ATE80949T1 - Ziel- und hintergrundfangmethoden sowie vorrichtung fuer affinitaetsuntersuchungen. - Google Patents

Ziel- und hintergrundfangmethoden sowie vorrichtung fuer affinitaetsuntersuchungen.

Info

Publication number
ATE80949T1
ATE80949T1 AT87309308T AT87309308T ATE80949T1 AT E80949 T1 ATE80949 T1 AT E80949T1 AT 87309308 T AT87309308 T AT 87309308T AT 87309308 T AT87309308 T AT 87309308T AT E80949 T1 ATE80949 T1 AT E80949T1
Authority
AT
Austria
Prior art keywords
target
sample
capture methods
affinity studies
background capture
Prior art date
Application number
AT87309308T
Other languages
English (en)
Inventor
Mark Leo Collins
Original Assignee
Amoco Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amoco Corp filed Critical Amoco Corp
Application granted granted Critical
Publication of ATE80949T1 publication Critical patent/ATE80949T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/005—Pretreatment specially adapted for magnetic separation
    • B03C1/01—Pretreatment specially adapted for magnetic separation by addition of magnetic adjuvants
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/02—Magnetic separation acting directly on the substance being separated
    • B03C1/025—High gradient magnetic separators
    • B03C1/031—Component parts; Auxiliary operations
    • B03C1/033—Component parts; Auxiliary operations characterised by the magnetic circuit
    • B03C1/0335—Component parts; Auxiliary operations characterised by the magnetic circuit using coils
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/02—Magnetic separation acting directly on the substance being separated
    • B03C1/28—Magnetic plugs and dipsticks
    • B03C1/288—Magnetic plugs and dipsticks disposed at the outer circumference of a recipient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/02—Magnetic separation acting directly on the substance being separated
    • B03C1/30—Combinations with other devices, not otherwise provided for
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C2201/00—Details of magnetic or electrostatic separation
    • B03C2201/18—Magnetic separation whereby the particles are suspended in a liquid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C2201/00—Details of magnetic or electrostatic separation
    • B03C2201/26—Details of magnetic or electrostatic separation for use in medical or biological applications
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/0098—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor involving analyte bound to insoluble magnetic carrier, e.g. using magnetic separation

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Silicon Compounds (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Sampling And Sample Adjustment (AREA)
AT87309308T 1986-10-23 1987-10-21 Ziel- und hintergrundfangmethoden sowie vorrichtung fuer affinitaetsuntersuchungen. ATE80949T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US92215586A 1986-10-23 1986-10-23
EP87309308A EP0265244B1 (de) 1986-10-23 1987-10-21 Ziel- und Hintergrundfangmethoden sowie Vorrichtung für Affinitätsuntersuchungen

Publications (1)

Publication Number Publication Date
ATE80949T1 true ATE80949T1 (de) 1992-10-15

Family

ID=25446589

Family Applications (1)

Application Number Title Priority Date Filing Date
AT87309308T ATE80949T1 (de) 1986-10-23 1987-10-21 Ziel- und hintergrundfangmethoden sowie vorrichtung fuer affinitaetsuntersuchungen.

Country Status (9)

Country Link
US (1) US5780224A (de)
EP (1) EP0265244B1 (de)
JP (1) JP2975603B2 (de)
CN (1) CN1016645B (de)
AT (1) ATE80949T1 (de)
AU (1) AU621812B2 (de)
CA (1) CA1309329C (de)
DE (1) DE3781860T2 (de)
ZA (1) ZA877772B (de)

Families Citing this family (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4882269A (en) * 1985-12-13 1989-11-21 Princeton University Amplified hybridization assay
US5714380A (en) 1986-10-23 1998-02-03 Amoco Corporation Closed vessel for isolating target molecules and for performing amplification
WO1988010313A1 (en) * 1987-06-26 1988-12-29 E.I. Du Pont De Nemours And Company Affinity removal of contaminating sequences from recombinant cloned na using capture beads
AU2735988A (en) * 1987-12-21 1989-07-13 Amoco Corporation Target and background capture methods with amplification for affinity assays
NO165894C (no) * 1988-05-24 1991-04-24 Gunnar Paulsen Analysemetode for gener.
US5817797A (en) * 1988-06-01 1998-10-06 The United States Of America As Represented By The Department Of Health And Human Services Sequencing DNA; a modification of the polymerase chain reaction
US5512439A (en) * 1988-11-21 1996-04-30 Dynal As Oligonucleotide-linked magnetic particles and uses thereof
DE68913555T2 (de) * 1988-11-21 1994-07-07 Dynal As Sonden aus nukleinsäuren.
US5759820A (en) * 1988-11-21 1998-06-02 Dynal As Process for producing cDNA
GB8827160D0 (en) * 1988-11-21 1988-12-29 Apothekernes Lab Detection & quantitative determination of rna & dna
GB8827167D0 (en) * 1988-11-21 1988-12-29 Apothekernes Lab In vitro mutagenesis
ATE122721T1 (de) * 1988-11-21 1995-06-15 Dynal As Verfahren zur herstellung von cdns.
DE3840462A1 (de) * 1988-12-01 1990-06-07 Berthold Lab Prof R Verfahren und vorrichtung zur messung der chemilumineszenz
EP0408738B1 (de) * 1989-02-03 1994-01-19 Eastman Kodak Company Nukleinsäureprüfungswerkstoff und seine anwendung für die detektion einer vorausbestimmten nukleinsäure
US5856092A (en) * 1989-02-13 1999-01-05 Geneco Pty Ltd Detection of a nucleic acid sequence or a change therein
ATE155821T1 (de) * 1989-03-10 1997-08-15 Vysis Inc Interferenzverhinderung mit affinitätseinfangschemas
AU5269590A (en) 1989-03-10 1990-10-09 Gene-Trak Systems Immobilized oligonucleotide probes and uses therefor
CA2011818A1 (en) * 1989-03-17 1990-09-17 Fred T. Oakes Methods for purification, amplification and detection of a nucleic acid
US5580970A (en) * 1989-12-01 1996-12-03 Amoco Corporation Detection of HPV transcripts
ATE152777T1 (de) * 1989-12-04 1997-05-15 Microprobe Corp Verstärkter einfang von ziel-nukleinsäuren mittels verwendung von oligonukleotiden, die kovalent an polymere gebunden sind
WO1992015708A1 (en) * 1991-02-27 1992-09-17 Amoco Corporation Methods for improving the sensitivity of hybridization assays
US5556748A (en) * 1991-07-30 1996-09-17 Xenopore Corporation Methods of sandwich hybridization for the quantitative analysis of oligonucleotides
US5437976A (en) * 1991-08-08 1995-08-01 Arizona Board Of Regents, The University Of Arizona Multi-domain DNA ligands bound to a solid matrix for protein and nucleic acid affinity chromatography and processing of solid-phase DNA
JPH0560761A (ja) * 1991-08-30 1993-03-12 Imuno Baion:Kk 重合体の分析方法
US5468852A (en) * 1992-02-18 1995-11-21 Shimadzu Corporation Oligonucleotides for detecting bacteria
WO1993022457A1 (en) * 1992-04-24 1993-11-11 Massachusetts Institute Of Technology Screening for genetic variation
US5312730A (en) * 1992-05-27 1994-05-17 Ciba Corning Diagnostics Corp. Immune complex transfer with lypophilic bridge
JP3197277B2 (ja) * 1993-05-10 2001-08-13 日水製薬株式会社 一種類以上の免疫学的配位子の分析方法，その分析試薬およびそのキット
EP0649910A1 (de) * 1993-10-22 1995-04-26 Sumitomo Electric Industries, Limited DNA-Probe zur Detektion allergischer Krankheiten, Detektionsprozess für allergische Krankheiten hervorrüfendes Gen mittels einer solchen Probe
DE4421058A1 (de) 1994-06-16 1995-12-21 Boehringer Mannheim Gmbh Verfahren zur magnetischen Abtrennung von Flüssigkeitskomponenten
US5837144A (en) * 1994-06-16 1998-11-17 Boehringer Mannheim Gmbh Method of magnetically separating liquid components
DE4434093A1 (de) * 1994-09-23 1996-03-28 Boehringer Mannheim Gmbh Verfahren zum qualitativen oder/und quantitativen Nachweis einer zu bestimmenden Substanz
US5604097A (en) * 1994-10-13 1997-02-18 Spectragen, Inc. Methods for sorting polynucleotides using oligonucleotide tags
US6919175B1 (en) 1995-04-01 2005-07-19 Roche Diagnostics Gmbh System for releasing and isolating nucleic acids
DE19512368A1 (de) * 1995-04-01 1996-10-02 Boehringer Mannheim Gmbh System zur Freisetzung und Isolierung von Nukleinsäuren
US5683875A (en) * 1995-05-04 1997-11-04 Hewlett-Packard Company Method for detecting a target nucleic acid analyte in a sample
US5853974A (en) 1995-06-07 1998-12-29 Chiron Corporation Enhancement of alkaline phosphatase with SDS in chemiluminescent substrates
US6534273B2 (en) 1997-05-02 2003-03-18 Gen-Probe Incorporated Two-step hybridization and capture of a polynucleotide
ES2271994T3 (es) 1997-05-02 2007-04-16 Gen-Probe Incorporated Hibridacion en dos pasos y captura de un polinucleotido.
JP2002500897A (ja) 1998-01-27 2002-01-15 クリニカル・マイクロ・センサーズ・インコーポレイテッド 電子的核酸検出の増幅
US6686150B1 (en) 1998-01-27 2004-02-03 Clinical Micro Sensors, Inc. Amplification of nucleic acids with electronic detection
US20040203078A1 (en) * 1998-07-22 2004-10-14 National Institute Of Advanced Industrial Science And Technology Labeled complex, process for producing same and process for utilizing same
US5973138A (en) * 1998-10-30 1999-10-26 Becton Dickinson And Company Method for purification and manipulation of nucleic acids using paramagnetic particles
US20030032029A1 (en) * 1998-12-21 2003-02-13 Nanogen, Inc. Three dimensional apparatus and method for integrating sample preparation and multiplex assays
US6852493B2 (en) 1999-05-14 2005-02-08 Iris Biotechnologies, Inc. Magnetic field enhanced hybridization of target molecules to immobilized probes
EP1206572B1 (de) * 1999-05-27 2003-02-12 Iris Biotechnologies, Inc. Verfahren für die erhöhung der hybridisierungsrate von nukleinsäuren
CA2380258C (en) 1999-07-26 2008-07-15 Clinical Micro Sensors, Inc. Sequence determination of nucleic acids using electronic detection
WO2001064864A2 (en) * 2000-02-28 2001-09-07 Maxygen, Inc. Single-stranded nucleic acid template-mediated recombination and nucleic acid fragment isolation
DE10211321A1 (de) * 2002-03-14 2003-09-25 Gnothis Holding Sa Ecublens Verwendung von Abfangsonden beim Nachweis von Nukleinsäuren
EP1498486A4 (de) * 2002-03-29 2005-08-03 Prec System Science Co Ltd Nukleinsäurebibliothek und proteinbibliothek
KR20050008720A (ko) 2002-05-17 2005-01-21 벡톤 디킨슨 앤드 컴퍼니 표적 핵산 서열의 분리, 증폭 및 검출을 위한 자동화 시스템
US7601491B2 (en) 2003-02-06 2009-10-13 Becton, Dickinson And Company Pretreatment method for extraction of nucleic acid from biological samples and kits therefor
US7759106B2 (en) 2004-05-19 2010-07-20 The United States Of America As Represented By The Secretary Of The Army Construction of live attenuated Shigella vaccine strains that express CFA/I antigens (CfaB and CfaE) and the B subunit of heat-labile enterotoxin (LTB) from enterotoxigenic E. coli
US8034554B2 (en) * 2004-07-01 2011-10-11 Gen-Probe Incorporated Methods and compositions to detect nucleic acids in a biological sample
US20060057613A1 (en) * 2004-07-26 2006-03-16 Nanosphere, Inc. Method for distinguishing methicillin resistant S. aureus from methicillin sensitive S. aureus in a mixed culture
US8615368B2 (en) 2005-03-10 2013-12-24 Gen-Probe Incorporated Method for determining the amount of an analyte in a sample
EP1930730B1 (de) 2005-03-10 2019-08-14 Gen-Probe Incorporated Systeme und Verfahren zur Durchführung von Tests zum Nachweis oder zur Quantifizierung von Analyten
US9051601B2 (en) * 2006-08-01 2015-06-09 Gen-Probe Incorporated Methods of nonspecific target capture of nucleic acids
WO2008045158A1 (en) 2006-10-10 2008-04-17 Illumina, Inc. Compositions and methods for representational selection of nucleic acids fro complex mixtures using hybridization
DE102006058374A1 (de) * 2006-12-08 2008-07-03 Biosensor Gmbh Analyseverfahren und portables Analysegerät
GB0701253D0 (en) 2007-01-23 2007-02-28 Diagnostics For The Real World Nucleic acid amplification and testing
EP2806037B1 (de) 2008-05-13 2016-09-21 Gen-Probe Incorporated Inaktivierbare Target-Capture-Oligomere zur Verwendung bei der selektiven Hybridisierung und beim Fangen von Zielnukleinsäuresequenzen
WO2010068473A1 (en) * 2008-11-25 2010-06-17 Gen-Probe Incorporated Compositions and methods for detecting small rnas, and uses thereof
CN102427885B (zh) 2009-05-15 2016-10-19 简·探针公司 用于在执行磁性分离工序的仪器中实现磁体的自动移动的方法和设备
JP2010183910A (ja) * 2010-05-17 2010-08-26 Sekisui Medical Co Ltd 核酸固定用磁性粒子
CN104450680A (zh) 2011-05-12 2015-03-25 精密科学公司 核酸的分离
US8993341B2 (en) 2011-05-12 2015-03-31 Exact Sciences Corporation Removal of PCR inhibitors
US8808990B2 (en) 2011-05-12 2014-08-19 Exact Sciences Corporation Serial isolation of multiple DNA targets from stool
WO2015089438A1 (en) 2013-12-13 2015-06-18 Northwestern University Biomarkers for post-traumatic stress states
KR102323205B1 (ko) * 2014-08-22 2021-11-08 삼성전자주식회사 표적물질 분리장치 및 표적물질 분리방법
CA2978450A1 (en) 2015-03-04 2016-09-09 The University Of Chicago Beta-catenin inhibitors in cancer immunotherapy
CN109715646B (zh) 2016-09-15 2023-02-10 雅培实验室 用于样品分析的装置和方法
WO2018186924A1 (en) 2017-01-17 2018-10-11 The University Of Chicago Dysfunctional antigen-specific cd8+ t cells in the tumor microenvironment
JP7232438B2 (ja) * 2018-04-27 2023-03-03 国立大学法人 東京大学 メチル含有基修飾核酸を精製、分離または濃縮する方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3970518A (en) * 1975-07-01 1976-07-20 General Electric Company Magnetic separation of biological particles
US4351824A (en) * 1981-02-05 1982-09-28 Icl Scientific Polystyrene latex reagents, methods of preparation, and use in immunological procedures
US4554088A (en) * 1983-05-12 1985-11-19 Advanced Magnetics Inc. Magnetic particles for use in separations
US4672040A (en) * 1983-05-12 1987-06-09 Advanced Magnetics, Inc. Magnetic particles for use in separations
NO843838L (no) * 1983-09-26 1985-03-27 Ortho Diagnostic Systems Inc Fremgangsmaate for detektering av nukleinsyre
CA1260372A (en) * 1984-04-27 1989-09-26 Elazar Rabbani Hybridization method for the detection of genetic materials
GB8507706D0 (en) * 1985-03-25 1985-05-01 Genetics Int Inc Magnetic nucleic acid sequences
US4824776A (en) * 1985-07-25 1989-04-25 Molecular Biosystems, Inc. Method for increasing the sensitivity of nucleic acid hybridization assays
US4752566A (en) * 1985-12-17 1988-06-21 Genetics Institute, Inc. Displacement polynucleotide method and reagent complex employing labeled probe polynucleotide
EP0230768B1 (de) * 1985-12-20 1992-03-18 Syntex (U.S.A.) Inc. Teilchentrennungsverfahren
ATE88761T1 (de) * 1986-01-10 1993-05-15 Amoco Corp Kompetitiver homogener test.

Also Published As

Publication number Publication date
EP0265244B1 (de) 1992-09-23
ZA877772B (en) 1988-04-20
CN87107800A (zh) 1988-07-13
US5780224A (en) 1998-07-14
EP0265244A2 (de) 1988-04-27
DE3781860T2 (de) 1993-05-06
JP2975603B2 (ja) 1999-11-10
CA1309329C (en) 1992-10-27
CN1016645B (zh) 1992-05-13
AU8009787A (en) 1988-04-28
EP0265244A3 (en) 1989-05-10
DE3781860D1 (de) 1992-10-29
JPS63188399A (ja) 1988-08-03
AU621812B2 (en) 1992-03-26

Similar Documents

Publication Publication Date Title
ATE80949T1 (de) Ziel- und hintergrundfangmethoden sowie vorrichtung fuer affinitaetsuntersuchungen.
FI891012A (fi) Menetelmä ja väline immuunikokeissa esiintyvien häiriötekijöiden kompensoimiseksi
ATE177206T1 (de) Vorrichtung zur chromatographischen bestimmung, die einander entgegenstellbare teile enthalten
NO891929D0 (no) Nye komposisjoner med loeselige signalmolekyler for in vitro overvaaking av diabetes mellitus.
NO875476L (no) Elektrokjemiluminiscente analyser.
AU3156489A (en) Solid-phase analytical device and method for using same
ES2097747T3 (es) Molecula de adhesion intercelular 2 y sus ligandos de union.
CA2033168A1 (en) Method of Optical Analysis
DE69528375D1 (de) Chemilumineszente dialkylsubstituierte 1,2-dioxetanverbindungen, synthesemethode und anwendung
DE69530315D1 (de) Rückgewinnung und verwendungen von spezifischen bindungsreagenzen
SE8406219D0 (sv) Sett och anordning for utforande av biokemiska analyser
DK314987A (da) Fremgangsmaade til specifik bestemmelse af serumfructosaminindhold samt hertil egnet reagensblanding
CA2084492A1 (en) Multivalent dextran reagent for use in precipitation tests
ES2069902T3 (es) Analisis de variante de analito.
SE7906799L (sv) Biologiskt indikatorsystem
ATE133582T1 (de) Verfahren zur aktivierung von polymeren trägern und damit hergestellte zusammensetzungen zur verwendung in der affinitätschromatographie
NO874937L (no) Stabil immobilisert haptenreagens for anvendelse i hetrogene, immunometriske analyser.
DE3785567D1 (de) Immunologischer testkit.
AU7534287A (en) Method for diagnostic immunoassay by solid phase separation
KR890006828A (ko) 효소 분석법
DK272288A (da) Fremgangsmaade til oprensning af proteiner
Hurley Development of an ELISA Method for the Measurement of CD44 Expression in Human Serum

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties