ATE531376T1 - Verwendung von thioarabinofuranosyl-verbindungen - Google Patents
Verwendung von thioarabinofuranosyl-verbindungenInfo
- Publication number
- ATE531376T1 ATE531376T1 AT99935854T AT99935854T ATE531376T1 AT E531376 T1 ATE531376 T1 AT E531376T1 AT 99935854 T AT99935854 T AT 99935854T AT 99935854 T AT99935854 T AT 99935854T AT E531376 T1 ATE531376 T1 AT E531376T1
- Authority
- AT
- Austria
- Prior art keywords
- group
- compounds
- monoalkylamino
- iid
- haloalkenyl
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 230000004543 DNA replication Effects 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical group FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 239000011737 fluorine Chemical group 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 125000000262 haloalkenyl group Chemical group 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 210000004962 mammalian cell Anatomy 0.000 abstract 1
- -1 monoalkylamino Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Transplantation (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9386998P | 1998-07-23 | 1998-07-23 | |
| PCT/US1999/016630 WO2000004866A2 (en) | 1998-07-23 | 1999-07-23 | Preparation of thioarabinofuranosyl compounds and use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE531376T1 true ATE531376T1 (de) | 2011-11-15 |
Family
ID=22241386
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99935854T ATE531376T1 (de) | 1998-07-23 | 1999-07-23 | Verwendung von thioarabinofuranosyl-verbindungen |
Country Status (9)
| Country | Link |
|---|---|
| US (5) | US6576621B1 (enExample) |
| EP (3) | EP2332551B1 (enExample) |
| JP (3) | JP4719356B2 (enExample) |
| AT (1) | ATE531376T1 (enExample) |
| AU (1) | AU747012B2 (enExample) |
| CA (1) | CA2338415C (enExample) |
| ES (3) | ES2402799T3 (enExample) |
| NZ (1) | NZ509405A (enExample) |
| WO (1) | WO2000004866A2 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ509405A (en) * | 1998-07-23 | 2004-10-29 | Southern Res Inst | Preparation of 1-(4-thio-thioarabinofuranosyl) cytosine derivatives and their use as anticancer agents and DNA replication inhibitors |
| US20060127990A1 (en) * | 2002-08-22 | 2006-06-15 | Geneticlab Co., Ltd | 4'-thionucleotide |
| US7524831B2 (en) * | 2005-03-02 | 2009-04-28 | Schering Corporation | Treatments for Flaviviridae virus infection |
| EP2124553B1 (en) * | 2007-03-23 | 2017-03-01 | Southern Research Institute | Method for treating and preventing arthritis |
| AR064165A1 (es) | 2007-12-06 | 2009-03-18 | Richmond Sa Com Ind Y Financie | Un procedimiento para la preparacion de capecitabina e intermediarios utilizables en dicho procedimiento |
| WO2009158412A2 (en) * | 2008-06-25 | 2009-12-30 | Endo Pharmaceuticals Solutions Inc. | Sustained delivery of exenatide and other polypeptides |
| US20110218170A1 (en) * | 2010-03-02 | 2011-09-08 | Southern Research Institute | Use of 2'-deoxy-4'-thiocytidine and its analogues as dna hypomethylating anticancer agents |
| SG10201603288XA (en) | 2012-03-28 | 2016-05-30 | Fujifilm Corp | Salt Of 1-(2-Deoxy-2-Fluoro-4-Thio-beta-D-Arabinofuranosyl)Cytosine |
| JP6175553B2 (ja) | 2014-02-18 | 2017-08-09 | 富士フイルム株式会社 | チオラン骨格型糖化合物の製造方法およびチオラン骨格型糖化合物 |
| JP6351107B2 (ja) * | 2014-02-18 | 2018-07-04 | 富士フイルム株式会社 | チオラン骨格型糖化合物の製造方法およびチオラン骨格型糖化合物 |
| JP6245527B2 (ja) * | 2014-03-24 | 2017-12-13 | 富士フイルム株式会社 | チオラン環もしくはチアン環骨格を有する化合物の製造方法 |
| TWI678373B (zh) | 2014-10-31 | 2019-12-01 | 日商富士軟片股份有限公司 | 硫代核苷衍生物或其鹽及醫藥組合物 |
| HK1252245A1 (zh) * | 2015-05-27 | 2019-05-24 | Idenix Pharmaceuticals Llc | 用於治疗癌症的核苷酸 |
| WO2017091836A1 (en) * | 2015-11-25 | 2017-06-01 | University Of South Carolina | Enhancement of cytarabine activity by inhibiting cdk8/19 |
| BR112019003946A2 (pt) | 2016-08-31 | 2019-05-21 | Fujifilm Corporation | agente antitumoral, reforçador do efeito antitumoral e kit antitumoral |
| MX2018002611A (es) | 2018-01-29 | 2019-07-30 | Fujifilm Corp | Agente antitumoral para cancer del tracto biliar y metodo para tratar cancer del tracto biliar. |
| AU2019256465B2 (en) * | 2018-04-19 | 2024-10-03 | Southern Research Institute | 4'-thio-nucleotide and -nucleoside prodrugs for the treatment of cancer |
| JP2022535849A (ja) * | 2019-06-05 | 2022-08-10 | サウザーン リサーチ インスチチュート | チアラビンベースおよびチアラビンのプロドラッグベースの治療 |
| CA3176543A1 (en) | 2020-04-23 | 2021-10-28 | Mark J. Suto | Composition for treating blood cancer using 4'-thio-5-aza-2'-deoxycytidine and uses thereof |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0491793B1 (en) * | 1989-09-15 | 2005-11-30 | Southern Research Institute | 2'-deoxy-4'-thioribonucleosides as antiviral and anticancer agents |
| IE74701B1 (en) * | 1989-10-04 | 1997-07-30 | Univ Birmingham | Further antiviral pyrimidine nucleosides |
| AU639973B2 (en) * | 1989-12-08 | 1993-08-12 | City Of Hope | Circumvention of human tumor drug resistance |
| JPH0925289A (ja) | 1995-07-14 | 1997-01-28 | Yamasa Shoyu Co Ltd | ４’−チオアラビノピリミジンヌクレオシドの製造方法 |
| JPH09249690A (ja) | 1995-07-14 | 1997-09-22 | Yamasa Shoyu Co Ltd | ４’−チオアラビノプリンヌクレオシド |
| JP2943690B2 (ja) | 1996-04-17 | 1999-08-30 | 日本電気株式会社 | セル衝突検出装置 |
| JP2001525667A (ja) | 1997-05-09 | 2001-12-11 | リボザイム・ファーマシューティカルズ・インコーポレーテッド | Ｃ−ｒａｆの発現レベルに関係した疾患または状態の酵素核酸処置 |
| US6548657B1 (en) * | 1997-06-09 | 2003-04-15 | Ribozyme Pharmaceuticals, Inc. | Method for screening nucleic acid catalysts |
| WO1999043690A1 (en) | 1998-02-25 | 1999-09-02 | Rational Drug Design Laboratories | L-4'-arabinofuranonucleoside compound and medicine composition comprising the same |
| NZ509405A (en) * | 1998-07-23 | 2004-10-29 | Southern Res Inst | Preparation of 1-(4-thio-thioarabinofuranosyl) cytosine derivatives and their use as anticancer agents and DNA replication inhibitors |
-
1999
- 1999-07-23 NZ NZ509405A patent/NZ509405A/en not_active IP Right Cessation
- 1999-07-23 ES ES10179999T patent/ES2402799T3/es not_active Expired - Lifetime
- 1999-07-23 JP JP2000560859A patent/JP4719356B2/ja not_active Expired - Fee Related
- 1999-07-23 ES ES10170453.4T patent/ES2438144T3/es not_active Expired - Lifetime
- 1999-07-23 ES ES99935854T patent/ES2376862T3/es not_active Expired - Lifetime
- 1999-07-23 AU AU51239/99A patent/AU747012B2/en not_active Expired
- 1999-07-23 WO PCT/US1999/016630 patent/WO2000004866A2/en not_active Ceased
- 1999-07-23 CA CA002338415A patent/CA2338415C/en not_active Expired - Lifetime
- 1999-07-23 EP EP10179999A patent/EP2332551B1/en not_active Expired - Lifetime
- 1999-07-23 AT AT99935854T patent/ATE531376T1/de active
- 1999-07-23 EP EP99935854A patent/EP1100512B1/en not_active Expired - Lifetime
- 1999-07-23 EP EP10170453.4A patent/EP2335706B1/en not_active Expired - Lifetime
-
2000
- 2000-01-28 US US09/493,247 patent/US6576621B1/en not_active Expired - Lifetime
-
2003
- 2003-04-07 US US10/407,135 patent/US6870052B2/en not_active Expired - Lifetime
-
2004
- 2004-09-13 US US10/938,542 patent/US7138385B2/en not_active Expired - Lifetime
-
2006
- 2006-08-24 US US11/509,030 patent/US7691820B2/en not_active Expired - Fee Related
-
2010
- 2010-02-23 US US12/710,537 patent/US8178510B2/en not_active Expired - Fee Related
- 2010-04-27 JP JP2010102499A patent/JP2010202655A/ja active Pending
- 2010-10-29 JP JP2010243705A patent/JP5357857B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO2000004866A3 (en) | 2000-04-20 |
| ES2376862T3 (es) | 2012-03-20 |
| WO2000004866A9 (en) | 2000-08-10 |
| US20050038025A1 (en) | 2005-02-17 |
| US6870052B2 (en) | 2005-03-22 |
| ES2402799T3 (es) | 2013-05-09 |
| US7138385B2 (en) | 2006-11-21 |
| JP2010202655A (ja) | 2010-09-16 |
| EP1100512A4 (en) | 2001-10-10 |
| EP2332551A1 (en) | 2011-06-15 |
| US6576621B1 (en) | 2003-06-10 |
| JP4719356B2 (ja) | 2011-07-06 |
| EP1100512B1 (en) | 2011-11-02 |
| EP2332551B1 (en) | 2013-01-09 |
| AU5123999A (en) | 2000-02-14 |
| CA2338415C (en) | 2006-10-10 |
| EP2335706B1 (en) | 2013-10-23 |
| NZ509405A (en) | 2004-10-29 |
| US20100216797A1 (en) | 2010-08-26 |
| JP5357857B2 (ja) | 2013-12-04 |
| EP2335706A1 (en) | 2011-06-22 |
| US20060287320A1 (en) | 2006-12-21 |
| JP2011032281A (ja) | 2011-02-17 |
| ES2438144T3 (es) | 2014-01-16 |
| US8178510B2 (en) | 2012-05-15 |
| CA2338415A1 (en) | 2000-02-03 |
| AU747012B2 (en) | 2002-05-09 |
| US7691820B2 (en) | 2010-04-06 |
| JP2002521318A (ja) | 2002-07-16 |
| US20030203872A1 (en) | 2003-10-30 |
| EP1100512A2 (en) | 2001-05-23 |
| WO2000004866A2 (en) | 2000-02-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| WO2000004866A3 (en) | Preparation of thioarabinofuranosyl compounds and use thereof | |
| ES2115163T3 (es) | Procedimiento para inhibir la proliferacion de celulas de musculos lisos y la restinosis. | |
| ATE149999T1 (de) | Monofluorierte derivate von n-propargyl-1- aminoindan und deren verwendung als monoamino- oxidaseinhibitoren | |
| ATE120738T1 (de) | 2,4-diamino-pyrimidin-3-oxid-derivate und deren verwendung bei der behandlung und zur verhütung von haarfall. | |
| MY119150A (en) | Azetidine derivatives, their preparation and medicaments containing them | |
| ATE223373T1 (de) | Amidderivate und ihre therapeutische verwendung | |
| PT83961A (de) | Pyrazolin-derivate ihre herstellung und ihre verwendung als mittel mit insektizider und akarizider wirkung | |
| NO942452D0 (no) | Amid- og ureaderivater med antihyperkolesteremisk aktivitet, deres fremstilling og terapeutiske anvendelser | |
| DK337589D0 (da) | 3r,s- og 3r-formerne af 3-substuerede 1-(2-aryl -eller heteroarylethyl)piperidin-forbindelser og deres anvendelse til fremstilling af et laegemiddel til behandling af sygdommme forbundet med aendret motilitet og/eller tonus af glatmuskel samt farmaceutiske praeparater indeholdende disse forbindelser | |
| FR2705962B1 (fr) | Arylpyrazoles fongicides. | |
| DK397988D0 (da) | Dihydropyridinforbindelser og deres avendelse til fremstilling af et laegemiddel til behandling af alergiske og inflammatoriske tilstande samt farmaceutiske praeparater indeholdende forbindelserne | |
| ATE49410T1 (de) | 1-aryl-5-alkoximinoalkylamino-pyrazole. | |
| TR200001941T1 (tr) | TNF ve PDE-IV önleyici aktiviteye sahip heterosiklik bileşiklerin N-oksitleri. | |
| NO870423L (no) | 5-substituerte oktahydroindolizin-analgetiske forbindelser og 7-keto mellomprodukter. | |
| DE59604901D1 (de) | Carbamoylcarbonsäureamide | |
| NO972943D0 (no) | 4-amino-2-ureido-pyrimidin-5-karboksylsyreamider, fremgangsmåter for deres fremstilling, legemidler inneholdende disse forbindelsene og deres anvendelse | |
| DE69909811T2 (de) | Substituierte isoxazolylthiophenverbindungen | |
| ATE218138T1 (de) | N-substituierte azabicycloheptan-derivate, ihre herstellung und verwendung | |
| TR199801683A2 (xx) | Yeni �re t�revleri. | |
| ES2192342T3 (es) | 2-(2,6-dioxo-3-fluoropiperidin-3-il)-isoindolinas sustituidas y su uso para reducir los niveles de tnfalfa. | |
| DK0462468T3 (da) | 9-amino-2-phenylbicyclo(3.3.1)nonaner og 9-amino-2-phenylbicyclo(3.3.1)non-2-ener og terapeutiske midler indeholdende disse | |
| IT1217900B (it) | Composti eterociclici azotati ad azione antifungina | |
| SI0937075T1 (en) | New Imidazo- and Oxazolopyridines as Phosphodiesterase Inhibitors. | |
| NO972942D0 (no) | 4-amino-2-ureido-pyrimidin-5-karboksylsyreamider, fremgangsmåter for deres fremstilling, legemidler inneholdende disse forbindelsene og deres anvendelse | |
| DK0662081T3 (da) | Ureidoacetamidderivater, deres fremstilling og lægemidler indeholdende disse derivater |