WO2001077129A3 - Haplotypes of the apoc1 gene - Google Patents

Haplotypes of the apoc1 gene Download PDF

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Publication number
WO2001077129A3
WO2001077129A3 PCT/US2001/011808 US0111808W WO0177129A3 WO 2001077129 A3 WO2001077129 A3 WO 2001077129A3 US 0111808 W US0111808 W US 0111808W WO 0177129 A3 WO0177129 A3 WO 0177129A3
Authority
WO
WIPO (PCT)
Prior art keywords
apoc1
gene
haplotypes
disclosed
apoc1 gene
Prior art date
Application number
PCT/US2001/011808
Other languages
French (fr)
Other versions
WO2001077129A2 (en
Inventor
Steven C Bentivegna
Anne Chew
Julie Y Choi
Beena Koshy
J Claiborne Stephens
Original Assignee
Genaissance Pharmaceuticals
Steven C Bentivegna
Anne Chew
Julie Y Choi
Beena Koshy
J Claiborne Stephens
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genaissance Pharmaceuticals, Steven C Bentivegna, Anne Chew, Julie Y Choi, Beena Koshy, J Claiborne Stephens filed Critical Genaissance Pharmaceuticals
Priority to AU2001253367A priority Critical patent/AU2001253367A1/en
Publication of WO2001077129A2 publication Critical patent/WO2001077129A2/en
Publication of WO2001077129A3 publication Critical patent/WO2001077129A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations

Abstract

Novel single nucleotide polymorphisms in the human apolipoprotein C1 (APOC1) gene are described. In addition, various genotypes, haplotypes and haplotype pairs for the APOC1 gene that exist in the population are described. Compositions and methods for haplotyping and/or genotyping the APOC1 gene in an individual are also disclosed. Polynucleotides containing one or more of the APOC1 polymorphisms disclosed herein are also described.
PCT/US2001/011808 2000-04-11 2001-04-10 Haplotypes of the apoc1 gene WO2001077129A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001253367A AU2001253367A1 (en) 2000-04-11 2001-04-10 Haplotypes of the apoc1 gene

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19654500P 2000-04-11 2000-04-11
US60/196,545 2000-04-11

Publications (2)

Publication Number Publication Date
WO2001077129A2 WO2001077129A2 (en) 2001-10-18
WO2001077129A3 true WO2001077129A3 (en) 2002-03-21

Family

ID=22725838

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/011808 WO2001077129A2 (en) 2000-04-11 2001-04-10 Haplotypes of the apoc1 gene

Country Status (2)

Country Link
AU (1) AU2001253367A1 (en)
WO (1) WO2001077129A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010017201A1 (en) * 2008-08-04 2010-02-11 The Board Of Regents Of The University Of Texas System Multiplexed diagnostic test for preterm labor

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
DATABASE GENBANK [online] February 1996 (1996-02-01), LAUER ET AL.: "Human apolipoprotein C-I (VLDL) gene", XP002906106, Database accession no. M20902.1 *
FREITAS ET AL.: "Duplication and diversification of the apolipoprotein CI (APOCI) genomic segment in association with retroelements", JOURNAL OF MOLECULAR EVOLUTION, vol. 50, April 2000 (2000-04-01), pages 391 - 396, XP002905769 *
LAUER ET AL.: "Two copies of the human apolipoprotein C-I gene are linked closely to the apolipoprotein E gene", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 263, no. 15, May 1988 (1988-05-01), pages 7277 - 7286, XP002905771 *
SAMBROOK ET AL.: "Molecular cloning: A laboratory manual", 1989, COLD SPRING HARBOR LABORATORY PRESS, COLD SPRING HARBOR, XP002905770 *
TEMPLETON A.: "A cladistic analysis of phenotypic associations with haplotypes inferred from restriction endonuclease mapping or DNA sequencing. V. Analysis of case/control sampling design: Alzheimer's disease and the apoprotein E locus", GENETICS, vol. 140, May 1995 (1995-05-01), pages 403 - 409, XP002905768 *

Also Published As

Publication number Publication date
AU2001253367A1 (en) 2001-10-23
WO2001077129A2 (en) 2001-10-18

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