ATE54915T1 - Indolin und 2-indolinon-derivate. - Google Patents

Indolin und 2-indolinon-derivate.

Info

Publication number
ATE54915T1
ATE54915T1 AT85303310T AT85303310T ATE54915T1 AT E54915 T1 ATE54915 T1 AT E54915T1 AT 85303310 T AT85303310 T AT 85303310T AT 85303310 T AT85303310 T AT 85303310T AT E54915 T1 ATE54915 T1 AT E54915T1
Authority
AT
Austria
Prior art keywords
indoline
indolinone derivatives
indolinone
derivatives
Prior art date
Application number
AT85303310T
Other languages
German (de)
English (en)
Inventor
David Wayne Robertson
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of ATE54915T1 publication Critical patent/ATE54915T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
AT85303310T 1984-05-14 1985-05-10 Indolin und 2-indolinon-derivate. ATE54915T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US61021084A 1984-05-14 1984-05-14
EP85303310A EP0161918B1 (en) 1984-05-14 1985-05-10 Indoline and 2-indolinone derivatives

Publications (1)

Publication Number Publication Date
ATE54915T1 true ATE54915T1 (de) 1990-08-15

Family

ID=24444125

Family Applications (1)

Application Number Title Priority Date Filing Date
AT85303310T ATE54915T1 (de) 1984-05-14 1985-05-10 Indolin und 2-indolinon-derivate.

Country Status (20)

Country Link
EP (1) EP0161918B1 (en:Method)
JP (1) JPH0643417B2 (en:Method)
KR (1) KR870000274B1 (en:Method)
AR (1) AR241531A1 (en:Method)
AT (1) ATE54915T1 (en:Method)
AU (1) AU577372B2 (en:Method)
CA (1) CA1248099A (en:Method)
DE (1) DE3578822D1 (en:Method)
DK (1) DK207785A (en:Method)
EG (1) EG17342A (en:Method)
ES (1) ES8609308A1 (en:Method)
GR (1) GR851121B (en:Method)
HU (1) HU194873B (en:Method)
IL (1) IL75122A (en:Method)
MY (1) MY101520A (en:Method)
NZ (1) NZ212023A (en:Method)
PH (1) PH21862A (en:Method)
PT (1) PT80414B (en:Method)
SU (1) SU1486060A3 (en:Method)
ZA (1) ZA853440B (en:Method)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4591591A (en) * 1984-03-08 1986-05-27 Eli Lilly And Company Pyridazinone derivatives as inotropic agents
DE3631085A1 (de) * 1986-09-12 1988-03-24 Boehringer Mannheim Gmbh Heterocyclisch substituierte indolinone, verfahren zu ihrer herstellung, arzneimittel sowie zwischenprodukte
DE3706427A1 (de) * 1987-02-27 1988-09-08 Boehringer Mannheim Gmbh Neue substituierte 3h-indole, zwischenprodukte, verfahren zu ihrer herstellung sowie arzneimittel
ES2037230T3 (es) * 1987-08-28 1993-06-16 Eli Lilly And Company Composiciones activadoras de la penetracion.
US5196416A (en) * 1987-08-28 1993-03-23 Eli Lilly And Company Transdermal flux-enhancing pharmaceutical compositions comprising azone, ethanol and water
DE68917485T2 (de) * 1988-01-23 1995-02-09 Kyowa Hakko Kogyo Kk Pyridazinon-Derivate und diese enthaltende pharmazeutische Zubereitungen.
GB8816944D0 (en) * 1988-07-15 1988-08-17 Sobio Lab Compounds
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
ES2559319T3 (es) 2007-06-04 2016-02-11 Synergy Pharmaceuticals Inc. Agonistas de guanilato cliclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
WO2009149279A2 (en) 2008-06-04 2009-12-10 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
EP2321341B1 (en) 2008-07-16 2017-02-22 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CA2828346C (en) 2011-03-01 2021-01-26 Synergy Pharmaceuticals Inc. Process of preparing guanylate cyclase c agonists
CA2902348C (en) 2013-02-25 2021-11-30 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
WO2014151206A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
HK1220611A1 (zh) 2013-03-15 2017-05-12 Bausch Health Ireland Limited 用於治疗胃肠道病症的组成物
SI3004138T1 (sl) 2013-06-05 2024-07-31 Bausch Health Ireland Limited Ultra čisti agonisti gvanilat ciklaze C, postopek za njihovo pripravo in uporabo
CN114404588A (zh) 2013-08-09 2022-04-29 阿德利克斯公司 用于抑制磷酸盐转运的化合物和方法
US20200368223A1 (en) 2019-05-21 2020-11-26 Ardelyx, Inc. Methods for inhibiting phosphate transport
US20240308973A1 (en) * 2023-03-10 2024-09-19 Zoetis Services Llc Phosphodiesterase 3 (pde3) inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES8101067A1 (es) * 1978-08-25 1980-12-01 Thomae Gmbh Dr K Procedimiento para la preparacion de nuevos bencimidazoles sustituidos en posicion 5 o 6 con un anillo de piridazinona
US4258185A (en) * 1978-10-17 1981-03-24 Yoshitomi Pharmaceutical Industries, Ltd. Pyridazinone compounds
DE3124699A1 (de) * 1981-06-24 1983-01-13 Basf Ag, 6700 Ludwigshafen Neue 2-aryl-3,4-diaza-bicyclo(4.n.0.)alken-(2)-one-(5),verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
JPS588016A (ja) * 1981-07-06 1983-01-18 Mitsubishi Chem Ind Ltd 強心剤

Also Published As

Publication number Publication date
IL75122A0 (en) 1985-09-29
CA1248099A (en) 1989-01-03
DK207785A (da) 1985-11-15
HU194873B (en) 1988-03-28
AU4240585A (en) 1985-11-21
PT80414B (en) 1987-04-16
HUT37783A (en) 1986-02-28
NZ212023A (en) 1988-04-29
JPH0643417B2 (ja) 1994-06-08
ES543078A0 (es) 1986-09-01
JPS6122080A (ja) 1986-01-30
ZA853440B (en) 1986-12-30
KR850008166A (ko) 1985-12-13
GR851121B (en:Method) 1985-11-25
PT80414A (en) 1985-06-01
EG17342A (en) 1991-03-30
PH21862A (en) 1988-03-25
DE3578822D1 (de) 1990-08-30
EP0161918A2 (en) 1985-11-21
EP0161918A3 (en) 1986-11-20
MY101520A (en) 1991-11-30
DK207785D0 (da) 1985-05-10
SU1486060A3 (ru) 1989-06-07
AU577372B2 (en) 1988-09-22
ES8609308A1 (es) 1986-09-01
IL75122A (en) 1989-02-28
KR870000274B1 (ko) 1987-02-23
EP0161918B1 (en) 1990-07-25
AR241531A1 (es) 1992-08-31

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee