ATE83927T1 - Thrombinzusammensetzung. - Google Patents

Thrombinzusammensetzung.

Info

Publication number
ATE83927T1
ATE83927T1 AT86307922T AT86307922T ATE83927T1 AT E83927 T1 ATE83927 T1 AT E83927T1 AT 86307922 T AT86307922 T AT 86307922T AT 86307922 T AT86307922 T AT 86307922T AT E83927 T1 ATE83927 T1 AT E83927T1
Authority
AT
Austria
Prior art keywords
preparation
thrombin
thrombin composition
buffer
disclosed
Prior art date
Application number
AT86307922T
Other languages
German (de)
English (en)
Inventor
Steven B Silbering
Russell U Nesbitt
Mahdi B Fawzi
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25154936&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE83927(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Application granted granted Critical
Publication of ATE83927T1 publication Critical patent/ATE83927T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0028—Polypeptides; Proteins; Degradation products thereof
    • A61L26/0047—Specific proteins or polypeptides not covered by groups A61L26/0033 - A61L26/0042
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4833—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S128/00—Surgery
    • Y10S128/22—Blood coagulation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Materials Engineering (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
AT86307922T 1985-10-28 1986-10-14 Thrombinzusammensetzung. ATE83927T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/791,836 US4696812A (en) 1985-10-28 1985-10-28 Thrombin preparations
EP86307922A EP0221700B1 (en) 1985-10-28 1986-10-14 A thrombin preparation

Publications (1)

Publication Number Publication Date
ATE83927T1 true ATE83927T1 (de) 1993-01-15

Family

ID=25154936

Family Applications (1)

Application Number Title Priority Date Filing Date
AT86307922T ATE83927T1 (de) 1985-10-28 1986-10-14 Thrombinzusammensetzung.

Country Status (14)

Country Link
US (1) US4696812A (forum.php)
EP (1) EP0221700B1 (forum.php)
JP (1) JPH0764747B2 (forum.php)
KR (1) KR870003793A (forum.php)
AT (1) ATE83927T1 (forum.php)
AU (1) AU586897B2 (forum.php)
CA (1) CA1272128A (forum.php)
DE (1) DE3687402T2 (forum.php)
DK (1) DK512686A (forum.php)
ES (1) ES2053442T3 (forum.php)
GR (1) GR3006727T3 (forum.php)
NZ (1) NZ217190A (forum.php)
PH (1) PH23444A (forum.php)
ZA (1) ZA868223B (forum.php)

Families Citing this family (62)

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US4965203A (en) * 1987-01-28 1990-10-23 Warner-Lambert Company Purified thrombin preparations
ZA88227B (en) * 1987-01-28 1988-06-30 Warner-Lambert Company Thrombin preparations
JPS6440433A (en) * 1987-08-05 1989-02-10 Green Cross Corp Aqueous liquid composition of thrombin
JP2715104B2 (ja) * 1988-08-18 1998-02-18 株式会社ミドリ十字 トロンビン乾燥製剤
US4891359A (en) * 1988-12-08 1990-01-02 Johnson & Johnson Patient Care, Inc. Hemostatic collagen paste composition
GB8903438D0 (en) * 1989-02-15 1989-04-05 May & Baker Ltd New compositions of matter
DK223389D0 (da) * 1989-05-05 1989-05-05 Ferrosan As Saarsvamp
US5281528A (en) * 1989-12-18 1994-01-25 Warner-Lambert Company Process for purified thromboplastin for ultra-pure thrombin preparation
US5318524A (en) * 1990-01-03 1994-06-07 Cryolife, Inc. Fibrin sealant delivery kit
US5219328A (en) * 1990-01-03 1993-06-15 Cryolife, Inc. Fibrin sealant delivery method
IE73210B1 (en) * 1990-01-24 1997-05-07 Warner Lambert Co Process for the production of thrombin and high purity thrombin preparation thereby obtained
JPH0813750B2 (ja) * 1990-03-01 1996-02-14 持田製薬株式会社 経口用トロンビン製剤
US5595735A (en) * 1990-05-23 1997-01-21 Johnson & Johnson Medical, Inc. Hemostatic thrombin paste composition
DE69122376D1 (de) * 1991-03-28 1996-10-31 Warner Lambert Co Hochreine Thrombinzubereitung
DK83092D0 (da) * 1992-06-24 1992-06-24 Unes As Fremgangsmaade til udvinding af thrombin
JP3230713B2 (ja) * 1992-10-23 2001-11-19 トヨタ自動車株式会社 ピークトルク低減機構
US5795780A (en) * 1993-06-23 1998-08-18 Bristol-Myers Squibb Company Method of use of autologous thrombin blood fraction in a cell culture with keratinocytes
US5506127A (en) * 1994-09-21 1996-04-09 Proba; Zbigniew Therapeutic grade thrombin produced by chromatography
DE69724243T2 (de) * 1996-04-04 2004-06-17 Baxter Ag Blutstillender schwamm auf kollagenbasis
WO2000062828A1 (en) 1996-04-30 2000-10-26 Medtronic, Inc. Autologous fibrin sealant and method for making the same
JP3401162B2 (ja) * 1996-11-21 2003-04-28 積水化学工業株式会社 血液凝固促進剤及び血液検査用容器
JP3927403B2 (ja) * 1996-11-21 2007-06-06 積水化学工業株式会社 血液凝固促進剤及び血液検査用容器
JP3927425B2 (ja) * 1996-11-21 2007-06-06 積水化学工業株式会社 血液凝固促進剤及び血液検査用容器
US6274090B1 (en) 1998-08-05 2001-08-14 Thermogenesis Corp. Apparatus and method of preparation of stable, long term thrombin from plasma and thrombin formed thereby
US6472162B1 (en) 1999-06-04 2002-10-29 Thermogenesis Corp. Method for preparing thrombin for use in a biological glue
AU7320300A (en) * 1999-09-27 2001-04-30 International Reagents Corporation Means of stabilizing thrombin and compositions
DE10012732A1 (de) 2000-03-18 2001-09-20 Aventis Behring Gmbh Thrombin-Zubereitungen und Verfahren zu ihrer Herstellung
US8187625B2 (en) * 2001-03-12 2012-05-29 Boston Scientific Scimed, Inc. Cross-linked gelatin composition comprising a wetting agent
US7923431B2 (en) * 2001-12-21 2011-04-12 Ferrosan Medical Devices A/S Haemostatic kit, a method of preparing a haemostatic agent and a method of promoting haemostatis
MXPA05006193A (es) 2002-12-11 2005-12-05 Ferrosan As Materiales basados en gelatina como hisopos.
US20040243044A1 (en) * 2003-06-02 2004-12-02 Penegor Stephen A. Hemostatic wound dressing
US7927626B2 (en) * 2003-08-07 2011-04-19 Ethicon, Inc. Process of making flowable hemostatic compositions and devices containing such compositions
CN1921896B (zh) 2004-01-30 2010-11-24 弗罗桑公司 止血喷雾剂和组合物
DE602005009191D1 (de) * 2004-06-22 2008-10-02 Zymogenetics Inc Thrombinzusammensetzungen
RU2369408C2 (ru) 2004-07-09 2009-10-10 Ферросан А/С Гемостатическая композиция, включающая гиалуроновую кислоту
ES2377118T3 (es) * 2004-09-21 2012-03-22 Trobio Ab Composición de proteasa estabilizada que comprende una serina proteasa, derivados de morfolino e inhibidores inversos de dicha serina proteasa
ES2226587B1 (es) * 2004-10-22 2005-12-16 Probitas Pharma, S.A. Composicion de trombina estable.
US7341392B2 (en) * 2005-04-22 2008-03-11 Dofair Co., Ltd. Lock device in an articulated joint for a foldable ladder
EP2021043B1 (en) * 2006-05-26 2011-01-12 Baxter International Inc. Injectable bone void filler
ES2361574T3 (es) * 2006-05-26 2011-06-20 Baxter International Inc. Composición de fibrina inyectable para el aumento óseo.
US20100143447A1 (en) * 2006-12-19 2010-06-10 Ferrosan A/S Wound or tissue dressing comprising lactic acid bacteria
JP5121725B2 (ja) * 2006-12-21 2013-01-16 積水メディカル株式会社 トロンビン含有溶液中のα−トロンビンの安定化方法
ES2381448T3 (es) * 2007-03-26 2012-05-28 Baxter International Inc. Material de relleno de huecos inyectable par el aumento de tejidos blandos
CA2687968C (en) * 2007-06-15 2016-09-27 Zymogenetics, Inc. Stabilized thrombin compositions
WO2009109194A2 (en) 2008-02-29 2009-09-11 Ferrosan A/S Device for promotion of hemostasis and/or wound healing
US10046081B2 (en) 2008-04-11 2018-08-14 The Henry M Jackson Foundation For The Advancement Of Military Medicine, Inc. Electrospun dextran fibers and devices formed therefrom
US9149557B2 (en) * 2008-04-16 2015-10-06 The Chemo-Sero-Therapeutic Research Institute Process for preparing bioabsorbable sheet preparation holding thrombin
IN2014DN08122A (forum.php) 2012-03-06 2015-05-01 Ferrosan Medical Devices As
EP2825216B1 (en) 2012-06-12 2015-08-19 Ferrosan Medical Devices A/S Dry haemostatic composition
US9149529B2 (en) 2012-10-24 2015-10-06 Orthovita, Inc. Stable compositions containing thrombin and methods for preparation and use thereof
JP6390873B2 (ja) 2013-06-21 2018-09-19 フェッローサン メディカル ディバイス エー／エス 減圧膨張させた乾燥組成物およびそれを保持するためのシリンジ
EP3470094B1 (en) 2013-12-11 2020-07-22 Ferrosan Medical Devices A/S Dry composition comprising an extrusion enhancer
BR112017007466B1 (pt) 2014-10-13 2021-03-02 Ferrosan Medical Devices A/S método para preparar uma composição seca, método para reconstituir a composição seca, pasta, composição seca, recipiente, kit homeostático, e, uso de uma composição seca
US10653837B2 (en) 2014-12-24 2020-05-19 Ferrosan Medical Devices A/S Syringe for retaining and mixing first and second substances
CN104569446A (zh) * 2015-02-04 2015-04-29 上海长岛生物技术有限公司 一种液体型凝血酶时间检测试剂及其制备方法
CN104630325B (zh) * 2015-02-04 2018-03-02 上海长岛生物技术有限公司 一种液体型纤维蛋白原检测试剂及其制备方法
EP3316930B1 (en) 2015-07-03 2019-07-31 Ferrosan Medical Devices A/S Syringe for mixing two components and for retaining a vacuum in a storage condition
US10828387B2 (en) 2015-11-12 2020-11-10 St. Teresa Medical, Inc. Method of sealing a durotomy
US10953128B2 (en) 2017-11-02 2021-03-23 St. Teresa Medical, Inc. Fibrin sealant products
EP4321182A3 (en) 2018-05-09 2024-05-29 Ferrosan Medical Devices A/S Method for preparing a haemostatic composition
IL261190A (en) 2018-08-16 2019-01-31 Omrix Biopharmaceuticals Ltd Stable liquid preparations of thrombin
IL262716A (en) * 2018-11-01 2018-11-29 Omrix Biopharmaceuticals Ltd Oxidized cellulose preparations

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US2433299A (en) * 1944-01-22 1947-12-23 Parke Davis & Co Blood coagulant and method of preserving same
US2532348A (en) * 1946-12-12 1950-12-05 Szent-Gyorgyi Albert Blood clotting preparation
JPS536483A (en) * 1976-07-02 1978-01-20 Tanabe Seiyaku Co Ltd Composition having enzymatic activity and its preparation
JPS5639782A (en) * 1979-09-04 1981-04-15 Dai Ichi Pure Chem Co Ltd Stabilization of thrombin
US4363319A (en) * 1980-06-30 1982-12-14 Applied Medical Devices, Inc. Ready-to-use bandage incorporating a coagulant composition and method of preparing same
JPS628137A (ja) * 1985-07-05 1987-01-16 Konishiroku Photo Ind Co Ltd 情報記録装置

Also Published As

Publication number Publication date
US4696812A (en) 1987-09-29
EP0221700A3 (en) 1987-08-26
DK512686A (da) 1987-04-29
ES2053442T3 (es) 1994-08-01
JPH0764747B2 (ja) 1995-07-12
JPS62106028A (ja) 1987-05-16
EP0221700A2 (en) 1987-05-13
ZA868223B (en) 1987-07-29
AU586897B2 (en) 1989-07-27
GR3006727T3 (forum.php) 1993-06-30
CA1272128A (en) 1990-07-31
DK512686D0 (da) 1986-10-27
KR870003793A (ko) 1987-05-04
NZ217190A (en) 1989-05-29
PH23444A (en) 1989-08-07
DE3687402D1 (de) 1993-02-11
EP0221700B1 (en) 1992-12-30
AU6451786A (en) 1987-04-30
DE3687402T2 (de) 1993-05-06

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
RZN Patent revoked