WO2002012562A3 - Haplotypes of the pla2g1b gene - Google Patents

Haplotypes of the pla2g1b gene Download PDF

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Publication number
WO2002012562A3
WO2002012562A3 PCT/US2001/024663 US0124663W WO0212562A3 WO 2002012562 A3 WO2002012562 A3 WO 2002012562A3 US 0124663 W US0124663 W US 0124663W WO 0212562 A3 WO0212562 A3 WO 0212562A3
Authority
WO
WIPO (PCT)
Prior art keywords
haplotypes
pla2g1b
gene
disclosed
pla2g1b gene
Prior art date
Application number
PCT/US2001/024663
Other languages
French (fr)
Other versions
WO2002012562A2 (en
Inventor
Amir Kazemi
Stefanie E Kliem
Beena Koshy
Original Assignee
Genaissance Pharmaceuticals
Amir Kazemi
Stefanie E Kliem
Beena Koshy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genaissance Pharmaceuticals, Amir Kazemi, Stefanie E Kliem, Beena Koshy filed Critical Genaissance Pharmaceuticals
Priority to AU2001284736A priority Critical patent/AU2001284736A1/en
Publication of WO2002012562A2 publication Critical patent/WO2002012562A2/en
Publication of WO2002012562A3 publication Critical patent/WO2002012562A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C12N9/20—Triglyceride splitting, e.g. by means of lipase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Novel genetic variants of the Phospholipase A2, Group IB (Pancreas) (PLA2G1B) gene are described. Various genotypes, haplotypes, and haplotype pairs that exist in the general United States population are disclosed for the PLA2G1B gene. Compositions and methods for haplotyping and/or genotyping the PLA2G1B gene in an individual are also disclosed. Polynucleotides defined by the haplotypes disclosed herein are also described.
PCT/US2001/024663 2000-08-04 2001-08-06 Haplotypes of the pla2g1b gene WO2002012562A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001284736A AU2001284736A1 (en) 2000-08-04 2001-08-06 Haplotypes of the pla2g1b gene

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22317900P 2000-08-04 2000-08-04
US60/223,179 2000-08-04

Publications (2)

Publication Number Publication Date
WO2002012562A2 WO2002012562A2 (en) 2002-02-14
WO2002012562A3 true WO2002012562A3 (en) 2003-07-24

Family

ID=22835386

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/024663 WO2002012562A2 (en) 2000-08-04 2001-08-06 Haplotypes of the pla2g1b gene

Country Status (2)

Country Link
AU (1) AU2001284736A1 (en)
WO (1) WO2002012562A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1581095A4 (en) * 2002-06-27 2006-10-18 Harkness Pharmaceuticals Inc Therapeutic methods for reducing fat deposition and treating associated conditions
EP2960252A1 (en) * 2014-06-26 2015-12-30 Institut Pasteur Phospholipase for treatment of immunosuppression

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5972614A (en) * 1995-12-06 1999-10-26 Genaissance Pharmaceuticals Genome anthologies for harvesting gene variants
US6004744A (en) * 1991-03-05 1999-12-21 Molecular Tool, Inc. Method for determining nucleotide identity through extension of immobilized primer

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6004744A (en) * 1991-03-05 1999-12-21 Molecular Tool, Inc. Method for determining nucleotide identity through extension of immobilized primer
US5972614A (en) * 1995-12-06 1999-10-26 Genaissance Pharmaceuticals Genome anthologies for harvesting gene variants

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
BEUTEN JOKE ET AL: "Mutation analysis of the human pancreatic phospholipase A-2 gene in a family with distal hereditary motor neuropathy type II linked to 12q24.", NEUROSCIENCE LETTERS, vol. 223, no. 1, 1997, pages 69 - 71, XP002224242, ISSN: 0304-3940 *
CLAIBORNE STEPHENS J: "SINGLE-NUCLEOTIDE POLYMORPHISMS, HAPLOTYPES AND THEIR RELEVANCE TO PHARMACOGENTICS", MOLECULAR DIAGNOSIS, NAPERVILLE, IL, US, vol. 4, no. 4, 1999, pages 309 - 317, XP002937520, ISSN: 1084-8592 *
CLARK A G ET AL: "HAPLOTYPE STRUCTURE AND POPULATION GENETIC INFERENCES FROM NUCLEOTIDE-SEQUENCE VARIATION IN HUMAN LIPOPROTEIN LIPASE", AMERICAN JOURNAL OF HUMAN GENETICS, UNIVERSITY OF CHICAGO PRESS, CHICAGO,, US, vol. 63, 1998, pages 595 - 612, XP002938535, ISSN: 0002-9297 *
DATABASE EMBL [online] XP002224243, Database accession no. M22970 *
DATABASE EMBL [online] XP002225091, Database accession no. AC073930 *
FROSSARD P M ET AL: "TaqI dimorphic site in a human pancreatic phospholipase A2 (PLA2) gene localized on chromosome 12.", HUMAN GENETICS. GERMANY JUN 1994, vol. 93, no. 6, June 1994 (1994-06-01), pages 720, XP009002510, ISSN: 0340-6717 *
HALUSHKA M K ET AL: "PATTERNS OF SINGLE-NUCLEOTIDE POLYMORPHISMS IN CANDIDATE GENES FOR BLOOD-PRESSURE HOMEOSTASIS", NATURE GENETICS, NATURE AMERICA, NEW YORK, US, vol. 22, July 1999 (1999-07-01), pages 239 - 247, XP000985696, ISSN: 1061-4036 *
SEILHAMER J J ET AL: "PANCREATIC PHOSPHOLIPASE A-2 ISOLATION OF THE HUMAN GENE AND COMPLEMENTARY DNA SPECIES FROM PORCINE PANCREAS AND HUMAN LUNG", DNA (NEW YORK), vol. 5, no. 6, 1986, pages 519 - 528, XP009003085, ISSN: 0198-0238 *
ULBRECHT M ET AL: "Assoziation of beta 2-adrenoreceptor variants with bronchial hyperresponsiveness", AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, AMERICAN LUNG ASSOCIATION, NEW YORK, NY, US, vol. 161, no. 2, February 2000 (2000-02-01), pages 469 - 474, XP002188594, ISSN: 1073-449X *

Also Published As

Publication number Publication date
AU2001284736A1 (en) 2002-02-18
WO2002012562A2 (en) 2002-02-14

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