AU2001270118A1 - Compositions and methods for the diagnosis and treatment of tumor - Google Patents
Compositions and methods for the diagnosis and treatment of tumorInfo
- Publication number
- AU2001270118A1 AU2001270118A1 AU2001270118A AU7011801A AU2001270118A1 AU 2001270118 A1 AU2001270118 A1 AU 2001270118A1 AU 2001270118 A AU2001270118 A AU 2001270118A AU 7011801 A AU7011801 A AU 7011801A AU 2001270118 A1 AU2001270118 A1 AU 2001270118A1
- Authority
- AU
- Australia
- Prior art keywords
- seq
- antibody
- polypeptide
- amino acid
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
- A61K47/6455—Polycationic oligopeptides, polypeptides or polyamino acids, e.g. for complexing nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6807—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug or compound being a sugar, nucleoside, nucleotide, nucleic acid, e.g. RNA antisense
- A61K47/6809—Antibiotics, e.g. antitumor antibiotics anthracyclins, adriamycin, doxorubicin or daunomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0091—Oxidoreductases (1.) oxidizing metal ions (1.16)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Toxicology (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Gastroenterology & Hepatology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
Applications Claiming Priority (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU75730/00 | 2000-08-24 | ||
PCT/US2000/023328 WO2001016318A2 (fr) | 1999-09-01 | 2000-08-24 | Polypeptides secretes et transmembranaires et acides nucleiques codant pour ceux-ci |
US23545100P | 2000-09-26 | 2000-09-26 | |
US60/235,451 | 2000-09-26 | ||
AU20554/01 | 2000-12-01 | ||
PCT/US2000/032678 WO2001040466A2 (fr) | 1999-12-01 | 2000-12-01 | Polypeptides secretes et transmembranaires et acides nucleiques codant ces polypeptides |
AU2001268028 | 2001-02-28 | ||
PCT/US2001/006520 WO2001068848A2 (fr) | 2000-03-01 | 2001-02-28 | Polypeptides secretes et transmembranaires et acides nucleiques codant pour ces polypeptides |
AU2001255168 | 2001-03-01 | ||
PCT/US2001/006666 WO2001066740A2 (fr) | 2000-03-03 | 2001-03-01 | Compositions et methodes de traitement de maladies d'origine immune |
PCT/US2001/020118 WO2002016429A2 (fr) | 2000-08-24 | 2001-06-22 | Compositions et procedes de diagnostic et traitement de tumeurs |
Publications (1)
Publication Number | Publication Date |
---|---|
AU2001270118A1 true AU2001270118A1 (en) | 2002-03-04 |
Family
ID=22885562
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2001270118A Abandoned AU2001270118A1 (en) | 2000-08-24 | 2001-06-22 | Compositions and methods for the diagnosis and treatment of tumor |
AU2001294814A Abandoned AU2001294814A1 (en) | 2000-09-26 | 2001-09-26 | Pumpcn compositions and uses thereof |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2001294814A Abandoned AU2001294814A1 (en) | 2000-09-26 | 2001-09-26 | Pumpcn compositions and uses thereof |
Country Status (8)
Country | Link |
---|---|
US (2) | US20040005598A1 (fr) |
EP (4) | EP1445318A2 (fr) |
JP (2) | JP2004520806A (fr) |
KR (1) | KR20030029847A (fr) |
AU (2) | AU2001270118A1 (fr) |
CA (2) | CA2420140A1 (fr) |
MX (1) | MXPA03001645A (fr) |
WO (2) | WO2002016429A2 (fr) |
Families Citing this family (122)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69536127D1 (de) * | 1995-05-19 | 2011-01-20 | Human Genome Sciences Inc | Transformierender wachstumsfaktor alpha hii |
EP1881069A1 (fr) * | 1995-05-19 | 2008-01-23 | Human Genome Sciences, Inc. | Facteur transformant de croissance alpha HII |
US20060052321A1 (en) | 2002-04-05 | 2006-03-09 | Raitano Arthur B | Nucleic acid and corresponding protein entitled 98P4B6 useful in treatment and detection of cancer |
US6833438B1 (en) | 1999-06-01 | 2004-12-21 | Agensys, Inc. | Serpentine transmembrane antigens expressed in human cancers and uses thereof |
US20040048798A1 (en) * | 1999-06-01 | 2004-03-11 | Raitano Arthur B. | Nucleic acid and corresponding protein entitle 98P4B6 useful in treatment and detection of cancer |
US20030149531A1 (en) | 2000-12-06 | 2003-08-07 | Hubert Rene S. | Serpentine transmembrane antigens expressed in human cancers and uses thereof |
JP4855577B2 (ja) | 1998-06-01 | 2012-01-18 | アジェンシス,インコーポレイテッド | ヒト癌で発現される新規蛇行性膜貫通抗原およびその使用 |
US20040141975A1 (en) | 1998-06-01 | 2004-07-22 | Raitano Arthur B. | Nucleic acid and corresponding protein entitled 98P4B6 useful in treatment and detection of cancer |
US6699664B1 (en) | 1998-12-17 | 2004-03-02 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of ovarian cancer |
US6468546B1 (en) | 1998-12-17 | 2002-10-22 | Corixa Corporation | Compositions and methods for therapy and diagnosis of ovarian cancer |
US7888477B2 (en) | 1998-12-17 | 2011-02-15 | Corixa Corporation | Ovarian cancer-associated antibodies and kits |
US6962980B2 (en) | 1999-09-24 | 2005-11-08 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of ovarian cancer |
US6858710B2 (en) | 1998-12-17 | 2005-02-22 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of ovarian cancer |
EP2266607A3 (fr) | 1999-10-01 | 2011-04-20 | Immunogen, Inc. | Des immunoconjugués pour le traitement des cancers. |
AU6802801A (en) * | 2000-03-01 | 2001-09-24 | Genentech Inc | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
US7097840B2 (en) * | 2000-03-16 | 2006-08-29 | Genentech, Inc. | Methods of treatment using anti-ErbB antibody-maytansinoid conjugates |
US7700359B2 (en) | 2000-06-02 | 2010-04-20 | Novartis Vaccines And Diagnostics, Inc. | Gene products differentially expressed in cancerous cells |
CA2420140A1 (fr) * | 2000-08-24 | 2002-02-28 | Genentech, Inc. | Compositions et procedes de diagnostic et traitement de tumeurs |
US6979556B2 (en) * | 2000-12-14 | 2005-12-27 | Genentech, Inc. | Separate-cistron contructs for secretion of aglycosylated antibodies from prokaryotes |
CA2454731C (fr) * | 2001-08-27 | 2010-11-02 | Genentech, Inc. | Systeme d'expression d'anticorps et ensemble |
US7494646B2 (en) | 2001-09-06 | 2009-02-24 | Agensys, Inc. | Antibodies and molecules derived therefrom that bind to STEAP-1 proteins |
EP2287186B1 (fr) | 2001-09-06 | 2014-12-31 | Agensys, Inc. | Acide nucléique et protéine corréspondante designés par STEAP-1 utiles dans le traitement et la détection du cancer |
US20050123925A1 (en) * | 2002-11-15 | 2005-06-09 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of tumor |
DE60326931D1 (de) | 2002-01-08 | 2009-05-14 | Novartis Vaccines & Diagnostic | In kanzerösen mammazellen differentiell exprimierte genprodukte und ihre verwendungsverfahren |
KR20040101502A (ko) * | 2002-04-16 | 2004-12-02 | 제넨테크, 인크. | 종양의 진단 및 치료 방법 및 이를 위한 조성물 |
US20050276812A1 (en) | 2004-06-01 | 2005-12-15 | Genentech, Inc. | Antibody-drug conjugates and methods |
EP1565488A4 (fr) * | 2002-05-15 | 2007-10-03 | Avalon Pharmaceuticals | Gene lie au cancer servant de cible pour la chimiotherapie |
AU2003253677A1 (en) * | 2002-06-11 | 2003-12-22 | Avalon Pharmaceuticals, Inc. | Cancer-linked gene as target for chemotherapy |
US8546541B2 (en) | 2002-06-20 | 2013-10-01 | Washington University | Compositions and methods for modulating lymphocyte activity |
CA2489803A1 (fr) | 2002-06-20 | 2003-12-31 | The Regents Of The University Of California | Compositions et procedes de modulation de l'activite lymphocytaire |
JP5840351B2 (ja) * | 2002-09-06 | 2016-01-06 | アジェンシス,インコーポレイテッド | 癌の処置および検出において有用な98p4b6と称される、核酸および対応タンパク質 |
ES2359055T3 (es) * | 2002-09-11 | 2011-05-18 | Genentech, Inc. | Composiciones y métodos para el diagnóstico y el tratamiento de tumores. |
EP1578996A4 (fr) * | 2002-10-18 | 2007-12-19 | Genentech Inc | Compositions et methodes pour diagnostiquer et traiter des tumeurs |
WO2004055042A1 (fr) * | 2002-12-18 | 2004-07-01 | Pepharm R & D Limited | Conjugues peptidiques bioactifs |
US8088387B2 (en) | 2003-10-10 | 2012-01-03 | Immunogen Inc. | Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates |
JP5105873B2 (ja) | 2003-07-02 | 2012-12-26 | ジェネンテック, インコーポレイテッド | Trp−p8活性化合物と治療的処置方法 |
BR122018071968B8 (pt) | 2003-11-06 | 2021-07-27 | Seattle Genetics Inc | conjugado de anticorpo-droga, composição farmacêutica, artigo de manufatura e uso de um conjugado de anticorpo-droga |
JP4527388B2 (ja) * | 2003-12-11 | 2010-08-18 | 東洋鋼鈑株式会社 | ポリペプチドとレセプターとの相互作用を検出する方法、該検出する方法を用いてリガンドまたはリガンド変異体をスクリーニングする方法および該検出する方法を用いる診断方法 |
AU2003292826A1 (en) | 2003-12-25 | 2005-07-21 | Fujitsu Limited | Organic el element, organic el display, process for fabricating organic el element, and system for fabricating organic el element |
BRPI0418766B8 (pt) | 2004-04-22 | 2021-05-25 | Agensys Inc | anticorpo ou seu fragmento, vetor, composição farmacêutica, ensaio e método para detectar a presença de proteína steap-1, bem como método para distribuir um agente citotóxico ou um agente de diagnóstico |
US20100111856A1 (en) | 2004-09-23 | 2010-05-06 | Herman Gill | Zirconium-radiolabeled, cysteine engineered antibody conjugates |
NZ580115A (en) | 2004-09-23 | 2010-10-29 | Genentech Inc | Cysteine engineered antibody light chains and conjugates |
JP4993645B2 (ja) | 2004-12-01 | 2012-08-08 | ジェネンテック, インコーポレイテッド | 抗体薬剤結合体および方法 |
WO2007137187A2 (fr) * | 2006-05-18 | 2007-11-29 | Molecular Profiling Institute, Inc. | Système et procédé destinés à déterminer une intervention médicale individualisée pour une pathologie |
EP2061814B1 (fr) | 2006-10-27 | 2012-06-06 | Genentech, Inc. | Anticorps et immunoconjugues, et leurs utilisations |
US7879369B2 (en) | 2007-09-18 | 2011-02-01 | Selvamedica, Llc | Combretum laurifolium Mart. extract and methods of extracting and using such extract |
MX2010003718A (es) | 2007-10-19 | 2010-04-21 | Genentech Inc | Anticuerpos anti-tenb2 producidos por ingenieria de cisteina y conjugados de farmaco y anticuerpo. |
US8303952B2 (en) | 2009-06-08 | 2012-11-06 | Washington University | Methods for inducing in vivo tolerance |
AU2010292172A1 (en) | 2009-09-09 | 2012-05-03 | Centrose, Llc | Extracellular targeted drug conjugates |
PE20130342A1 (es) | 2010-04-15 | 2013-04-20 | Spirogen Sarl | Pirrolobenzodiacepinas y conjugados de las mismas |
CN114246952A (zh) | 2010-06-08 | 2022-03-29 | 基因泰克公司 | 半胱氨酸改造的抗体和偶联物 |
JP5889912B2 (ja) | 2010-11-17 | 2016-03-22 | ジェネンテック, インコーポレイテッド | アラニニルメイタンシノール抗体コンジュゲート |
JP5987053B2 (ja) | 2011-05-12 | 2016-09-06 | ジェネンテック, インコーポレイテッド | フレームワークシグネチャーペプチドを用いて動物サンプルにおける治療抗体を検出するための多重反応モニタリングlc−ms/ms法 |
PT2750713E (pt) | 2011-10-14 | 2016-01-20 | Genentech Inc | Pirrolobenzodiazepinas e conjugados das mesmas |
WO2013130093A1 (fr) | 2012-03-02 | 2013-09-06 | Genentech, Inc. | Biomarqueurs pour un traitement à base de composés chimiothérapeutiques anti-tubuline |
PT2906296T (pt) | 2012-10-12 | 2018-06-01 | Medimmune Ltd | Conjugados de pirrolobenzodiazepina-anticorpo |
KR101995621B1 (ko) | 2012-10-12 | 2019-07-03 | 에이디씨 테라퓨틱스 에스에이 | 피롤로벤조디아제핀-항-cd22 항체 컨주게이트 |
JP6270859B2 (ja) | 2012-10-12 | 2018-01-31 | エイディーシー・セラピューティクス・エス・アー・エール・エルAdc Therapeutics Sarl | ピロロベンゾジアゼピン−抗体結合体 |
CA2887895C (fr) | 2012-10-12 | 2019-10-29 | Adc Therapeutics Sarl | Conjugues d'anticorps cd19-anti-pyrrolobenzodiazepine |
WO2014057120A1 (fr) | 2012-10-12 | 2014-04-17 | Adc Therapeutics Sàrl | Conjugués anticorps - pyrrolobenzodiazépine |
RS53818B1 (en) | 2012-10-12 | 2015-06-30 | Spirogen Sàrl | PIROLOBENZODIAZEPINI I NJIHOVI conjugated |
ES2680153T3 (es) | 2012-10-12 | 2018-09-04 | Adc Therapeutics Sa | Conjugados de anticuerpos anti-PSMA-pirrolobenzodiazepinas |
US9353150B2 (en) | 2012-12-04 | 2016-05-31 | Massachusetts Institute Of Technology | Substituted pyrazino[1′,2′:1 ,5]pyrrolo[2,3-b]-indole-1,4-diones for cancer treatment |
CN105246894A (zh) | 2012-12-21 | 2016-01-13 | 斯皮罗根有限公司 | 用于治疗增殖性和自身免疫疾病的非对称吡咯并苯并二氮杂卓二聚物 |
CN110452242A (zh) | 2012-12-21 | 2019-11-15 | 麦迪穆有限责任公司 | 吡咯并苯并二氮杂卓及其结合物 |
KR102057755B1 (ko) | 2013-03-13 | 2019-12-19 | 메디뮨 리미티드 | 피롤로벤조디아제핀 및 그의 컨쥬게이트 |
CA2905181C (fr) | 2013-03-13 | 2020-06-02 | Medimmune Limited | Pyrrolobenzodiazepines et ses conjugues servant a fournir une therapie ciblee |
JP6340019B2 (ja) | 2013-03-13 | 2018-06-06 | メドイミューン・リミテッドMedImmune Limited | ピロロベンゾジアゼピン及びそのコンジュゲート |
KR20160042080A (ko) | 2013-08-12 | 2016-04-18 | 제넨테크, 인크. | 1-(클로로메틸)-2,3-디히드로-1H-벤조[e]인돌 이량체 항체-약물 접합체 화합물, 및 사용 및 치료 방법 |
US9950078B2 (en) | 2013-10-11 | 2018-04-24 | Medimmune Limited | Pyrrolobenzodiazepine-antibody conjugates |
GB201317982D0 (en) | 2013-10-11 | 2013-11-27 | Spirogen Sarl | Pyrrolobenzodiazepines and conjugates thereof |
EP3054983B1 (fr) | 2013-10-11 | 2019-03-20 | Medimmune Limited | Conjugués anticorps-pyrrolobenzodiazépines |
US9956299B2 (en) | 2013-10-11 | 2018-05-01 | Medimmune Limited | Pyrrolobenzodiazepine—antibody conjugates |
WO2015095212A1 (fr) | 2013-12-16 | 2015-06-25 | Genentech, Inc. | Composés conjugués anticorps-médicament dimérique à base de 1-(chlorométhyl)-2,3-dihydro-1 h-benzo [e]indole, et méthodes d'utilisation et de traitement |
JP6671292B2 (ja) | 2013-12-16 | 2020-03-25 | ジェネンテック, インコーポレイテッド | ペプチド模倣化合物及びその抗体−薬物コンジュゲート |
MX2016007826A (es) | 2013-12-16 | 2017-03-31 | Genentech Inc | Compuestos peptidomimeticos y sus conjugados de anticuerpo-farmaco. |
WO2016037644A1 (fr) | 2014-09-10 | 2016-03-17 | Medimmune Limited | Pyrrolobenzodiazépines et leurs conjugués |
KR20170052600A (ko) | 2014-09-12 | 2017-05-12 | 제넨테크, 인크. | 시스테인 가공된 항체 및 콘주게이트 |
GB201416112D0 (en) | 2014-09-12 | 2014-10-29 | Medimmune Ltd | Pyrrolobenzodiazepines and conjugates thereof |
EP3191134B1 (fr) | 2014-09-12 | 2019-11-20 | Genentech, Inc. | Intermédiaires disulfure d'anthracycline, conjugué anticorps-médicaments et procédés |
CA2959689A1 (fr) | 2014-09-17 | 2016-03-24 | Genentech, Inc. | Pyrrolobenzodiazepines et conjugues a base de disulfure d'anticorps associes |
EP3223854A1 (fr) | 2014-11-25 | 2017-10-04 | ADC Therapeutics SA | Conjugués anticorps-pyrrolobenzodiazépine |
CN107206101B (zh) | 2014-12-03 | 2021-06-25 | 基因泰克公司 | 季铵化合物及其抗体-药物缀合物 |
GB201506411D0 (en) | 2015-04-15 | 2015-05-27 | Bergenbio As | Humanized anti-axl antibodies |
GB201506402D0 (en) | 2015-04-15 | 2015-05-27 | Berkel Patricius H C Van And Howard Philip W | Site-specific antibody-drug conjugates |
MA43345A (fr) | 2015-10-02 | 2018-08-08 | Hoffmann La Roche | Conjugués anticorps-médicaments de pyrrolobenzodiazépine et méthodes d'utilisation |
MA43354A (fr) | 2015-10-16 | 2018-08-22 | Genentech Inc | Conjugués médicamenteux à pont disulfure encombré |
MA45326A (fr) | 2015-10-20 | 2018-08-29 | Genentech Inc | Conjugués calichéamicine-anticorps-médicament et procédés d'utilisation |
GB201601431D0 (en) | 2016-01-26 | 2016-03-09 | Medimmune Ltd | Pyrrolobenzodiazepines |
GB201602359D0 (en) | 2016-02-10 | 2016-03-23 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
GB201602356D0 (en) | 2016-02-10 | 2016-03-23 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
JP6943872B2 (ja) | 2016-03-25 | 2021-10-06 | ジェネンテック, インコーポレイテッド | 多重全抗体及び抗体複合体化薬物定量化アッセイ |
GB201607478D0 (en) | 2016-04-29 | 2016-06-15 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
WO2017197045A1 (fr) | 2016-05-11 | 2017-11-16 | Movassaghi Mohammad | Synthèse totale convergente et énantiosélective d'analogues de la communesine |
PL3458101T3 (pl) | 2016-05-20 | 2021-05-31 | F. Hoffmann-La Roche Ag | Koniugaty PROTAC-przeciwciało i sposoby ich stosowania |
US20170370906A1 (en) | 2016-05-27 | 2017-12-28 | Genentech, Inc. | Bioanalytical analysis of site-specific antibody drug conjugates |
US10639378B2 (en) | 2016-06-06 | 2020-05-05 | Genentech, Inc. | Silvestrol antibody-drug conjugates and methods of use |
CN109689111B (zh) | 2016-08-11 | 2024-04-05 | 基因泰克公司 | 吡咯并苯并二氮杂䓬前药及其抗体缀合物 |
MX2019003325A (es) * | 2016-09-23 | 2019-08-05 | Regeneron Pharma | Anticuerpos anti-steap2, conjugados anticuerpo-farmaco, y moleculas de fijacion al antigeno biespecificas que se fijan a steap2 y cd3, y usos de estos. |
CN110139674B (zh) | 2016-10-05 | 2023-05-16 | 豪夫迈·罗氏有限公司 | 制备抗体药物缀合物的方法 |
GB201617466D0 (en) | 2016-10-14 | 2016-11-30 | Medimmune Ltd | Pyrrolobenzodiazepine conjugates |
US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
GB201702031D0 (en) | 2017-02-08 | 2017-03-22 | Medlmmune Ltd | Pyrrolobenzodiazepine-antibody conjugates |
US11160872B2 (en) | 2017-02-08 | 2021-11-02 | Adc Therapeutics Sa | Pyrrolobenzodiazepine-antibody conjugates |
CN110494452B (zh) | 2017-04-03 | 2023-08-25 | 豪夫迈·罗氏有限公司 | 结合steap-1的抗体 |
CN110582505B (zh) | 2017-04-18 | 2021-04-02 | 免疫医疗有限公司 | 吡咯并苯并二氮杂*缀合物 |
CN110536703A (zh) | 2017-04-20 | 2019-12-03 | Adc治疗有限公司 | 使用抗axl抗体-药物缀合物的组合疗法 |
US11318211B2 (en) | 2017-06-14 | 2022-05-03 | Adc Therapeutics Sa | Dosage regimes for the administration of an anti-CD19 ADC |
SI3668874T1 (sl) | 2017-08-18 | 2022-04-29 | Medimmune Limited | Pirolobenzodiazepinski konjugati |
JP7437301B2 (ja) | 2017-08-25 | 2024-02-22 | ファイヴ プライム セラピューティクス インク | B7-h4抗体及びその使用方法 |
RU2020113749A (ru) | 2017-09-20 | 2021-10-20 | пиЭйч ФАРМА Ко., ЛТД. | Аналоги таиланстатина |
US10640508B2 (en) | 2017-10-13 | 2020-05-05 | Massachusetts Institute Of Technology | Diazene directed modular synthesis of compounds with quaternary carbon centers |
GB201803342D0 (en) | 2018-03-01 | 2018-04-18 | Medimmune Ltd | Methods |
EA202091810A1 (ru) | 2018-03-02 | 2021-01-29 | Файв Прайм Терапьютикс, Инк. | Антитела к b7-h4 и способы их применения |
GB201806022D0 (en) | 2018-04-12 | 2018-05-30 | Medimmune Ltd | Pyrrolobenzodiazepines and conjugates thereof |
GB201814281D0 (en) | 2018-09-03 | 2018-10-17 | Femtogenix Ltd | Cytotoxic agents |
AU2019365238A1 (en) | 2018-10-24 | 2021-05-13 | F. Hoffmann-La Roche Ag | Conjugated chemical inducers of degradation and methods of use |
EP3894427A1 (fr) | 2018-12-10 | 2021-10-20 | Genentech, Inc. | Peptides de photoréticulation pour conjugaison spécifique de site à des protéines contenant fc |
GB201901197D0 (en) | 2019-01-29 | 2019-03-20 | Femtogenix Ltd | G-A Crosslinking cytotoxic agents |
GB2597532A (en) | 2020-07-28 | 2022-02-02 | Femtogenix Ltd | Cytotoxic compounds |
AR128331A1 (es) | 2022-01-26 | 2024-04-17 | Genentech Inc | Inductores químicos de degradación conjugados con anticuerpos y métodos de estos |
AR128330A1 (es) | 2022-01-26 | 2024-04-17 | Genentech Inc | Inductores químicos de degradación conjugados con anticuerpo y métodos de estos |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2026147C (fr) * | 1989-10-25 | 2006-02-07 | Ravi J. Chari | Agents cytotoxiques comprenant des maytansinoides et leur usage therapeutique |
US5411860A (en) * | 1992-04-07 | 1995-05-02 | The Johns Hopkins University | Amplification of human MDM2 gene in human tumors |
EP0654092B1 (fr) * | 1992-06-26 | 2003-09-10 | The Trustees Of Princeton University | Procede de detection de cellules precancereuses ou cancereuses au moyen d'anticorps ou de sondes de p90 et de p53 |
US6410506B1 (en) * | 1995-05-19 | 2002-06-25 | Human Genome Sciences, Inc. | Transforming growth factor α HII |
US6800746B2 (en) * | 1997-02-25 | 2004-10-05 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of prostate cancer |
WO1999025825A2 (fr) * | 1997-11-13 | 1999-05-27 | Genset | ADNc ETENDUS POUR PROTEINES SECRETEES |
EP1032706A1 (fr) * | 1997-11-18 | 2000-09-06 | Abbott Laboratories | Reactifs et procedes utiles pour detecter des maladies de la poitrine |
DE69935905D1 (de) * | 1998-01-15 | 2007-06-06 | Whitehead Biomedical Inst | Fettsäure transportproteine |
ES2312205T3 (es) * | 1998-03-10 | 2009-02-16 | Genentech, Inc. | Nuevo polipeptido y acidos nucleicos que lo codifican. |
US6048970A (en) * | 1998-05-22 | 2000-04-11 | Incyte Pharmaceuticals, Inc. | Prostate growth-associated membrane proteins |
WO2001040276A2 (fr) * | 1999-12-06 | 2001-06-07 | Agensys, Inc | Nouveaux antigenes transmembranaires du type serpentin exprimes dans des cancers humains et utilisation de ces antigenes |
US7026448B2 (en) * | 1998-09-01 | 2006-04-11 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
NZ531664A (en) * | 1998-09-01 | 2005-07-29 | Genentech Inc | Pro1317 polypeptides and sequences thereof with homology to the semaphorin B glycoprotein family |
WO2000018915A2 (fr) * | 1998-09-25 | 2000-04-06 | Incyte Genomics, Inc. | Proteines organisationnelles associees aux membranes |
US20020119158A1 (en) * | 1998-12-17 | 2002-08-29 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of ovarian cancer |
AU2883700A (en) * | 1999-06-23 | 2001-01-09 | Genentech Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
EP1514933A1 (fr) * | 1999-07-08 | 2005-03-16 | Research Association for Biotechnology | Protéine sécrétoire ou protéine de membrane |
US6420378B1 (en) * | 1999-10-15 | 2002-07-16 | Supergen, Inc. | Inhibition of abnormal cell proliferation with camptothecin and combinations including the same |
EP1234030A4 (fr) * | 1999-11-19 | 2003-05-07 | Human Genome Sciences Inc | 18 proteines secretees humaines |
AU1807401A (en) * | 1999-11-30 | 2001-06-12 | Corixa Corporation | Compositions and methods for therapy and diagnosis of breast cancer |
US20020051990A1 (en) * | 2000-06-09 | 2002-05-02 | Eric Ople | Novel gene targets and ligands that bind thereto for treatment and diagnosis of ovarian carcinomas |
JP2004502417A (ja) * | 2000-06-30 | 2004-01-29 | アムジェン インコーポレーテッド | B7様分子およびその使用 |
CA2420140A1 (fr) * | 2000-08-24 | 2002-02-28 | Genentech, Inc. | Compositions et procedes de diagnostic et traitement de tumeurs |
-
2001
- 2001-06-22 CA CA002420140A patent/CA2420140A1/fr not_active Abandoned
- 2001-06-22 EP EP04011258A patent/EP1445318A2/fr not_active Withdrawn
- 2001-06-22 JP JP2002521524A patent/JP2004520806A/ja active Pending
- 2001-06-22 MX MXPA03001645A patent/MXPA03001645A/es unknown
- 2001-06-22 EP EP04011151A patent/EP1445317A3/fr not_active Withdrawn
- 2001-06-22 WO PCT/US2001/020118 patent/WO2002016429A2/fr not_active Application Discontinuation
- 2001-06-22 AU AU2001270118A patent/AU2001270118A1/en not_active Abandoned
- 2001-06-22 EP EP01948667A patent/EP1311674A2/fr not_active Withdrawn
- 2001-06-22 KR KR10-2003-7002685A patent/KR20030029847A/ko not_active Application Discontinuation
- 2001-09-26 CA CA002423991A patent/CA2423991A1/fr not_active Abandoned
- 2001-09-26 WO PCT/US2001/030290 patent/WO2002026822A2/fr not_active Application Discontinuation
- 2001-09-26 JP JP2002531204A patent/JP2004524816A/ja active Pending
- 2001-09-26 EP EP01975495A patent/EP1320549A2/fr not_active Withdrawn
- 2001-09-26 AU AU2001294814A patent/AU2001294814A1/en not_active Abandoned
-
2003
- 2003-03-19 US US10/392,190 patent/US20040005598A1/en not_active Abandoned
-
2004
- 2004-01-15 US US10/758,377 patent/US20040126807A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JP2004524816A (ja) | 2004-08-19 |
EP1320549A2 (fr) | 2003-06-25 |
WO2002026822A2 (fr) | 2002-04-04 |
CA2423991A1 (fr) | 2002-04-04 |
WO2002026822A3 (fr) | 2003-03-13 |
EP1445318A2 (fr) | 2004-08-11 |
WO2002016429A3 (fr) | 2003-01-03 |
MXPA03001645A (es) | 2004-05-14 |
WO2002016429A2 (fr) | 2002-02-28 |
US20040126807A1 (en) | 2004-07-01 |
JP2004520806A (ja) | 2004-07-15 |
EP1445317A3 (fr) | 2004-12-15 |
EP1445317A2 (fr) | 2004-08-11 |
AU2001294814A1 (en) | 2002-04-08 |
US20040005598A1 (en) | 2004-01-08 |
EP1311674A2 (fr) | 2003-05-21 |
CA2420140A1 (fr) | 2002-02-28 |
KR20030029847A (ko) | 2003-04-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA2505705C (fr) | Compositions et methodes pour le diagnostic et le traitement d'une tumeur | |
US20030060612A1 (en) | Compositions and methods for the diagnosis and treatment of tumor | |
AU2001270118A1 (en) | Compositions and methods for the diagnosis and treatment of tumor | |
NZ535925A (en) | An isolated antibody that binds to a particular polypeptide | |
AU2002318371A1 (en) | Compositions and methods for the diagnosis and treatment of tumor | |
WO2003000113A2 (fr) | Compositions et procedes destines au diagnostic et au traitement de tumeurs | |
EP1578371A2 (fr) | Compositions et methodes de diagnostic et de traitement des tumeurs | |
US20090227776A1 (en) | Compositions and methods for the diagnosis and treatment of tumor | |
EP1572091A2 (fr) | Compositions et methodes de diagnostic et de traitement de tumeurs | |
EP1628679A2 (fr) | Compositions et procedes pour le diagnostic et le traitement de tumeurs d'origine gliale | |
US6914130B2 (en) | Compositions and methods for the diagnosis and treatment of tumor | |
WO2002016581A2 (fr) | Compositions et methodes pour le diagnostic et le traitement de tumeurs | |
AU2001286785A1 (en) | Compositions and methods for the diagnosis and treatment of tumor | |
WO2002016602A2 (fr) | Compositions et procedes conçus pour le diagnostic et le traitement de tumeur | |
EP1578760A2 (fr) | Compositions et methodes de diagnostic et de traitement de tumeurs | |
ZA200506507B (en) | Identification of cellular polypeptides differentially expressed by tumor cells | |
ZA200301202B (en) | Compositions and methods for the diagnosis and treatment of tumor. | |
EP1694864A2 (fr) | Compositions et methodes de diagnostic et de traitement d'une tumeur | |
AU2001284906A1 (en) | Compositions and methods for the diagnosis and treatment of tumor | |
WO2003090600A2 (fr) | Compositions et procedes permettant de diagnostiquer et de traiter une tumeur | |
EP1494709A2 (fr) | Compositions et procedes pour le diagnostic et le traitement de tumeurs | |
WO2003053334A2 (fr) | Compositions et methodes de diagnostic et de traitement de tumeur |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MK4 | Application lapsed section 142(2)(d) - no continuation fee paid for the application |