ATE519863T1 - Nicht-fluoreszente energieübertragung - Google Patents
Nicht-fluoreszente energieübertragungInfo
- Publication number
- ATE519863T1 ATE519863T1 AT06806056T AT06806056T ATE519863T1 AT E519863 T1 ATE519863 T1 AT E519863T1 AT 06806056 T AT06806056 T AT 06806056T AT 06806056 T AT06806056 T AT 06806056T AT E519863 T1 ATE519863 T1 AT E519863T1
- Authority
- AT
- Austria
- Prior art keywords
- moieties
- donor
- fluorescent
- fluorescent energy
- biomolecules
- Prior art date
Links
- 238000000034 method Methods 0.000 abstract 2
- 239000011541 reaction mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/6818—Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Luminescent Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US72420205P | 2005-10-05 | 2005-10-05 | |
| PCT/EP2006/009646 WO2007039301A2 (en) | 2005-10-05 | 2006-10-05 | Non-fluorescent energy transfer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE519863T1 true ATE519863T1 (de) | 2011-08-15 |
Family
ID=37574999
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06806056T ATE519863T1 (de) | 2005-10-05 | 2006-10-05 | Nicht-fluoreszente energieübertragung |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7741467B2 (enExample) |
| EP (1) | EP1934374B1 (enExample) |
| JP (1) | JP4843044B2 (enExample) |
| CN (1) | CN101321878B (enExample) |
| AT (1) | ATE519863T1 (enExample) |
| CA (1) | CA2624917C (enExample) |
| ES (1) | ES2371088T3 (enExample) |
| WO (1) | WO2007039301A2 (enExample) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7745125B2 (en) | 2004-06-28 | 2010-06-29 | Roche Molecular Systems, Inc. | 2′-terminator related pyrophosphorolysis activated polymerization |
| FI20070163A0 (fi) * | 2007-02-27 | 2007-02-27 | Hidex Oy | Parannettu homogeeninen luminesenssibiotesti |
| US8988679B2 (en) * | 2007-04-18 | 2015-03-24 | Becton, Dickinson And Company | SERS nanotag assays |
| US8206929B2 (en) * | 2009-01-07 | 2012-06-26 | Roche Molecular Systems, Inc. | Nucleic acid amplification with allele-specific suppression of sequence variants |
| US8486719B2 (en) * | 2009-02-20 | 2013-07-16 | Perkinelmer Biosignal, Inc. | Multiplex assay methods and compositions |
| GB2480792B (en) * | 2009-03-02 | 2018-11-14 | Co Diagnostics Inc | Energy transfer hairpin oligonucleotide probes |
| US8674080B2 (en) | 2009-04-09 | 2014-03-18 | Roche Molecular Systems, Inc. | Dye composition for liquid transfer control |
| CA2965661C (en) * | 2014-10-23 | 2023-09-26 | Ricardo Mancebo | Reagents and methods for isothermal chain reaction |
| US9745618B2 (en) | 2014-11-19 | 2017-08-29 | Roche Molecular Systems, Inc. | Photoblocked probes and methods for sequential detection of nucleic acids |
| US9920381B2 (en) | 2014-12-02 | 2018-03-20 | Roche Molecular Systems, Inc. | Compositions and methods for detecting MECC-containing methicillin-resistant Staphylococcus aureus |
| CA3017265C (en) | 2016-03-11 | 2022-08-16 | F. Hoffmann-La Roche Ag | Compositions and methods for detection of zika virus |
| US10612101B2 (en) | 2016-05-27 | 2020-04-07 | Roche Molecular Systems, Inc. | Compositions and methods for detection of Mycoplasma genitalium |
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| CN111786260B (zh) * | 2016-06-03 | 2025-01-24 | 通用医疗公司 | 用于微激光器粒子的系统和方法 |
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| CN109642253A (zh) | 2016-08-02 | 2019-04-16 | 豪夫迈·罗氏有限公司 | 用于提高核酸的扩增和检测/定量的效率的辅助寡核苷酸 |
| US10793923B2 (en) | 2016-11-09 | 2020-10-06 | Roche Molecular Systems, Inc. | Compositions and methods for detection of BK virus |
| US10760137B2 (en) | 2017-07-18 | 2020-09-01 | Roche Molecular Systems, Inc. | Compositions and methods for detection of Babesia |
| WO2019063661A1 (en) | 2017-09-29 | 2019-04-04 | Roche Diagnostics Gmbh | COMPOSITIONS AND METHODS FOR THE DETECTION OF TRICHOMONAS VAGINALIS |
| EP3746569A1 (en) | 2018-01-31 | 2020-12-09 | Juno Therapeutics, Inc. | Methods and reagents for assessing the presence or absence of replication competent virus |
| US11604186B2 (en) * | 2018-10-17 | 2023-03-14 | Molecular Devices (Austria) GmbH | Real time western blot assays utilizing fluorescence resonance energy transfer (FRET) |
| US12344905B2 (en) | 2018-12-03 | 2025-07-01 | Roche Molecular Systems, Inc. | Compositions and methods for detection of Candida auris |
| JP7628085B2 (ja) | 2019-05-02 | 2025-02-07 | エフ． ホフマン－ラ ロシュ アーゲー | 鎖分離温度に基づくＤＮＡに対してＲＮＡ標的の優先的／選択的増幅のためのｄＩＴＰの利用 |
| JP7592027B2 (ja) | 2019-05-07 | 2024-11-29 | エフ． ホフマン－ラ ロシュ アーゲー | ナイセリア・ゴノレア（Ｎｅｉｓｓｅｒｉａ Ｇｏｎｏｒｒｏｈｅａｅ）を検出するための組成物および方法 |
| JP7649285B2 (ja) | 2019-07-25 | 2025-03-19 | エフ． ホフマン－ラ ロシュ アーゲー | エプスタイン・バーウイルス（ｅｂｖ）を検出するための組成物および方法 |
| CN114286866A (zh) | 2019-08-27 | 2022-04-05 | 豪夫迈·罗氏有限公司 | 用于扩增和检测包括从cccDNA转录的HBV RNA在内的乙型肝炎病毒RNA的组合物和方法 |
| US11441167B2 (en) | 2019-11-20 | 2022-09-13 | Roche Molecular Systems, Inc. | Compositions and methods for rapid identification and phenotypic antimicrobial susceptibility testing of bacteria and fungi |
| JP7716408B2 (ja) | 2019-12-27 | 2025-07-31 | エフ． ホフマン－ラ ロシュ アーゲー | メチシリン耐性黄色ブドウ球菌を検出するための組成物および方法 |
| US20220356537A1 (en) | 2019-12-31 | 2022-11-10 | Roche Molecular Systems, Inc. | Quantitative pcr screening of inducible prophage from bacterial isolates |
| CN116171333A (zh) | 2020-03-09 | 2023-05-26 | 豪夫迈·罗氏有限公司 | 用于检测严重急性呼吸综合征冠状病毒2(sars-cov-2)、甲型流感和乙型流感的组合物和方法 |
| AU2021322710A1 (en) | 2020-08-06 | 2023-02-02 | F. Hoffmann-La Roche Ag | Compositions and methods for the detection of severe acute respiratory syndrome coronavirus 2 (SARS-2), influenza A, and influenza B |
| CN112630198A (zh) * | 2020-09-15 | 2021-04-09 | 北京工业大学 | 一种基于回音壁模式光学微腔的传感检测方法 |
| CN116615563A (zh) | 2020-12-04 | 2023-08-18 | 豪夫迈·罗氏有限公司 | 用于检测疟疾的组合物和方法 |
| US20220205020A1 (en) | 2020-12-30 | 2022-06-30 | Roche Molecular Systems, Inc. | Compositions and methods for detection of bacteria and fungi associated with bacterial and candida vaginosis |
| JP2024505686A (ja) | 2021-02-05 | 2024-02-07 | エフ． ホフマン－ラ ロシュ アーゲー | ヒトパラインフルエンザウイルス１－４（ｈｐｉｖ１－４）の検出のための組成物及び方法 |
| US20220290221A1 (en) | 2021-03-15 | 2022-09-15 | Roche Molecular Systems, Inc. | Compositions and methods for detecting severe acute respiratory syndrome coronavirus 2 (sars-cov-2) variants having spike protein mutations |
| US20240240273A1 (en) | 2021-05-06 | 2024-07-18 | Roche Molecular Systems, Inc. | Compositions and Methods for Detecting Hepatitis Delta Virus by a Dual-Target Assay |
| CN118202069A (zh) | 2021-11-05 | 2024-06-14 | 豪夫迈·罗氏有限公司 | 用于检测疟疾的组合物和方法 |
| WO2023089186A1 (en) | 2021-11-22 | 2023-05-25 | F. Hoffmann-La Roche Ag | Compositions and methods for detecting vana and/or vanb genes associated with multidrug resistance |
| CN118434883A (zh) | 2021-12-24 | 2024-08-02 | 豪夫迈·罗氏有限公司 | Lamp扩增产物的改进检测 |
| CN119452104A (zh) | 2022-06-30 | 2025-02-14 | 豪夫迈·罗氏有限公司 | 用于检测性病淋巴肉芽肿(lgv)沙眼衣原体血清变型的组合物和方法 |
| WO2024042042A1 (en) | 2022-08-24 | 2024-02-29 | F. Hoffmann-La Roche Ag | Compositions and methods for detecting monkeypox virus |
| CN120418449A (zh) | 2022-12-25 | 2025-08-01 | 豪夫迈·罗氏有限公司 | 用于检测耐碳青霉烯的醋酸钙不动杆菌-鲍氏不动杆菌(crab)的组合物和方法 |
| CN120457216A (zh) | 2022-12-28 | 2025-08-08 | 豪夫迈·罗氏有限公司 | 针对多个乙型肝炎病毒基因靶标的数字pcr测定设计及用于其的不可延伸的阻断剂寡核苷酸 |
| WO2024175749A1 (en) | 2023-02-25 | 2024-08-29 | F. Hoffmann-La Roche Ag | Compositions and methods for candida species detection |
| CN120917150A (zh) | 2023-03-03 | 2025-11-07 | 豪夫迈·罗氏有限公司 | 用于检测b族链球菌（无乳链球菌）和克林霉素抗性基因决定子的组合物和方法 |
| WO2025027080A1 (en) | 2023-08-03 | 2025-02-06 | F. Hoffmann-La Roche Ag | Use of 5'-tailed long primers to improve amplification performance when targeting short primer-binding sites |
| WO2025202488A1 (en) | 2024-03-28 | 2025-10-02 | Roche Diagnostics Gmbh | Enhancer of nucleic acid amplification |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4318846A (en) | 1979-09-07 | 1982-03-09 | Syva Company | Novel ether substituted fluorescein polyamino acid compounds as fluorescers and quenchers |
| US4458066A (en) | 1980-02-29 | 1984-07-03 | University Patents, Inc. | Process for preparing polynucleotides |
| DE3071373D1 (en) | 1980-10-27 | 1986-03-06 | Syva Co | Novel ether substituted fluorescein compounds as fluorescers and quenchers |
| EP0144914A3 (en) | 1983-12-12 | 1986-08-13 | Miles Inc. | Hybridization assay employing labeled pairs of hybrid binding reagents |
| US5366860A (en) | 1989-09-29 | 1994-11-22 | Applied Biosystems, Inc. | Spectrally resolvable rhodamine dyes for nucleic acid sequence determination |
| US5188934A (en) | 1989-11-14 | 1993-02-23 | Applied Biosystems, Inc. | 4,7-dichlorofluorescein dyes as molecular probes |
| US5210015A (en) | 1990-08-06 | 1993-05-11 | Hoffman-La Roche Inc. | Homogeneous assay system using the nuclease activity of a nucleic acid polymerase |
| EP0476545B1 (en) | 1990-09-14 | 1997-05-07 | Tosoh Corporation | Method of and kit for immunoassay |
| US5565322A (en) * | 1991-11-07 | 1996-10-15 | Nanogen, Inc. | Hybridization of polynucleotides conjugated with chromophores and fluorophores to generate donor-to donor energy transfer system |
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| US5654419A (en) | 1994-02-01 | 1997-08-05 | The Regents Of The University Of California | Fluorescent labels and their use in separations |
| US6028190A (en) | 1994-02-01 | 2000-02-22 | The Regents Of The University Of California | Probes labeled with energy transfer coupled dyes |
| AU698953B2 (en) | 1994-04-29 | 1998-11-12 | Applied Biosystems, Llc | System for real time detection of nucleic acid amplification products |
| US5945526A (en) | 1996-05-03 | 1999-08-31 | Perkin-Elmer Corporation | Energy transfer dyes with enhanced fluorescence |
| US5863727A (en) | 1996-05-03 | 1999-01-26 | The Perkin-Elmer Corporation | Energy transfer dyes with enhanced fluorescence |
| US5800996A (en) | 1996-05-03 | 1998-09-01 | The Perkin Elmer Corporation | Energy transfer dyes with enchanced fluorescence |
| US6117635A (en) | 1996-07-16 | 2000-09-12 | Intergen Company | Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon |
| US5853992A (en) * | 1996-10-04 | 1998-12-29 | The Regents Of The University Of California | Cyanine dyes with high-absorbance cross section as donor chromophores in energy transfer labels |
| US6365346B1 (en) | 1998-02-18 | 2002-04-02 | Dade Behring Inc. | Quantitative determination of nucleic acid amplification products |
| US6768000B1 (en) | 1998-06-12 | 2004-07-27 | Intergen Company | Multi-fluorescent hairpin energy transfer oligonucleotides |
| US6037130A (en) * | 1998-07-28 | 2000-03-14 | The Public Health Institute Of The City Of New York, Inc. | Wavelength-shifting probes and primers and their use in assays and kits |
| US6610842B1 (en) | 1999-05-06 | 2003-08-26 | Isis Pharmaceuticals, Inc. | Processes for the synthesis of oligomers using phosphoramidite compositions |
| US6524644B1 (en) | 1999-08-26 | 2003-02-25 | Enthone Inc. | Process for selective deposition of OSP coating on copper, excluding deposition on gold |
| US6114518A (en) | 1999-09-30 | 2000-09-05 | Becton, Dickinson And Company | Synthesis and use of labelled phosphoramidite compositions |
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| US6534646B2 (en) | 2001-06-04 | 2003-03-18 | Barrskogen, Inc. | Oligonucleotide labeling reagents |
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| US20050164316A1 (en) * | 2001-06-27 | 2005-07-28 | Bray Terry L. | Biophotonic sensors and methods of use thereof |
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| US20040197793A1 (en) | 2002-08-30 | 2004-10-07 | Arjang Hassibi | Methods and apparatus for biomolecule detection, identification, quantification and/or sequencing |
| US20050118619A1 (en) * | 2003-09-22 | 2005-06-02 | Wensheng Xia | Dark quenchers for fluorescence resonance energy transfer (FRET) in bioassays |
| BRPI0512212A (pt) | 2004-06-18 | 2008-02-19 | Exxonmobil Upstream Res Co | métodos de produzir gás natural liquefeito, de projetar uma usina de liquefação de gás natural liquefeito, de projetar uma capacidade de processamento expandida de uma usina de liquefação de gás natural liquefeito e de operar uma usina de liquefação de gás natural liquefeito, e, usina de liquefação de gás natural liquefeito |
-
2006
- 2006-10-05 US US11/544,460 patent/US7741467B2/en not_active Expired - Fee Related
- 2006-10-05 ES ES06806056T patent/ES2371088T3/es active Active
- 2006-10-05 WO PCT/EP2006/009646 patent/WO2007039301A2/en not_active Ceased
- 2006-10-05 CN CN200680045298.1A patent/CN101321878B/zh not_active Expired - Fee Related
- 2006-10-05 CA CA2624917A patent/CA2624917C/en not_active Expired - Fee Related
- 2006-10-05 EP EP06806056A patent/EP1934374B1/en not_active Not-in-force
- 2006-10-05 AT AT06806056T patent/ATE519863T1/de active
- 2006-10-05 JP JP2008533937A patent/JP4843044B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1934374A2 (en) | 2008-06-25 |
| US7741467B2 (en) | 2010-06-22 |
| HK1125678A1 (en) | 2009-08-14 |
| EP1934374B1 (en) | 2011-08-10 |
| US20070077588A1 (en) | 2007-04-05 |
| CA2624917A1 (en) | 2007-04-12 |
| CN101321878B (zh) | 2013-03-27 |
| JP4843044B2 (ja) | 2011-12-21 |
| WO2007039301A3 (en) | 2007-05-24 |
| CN101321878A (zh) | 2008-12-10 |
| CA2624917C (en) | 2013-07-09 |
| JP2009512837A (ja) | 2009-03-26 |
| ES2371088T3 (es) | 2011-12-27 |
| WO2007039301A2 (en) | 2007-04-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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