J Claiborne Stephens filed Critical Genaissance Pharmaceuticals
Priority to AU2001253386A priority Critical patent/AU2001253386A1/en
Publication of WO2001077363A2 publication Critical patent/WO2001077363A2/en
Publication of WO2001077363A3 publication Critical patent/WO2001077363A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G16B30/10—Sequence alignment; Homology search
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids

Abstract

Novel single nucleotide polymorphisms in the human IMP dehydrogenase 2 (IMPDH2) gene are described. In addition, various genotypes, haplotypes and haplotype pairs for the IMPDH2 gene that exist in the population are described. Compositions and methods for haplotyping and/or genotyping the IMPDH2 gene in an individual are also disclosed. Polynucleotides containing one or more of the IMPDH2 polymorphisms disclosed herein are also described.
PCT/US2001/011851 2000-04-11 2001-04-11 Haplotypes of the impdh2 gene WO2001077363A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001253386A AU2001253386A1 (en) 2000-04-11 2001-04-11 Haplotypes of the impdh2 gene

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19624800P 2000-04-11 2000-04-11
US60/196,248 2000-04-11

Publications (2)

Publication Number Publication Date
WO2001077363A2 WO2001077363A2 (en) 2001-10-18
WO2001077363A3 true WO2001077363A3 (en) 2002-03-14

Family

ID=22724608

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/011851 WO2001077363A2 (en) 2000-04-11 2001-04-11 Haplotypes of the impdh2 gene

Country Status (2)

Country Link
AU (1) AU2001253386A1 (en)
WO (1) WO2001077363A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008545444A (en) * 2005-06-13 2008-12-18 エフ．ホフマン−ラ ロシュ アーゲー IL10SNP associated with acute rejection
JP2008545445A (en) * 2005-06-13 2008-12-18 エフ．ホフマン−ラ ロシュ アーゲー MDR1 SNP in acute rejection
JP2008545446A (en) * 2005-06-13 2008-12-18 エフ．ホフマン−ラ ロシュ アーゲー IMPDH2SNP associated with acute rejection

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
GLESNE D.A. ET AL.: "Cloning and sequence of the human type II IMP dehydrogenase gene", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 205, November 1994 (1994-11-01), pages 537 - 544, XP002905466 *
LIGHTFOOT T. ET AL.: "Gene amplification and dual point mutations of mouse IMP dehydrogenase associated with cellular resistance to mycophenolic acid", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1217, 1994, pages 156 - 162, XP002905467 *

Also Published As

Publication number Publication date
WO2001077363A2 (en) 2001-10-18
AU2001253386A1 (en) 2001-10-23

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