ATE555191T1 - Synthetische oberflächen zur kultivierung von zellen in chemisch definierten medien - Google Patents

Synthetische oberflächen zur kultivierung von zellen in chemisch definierten medien

Info

Publication number
ATE555191T1
ATE555191T1 AT09708754T AT09708754T ATE555191T1 AT E555191 T1 ATE555191 T1 AT E555191T1 AT 09708754 T AT09708754 T AT 09708754T AT 09708754 T AT09708754 T AT 09708754T AT E555191 T1 ATE555191 T1 AT E555191T1
Authority
AT
Austria
Prior art keywords
meth
swellable
acrylate
acrylate monomer
chemically defined
Prior art date
Application number
AT09708754T
Other languages
English (en)
Inventor
Andrei Fadeev
Jennifer Gehman
Zara Melkoumian
David Weber
Yue Zhou
Ralph Brandenberger
Original Assignee
Geron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Geron Corp filed Critical Geron Corp
Application granted granted Critical
Publication of ATE555191T1 publication Critical patent/ATE555191T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0068—General culture methods using substrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/30—Synthetic polymers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2537/00—Supports and/or coatings for cell culture characterised by physical or chemical treatment
    • C12N2537/10—Cross-linking

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Developmental Biology & Embryology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT09708754T 2008-01-30 2009-01-30 Synthetische oberflächen zur kultivierung von zellen in chemisch definierten medien ATE555191T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6293708P 2008-01-30 2008-01-30
US6289008P 2008-01-30 2008-01-30
PCT/US2009/000597 WO2009099555A2 (en) 2008-01-30 2009-01-30 Synthetic surfaces for culturing cells in chemically defined media

Publications (1)

Publication Number Publication Date
ATE555191T1 true ATE555191T1 (de) 2012-05-15

Family

ID=40899640

Family Applications (1)

Application Number Title Priority Date Filing Date
AT09708754T ATE555191T1 (de) 2008-01-30 2009-01-30 Synthetische oberflächen zur kultivierung von zellen in chemisch definierten medien

Country Status (12)

Country Link
US (3) US8354274B2 (de)
EP (3) EP2247747B1 (de)
JP (2) JP5501981B2 (de)
KR (2) KR20100131992A (de)
CN (2) CN102137924A (de)
AT (1) ATE555191T1 (de)
AU (2) AU2009210837A1 (de)
BR (2) BRPI0906724A2 (de)
CA (2) CA2713754A1 (de)
DK (1) DK2247716T3 (de)
IL (2) IL207296A (de)
WO (2) WO2009099555A2 (de)

Families Citing this family (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5560393B2 (ja) * 2005-06-22 2014-07-23 アステリアス バイオセラピューティクス インコーポレイテッド 心筋細胞系列細胞への霊長類多能性幹細胞の分化
CA2714010C (en) 2008-01-30 2020-06-16 Corning Incorporated Synthetic surfaces for culturing stem cell derived oligodendrocyte progenitor cells
US8329469B2 (en) * 2008-01-30 2012-12-11 Geron Corporation Swellable (meth)acrylate surfaces for culturing cells in chemically defined media
SG188098A1 (en) * 2008-01-30 2013-03-28 Geron Corp Synthetic surfaces for culturing stem cell derived cardiomyocytes
US8354274B2 (en) * 2008-01-30 2013-01-15 Geron Corporation Synthetic surfaces for culturing cells in chemically defined media
HUE025852T2 (en) 2008-06-26 2016-04-28 Orphazyme Aps Use of HSP70 to regulate enzyme activity
US8603820B2 (en) * 2009-05-21 2013-12-10 Corning Incorporated Derivatized peptide-conjugated (meth) acrylate cell culture surface and methods of making
CN102482385B (zh) * 2009-05-28 2014-10-15 康宁股份有限公司 用来培养细胞的合成微型载体
WO2011017050A1 (en) 2009-07-28 2011-02-10 Corning Incorporated Synthetic microcarriers for culturing cells
EP2361968B1 (de) 2010-02-26 2014-11-19 Corning Incorporated Synthetische Polysaccharid-Mikroträger zur Kultivierung von Zellen
US20110027888A1 (en) * 2009-07-29 2011-02-03 Beltzer James P Coated Fibers for Culturing Cells
US20110183418A1 (en) * 2009-07-29 2011-07-28 Arthur Winston Martin Peptide-Polymer Cell Culture Articles and Methods of Making
US20110186165A1 (en) * 2009-10-05 2011-08-04 Borenstein Jeffrey T Three-dimensional microfluidic platforms and methods of use and manufacture thereof
ES2779048T3 (es) 2009-11-12 2020-08-13 Technion Res & Dev Foundation Medios de cultivo, cultivos celulares y métodos de cultivo de células madre pluripotentes en un estado indiferenciado
US20110207216A1 (en) 2010-02-25 2011-08-25 Arthur Winston Martin Synthetic Peptide (Meth) Acrylate Microcarriers
EP2556147B1 (de) 2010-04-08 2018-10-03 The University Court Of The University of Edinburgh Chondrogene vorläuferzellen, protokoll für zellableitung und verwendung
JP5887496B2 (ja) 2010-05-11 2016-03-16 パナソニックＩｐマネジメント株式会社 細胞培養基材及びそれを用いた細胞培養方法
EP2412798A1 (de) * 2010-07-27 2012-02-01 Gambro Lundia AB Biomimetische Membran zur Kultivierung von Zellen
WO2012014003A1 (en) * 2010-07-28 2012-02-02 Corning Incorporated Pre-polymer preparations for cell culture coatings
US20120052579A1 (en) * 2010-08-27 2012-03-01 Simon Kelly Shannon Peptide-modified microcarriers for cell culture
WO2012027218A2 (en) * 2010-08-27 2012-03-01 Corning Incorporated Peptide-modified surfaces for cell culture
US20120071575A1 (en) * 2010-08-27 2012-03-22 Derosa Michael Edward Microporous Thermoplastic Article
EP2625577B1 (de) 2010-10-08 2019-06-26 Terumo BCT, Inc. Anpassbares verfahren und systeme für züchtung und ernte von zellen in einem hohlfaser-bioreaktorsystem
RU2013125923A (ru) * 2010-11-30 2015-01-10 Орфазиме Апс СПОСОБЫ УВЕЛИЧЕНИЯ ВНУТРИКЛЕТОЧНОЙ АКТИВНОСТИ Hsp70
AU2012256403B2 (en) 2011-03-17 2016-10-20 Corning Incorporated Synthetic coating for cell culture
EP2691512B1 (de) 2011-03-29 2019-05-01 Asterias Biotherapeutics, Inc. Angereicherte populationen von herzmuskelzellen aus pluripotenten stammzellen
EP2700707B1 (de) * 2011-04-21 2018-06-06 Nipro Corporation Zellkulturverfahren und zellkulturkit
WO2012150475A1 (en) * 2011-05-05 2012-11-08 Corning Incorporated Synthetic composition and coating for cell culture.
US9376655B2 (en) * 2011-09-29 2016-06-28 Life Technologies Corporation Filter systems for separating microcarriers from cell culture solutions
EP2788471A1 (de) * 2011-12-06 2014-10-15 Singapore Health Services Pte Ltd Verfahren zur herstellung von verbesserten cardiomyozytenähnlichen zellen
CN103146572B (zh) * 2011-12-07 2016-01-06 清华大学 一种实现细胞集落均质性生长的装置和方法
JP5731421B2 (ja) * 2012-02-15 2015-06-10 株式会社島津製作所 細胞培養デバイス
KR101461133B1 (ko) * 2012-05-29 2014-11-13 광주과학기술원 헤파린 기반 수화젤을 포함하는 줄기세포 배양기판 및 그 제조방법
CA2877757A1 (en) * 2012-06-29 2014-01-03 Polymers Crc Ltd. Process for modifying a polymeric surface
TWI512103B (zh) 2012-11-12 2015-12-11 Ind Tech Res Inst 細胞培養系統、以及無血清細胞培養方法
US20140141503A1 (en) * 2012-11-20 2014-05-22 Corning Incorporated Cell culture substrate having uniform surface coating
CN103087916B (zh) * 2013-01-17 2014-04-16 黑龙江省重生生物科技有限公司 一种涂覆有Matrigel的细胞培养板及其制备方法和应用
GB201316815D0 (en) 2013-09-23 2013-11-06 Renishaw Plc Additive manufacturing apparatus and method
TWI601817B (zh) 2013-10-02 2017-10-11 國立中央大學 細胞培養製品及其製造方法
JP6633522B2 (ja) 2013-11-16 2020-01-22 テルモ ビーシーティー、インコーポレーテッド バイオリアクターにおける細胞増殖
US10150948B2 (en) 2013-12-11 2018-12-11 The Regents Of The University Of California Compositions and methods for producing and administering brown adipocytes
JP6456969B2 (ja) 2014-02-21 2019-01-23 マサチューセッツ インスティテュート オブ テクノロジー 膨張顕微鏡法
WO2015148704A1 (en) 2014-03-25 2015-10-01 Terumo Bct, Inc. Passive replacement of media
JP6357006B2 (ja) * 2014-04-18 2018-07-11 東京応化工業株式会社 細胞培養基材形成用の感光性樹脂組成物
PL3193840T3 (pl) 2014-09-15 2021-12-06 Orphazyme A/S Preparat arimoklomolu
WO2016049421A1 (en) 2014-09-26 2016-03-31 Terumo Bct, Inc. Scheduled feed
EP3263692A4 (de) 2015-02-25 2018-10-17 Ebara Jitsugyo Co. Ltd. Substrat für zellen und verfahren zur herstellung davon
US20180086864A1 (en) * 2015-03-31 2018-03-29 Mitsui Chemicals, Inc. Medical instrument, fluorine-containing cyclic olefin polymer, fluorine-containing cyclic olefin polymer composition, and cell culture method
US10526649B2 (en) 2015-04-14 2020-01-07 Massachusetts Institute Of Technology Augmenting in situ nucleic acid sequencing of expanded biological samples with in vitro sequence information
US10059990B2 (en) 2015-04-14 2018-08-28 Massachusetts Institute Of Technology In situ nucleic acid sequencing of expanded biological samples
US11408890B2 (en) 2015-04-14 2022-08-09 Massachusetts Institute Of Technology Iterative expansion microscopy
WO2016205678A1 (en) 2015-06-19 2016-12-22 Emory University Methods of measuring cell purity for making quality control determinations and related compositions
WO2017004592A1 (en) 2015-07-02 2017-01-05 Terumo Bct, Inc. Cell growth with mechanical stimuli
WO2017027368A1 (en) 2015-08-07 2017-02-16 Massachusetts Institute Of Technology Protein retention expansion microscopy
US10364457B2 (en) 2015-08-07 2019-07-30 Massachusetts Institute Of Technology Nanoscale imaging of proteins and nucleic acids via expansion microscopy
WO2017036533A1 (en) 2015-09-03 2017-03-09 Ecole Polytechnique Federale De Lausanne (Epfl) Three-dimensional hydrogels for culturing adult epithelial stem cells and organoids
JPWO2017110923A1 (ja) 2015-12-24 2018-10-18 Ａｇｃ株式会社 樹脂組成物、基材および細胞培養方法
CN107227297A (zh) * 2016-03-23 2017-10-03 中国科学院沈阳自动化研究所 一种快速无掩模的细胞二维图形化制作方法
EP3442530A1 (de) 2016-04-13 2019-02-20 Orphazyme A/S Hitzeschockproteinen und cholesterinhomöostase
RS61291B1 (sr) 2016-04-29 2021-02-26 Orphazyme As Arimoklomol za lečenje poremećaja povezanih sa glukocerebrozidazom
US11965175B2 (en) 2016-05-25 2024-04-23 Terumo Bct, Inc. Cell expansion
US11104874B2 (en) 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
EP3290510A1 (de) * 2016-08-31 2018-03-07 Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen Modellsatz für suspensionszelllinien
US11873508B2 (en) * 2017-01-20 2024-01-16 Agency For Science, Technology And Research Thermoresponsive microcarrier system and uses thereof
WO2018136856A1 (en) 2017-01-23 2018-07-26 Massachusetts Institute Of Technology Multiplexed signal amplified fish via splinted ligation amplification and sequencing
JP6721881B2 (ja) * 2017-02-23 2020-07-15 日本電信電話株式会社 細胞足場材料、細胞モデル、及び細胞足場材料の製造方法
WO2018157074A1 (en) 2017-02-24 2018-08-30 Massachusetts Institute Of Technology Methods for diagnosing neoplastic lesions
WO2018157048A1 (en) 2017-02-24 2018-08-30 Massachusetts Institute Of Technology Methods for examining podocyte foot processes in human renal samples using conventional optical microscopy
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
EP3656841A1 (de) 2017-03-31 2020-05-27 Terumo BCT, Inc. Zellexpansion
US11180804B2 (en) 2017-07-25 2021-11-23 Massachusetts Institute Of Technology In situ ATAC sequencing
US11873374B2 (en) 2018-02-06 2024-01-16 Massachusetts Institute Of Technology Swellable and structurally homogenous hydrogels and methods of use thereof
CN108047455B (zh) * 2018-02-09 2020-12-25 中国人民解放军陆军军医大学 用于抗原载体的两亲性超支化聚合物及其制备方法和应用
CN108329483B (zh) * 2018-02-09 2020-12-29 中国人民解放军陆军军医大学 两亲性超支化聚合物及其制备方法和应用
JP7315652B2 (ja) * 2018-08-16 2023-07-26 テルモ株式会社 細胞培養基材
WO2020036205A1 (en) * 2018-08-16 2020-02-20 Terumo Kabushiki Kaisha Cell culture substrate
CN109187943B (zh) * 2018-08-24 2021-07-30 四川新健康成生物股份有限公司 一种抗干扰试剂杯以及试剂杯内抗干扰涂层的制备方法
US20220073853A1 (en) * 2018-12-20 2022-03-10 Terumo Kabushiki Kaisha Cell culture substrate
JP2020115787A (ja) * 2019-01-24 2020-08-06 住友ゴム工業株式会社 細胞培養装置及び細胞培養方法
US11802822B2 (en) 2019-12-05 2023-10-31 Massachusetts Institute Of Technology Multiplexed expansion (MultiExM) pathology
CN112079930B (zh) * 2020-07-11 2022-09-09 兰州大学 具有良好支持人诱导多能干细胞生长性能的非天然多肽
CN111979124A (zh) * 2020-08-04 2020-11-24 南京利康立德生物科技有限公司 生物培养芯片及其制备和应用
MX2023005954A (es) 2020-11-19 2023-09-04 Zevra Denmark As Procesos para preparar citrato de arimoclomol e intermediarios del mismo.
US12043823B2 (en) 2021-03-23 2024-07-23 Terumo Bct, Inc. Cell capture and expansion
CN114214266B (zh) * 2021-11-18 2022-09-02 创芯国际生物科技(广州)有限公司 一种凝胶组合物、生物支架凝胶及其制备方法和应用
JPWO2023127778A1 (de) * 2021-12-27 2023-07-06

Family Cites Families (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3502545A (en) * 1968-09-27 1970-03-24 Monsanto Co Process for the separation of water-soluble polymeric materials from unbound protein or peptide using semiporous gel
AR208398A1 (es) * 1974-03-29 1976-12-27 Smith & Nephew Res Un copolimero hidrogel ligeramente entrelazado
JPS58146280A (ja) * 1982-02-26 1983-08-31 Japan Atom Energy Res Inst 増殖能を有する酵母固定化物の製造方法
US4792525A (en) 1982-08-04 1988-12-20 La Jolla Cancer Research Foundation Tetrapeptide
US5695997A (en) * 1982-08-04 1997-12-09 La Jolla Cancer Research Foundation Tetrapeptide
US4578079A (en) 1982-08-04 1986-03-25 La Jolla Cancer Research Foundation Tetrapeptide
US4661111A (en) 1982-08-04 1987-04-28 La Jolla Cancer Research Foundation Polypeptide
US5916875A (en) 1983-11-22 1999-06-29 La Jolla Cancer Research Foundation Tetrapeptide
US4908236A (en) * 1986-12-04 1990-03-13 Millipore Corporation Transparent porous membrane having hydrophilic surface and process
JPH02504221A (ja) * 1987-04-22 1990-12-06 ベイ　ミカエル 細胞培養法、培養物及び培養製品
EP0394326B1 (de) 1987-12-10 1996-07-31 La Jolla Cancer Research Foundation Verfahren zur herstellung von conformationnell stabilisierten zelladhäsionspeptiden
JPH01309682A (ja) 1988-06-03 1989-12-14 Sanyo Chem Ind Ltd 動物細胞培養用基体
US5278063A (en) 1989-09-28 1994-01-11 Board Of Regents The University Of Texas System Chemical modification of promote animal cell adhesion on surfaces
US5330911A (en) 1989-09-28 1994-07-19 Board Of Regents, The University Of Texas System Surfaces having desirable cell adhesive effects
DE69118826T2 (de) * 1990-11-27 1996-11-14 Fuji Photo Film Co Ltd Propenamidderivate, deren Polymere, Copolymere und deren Verwendung
KR100266912B1 (ko) * 1992-02-28 2000-12-01 파라비 레이 조직접촉물질이며 방출조절운반체인 광중합성 생분해성 하이드로겔
EP0567886A3 (de) * 1992-04-21 1994-11-02 Kurashiki Boseki Kk Beschichtungszusammensetzung zur Züchtung von haftenden Tierzellen und Verfahren zur Züchtung der Zellen in serumfreien Verhältnissen.
ATE188714T1 (de) 1992-09-29 2000-01-15 Toray Industries Hydrophiles material, sowie daraus hergestelltes semipermeables membran
US5523226A (en) * 1993-05-14 1996-06-04 Biotechnology Research And Development Corp. Transgenic swine compositions and methods
JPH078273A (ja) 1993-06-14 1995-01-13 Kurabo Ind Ltd 接着性動物細胞の無血清培養法
US6284503B1 (en) 1993-08-20 2001-09-04 University Of Utah Research Foundation Composition and method for regulating the adhesion of cells and biomolecules to hydrophobic surfaces
US6074614A (en) * 1995-06-07 2000-06-13 Molecular Devices Corporation Multi-assay plate cover for elimination of meniscus
US6121027A (en) 1997-08-15 2000-09-19 Surmodics, Inc. Polybifunctional reagent having a polymeric backbone and photoreactive moieties and bioactive groups
US6316522B1 (en) 1997-08-18 2001-11-13 Scimed Life Systems, Inc. Bioresorbable hydrogel compositions for implantable prostheses
WO1999026732A1 (de) * 1997-11-20 1999-06-03 E.I. Du Pont De Nemours And Company, Inc. Verfahren zur mehrschichtigen lackierung von substraten
US6610836B1 (en) * 1999-01-29 2003-08-26 Genome Therapeutics Corporation Nucleic acid amino acid sequences relating to Klebsiella pneumoniae for diagnostics and therapeutics
JP4907824B2 (ja) * 2000-01-05 2012-04-04 ノバルティス アーゲー ヒドロゲル
AU2001278943A1 (en) 2000-07-17 2002-01-30 University Of Utah Research Foundation Hydrogel films and methods of making and using therefor
JP2002191353A (ja) 2000-10-17 2002-07-09 Sanyo Chem Ind Ltd 細胞培養支持体及びその製造方法
US7575939B2 (en) * 2000-10-30 2009-08-18 Sru Biosystems, Inc. Optical detection of label-free biomolecular interactions using microreplicated plastic sensor elements
JP5057629B2 (ja) 2001-02-06 2012-10-24 マサチューセッツ インスティテュート オブ テクノロジー ペプチド足場での組織細胞のカプセル化およびその使用
AU2002258913A1 (en) 2001-04-23 2002-11-05 Wisconsin Alumni Research Foundation Bifunctional-modified hydrogels
US20050276858A1 (en) * 2001-04-23 2005-12-15 Kao Weiyuan J Bifunctional-modified hydrogels
US6844028B2 (en) 2001-06-26 2005-01-18 Accelr8 Technology Corporation Functional surface coating
US6598586B2 (en) 2001-07-17 2003-07-29 Murray, Inc. Dual arm choke and throttle control
WO2003029418A2 (en) 2001-10-02 2003-04-10 Becton, Dickinson And Company Proliferation and differentiation of stem cells using extracellular matrix and other molecules
WO2003053216A2 (en) * 2001-12-06 2003-07-03 University Of Washington Biodegradable, porous structures useful for growing living tissue, and methods of manufacture
US8298606B2 (en) * 2002-03-08 2012-10-30 The Regents Of The University Of California Methods and compositions for stabilizing the myocardium
JP2005523009A (ja) * 2002-04-19 2005-08-04 パムジーン ベー．ベー． 基板プレート、基板プレートを製造するための方法および装置、および基板プレートを含む、バイオアッセイを実行するためのシステム
ES2449017T3 (es) 2002-06-21 2014-03-17 The University Of Utah Research Foundation Compuestos reticulados, y métodos de preparación y uso de los mismos
US20050019747A1 (en) * 2002-08-07 2005-01-27 Anderson Daniel G. Nanoliter-scale synthesis of arrayed biomaterials and screening thereof
EP1741457A1 (de) * 2002-08-09 2007-01-10 Ottawa Health Research Institute Okularimplantate
US7569222B2 (en) * 2002-11-18 2009-08-04 Woerly Stephane Hydrogel membrane composition and use thereof
WO2004055057A1 (en) 2002-12-18 2004-07-01 The University Of Melbourne Hydrogel preparation and process of manufacture thereof
EP1616939A1 (de) * 2003-03-24 2006-01-18 National Institute for Environmental Studies Zellkulturmedium und verfestigte präparation eines zelladhäsionsproteins oder -peptids
US20040197557A1 (en) * 2003-03-27 2004-10-07 Eshraghi Ray R Process for manufacturing hollow fibers
AR046076A1 (es) * 2003-07-18 2005-11-23 Otsuka Pharma Co Ltd Procedimiento para obtener una poblacion homogenea de celulas precursoras de oligodendrocitos y poblacion obtenida
WO2005014697A1 (en) 2003-08-06 2005-02-17 The Procter & Gamble Company Coated water-swellable material
US7074615B2 (en) * 2003-08-15 2006-07-11 Becton, Dickinson And Company Peptides for enhanced cell attachment and cell growth
WO2005021580A2 (en) 2003-08-28 2005-03-10 Arizona Board Of Regents Hydrogels for modulating cell migration and matrix deposition
EP1675943A4 (de) * 2003-09-15 2007-12-05 Massachusetts Inst Technology Synthese von in einem array angeordneten biomaterialien im nanolitermassstab und screening davon
US20050136536A1 (en) 2003-09-15 2005-06-23 Anderson Daniel G. Embryonic epithelial cells
US20050059150A1 (en) 2003-09-17 2005-03-17 Becton, Dickinson And Company Environments that maintain function of primary liver cells
US7384984B2 (en) * 2003-12-10 2008-06-10 3M Innovative Properties Company Reactive hydrophilic oligomers
JP2007536936A (ja) * 2004-05-14 2007-12-20 ベクトン・ディキンソン・アンド・カンパニー 幹細胞集団および使用方法
WO2005115490A2 (en) * 2004-05-25 2005-12-08 Surmodics, Inc. Natural biodegradable polysaccharide coatings for meical articles
JP2006042794A (ja) 2004-06-28 2006-02-16 Sanyo Chem Ind Ltd 細胞培養用樹脂ビーズ
JP2006174826A (ja) 2004-11-24 2006-07-06 Sanyo Chem Ind Ltd 細胞培養用感温膨潤性樹脂ビーズ
JPWO2006087809A1 (ja) * 2005-02-18 2008-07-03 シーシーアイ株式会社 熱媒体液組成物
US20060228386A1 (en) * 2005-02-22 2006-10-12 University Of Tennessee Research Foundation Polymeric microstructures
WO2006105278A2 (en) 2005-03-29 2006-10-05 The Regents Of The University Of California Controlling stem cell destiny destiny with tunable network
WO2006138718A2 (en) * 2005-06-17 2006-12-28 Drexel University Three-dimensional scaffolds for tissue engineering made by processing complex extracts of natural extracellular matrices
WO2007012050A2 (en) * 2005-07-20 2007-01-25 Surmodics, Inc. Polymer coated nanofibrillar structures and methods for cell maintenance and differentiation
US20090087907A1 (en) 2005-07-29 2009-04-02 Alice Pebay Compositions and Methods for Growth of Pluripotent Cells
US20070029924A1 (en) * 2005-08-03 2007-02-08 Nobuyuki Ushifusa Image display device
EP2004735A4 (de) 2006-03-15 2014-03-12 Univ Sydney Aktivierte polymere, die biologische moleküle binden
US8241908B2 (en) * 2006-05-16 2012-08-14 Becton, Dickinson And Company Extracellular matrix coated surface for culturing cells
JP2010530955A (ja) * 2006-12-29 2010-09-16 ユニヴァーシティ オブ ワシントン 二重機能性非汚染表面および材料
KR101107875B1 (ko) * 2007-02-09 2012-01-25 미츠비시 레이온 가부시키가이샤 투명 성형체 및 이것을 이용한 반사 방지 물품
WO2008118392A2 (en) 2007-03-22 2008-10-02 The Regents Of The University Of California Synthetic cell platforms and methods of use thereof
US8574906B2 (en) 2007-08-09 2013-11-05 Corning Incorporated Cell culture surfaces having hydrogel supported proteins
WO2009032117A2 (en) * 2007-08-31 2009-03-12 Corning Incorporated Reactive surface on a polymeric substrate
US20090110907A1 (en) * 2007-10-29 2009-04-30 Jiang Dayue D Membranes Based On Poly (Vinyl Alcohol-Co-Vinylamine)
US8354274B2 (en) * 2008-01-30 2013-01-15 Geron Corporation Synthetic surfaces for culturing cells in chemically defined media
CN102482385B (zh) * 2009-05-28 2014-10-15 康宁股份有限公司 用来培养细胞的合成微型载体

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