WO2002048400A1 - Procede d'estimation du risque de l'expression d'effets secondaires causes par l'administration de compose metabolise, soit automatiquement, soit comme intermediaire metabolique, par l'enzyme ugt1a1 - Google Patents

Procede d'estimation du risque de l'expression d'effets secondaires causes par l'administration de compose metabolise, soit automatiquement, soit comme intermediaire metabolique, par l'enzyme ugt1a1 Download PDF

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Publication number
WO2002048400A1
WO2002048400A1 PCT/JP2001/010813 JP0110813W WO0248400A1 WO 2002048400 A1 WO2002048400 A1 WO 2002048400A1 JP 0110813 W JP0110813 W JP 0110813W WO 0248400 A1 WO0248400 A1 WO 0248400A1
Authority
WO
WIPO (PCT)
Prior art keywords
administration
side effect
expression
effect caused
irinotecan
Prior art date
Application number
PCT/JP2001/010813
Other languages
English (en)
French (fr)
Inventor
Yoshinori Hasegawa
Yu-Uichi Ando
Kaoru Shimokata
Original Assignee
Nagoya Industrial Science Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to KR1020037007790A priority Critical patent/KR101651287B1/ko
Priority to DE60142309T priority patent/DE60142309D1/de
Priority to KR1020167005073A priority patent/KR101651391B1/ko
Priority to EP01270625A priority patent/EP1352970B1/en
Priority to AU2002221112A priority patent/AU2002221112A1/en
Priority to AT01270625T priority patent/ATE469966T1/de
Application filed by Nagoya Industrial Science Research Institute filed Critical Nagoya Industrial Science Research Institute
Priority to JP2002550114A priority patent/JP4447835B2/ja
Publication of WO2002048400A1 publication Critical patent/WO2002048400A1/ja
Priority to US10/459,729 priority patent/US20040058363A1/en
Priority to US11/543,055 priority patent/US20070082357A1/en
Priority to US12/453,291 priority patent/US20090263818A1/en
Priority to US13/026,719 priority patent/US20110151474A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
PCT/JP2001/010813 2000-12-12 2001-12-10 Procede d'estimation du risque de l'expression d'effets secondaires causes par l'administration de compose metabolise, soit automatiquement, soit comme intermediaire metabolique, par l'enzyme ugt1a1 WO2002048400A1 (fr)

Priority Applications (11)

Application Number Priority Date Filing Date Title
DE60142309T DE60142309D1 (de) 2000-12-12 2001-12-10 On einer durch die verabreichung einer verbindung, die entweder per se durch ugt1a1 metabolisiert wird oder deren zwischenverbindung durch das enzym metabolisiert wird, hervorgerufenen unerwünschten arzneimittelwirkung
KR1020167005073A KR101651391B1 (ko) 2000-12-12 2001-12-10 Ｕｇｔ1ａ1 효소에 의해 그 자체 또는 중간 대사물이 대사되는 화합물의 투여에 따른 부작용 발현 리스크를 예측하는 방법
EP01270625A EP1352970B1 (en) 2000-12-12 2001-12-10 Method of estimating the risk of expression of adverse drug reaction caused by the administration of a compound, which is either metabloized per se by ugt1a1 or whose intermediate is metabolized by the enzyme
AU2002221112A AU2002221112A1 (en) 2000-12-12 2001-12-10 Method of estimating risk of the expression of side effect caused by the administration of compound metabolized, either per se or as its metabolic intermediate,by ugt1a1 enzyme
AT01270625T ATE469966T1 (de) 2000-12-12 2001-12-10 Verfahren zur abschätzung des risikos der expression einer durch die verabreichung einer verbindung, die entweder per se durch ugt1a1 metabolisiert wird oder deren zwischenverbindung durch das enzym metabolisiert wird, hervorgerufenen unerwünschten arzneimittelwirkung
KR1020037007790A KR101651287B1 (ko) 2000-12-12 2001-12-10 Ｕｇｔ1ａ1 효소에 의해 그 자체 또는 중간 대사물이대사되는 화합물의 투여에 따른 부작용 발현 리스크를예측하는 방법
JP2002550114A JP4447835B2 (ja) 2000-12-12 2001-12-10 Ｕｇｔ１ａ１酵素によってそれ自体又は中間代謝物が代謝される化合物の投与による副作用発現リスクを予測する方法
US10/459,729 US20040058363A1 (en) 2000-12-12 2003-06-12 Method of estimating the risk of expression of adverse drug reaction caused by the administration of a compound, which is either metabolized per se by UGT1A1 enzyme or whose metabolic intermediate is metabolized by the enzyme
US11/543,055 US20070082357A1 (en) 2000-12-12 2006-10-05 Method of estimating the risk of expression of adverse drug reaction caused by the administration of a compound, which is either metabolized per se by UGT1A1 enzyme or whose metabolic intermediate is metabolized by the enzyme
US12/453,291 US20090263818A1 (en) 2000-12-12 2009-05-06 Method of estimating the risk of expression of adverse drug reaction caused by the administration of a compound, which is either metabolized per se by UGT1A1 enzyme or whose metabolic intermediate is metabolized by the enzyme
US13/026,719 US20110151474A1 (en) 2000-12-12 2011-02-14 Method of estimating the risk of expression of adverse drug reaction caused by the administration of a compound, which is either metabolized per se by ugt1a1 enzyme or whose metabolic intermediate is metabolized by the enzyme

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2000376756 2000-12-12
JP2000-376756 2000-12-12

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/459,729 Continuation US20040058363A1 (en) 2000-12-12 2003-06-12 Method of estimating the risk of expression of adverse drug reaction caused by the administration of a compound, which is either metabolized per se by UGT1A1 enzyme or whose metabolic intermediate is metabolized by the enzyme

Publications (1)

Publication Number Publication Date
WO2002048400A1 true WO2002048400A1 (fr) 2002-06-20

Family

ID=18845576

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2001/010813 WO2002048400A1 (fr) 2000-12-12 2001-12-10 Procede d'estimation du risque de l'expression d'effets secondaires causes par l'administration de compose metabolise, soit automatiquement, soit comme intermediaire metabolique, par l'enzyme ugt1a1

Country Status (10)

Country Link
US (4) US20040058363A1 (ja)
EP (1) EP1352970B1 (ja)
JP (2) JP4447835B2 (ja)
KR (2) KR101651287B1 (ja)
CN (1) CN100374575C (ja)
AT (1) ATE469966T1 (ja)
AU (1) AU2002221112A1 (ja)
DE (1) DE60142309D1 (ja)
ES (1) ES2346848T3 (ja)
WO (1) WO2002048400A1 (ja)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004027088A2 (en) * 2002-09-20 2004-04-01 UNIVERSITé LAVAL Method for determining the predisposition of patients to toxicity or lack of efficacy of a drug
JP2007509604A (ja) * 2003-10-06 2007-04-19 ノバルティス アクチエンゲゼルシャフト 薬剤誘発下痢の予測のためのバイオマーカー
WO2007055261A1 (ja) * 2005-11-10 2007-05-18 The New Industry Research Organization Ｕｇｔ１ａ１遺伝子多型の検査法
WO2008066136A1 (en) * 2006-11-30 2008-06-05 Arkray, Inc. Primer set for amplification of ugt1a1 gene, reagent for amplification of ugt1a1 gene comprising the same, and use of the same
WO2016006532A1 (ja) * 2014-07-07 2016-01-14 株式会社日立製作所 薬効分析システム及び薬効分析方法
US11692216B2 (en) 2015-02-17 2023-07-04 Yamaguchi University Method for assisting prediction of risk of occurrence of side effect of irinotecan

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6395481B1 (en) * 1999-02-16 2002-05-28 Arch Development Corp. Methods for detection of promoter polymorphism in a UGT gene promoter
US20030099960A1 (en) * 2001-01-26 2003-05-29 The University Of Chicago Compositions and methods for optimizing UGT2B7 substrate dosings and for predicting UGT2B7 substrate toxicity
US20040203034A1 (en) * 2003-01-03 2004-10-14 The University Of Chicago Optimization of cancer treatment with irinotecan
CA2527320A1 (en) 2003-05-30 2004-12-16 University Of Chicago Methods and compositions for predicting irinotecan toxicity
US20090247475A1 (en) * 2004-03-05 2009-10-01 The Regents Of The University Of California Methods and compositions relating to pharmacogenetics of different gene variants in the context of irinotecan-based therapies
EP1790343A1 (en) * 2005-11-11 2007-05-30 Emotional Brain B.V. Pharmaceuticals formulations and uses thereof in the treatment of female sexual dysfunction
GB2432365A (en) * 2005-11-18 2007-05-23 Dxs Ltd A nucleic acid molecule for detecting polymorphisms in the UGT1A1 promoter
JP4884899B2 (ja) * 2006-09-19 2012-02-29 東洋鋼鈑株式会社 イリノテカンの副作用の発生危険度を判定する方法およびそのためのキット
KR200452078Y1 (ko) * 2009-03-10 2011-01-28 주식회사 디아이디 벽지샘플북의 손잡이
JP2011250726A (ja) * 2010-06-01 2011-12-15 Toyo Kohan Co Ltd イリノテカンの副作用の発生危険度を判定する方法及びそのためのキット
CN102816858B (zh) * 2012-09-06 2014-02-19 上海源奇生物医药科技有限公司 一种检测ugt1a1基因型的引物和探针、及其试剂盒
CN107043808A (zh) * 2017-01-19 2017-08-15 上海赛安生物医药科技有限公司 Ugt1a1基因多态性检测引物肽核酸及其试剂盒
CN109371127A (zh) * 2018-10-22 2019-02-22 江苏美因康生物科技有限公司 一种同时快速检测ugt1a1*6型与ugt1a1*28型基因多态性的试剂盒及方法

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EP1084271A2 (en) * 1998-05-07 2001-03-21 Axys Pharmaceuticals, Inc. Genotyping the human udp-glucuronosyltransferase 1 (ugt1) gene
US6395481B1 (en) * 1999-02-16 2002-05-28 Arch Development Corp. Methods for detection of promoter polymorphism in a UGT gene promoter

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ANDO Y. ET AL: "Polymorphisms of UDP-glucuronosyltransferase gene and irinotecan toxicity: a pharmacogenetic analysis", CANCER RESEARCH, vol. 60, 15 December 2000 (2000-12-15), pages 6921 - 6926, XP002909302 *
ANDO Y. ET AL: "UGT1A1 genotypes and glucuronidation of SN-3 8, the active metabolite of irinotecan", ANNALS OF ONCOLOGY, vol. 9, no. 8, 1998, pages 845 - 847, XP002909100 *
AONO S. ET AL: "Analysis of genes for bilirubin UDP-glucurono syltransferase in Gilbert's syndrome", THE LANCET, vol. 345, 1995, pages 958 - 959, XP002909301 *
IYER L. ET AL: "Phenotype-genotype correlation of in vitro SN-38 (active metabolite of irinotecan) and bilirubin glucuronidation in human liver tissue with UGT1A1 promoter polymorphism", CLINICAL PHARMACOLOGY AND THERAPEUTICS, vol. 65, no. 5, 1999, pages 576 - 582, XP002909099 *
MARUO Y. ET AL: "Prolonged unconjugated hyperbilirubinemia associated with breast milk and mutations of the bilirubin uridine diphosphate-glucuronosyltransferase gene", PEDIATRICS, vol. 106, no. 5, November 2000 (2000-11-01), pages E59, XP002909303 *

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004027088A2 (en) * 2002-09-20 2004-04-01 UNIVERSITé LAVAL Method for determining the predisposition of patients to toxicity or lack of efficacy of a drug
WO2004027088A3 (en) * 2002-09-20 2004-08-19 Univ Laval Method for determining the predisposition of patients to toxicity or lack of efficacy of a drug
JP2007509604A (ja) * 2003-10-06 2007-04-19 ノバルティス アクチエンゲゼルシャフト 薬剤誘発下痢の予測のためのバイオマーカー
WO2007055261A1 (ja) * 2005-11-10 2007-05-18 The New Industry Research Organization Ｕｇｔ１ａ１遺伝子多型の検査法
JPWO2007055261A1 (ja) * 2005-11-10 2009-04-30 財団法人新産業創造研究機構 Ｕｇｔ１ａ１遺伝子多型の検査法
WO2008066136A1 (en) * 2006-11-30 2008-06-05 Arkray, Inc. Primer set for amplification of ugt1a1 gene, reagent for amplification of ugt1a1 gene comprising the same, and use of the same
US8357516B2 (en) 2006-11-30 2013-01-22 Arkray, Inc. Primer set for amplification of UGT1A1 gene, reagent for amplification of UGT1A1 gene containing the same, and the uses thereof
JP5307538B2 (ja) * 2006-11-30 2013-10-02 アークレイ株式会社 Ｕｇｔ１ａ１遺伝子増幅用プライマーセット、それを含むｕｇｔ１ａ１遺伝子増幅用試薬およびその用途
US9175272B2 (en) 2006-11-30 2015-11-03 Arkray, Inc. Probes for detection of UGT1A1 gene, reagent containing the same, and the uses thereof
WO2016006532A1 (ja) * 2014-07-07 2016-01-14 株式会社日立製作所 薬効分析システム及び薬効分析方法
JP2016018321A (ja) * 2014-07-07 2016-02-01 株式会社日立製作所 薬効分析システム及び薬効分析方法
US11692216B2 (en) 2015-02-17 2023-07-04 Yamaguchi University Method for assisting prediction of risk of occurrence of side effect of irinotecan

Also Published As

Publication number Publication date
US20110151474A1 (en) 2011-06-23
ATE469966T1 (de) 2010-06-15
AU2002221112A1 (en) 2002-06-24
EP1352970A4 (en) 2004-08-25
KR101651391B1 (ko) 2016-08-25
KR101651287B1 (ko) 2016-08-26
DE60142309D1 (de) 2010-07-15
JP2009195247A (ja) 2009-09-03
JPWO2002048400A1 (ja) 2004-04-15
CN1547613A (zh) 2004-11-17
JP4447835B2 (ja) 2010-04-07
US20090263818A1 (en) 2009-10-22
US20040058363A1 (en) 2004-03-25
ES2346848T3 (es) 2010-10-21
EP1352970B1 (en) 2010-06-02
CN100374575C (zh) 2008-03-12
US20070082357A1 (en) 2007-04-12
EP1352970A1 (en) 2003-10-15
KR20030053064A (ko) 2003-06-27
JP4616919B2 (ja) 2011-01-19
KR20160031023A (ko) 2016-03-21

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