ATE546522T1 - Artikel mit darauf angeordeten lokalisierten molekülen und herstellungsverfahren dafür - Google Patents

Artikel mit darauf angeordeten lokalisierten molekülen und herstellungsverfahren dafür

Info

Publication number
ATE546522T1
ATE546522T1 AT07754529T AT07754529T ATE546522T1 AT E546522 T1 ATE546522 T1 AT E546522T1 AT 07754529 T AT07754529 T AT 07754529T AT 07754529 T AT07754529 T AT 07754529T AT E546522 T1 ATE546522 T1 AT E546522T1
Authority
AT
Austria
Prior art keywords
regions
articles
production processes
substrate
molecules located
Prior art date
Application number
AT07754529T
Other languages
English (en)
Inventor
David Rank
Jeffery Wegener
Jonas Korlach
Daniel Roitman
Yue Xu
John Lyle
Stephen Turner
Paul Peluso
Geoff Otto
Ronald Cicero
Original Assignee
Pacific Biosciences California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pacific Biosciences California filed Critical Pacific Biosciences California
Application granted granted Critical
Publication of ATE546522T1 publication Critical patent/ATE546522T1/de

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y20/00—Nanooptics, e.g. quantum optics or photonic crystals
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00427—Means for dispensing and evacuation of reagents using masks
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00436—Maskless processes
    • B01J2219/0045—Maskless processes using optical fibres
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/0061—The surface being organic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00612—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports the surface being inorganic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00614—Delimitation of the attachment areas
    • B01J2219/00617—Delimitation of the attachment areas by chemical means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00623—Immobilisation or binding
    • B01J2219/00626—Covalent
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00632—Introduction of reactive groups to the surface
    • B01J2219/00635—Introduction of reactive groups to the surface by reactive plasma treatment
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00632—Introduction of reactive groups to the surface
    • B01J2219/00637—Introduction of reactive groups to the surface by coating it with another layer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00639—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00709—Type of synthesis
    • B01J2219/00711—Light-directed synthesis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00722—Nucleotides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T29/00—Metal working
    • Y10T29/49—Method of mechanical manufacture
    • Y10T29/49002—Electrical device making

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nanotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Optics & Photonics (AREA)
  • Composite Materials (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • General Physics & Mathematics (AREA)
  • Materials Engineering (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Weting (AREA)
  • Dispersion Chemistry (AREA)
  • Optical Integrated Circuits (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT07754529T 2006-03-30 2007-03-29 Artikel mit darauf angeordeten lokalisierten molekülen und herstellungsverfahren dafür ATE546522T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/394,352 US8975216B2 (en) 2006-03-30 2006-03-30 Articles having localized molecules disposed thereon and methods of producing same
PCT/US2007/008019 WO2007123763A2 (en) 2006-03-30 2007-03-29 Articles having localized molecules disposed thereon and methods of producing same

Publications (1)

Publication Number Publication Date
ATE546522T1 true ATE546522T1 (de) 2012-03-15

Family

ID=38576111

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07754529T ATE546522T1 (de) 2006-03-30 2007-03-29 Artikel mit darauf angeordeten lokalisierten molekülen und herstellungsverfahren dafür

Country Status (10)

Country Link
US (8) US8975216B2 (de)
EP (1) EP2002019B1 (de)
JP (1) JP2009532032A (de)
CN (2) CN102212515B (de)
AT (1) ATE546522T1 (de)
AU (1) AU2007241049B2 (de)
CA (1) CA2645758C (de)
DK (1) DK2002019T3 (de)
ES (1) ES2385015T3 (de)
WO (1) WO2007123763A2 (de)

Families Citing this family (192)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060160916A1 (en) * 2004-08-13 2006-07-20 Dyer Daniel J Process for modifying substrates with grafted polymers
US8535616B2 (en) * 2005-08-02 2013-09-17 Moxtek, Inc. Sub-wavelength metallic apertures as light enhancement devices
US7763423B2 (en) * 2005-09-30 2010-07-27 Pacific Biosciences Of California, Inc. Substrates having low density reactive groups for monitoring enzyme activity
US9528939B2 (en) 2006-03-10 2016-12-27 Indx Lifecare, Inc. Waveguide-based optical scanning systems
US9423397B2 (en) 2006-03-10 2016-08-23 Indx Lifecare, Inc. Waveguide-based detection system with scanning light source
US9976192B2 (en) 2006-03-10 2018-05-22 Ldip, Llc Waveguide-based detection system with scanning light source
US8975216B2 (en) 2006-03-30 2015-03-10 Pacific Biosciences Of California Articles having localized molecules disposed thereon and methods of producing same
US8088580B2 (en) * 2006-06-07 2012-01-03 Sumitomo Bakelite Company, Ltd. RNA detection method
JP2010510247A (ja) * 2006-11-21 2010-04-02 アプライド バイオシステムズ インコーポレイテッド 酸化物層上に不動態化表面を形成するための中間体および方法およびこれにより製造される製品
US10434492B2 (en) * 2007-01-26 2019-10-08 Sigma-Aldrich Co. Llc Compositions and methods for solid phase extraction of lipids
US10928366B2 (en) * 2007-01-26 2021-02-23 Sigma-Aldrich Co. Llc Compositions and methods for combining protein precipitation and solid phase extraction
US20080220537A1 (en) * 2007-03-07 2008-09-11 Pacific Biosciences Of California, Inc. Substrates and methods for selective immobilization of active molecules
US20080234143A1 (en) * 2007-03-23 2008-09-25 Pacific Biosciences Of California, Inc. Mechanical methods for producing substrates having selectively immobilized molecules
WO2008121375A2 (en) * 2007-03-29 2008-10-09 Pacific Biosciences Of California, Inc. Modified surfaces for immobilization of active molecules
EP2255014A4 (de) 2008-02-12 2011-05-18 Pacific Biosciences California Zusammensetzungen und verfahren zur verwendung bei analysereaktionen
US8652781B2 (en) 2008-02-12 2014-02-18 Pacific Biosciences Of California, Inc. Cognate sampling kinetics
US8530164B2 (en) 2008-09-05 2013-09-10 Pacific Biosciences Of California, Inc. Method for sequencing using branching fraction of incorporatable nucleotides
CA2991818C (en) 2008-03-28 2022-10-11 Pacific Biosciences Of California, Inc. Compositions and methods for nucleic acid sequencing
US8420366B2 (en) 2008-03-31 2013-04-16 Pacific Biosciences Of California, Inc. Generation of modified polymerases for improved accuracy in single molecule sequencing
EP2274446B1 (de) 2008-03-31 2015-09-09 Pacific Biosciences of California, Inc. Systeme und verfahren für polymeraseenzymreaktionen in zwei langsamen schritten
US8999676B2 (en) 2008-03-31 2015-04-07 Pacific Biosciences Of California, Inc. Recombinant polymerases for improved single molecule sequencing
WO2009145820A2 (en) 2008-03-31 2009-12-03 Pacific Biosciences Of California, Inc. Generation of modified polymerases for improved accuracy in single molecule sequencing
US9637380B2 (en) 2008-03-31 2017-05-02 Pacific Biosciences Of California, Inc. Nanoscale apertures having islands of functionality
EP2286217B1 (de) * 2008-03-31 2015-02-18 Pacific Biosciences of California, Inc. Verfahren und zusammensetzung zur ladung von einzelmolekülen
EP2279268A4 (de) * 2008-04-04 2011-12-07 Life Technologies Corp Scanning-system und verfahren zur bildgebung und sequenzierung
US9518288B2 (en) 2008-04-11 2016-12-13 University Of Utah Research Foundation Methods and compositions related to quantitative, array based methylation analysis
US20110250402A1 (en) * 2008-06-02 2011-10-13 Applied Biosystems, Llc Localization of near-field resonances in bowtie antennae: influence of adhesion layers
JP4997181B2 (ja) * 2008-06-13 2012-08-08 株式会社日立ハイテクノロジーズ 核酸分析デバイス及び核酸分析装置
GB2461026B (en) 2008-06-16 2011-03-09 Plc Diagnostics Inc System and method for nucleic acids sequencing by phased synthesis
US8173198B2 (en) * 2008-07-23 2012-05-08 Life Technologies Corporation Deposition of metal oxides onto surfaces as an immobilization vehicle for carboxylated or phophated particles or polymers
AU2009292629B2 (en) 2008-09-16 2014-03-20 Pacific Biosciences Of California, Inc. Substrates and optical systems and methods of use thereof
DK2398915T3 (en) * 2009-02-20 2016-12-12 Synthetic Genomics Inc Synthesis of nucleic acids sequence verified
US9778188B2 (en) 2009-03-11 2017-10-03 Industrial Technology Research Institute Apparatus and method for detection and discrimination molecular object
JP5618497B2 (ja) * 2009-05-15 2014-11-05 株式会社日立ハイテクノロジーズ 核酸分析方法及び核酸分析装置
US8501406B1 (en) 2009-07-14 2013-08-06 Pacific Biosciences Of California, Inc. Selectively functionalized arrays
WO2011031313A2 (en) * 2009-09-11 2011-03-17 Pacific Biosciences Of California, Inc. Zero-mode waveguides with non-reflecting walls
US8367159B2 (en) * 2009-09-11 2013-02-05 Pacific Biosciences Of California, Inc. Methods for producing ZMWs with islands of functionality
ES2544635T3 (es) 2010-03-01 2015-09-02 Quanterix Corporation Métodos para extender el rango dinámico en ensayos para la detección de moléculas o partículas
US9482615B2 (en) 2010-03-15 2016-11-01 Industrial Technology Research Institute Single-molecule detection system and methods
PT2556171E (pt) 2010-04-05 2015-12-21 Prognosys Biosciences Inc Ensaios biológicos codificados espacialmente
US10787701B2 (en) 2010-04-05 2020-09-29 Prognosys Biosciences, Inc. Spatially encoded biological assays
US20190300945A1 (en) 2010-04-05 2019-10-03 Prognosys Biosciences, Inc. Spatially Encoded Biological Assays
US9276226B2 (en) * 2010-05-19 2016-03-01 Northwestern University Organic-inorganic hybrid multilayer gate dielectrics for thin-film transistors
US9670243B2 (en) 2010-06-02 2017-06-06 Industrial Technology Research Institute Compositions and methods for sequencing nucleic acids
US8865077B2 (en) 2010-06-11 2014-10-21 Industrial Technology Research Institute Apparatus for single-molecule detection
US8865078B2 (en) * 2010-06-11 2014-10-21 Industrial Technology Research Institute Apparatus for single-molecule detection
US8986930B2 (en) 2010-07-12 2015-03-24 Pacific Biosciences Of California, Inc. Sequencing reactions with alkali metal cations for pulse width control
US8936911B2 (en) 2010-09-22 2015-01-20 Pacific Biosciences Of California, Inc. Purified extended polymerase/template complex for sequencing
DK2625502T3 (en) 2010-10-06 2018-12-17 Biocare Medical Llc Method and system for efficient processing of biological samples
KR101789586B1 (ko) 2010-12-06 2017-10-26 삼성디스플레이 주식회사 광 산란 기판, 이의 제조 방법, 이를 포함하는 유기 발광 표시 장치 및 유기 발광 표시 장치의 제조 방법
WO2012092265A1 (en) 2010-12-27 2012-07-05 Ibis Biosciences, Inc. Nucleic acid sample preparation methods and compositions
US9952237B2 (en) 2011-01-28 2018-04-24 Quanterix Corporation Systems, devices, and methods for ultra-sensitive detection of molecules or particles
US9945763B1 (en) 2011-02-18 2018-04-17 Biocare Medical, Llc Methods and systems for immunohistochemistry heat retrieval of biological samples
EP2689028B1 (de) 2011-03-23 2017-08-30 Pacific Biosciences Of California, Inc. Isolierung von polymerase-nukleinsäurekomplexen und deren ladung auf substrate
EP2694709B1 (de) 2011-04-08 2016-09-14 Prognosys Biosciences, Inc. Peptidkonstrukte und testsysteme dafür
GB201106254D0 (en) 2011-04-13 2011-05-25 Frisen Jonas Method and product
WO2013022778A1 (en) 2011-08-05 2013-02-14 Ibis Biosciences, Inc. Nucleic acid sequencing by electrochemical detection
EP2766498B1 (de) 2011-10-14 2019-06-19 President and Fellows of Harvard College Sequenzierung durch strukturanordnung
US9347900B2 (en) 2011-10-14 2016-05-24 Pacific Biosciences Of California, Inc. Real-time redox sequencing
US9759842B2 (en) 2011-11-01 2017-09-12 The Trustees Of Columbia University In The City Of New York Functionalized surfaces and methods related thereto
US20130294972A1 (en) * 2011-11-01 2013-11-07 The Trustees Of Columbia Univeristy In The City Of New York Zero-mode waveguide for single biomolecule fluorescence imaging
US9267917B2 (en) 2011-11-04 2016-02-23 Pacific Biosciences Of California, Inc. Nanopores in zero mode waveguides
US11021737B2 (en) 2011-12-22 2021-06-01 President And Fellows Of Harvard College Compositions and methods for analyte detection
CA2859761C (en) 2011-12-22 2023-06-20 President And Fellows Of Harvard College Compositions and methods for analyte detection
WO2013102081A2 (en) 2011-12-29 2013-07-04 Ibis Biosciences, Inc. Macromolecule delivery to nanowells
US9855559B2 (en) 2011-12-30 2018-01-02 Abbott Molecular Inc. Microorganism nucleic acid purification from host samples
CN104334739A (zh) 2012-01-13 2015-02-04 Data生物有限公司 通过新一代测序进行基因分型
US8906660B2 (en) 2012-02-01 2014-12-09 Pacific Biosciences Of California, Inc. Recombinant polymerases with increased phototolerance
WO2013123258A1 (en) 2012-02-15 2013-08-22 Pacific Biosciences Of California, Inc. Polymerase enzyme substrates with protein shield
WO2013166303A1 (en) 2012-05-02 2013-11-07 Ibis Biosciences, Inc. Dna sequencing
ES2683978T3 (es) 2012-05-02 2018-10-01 Ibis Biosciences, Inc. Secuenciación de ADN
EP3783111A1 (de) 2012-05-02 2021-02-24 Ibis Biosciences, Inc. Dna-sequenzierung
WO2013184754A2 (en) 2012-06-05 2013-12-12 President And Fellows Of Harvard College Spatial sequencing of nucleic acids using dna origami probes
US8956816B2 (en) 2012-06-05 2015-02-17 Pacific Biosciences Of California, Inc. Methods and compositions for performing analytical operations
US9116118B2 (en) 2012-06-08 2015-08-25 Pacific Biosciences Of California, Inc. Modified base detection with nanopore sequencing
US9372308B1 (en) 2012-06-17 2016-06-21 Pacific Biosciences Of California, Inc. Arrays of integrated analytical devices and methods for production
ES2730737T3 (es) 2012-09-17 2019-11-12 Grace W R & Co Material de soporte de partículas funcionalizado y métodos de fabricación y uso del mismo
AU2013330344B2 (en) 2012-09-17 2018-07-05 W. R. Grace & Co.-Conn. Chromatography media and devices
US9399766B2 (en) 2012-10-01 2016-07-26 Pacific Biosciences Of California, Inc. Recombinant polymerases for incorporation of protein shield nucleotide analogs
JP6510978B2 (ja) 2012-10-16 2019-05-08 アボツト・モレキユラー・インコーポレイテツド 核酸を配列決定する方法および装置
USRE50065E1 (en) 2012-10-17 2024-07-30 10X Genomics Sweden Ab Methods and product for optimising localised or spatial detection of gene expression in a tissue sample
EP2971184B1 (de) 2013-03-12 2019-04-17 President and Fellows of Harvard College Verfahren zur erzeugung einer dreidimensionalen nukleinsäure mit matrix
CN111187811B (zh) 2013-05-06 2024-03-08 加利福尼亚太平洋生物科学股份有限公司 实时电子测序
EP3603679B1 (de) 2013-06-04 2022-08-10 President and Fellows of Harvard College Rna-geführte transkriptionsregulation
EP3008094B1 (de) 2013-06-14 2018-12-26 Pacific Biosciences Of California, Inc. Bis-biotinylierungsetiketten
US10544449B2 (en) 2013-06-14 2020-01-28 Pacific Biosciences Of California, Inc. Bis-biotinylation tags
DK3013984T3 (da) 2013-06-25 2023-06-06 Prognosys Biosciences Inc Metode til bestemmelse af spatiale mønstre i biologiske targets i en prøve
WO2015026853A2 (en) 2013-08-19 2015-02-26 Abbott Molecular Inc. Next-generation sequencing libraries
WO2015042708A1 (en) 2013-09-25 2015-04-02 Bio-Id Diagnostic Inc. Methods for detecting nucleic acid fragments
KR102240166B1 (ko) 2013-11-17 2021-04-14 퀀텀-에스아이 인코포레이티드 분자들을 프로빙 검출 및 분석하기 위한 외부 광원을 구비한 통합 디바이스
US10768181B2 (en) 2013-12-17 2020-09-08 The Brigham And Women's Hospital, Inc. Detection of an antibody against a pathogen
ES2887110T3 (es) 2014-01-16 2021-12-21 Grace W R & Co Medios para cromatografía de afinidad y dispositivos para cromatografía
US10018566B2 (en) 2014-02-28 2018-07-10 Ldip, Llc Partially encapsulated waveguide based sensing chips, systems and methods of use
US9646854B2 (en) * 2014-03-28 2017-05-09 Intel Corporation Embedded circuit patterning feature selective electroless copper plating
JP6914189B2 (ja) 2014-05-02 2021-08-04 ダブリュー・アール・グレース・アンド・カンパニー−コーンＷ Ｒ Ｇｒａｃｅ ＆ Ｃｏ−Ｃｏｎｎ 官能化担体材料並びに官能化担体材料を作製及び使用する方法
CN114214314A (zh) 2014-06-24 2022-03-22 生物辐射实验室股份有限公司 数字式pcr条码化
WO2015200833A2 (en) 2014-06-27 2015-12-30 Abbott Laboratories COMPOSITIONS AND METHODS FOR DETECTING HUMAN PEGIVIRUS 2 (HPgV-2)
JP6794350B2 (ja) 2014-07-02 2020-12-02 ライフ テクノロジーズ コーポレーション 半導体センサの表面処理
CN112903638A (zh) 2014-08-08 2021-06-04 宽腾矽公司 用于对分子进行探测、检测和分析的带外部光源的集成装置
US9921157B2 (en) 2014-08-08 2018-03-20 Quantum-Si Incorporated Optical system and assay chip for probing, detecting and analyzing molecules
MX2021007934A (es) 2014-08-08 2023-01-17 Quantum Si Inc Dispositivo integrado para el depósito temporal de fotones recibidos.
EP3633047B1 (de) 2014-08-19 2022-12-28 Pacific Biosciences of California, Inc. Verfahren zur sequenzierung von nukleinsäuren basierend auf einer anreicherung von nukleinsäuren
CN107003241B (zh) 2014-08-27 2022-01-11 加利福尼亚太平洋生物科学股份有限公司 集成分析器件阵列
US10550428B2 (en) 2014-09-17 2020-02-04 Ibis Biosciences, Inc. Sequencing by synthesis using pulse read optics
US10302972B2 (en) 2015-01-23 2019-05-28 Pacific Biosciences Of California, Inc. Waveguide transmission
WO2016138427A1 (en) 2015-02-27 2016-09-01 Indx Lifecare, Inc. Waveguide-based detection system with scanning light source
WO2016149397A1 (en) 2015-03-16 2016-09-22 Pacific Biosciences Of California, Inc. Integrated devices and systems for free-space optical coupling
EP3274473B1 (de) 2015-03-24 2020-10-28 Pacific Biosciences of California, Inc. Verfahren und zusammensetzungen zum laden einer einzelmolekülzusammensetzung
FI3901281T3 (fi) 2015-04-10 2023-01-31 Biologisten näytteiden spatiaalisesti eroteltu moninkertainen nukleiinihappoanalyysi
EP3292220B1 (de) 2015-05-07 2022-07-13 Pacific Biosciences of California, Inc. Multiprozessor-pipeline-architektur
US11466316B2 (en) 2015-05-20 2022-10-11 Quantum-Si Incorporated Pulsed laser and bioanalytic system
US10605730B2 (en) 2015-05-20 2020-03-31 Quantum-Si Incorporated Optical sources for fluorescent lifetime analysis
EP3302784B1 (de) 2015-06-05 2021-10-06 W.R. Grace & Co.-Conn. Adsorbierende klärmittel für bioprozesstechnik und verfahren zur herstellung und verwendung davon
EP3308204A4 (de) 2015-06-12 2019-03-13 Pacific Biosciences of California, Inc. Wellenleitervorrichtungen mit integriertem ziel und systeme zur optischen kopplung
EP3332032B1 (de) 2015-08-06 2023-12-27 Pacific Biosciences Of California, Inc. Integrierte schaltungen zur selektiven adressierung spärlich angeordneter, elektronischer messvorrichtungen
US10280411B2 (en) 2015-10-27 2019-05-07 Pacific Biosciences of California, In.c Methods, systems, and reagents for direct RNA sequencing
TWI794145B (zh) 2015-10-28 2023-03-01 美商加州太平洋生物科學公司 包含整合性帶通濾波器之光學裝置陣列
WO2017079406A1 (en) 2015-11-03 2017-05-11 President And Fellows Of Harvard College Method and apparatus for volumetric imaging of a three-dimensional nucleic acid containing matrix
WO2017087662A1 (en) 2015-11-17 2017-05-26 Pacific Biosciences Of California, Inc. Packaging methods for fabrication of analytical device packages and analytical device packages made thereof
EP3377656A4 (de) * 2015-11-18 2019-03-27 Pacific Biosciences of California, Inc. Laden von nukleinsäuren auf substrate
WO2017087696A1 (en) 2015-11-18 2017-05-26 Pacific Biosciences Of California, Inc. Methods and compositions for loading of polymerase complexes
US10730030B2 (en) 2016-01-08 2020-08-04 Bio-Rad Laboratories, Inc. Multiple beads per droplet resolution
JP6975466B2 (ja) * 2016-02-02 2021-12-01 学校法人沖縄科学技術大学院大学学園 アミノシランを用いるマイクロ及びナノコンタクトプリンティング：多重バイオアッセイのためのマイクロ流体デバイスのパターニング表面
US10441174B2 (en) 2016-02-17 2019-10-15 Tesseract Health, Inc. Sensor and device for lifetime imaging and detection applications
CN116200465A (zh) 2016-04-25 2023-06-02 哈佛学院董事及会员团体 用于原位分子检测的杂交链反应方法
US11226290B2 (en) 2016-06-01 2022-01-18 Quantum-Si Incorporated Photonic structures and integrated device for detecting and analyzing molecules
US10544457B2 (en) 2016-06-14 2020-01-28 Pacific Biosciences Of California, Inc. Methods and compositions for enriching compositions for polymerase enzyme complexes
US10711300B2 (en) 2016-07-22 2020-07-14 Pacific Biosciences Of California, Inc. Methods and compositions for delivery of molecules and complexes to reaction sites
US11543417B2 (en) 2016-08-29 2023-01-03 Oslo Universitetssykehus Hf ChIP-seq assays
EP4428536A2 (de) 2016-08-31 2024-09-11 President and Fellows of Harvard College Verfahren zur kombination des nachweises von biomolekülen in einem einzigen test mit fluoreszenter in-situ-sequenzierung
JP7239465B2 (ja) 2016-08-31 2023-03-14 プレジデント アンド フェローズ オブ ハーバード カレッジ 蛍光ｉｎ ｓｉｔｕ配列決定による検出のための核酸配列ライブラリの作製法
US11667951B2 (en) 2016-10-24 2023-06-06 Geneinfosec, Inc. Concealing information present within nucleic acids
BR112019012069A2 (pt) 2016-12-16 2019-11-12 Quantum-Si Incorporated conjunto de modelagem e direcionamento de feixe compacto
CA3047133A1 (en) 2016-12-16 2018-06-21 Quantum-Si Incorporated Compact mode-locked laser module
BR112019012414A2 (pt) 2016-12-19 2020-02-27 Quantum-Si Incorporated Carregamento de moléculas em poços de amostra para análise
CN110139932B (zh) 2016-12-19 2024-05-17 生物辐射实验室股份有限公司 液滴加标的相邻性保留的标签化dna
TWI836905B (zh) 2016-12-22 2024-03-21 美商寬騰矽公司 具有直接合併像素之整合式光電偵測器
EP3448396A4 (de) 2017-04-14 2020-01-22 President and Fellows of Harvard College Verfahren zur erzeugung eines mikrofilamentnetzwerks aus zellen
WO2018204810A1 (en) * 2017-05-05 2018-11-08 Quantum-Si Incorporated Substrates having modified surface reactivity and antifouling properties in biological reactions
EP3642363A1 (de) 2017-06-20 2020-04-29 Bio-Rad Laboratories, Inc. Mda mit bead-oligonukleotid
CA3069139A1 (en) * 2017-07-07 2019-01-10 Aviana Molecular Technologies, Llc Bioactive coating for surface acoustic wave sensor
WO2019023146A1 (en) * 2017-07-24 2019-01-31 Quantum-Si Incorporated PHOTONIC STRUCTURES WITH OPTICAL RELEASE
JP7391828B2 (ja) 2017-07-24 2023-12-05 クアンタム－エスアイ インコーポレイテッド 携帯型大規模並列バイオ光電子機器
US11162138B2 (en) 2017-10-30 2021-11-02 Pacific Biosciences Of California, Inc. Multi-amplitude modular labeled compounds
WO2019089959A1 (en) 2017-11-02 2019-05-09 Bio-Rad Laboratories, Inc. Transposase-based genomic analysis
EP3729090A4 (de) 2017-12-22 2021-09-22 Pacific Biosciences Of California, Inc. Modifizierte biotin-bindende proteine zur immobilisierung
MX2020007284A (es) 2018-01-08 2020-09-10 Quantum Si Inc Sistema y metodos para la carga electrocinetica de camaras de reaccion a escala submicrometrica.
BR112020014542A2 (pt) 2018-01-26 2020-12-08 Quantum-Si Incorporated Aprendizado de máquina habilitado por aplicação de pulso e de base para dispositivos de sequenciamento
WO2019152395A1 (en) 2018-01-31 2019-08-08 Bio-Rad Laboratories, Inc. Methods and compositions for deconvoluting partition barcodes
EP3598133B1 (de) 2018-04-06 2021-02-17 Northeastern University System und verfahren zur identifizierung und quantifizierung von spezies mit nanoporen unter verwendung von komplexen von nanopartikeln mit trägerpartikeln
US11512002B2 (en) 2018-04-18 2022-11-29 University Of Virginia Patent Foundation Silica materials and methods of making thereof
CA3098712A1 (en) 2018-05-03 2019-11-07 Quantum-Si Incorporated Characterizing an optical element
BR112020022270A2 (pt) 2018-05-14 2021-02-23 Quantum-Si Incorporated sistemas e métodos para unificar modelos estatísticos para diferentes modalidades de dados
US11971963B2 (en) 2018-05-30 2024-04-30 Quantum-Si Incorporated Methods and apparatus for multi-modal prediction using a trained statistical model
US11967436B2 (en) 2018-05-30 2024-04-23 Quantum-Si Incorporated Methods and apparatus for making biological predictions using a trained multi-modal statistical model
US11180796B2 (en) 2018-06-13 2021-11-23 International Business Machines Corporation Detection of mutations regarding one or more deoxyribonucleic acid sequences using deterministic lateral displacement arrays
US11149298B2 (en) 2018-06-13 2021-10-19 International Business Machines Corporation Detection of nucleic acid sequences using deterministic lateral displacement arrays
CN117358173A (zh) * 2018-06-14 2024-01-09 康宁股份有限公司 用于生物分子分析的图案化的流动池
CN112424587A (zh) 2018-06-15 2021-02-26 宽腾矽公司 用于具有脉冲光源的先进分析仪器的数据采集控制
KR20210022688A (ko) 2018-06-22 2021-03-03 퀀텀-에스아이 인코포레이티드 가변 검출 시간의 전하 저장 빈을 갖는 집적 광검출기
US11332787B2 (en) 2018-06-29 2022-05-17 Pacific Biosciences Of California, Inc. Methods and compositions for delivery of molecules and complexes to reaction sites
SG11202101934SA (en) 2018-07-30 2021-03-30 Readcoor Llc Methods and systems for sample processing or analysis
CN118406747A (zh) 2018-08-20 2024-07-30 生物辐射实验室股份有限公司 通过分区中条码珠共定位生成核苷酸序列
JP7428701B2 (ja) 2018-08-29 2024-02-06 クアンタム－エスアイ インコーポレイテッド サンプルウェル作製技法および集積センサデバイス用の構造
WO2020076976A1 (en) 2018-10-10 2020-04-16 Readcoor, Inc. Three-dimensional spatial molecular indexing
WO2020142643A1 (en) 2019-01-03 2020-07-09 Quantum-Si Incorporated Optical waveguides and couplers for delivering light to an array of photonic elements
US11649485B2 (en) 2019-01-06 2023-05-16 10X Genomics, Inc. Generating capture probes for spatial analysis
US11926867B2 (en) 2019-01-06 2024-03-12 10X Genomics, Inc. Generating capture probes for spatial analysis
AU2020294144A1 (en) 2019-06-14 2022-01-27 Quantum-Si Incorporated Sliced grating coupler with increased beam alignment sensitivity
KR20220024702A (ko) 2019-06-19 2022-03-03 퀀텀-에스아이 인코포레이티드 통합 디바이스를 위한 광학 나노구조 제거기 및 관련 방법들
CN114729886A (zh) 2019-06-28 2022-07-08 宽腾矽公司 光学和电学第二路径排斥
KR20220042449A (ko) 2019-08-08 2022-04-05 퀀텀-에스아이 인코포레이티드 집적 광학 디바이스들에서의 증가된 방출 수집 효율
US20220334097A1 (en) * 2019-09-26 2022-10-20 Northeastern University System for Sensing a Molecule
JP2022551523A (ja) 2019-10-11 2022-12-09 クアンタム－エスアイ インコーポレイテッド 気相における表面修飾
US11703476B2 (en) 2019-10-28 2023-07-18 Northeastern University Method and apparatus for sensing a molecule
CN111123429B (zh) * 2019-12-24 2022-03-08 中国科学院苏州生物医学工程技术研究所 涂覆有锚定物质的零模波导孔的制备方法及波导孔结构
CN111123428B (zh) * 2019-12-24 2022-03-08 中国科学院苏州生物医学工程技术研究所 一种零模波导孔孔壁的修饰方法及零模波导孔结构
CN111090144B (zh) * 2019-12-31 2022-03-08 中国科学院苏州生物医学工程技术研究所 具有功能化的零模波导孔的制备方法及波导孔结构
WO2021146473A1 (en) 2020-01-14 2021-07-22 Quantum-Si Incorporated Integrated sensor for lifetime characterization
AU2021208557A1 (en) 2020-01-14 2022-09-01 Quantum-Si Incorporated Sensor for lifetime plus spectral characterization
US11821035B1 (en) 2020-01-29 2023-11-21 10X Genomics, Inc. Compositions and methods of making gene expression libraries
WO2021152586A1 (en) 2020-01-30 2021-08-05 Yeda Research And Development Co. Ltd. Methods of analyzing microbiome, immunoglobulin profile and physiological state
US12076701B2 (en) 2020-01-31 2024-09-03 10X Genomics, Inc. Capturing oligonucleotides in spatial transcriptomics
US12110541B2 (en) 2020-02-03 2024-10-08 10X Genomics, Inc. Methods for preparing high-resolution spatial arrays
EP4111178A1 (de) 2020-03-02 2023-01-04 Quantum-si Incorporated Integrierter sensor zur mehrdimensionalen signalanalyse
US20210318238A1 (en) 2020-04-08 2021-10-14 Quantum-Si Incorporated Integrated sensor with reduced skew
WO2021214766A1 (en) 2020-04-21 2021-10-28 Yeda Research And Development Co. Ltd. Methods of diagnosing viral infections and vaccines thereto
JP7497457B2 (ja) * 2020-04-23 2024-06-10 ビージーアイ シェンチェン シーケンシングチップ及びその製造方法
US12031177B1 (en) 2020-06-04 2024-07-09 10X Genomics, Inc. Methods of enhancing spatial resolution of transcripts
US12085442B2 (en) 2020-10-22 2024-09-10 Quantum-Si Incorporated Integrated circuit with sequentially-coupled charge storage and associated techniques
US20220205992A1 (en) * 2020-12-28 2022-06-30 Quanterix Corporation Materials and kits relating to association of reporter species and targeting entities with beads
CN112680320A (zh) * 2021-01-21 2021-04-20 季华实验室 零模波导孔结构及其制备方法、以及其使用方法

Family Cites Families (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US161195A (en) * 1875-03-23 Improvement in valve-gears
US129980A (en) * 1872-07-30 Improvement in bird-cages
US161194A (en) * 1875-03-23 Improvement in filters
US156974A (en) * 1874-11-17 Improvement in radiators for steam-heaters
US4994373A (en) 1983-01-27 1991-02-19 Enzo Biochem, Inc. Method and structures employing chemically-labelled polynucleotide probes
US5821058A (en) 1984-01-16 1998-10-13 California Institute Of Technology Automated DNA sequencing technique
US6235488B1 (en) * 1988-09-29 2001-05-22 Agilent Technologies, Inc. Surface preparation for chemical-specific binding
US5198543A (en) * 1989-03-24 1993-03-30 Consejo Superior Investigaciones Cientificas PHI29 DNA polymerase
US5001050A (en) * 1989-03-24 1991-03-19 Consejo Superior Investigaciones Cientificas PHφ29 DNA polymerase
US5547839A (en) 1989-06-07 1996-08-20 Affymax Technologies N.V. Sequencing of surface immobilized polymers utilizing microflourescence detection
US5424186A (en) * 1989-06-07 1995-06-13 Affymax Technologies N.V. Very large scale immobilized polymer synthesis
US5143854A (en) * 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
CA2044616A1 (en) 1989-10-26 1991-04-27 Roger Y. Tsien Dna sequencing
US5412087A (en) * 1992-04-24 1995-05-02 Affymax Technologies N.V. Spatially-addressable immobilization of oligonucleotides and other biological polymers on surfaces
JP3281053B2 (ja) * 1991-12-09 2002-05-13 株式会社東芝 パターン形成方法
DE69434520T3 (de) * 1993-07-30 2009-10-15 Affymax, Inc., Palo Alto Biotinylierung von proteinen
DE4435728A1 (de) * 1994-01-19 1995-07-20 Boehringer Mannheim Gmbh Biotinsilan-Verbindungen und diese Verbindungen enthaltende Bindematrix
DE4424106A1 (de) * 1994-07-08 1996-01-11 Bayer Ag Schichtstoffe
WO1996027025A1 (en) 1995-02-27 1996-09-06 Ely Michael Rabani Device, compounds, algorithms, and methods of molecular characterization and manipulation with molecular parallelism
US5624711A (en) 1995-04-27 1997-04-29 Affymax Technologies, N.V. Derivatization of solid supports and methods for oligomer synthesis
SE9602574D0 (sv) * 1996-06-28 1996-06-28 Siemens Elema Ab Method and arrangement for locating a measurement and/or treatment catheter in a vessel or organ of a patient
US6028025A (en) * 1996-10-21 2000-02-22 Massachusetts Institute Of Technology Metalloporphyrin oxidation catalyst covalently coupled to an inorganic surface and method making same
US6887665B2 (en) * 1996-11-14 2005-05-03 Affymetrix, Inc. Methods of array synthesis
ES2183394T5 (es) 1997-07-28 2012-05-03 Gen-Probe Incorporated Análisis de la secuencia de ácidos nucleicos
IL141148A0 (en) 1998-07-30 2002-02-10 Solexa Ltd Arrayed biomolecules and their use in sequencing
US6787308B2 (en) * 1998-07-30 2004-09-07 Solexa Ltd. Arrayed biomolecules and their use in sequencing
US6210896B1 (en) 1998-08-13 2001-04-03 Us Genomics Molecular motors
US6232075B1 (en) 1998-12-14 2001-05-15 Li-Cor, Inc. Heterogeneous assay for pyrophosphate detection
DE60044490D1 (de) 1999-02-23 2010-07-15 Caliper Life Sciences Inc Manipulation von mikroteilchen in mikrofluiden systemen
JP2002537858A (ja) 1999-03-10 2002-11-12 エーエスエム サイエンティフィック， インコーポレイテッド 核酸の配列を直接決定するための方法
AU769571B2 (en) * 1999-04-28 2004-01-29 Universitat Zurich Polyionic coatings in analytic and sensor devices
US7056661B2 (en) 1999-05-19 2006-06-06 Cornell Research Foundation, Inc. Method for sequencing nucleic acid molecules
US6818395B1 (en) 1999-06-28 2004-11-16 California Institute Of Technology Methods and apparatus for analyzing polynucleotide sequences
US6982146B1 (en) 1999-08-30 2006-01-03 The United States Of America As Represented By The Department Of Health And Human Services High speed parallel molecular nucleic acid sequencing
AU7086800A (en) 1999-08-30 2001-03-26 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The High speed parallel molecular nucleic acid sequencing
US6917726B2 (en) * 2001-09-27 2005-07-12 Cornell Research Foundation, Inc. Zero-mode clad waveguides for performing spectroscopy with confined effective observation volumes
US6869764B2 (en) 2000-06-07 2005-03-22 L--Cor, Inc. Nucleic acid sequencing using charge-switch nucleotides
GB0016473D0 (en) 2000-07-05 2000-08-23 Amersham Pharm Biotech Uk Ltd Sequencing method
GB0016472D0 (en) 2000-07-05 2000-08-23 Amersham Pharm Biotech Uk Ltd Sequencing method and apparatus
JP2004504607A (ja) * 2000-07-19 2004-02-12 ポインティリスト・インコーポレイテッド ネスト化ソーティングおよびハイスループットスクリーニングのための結合タンパク質およびタグのコレクションならびにそれら使用
US20040224316A1 (en) * 2000-08-10 2004-11-11 Tully Timothy P. Augmented cognitive training
ES2300358T3 (es) * 2000-09-05 2008-06-16 Bayer Technology Services Gmbh Procedimiento para la precipitacion de monocapas y capas multiples de acidos organofosforicos y organofosfonicos y sus sales, asi como su uso.
US7560254B2 (en) 2001-08-29 2009-07-14 Ge Healthcare Bio-Sciences Corp. Allele specific primer extension
US7033762B2 (en) 2001-08-29 2006-04-25 Amersham Biosciences Corp Single nucleotide amplification and detection by polymerase
US7244566B2 (en) 2001-08-29 2007-07-17 Ge Healthcare Bio-Sciences Corp. Analyte detection
AU2003280177A1 (en) * 2002-02-21 2004-05-13 Sense Proteomic Limited Enzyme array and assay
JP3696171B2 (ja) * 2002-04-16 2005-09-14 株式会社東芝 直接型液体燃料電池発電装置の検査方法、検査装置、及び直接型液体燃料電池発電装置
US7332273B2 (en) * 2002-06-20 2008-02-19 Affymetrix, Inc. Antireflective coatings for high-resolution photolithographic synthesis of DNA arrays
US6991726B2 (en) 2002-07-01 2006-01-31 Usfilter Corporation Filter having a media retaining plate
US20050233473A1 (en) * 2002-08-16 2005-10-20 Zyomyx, Inc. Methods and reagents for surface functionalization
WO2004017042A2 (en) 2002-08-16 2004-02-26 Zyomyx, Inc. Methods and reagents for surface functionalization
US7132122B2 (en) * 2002-10-30 2006-11-07 The Regents Of The University Of California Direct micro-patterning of lipid bilayers using UV light and selected uses thereof
US20040221319A1 (en) * 2002-12-06 2004-11-04 Ian Zenoni Application streamer
AU2003297859A1 (en) * 2002-12-13 2004-07-09 The Trustees Of Columbia University In The City Of New York Biomolecular coupling methods using 1,3-dipolar cycloaddition chemistry
US20040234964A1 (en) * 2003-05-19 2004-11-25 Affymetrix, Inc. Methods for reducing background on polynucleotide arrays
WO2005019831A2 (en) * 2003-08-18 2005-03-03 Tethys Bioscience, Inc. Methods for reducing complexity of a sample using small epitope antibodies
EP1516665A1 (de) * 2003-09-18 2005-03-23 Sony International (Europe) GmbH Verfahren zu der Immobilisierung und dem Spannen einer Nukleinsäure auf ein Substrat
EP1730307A4 (de) * 2004-03-03 2008-11-05 Univ Columbia Photospaltbare fluoreszenznukleotide für die dna-sequenzierung auf einem mittels stellenspezifischer kopplungschemie konstruierten chip
WO2006044078A2 (en) * 2004-09-17 2006-04-27 Pacific Biosciences Of California, Inc. Apparatus and method for analysis of molecules
US7170050B2 (en) * 2004-09-17 2007-01-30 Pacific Biosciences Of California, Inc. Apparatus and methods for optical analysis of molecules
US7964380B2 (en) * 2005-01-21 2011-06-21 Argylia Technologies Nanoparticles for manipulation of biopolymers and methods of thereof
EP2278303A3 (de) * 2005-06-10 2012-02-22 Life Technologies Corporation Verfahren und Vorrichtung für die genetische Multiplex-Analyse
WO2007019479A2 (en) * 2005-08-04 2007-02-15 Helicos Biosciences Corporation Multi-channel flow cells
US7805081B2 (en) * 2005-08-11 2010-09-28 Pacific Biosciences Of California, Inc. Methods and systems for monitoring multiple optical signals from a single source
US7763423B2 (en) * 2005-09-30 2010-07-27 Pacific Biosciences Of California, Inc. Substrates having low density reactive groups for monitoring enzyme activity
WO2007064597A2 (en) 2005-11-28 2007-06-07 Pacific Biosciences Of California, Inc. Uniform surfaces for hybrid material substrates and methods for making and using same
US7998717B2 (en) * 2005-12-02 2011-08-16 Pacific Biosciences Of California, Inc. Mitigation of photodamage in analytical reactions
US20100260465A1 (en) 2005-12-22 2010-10-14 Pacific Biosciences Of California, Inc. Protein engineering strategies to optimize activity of surface attached proteins
EP3056575B1 (de) * 2005-12-22 2017-10-11 Pacific Biosciences Of California, Inc. Polymerasen zur nukleotid-analog-einfügung
US8975216B2 (en) * 2006-03-30 2015-03-10 Pacific Biosciences Of California Articles having localized molecules disposed thereon and methods of producing same
EP2027253A4 (de) * 2006-06-12 2014-04-30 Pacific Biosciences California Substrate zur ausführung von analytischen reaktionen
JP2010510247A (ja) * 2006-11-21 2010-04-02 アプライド バイオシステムズ インコーポレイテッド 酸化物層上に不動態化表面を形成するための中間体および方法およびこれにより製造される製品
US9637380B2 (en) 2008-03-31 2017-05-02 Pacific Biosciences Of California, Inc. Nanoscale apertures having islands of functionality
AU2009300369B2 (en) * 2008-09-30 2014-08-14 Pacific Biosciences Of California, Inc. Ultra-high multiplex analytical systems and methods
US8501406B1 (en) 2009-07-14 2013-08-06 Pacific Biosciences Of California, Inc. Selectively functionalized arrays
WO2011031313A2 (en) * 2009-09-11 2011-03-17 Pacific Biosciences Of California, Inc. Zero-mode waveguides with non-reflecting walls
WO2011112260A2 (en) * 2010-03-11 2011-09-15 Pacific Biosciences Of California, Inc. Micromirror arrays having self aligned features

Also Published As

Publication number Publication date
US10655172B2 (en) 2020-05-19
WO2007123763A2 (en) 2007-11-01
DK2002019T3 (da) 2012-06-18
US8772202B2 (en) 2014-07-08
US20200377940A1 (en) 2020-12-03
US8802600B2 (en) 2014-08-12
CN102212515B (zh) 2014-01-08
CN102212515A (zh) 2011-10-12
EP2002019A2 (de) 2008-12-17
US20070238679A1 (en) 2007-10-11
US11186871B2 (en) 2021-11-30
US8193123B2 (en) 2012-06-05
CA2645758A1 (en) 2007-11-01
US8975216B2 (en) 2015-03-10
CA2645758C (en) 2016-08-09
US20140315756A1 (en) 2014-10-23
EP2002019B1 (de) 2012-02-22
US20120302459A1 (en) 2012-11-29
WO2007123763A3 (en) 2008-11-06
AU2007241049A1 (en) 2007-11-01
EP2002019A4 (de) 2009-07-15
US20080032301A1 (en) 2008-02-07
US20080176769A1 (en) 2008-07-24
US20220098660A1 (en) 2022-03-31
AU2007241049B2 (en) 2012-07-05
CN101426910A (zh) 2009-05-06
US9944980B2 (en) 2018-04-17
JP2009532032A (ja) 2009-09-10
ES2385015T3 (es) 2012-07-17
US20080153100A1 (en) 2008-06-26

Similar Documents

Publication Publication Date Title
ATE546522T1 (de) Artikel mit darauf angeordeten lokalisierten molekülen und herstellungsverfahren dafür
ATE435667T1 (de) Mit polykationen oberflächenbehandeltes wasserabsorbierende polymergebilde
NO20073996L (no) Hurtig bearbeidingssystem og fremgangsmate for fremstilling av slipeartikler
DE602007008355D1 (de) Verfahren zur Herstellung von mikrofluidischen Vorrichtungen
EP1981085A4 (de) Tft-substrat, reflektives tft-substrat und herstellungsverfahren für derartige substrate
ATE514547T1 (de) Folien, daraus hergestellte artikel und herstellungsverfahren dafür
BRPI0817416A2 (pt) Processo limitador da multiplicação de microorganismos
EP1719758A4 (de) Verfahren zur herstellung von monatin
WO2006041592A3 (en) Large-scale manufacturing process for the production of pharmaceutical compositions
ATE471350T1 (de) Superhydrophiles oder superhydrophobes produkt, herstellungsverfahren dafür und verwendung davon
DE60323340D1 (de) Verfahren zur herstellung interferierender rna-moleküle in säugetierzellen und therapeutische anwendungen solcher moleküle
ATE529534T1 (de) Verfahren unter verwendung eines oligonukleotids mit doppelspezifität und oligonukleotid mit doppelspezifität
GB2423774B (en) Method of culturing neurons, neuron culture substrate, neurons, neuron system, and method for manufacturing neuron system
TW200741821A (en) Method for manufacturing compound material wafers and method for recycling a used donor substrate
WO2007098484A8 (en) High-yield activation of polymer surfaces for covalent attachment of molecules
BRPI0818374A8 (pt) Substratos porosos hidrofílicos
WO2010114274A3 (en) Apparatus for depositing film and method for depositing film and system for depositing film
ATE458802T1 (de) Laminatmaterial für saugfähige artikel und herstellungsverfahren dafür
BRPI0713312A2 (pt) Processo para a produção de um revestimento absorvedor de base sol-gel para aquecimento solar
GB0624376D0 (en) A universal method for selective area growth of organic molecular by vapour deposition
ATE469976T1 (de) Mikrobielle vitamin-c-produktion
DE60336410D1 (de) Verfahren zur herstellung von abtrennbaren substraten
WO2009037600A3 (en) Solid substrate with surface bound molecules and methods for producing and using the same
ATE371683T1 (de) Polarisierte gegenstände und herstellungsverfahren dafür
AR055738A1 (es) Metodos para proveer dispositivos biomedicos con recubrimientos antimicrobianos hidrofilicos