AU747012B2 - Preparation of thioarabinofuranosyl compounds and use thereof - Google Patents

Preparation of thioarabinofuranosyl compounds and use thereof Download PDF

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Publication number
AU747012B2
AU747012B2 AU51239/99A AU5123999A AU747012B2 AU 747012 B2 AU747012 B2 AU 747012B2 AU 51239/99 A AU51239/99 A AU 51239/99A AU 5123999 A AU5123999 A AU 5123999A AU 747012 B2 AU747012 B2 AU 747012B2
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AU
Australia
Prior art keywords
compound
thio
group
arac
reacting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU51239/99A
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English (en)
Other versions
AU5123999A (en
Inventor
John A. Montgomery
John A. Secrist Iii
Kamal N. Tiwari
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Southern Research Institute
Original Assignee
Southern Research Institute
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Filing date
Publication date
Application filed by Southern Research Institute filed Critical Southern Research Institute
Publication of AU5123999A publication Critical patent/AU5123999A/en
Application granted granted Critical
Publication of AU747012B2 publication Critical patent/AU747012B2/en
Priority to AU2002300586A priority Critical patent/AU2002300586B2/en
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Transplantation (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AU51239/99A 1998-07-23 1999-07-23 Preparation of thioarabinofuranosyl compounds and use thereof Expired AU747012B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002300586A AU2002300586B2 (en) 1998-07-23 2002-08-09 A method for treating solid tumors

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9386998P 1998-07-23 1998-07-23
US60/093869 1998-07-23
PCT/US1999/016630 WO2000004866A2 (en) 1998-07-23 1999-07-23 Preparation of thioarabinofuranosyl compounds and use thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2002300586A Division AU2002300586B2 (en) 1998-07-23 2002-08-09 A method for treating solid tumors

Publications (2)

Publication Number Publication Date
AU5123999A AU5123999A (en) 2000-02-14
AU747012B2 true AU747012B2 (en) 2002-05-09

Family

ID=22241386

Family Applications (1)

Application Number Title Priority Date Filing Date
AU51239/99A Expired AU747012B2 (en) 1998-07-23 1999-07-23 Preparation of thioarabinofuranosyl compounds and use thereof

Country Status (9)

Country Link
US (5) US6576621B1 (enExample)
EP (3) EP2335706B1 (enExample)
JP (3) JP4719356B2 (enExample)
AT (1) ATE531376T1 (enExample)
AU (1) AU747012B2 (enExample)
CA (1) CA2338415C (enExample)
ES (3) ES2376862T3 (enExample)
NZ (1) NZ509405A (enExample)
WO (1) WO2000004866A2 (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ509405A (en) * 1998-07-23 2004-10-29 Southern Res Inst Preparation of 1-(4-thio-thioarabinofuranosyl) cytosine derivatives and their use as anticancer agents and DNA replication inhibitors
US20060127990A1 (en) * 2002-08-22 2006-06-15 Geneticlab Co., Ltd 4'-thionucleotide
US7524831B2 (en) 2005-03-02 2009-04-28 Schering Corporation Treatments for Flaviviridae virus infection
JP5417184B2 (ja) * 2007-03-23 2014-02-12 サザン リサーチ インスティテュート 関節炎を治療及び予防する方法
AR064165A1 (es) 2007-12-06 2009-03-18 Richmond Sa Com Ind Y Financie Un procedimiento para la preparacion de capecitabina e intermediarios utilizables en dicho procedimiento
US8071537B2 (en) * 2008-06-25 2011-12-06 Endo Pharmaceuticals Solutions Inc. Implantable device for the sustained release of a polypeptide
US20110218170A1 (en) * 2010-03-02 2011-09-08 Southern Research Institute Use of 2'-deoxy-4'-thiocytidine and its analogues as dna hypomethylating anticancer agents
KR101770246B1 (ko) 2012-03-28 2017-08-22 후지필름 가부시키가이샤 1-(2-디옥시-2-플루오로-4-티오-β-D-아라비노푸라노실)시토신의 염
WO2015125781A1 (ja) 2014-02-18 2015-08-27 富士フイルム株式会社 チオラン骨格型糖化合物の製造方法およびチオラン骨格型糖化合物
JP6351107B2 (ja) * 2014-02-18 2018-07-04 富士フイルム株式会社 チオラン骨格型糖化合物の製造方法およびチオラン骨格型糖化合物
JP6245527B2 (ja) * 2014-03-24 2017-12-13 富士フイルム株式会社 チオラン環もしくはチアン環骨格を有する化合物の製造方法
TWI678373B (zh) 2014-10-31 2019-12-01 日商富士軟片股份有限公司 硫代核苷衍生物或其鹽及醫藥組合物
EP3303361A1 (en) * 2015-05-27 2018-04-11 Idenix Pharmaceuticals LLC Nucleotides for the treatment of cancer
WO2017091836A1 (en) * 2015-11-25 2017-06-01 University Of South Carolina Enhancement of cytarabine activity by inhibiting cdk8/19
RU2752172C2 (ru) 2016-08-31 2021-07-23 Фуджифилм Корпорэйшн Противоопухолевый агент, усилитель противоопухолевого действия и противоопухолевый набор
MX2018002611A (es) 2018-01-29 2019-07-30 Fujifilm Corp Agente antitumoral para cancer del tracto biliar y metodo para tratar cancer del tracto biliar.
US20210363170A1 (en) * 2018-04-19 2021-11-25 Southern Research Institute 4'-thio-nucleotide and -nucleoside prodrugs for the treatment of cancer
CN113993521A (zh) 2019-06-05 2022-01-28 南方研究院 基于噻拉滨和噻拉滨前药的治疗
AU2021260964A1 (en) 2020-04-23 2022-12-01 Pinotbio, Inc. Composition for treating blood cancer using 4'-thio-5-aza-2'-deoxycytidine and uses thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2253732T3 (es) * 1989-09-15 2006-06-01 Southern Research Institute 2'-deoxi-4'-tioribonucleosidos como agentes antivirales y anticancerosos.
IE74701B1 (en) * 1989-10-04 1997-07-30 Univ Birmingham Further antiviral pyrimidine nucleosides
WO1991008743A1 (en) * 1989-12-08 1991-06-27 City Of Hope Circumvention of human tumor drug resistance
JPH0925289A (ja) 1995-07-14 1997-01-28 Yamasa Shoyu Co Ltd ４’−チオアラビノピリミジンヌクレオシドの製造方法
JPH09249690A (ja) 1995-07-14 1997-09-22 Yamasa Shoyu Co Ltd ４’−チオアラビノプリンヌクレオシド
JP2943690B2 (ja) 1996-04-17 1999-08-30 日本電気株式会社 セル衝突検出装置
AU749561B2 (en) 1997-05-09 2002-06-27 Ribozyme Pharmaceuticals, Inc. Nucleic acid molecules having endonuclease and/or catalytic activity
US6548657B1 (en) * 1997-06-09 2003-04-15 Ribozyme Pharmaceuticals, Inc. Method for screening nucleic acid catalysts
WO1999043690A1 (en) 1998-02-25 1999-09-02 Rational Drug Design Laboratories L-4'-arabinofuranonucleoside compound and medicine composition comprising the same
NZ509405A (en) * 1998-07-23 2004-10-29 Southern Res Inst Preparation of 1-(4-thio-thioarabinofuranosyl) cytosine derivatives and their use as anticancer agents and DNA replication inhibitors

Also Published As

Publication number Publication date
CA2338415C (en) 2006-10-10
US20050038025A1 (en) 2005-02-17
US6870052B2 (en) 2005-03-22
ES2402799T3 (es) 2013-05-09
JP2011032281A (ja) 2011-02-17
CA2338415A1 (en) 2000-02-03
JP4719356B2 (ja) 2011-07-06
ATE531376T1 (de) 2011-11-15
WO2000004866A9 (en) 2000-08-10
US8178510B2 (en) 2012-05-15
EP2335706B1 (en) 2013-10-23
EP2335706A1 (en) 2011-06-22
WO2000004866A3 (en) 2000-04-20
EP2332551A1 (en) 2011-06-15
JP2002521318A (ja) 2002-07-16
US7138385B2 (en) 2006-11-21
US20030203872A1 (en) 2003-10-30
EP1100512A2 (en) 2001-05-23
JP2010202655A (ja) 2010-09-16
JP5357857B2 (ja) 2013-12-04
US7691820B2 (en) 2010-04-06
AU5123999A (en) 2000-02-14
WO2000004866A2 (en) 2000-02-03
EP1100512B1 (en) 2011-11-02
NZ509405A (en) 2004-10-29
US20100216797A1 (en) 2010-08-26
US20060287320A1 (en) 2006-12-21
EP2332551B1 (en) 2013-01-09
EP1100512A4 (en) 2001-10-10
ES2438144T3 (es) 2014-01-16
US6576621B1 (en) 2003-06-10
ES2376862T3 (es) 2012-03-20

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FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired