ATE483822T1 - Primer für nukleinsäureamplifikation in pcr- basierten klonalitätsstudien - Google Patents

Primer für nukleinsäureamplifikation in pcr- basierten klonalitätsstudien

Info

Publication number
ATE483822T1
ATE483822T1 AT03756746T AT03756746T ATE483822T1 AT E483822 T1 ATE483822 T1 AT E483822T1 AT 03756746 T AT03756746 T AT 03756746T AT 03756746 T AT03756746 T AT 03756746T AT E483822 T1 ATE483822 T1 AT E483822T1
Authority
AT
Austria
Prior art keywords
rearrangement
primers
pcr
tcrd
nucleic acid
Prior art date
Application number
AT03756746T
Other languages
English (en)
Inventor
Dongen Jacobus Van
Anthonie Langerak
Eduardus Schuuring
Miquel Jesus San
Sanz Ramon Garzia
Antonio Parreira
John Smith
Frances Lavender
Gareth Morgan
Paul Evans
Michael Kneba
Michael Hummel
Elizabeth Macintyre
Christian Bastard
Frederic Davi
Monika Brueggemann
Original Assignee
Univ Erasmus
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32094087&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE483822(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ Erasmus filed Critical Univ Erasmus
Application granted granted Critical
Publication of ATE483822T1 publication Critical patent/ATE483822T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
AT03756746T 2002-10-11 2003-10-13 Primer für nukleinsäureamplifikation in pcr- basierten klonalitätsstudien ATE483822T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41777902P 2002-10-11 2002-10-11
PCT/NL2003/000690 WO2004033728A2 (en) 2002-10-11 2003-10-13 Nucleic acid amplification primers for pcr-based clonality studies

Publications (1)

Publication Number Publication Date
ATE483822T1 true ATE483822T1 (de) 2010-10-15

Family

ID=32094087

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03756746T ATE483822T1 (de) 2002-10-11 2003-10-13 Primer für nukleinsäureamplifikation in pcr- basierten klonalitätsstudien

Country Status (12)

Country Link
US (3) US8859748B2 (de)
EP (3) EP2418287B1 (de)
JP (1) JP4708029B2 (de)
CN (1) CN1965089A (de)
AT (1) ATE483822T1 (de)
AU (1) AU2003300565A1 (de)
CA (1) CA2501863A1 (de)
DE (1) DE60334471D1 (de)
DK (2) DK2418287T3 (de)
ES (3) ES2442791T3 (de)
HK (2) HK1167436A1 (de)
WO (1) WO2004033728A2 (de)

Families Citing this family (99)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6143496A (en) * 1997-04-17 2000-11-07 Cytonix Corporation Method of sampling, amplifying and quantifying segment of nucleic acid, polymerase chain reaction assembly having nanoliter-sized sample chambers, and method of filling assembly
JP2002233382A (ja) * 2001-02-09 2002-08-20 Sapporo Breweries Ltd ビール酵母の識別方法
BR0313024A (pt) * 2002-07-30 2005-07-12 Wyeth Corp Formulações parenterais contendo um hidroxiéster de rapamicina
AU2003902299A0 (en) * 2003-05-13 2003-05-29 Flinders Medical Centre A method of analysing a marker nucleic acid molecule
CA2544367A1 (en) * 2003-10-29 2005-05-12 Ribomed Biotechnologies, Inc. Compositions, methods and detection technologies for reiterative oligonucleotide synthesis
FR2863274B1 (fr) * 2003-12-05 2012-11-16 Commissariat Energie Atomique Procede d'evaluation quantitative d'un rearrangement ou d'une recombinaison genetique ciblee d'un individu et ses applications.
WO2006046860A1 (en) * 2004-10-25 2006-05-04 Erasmus Universiteit Rotterdam Determining the replicative history of lymphocytes
US10731215B2 (en) * 2005-04-15 2020-08-04 Epigenomics Ag Method for determining the presence or absence of methylation in a sample
CA2611671C (en) 2005-06-15 2013-10-08 Callida Genomics, Inc. Single molecule arrays for genetic and chemical analysis
WO2007123392A1 (en) * 2006-04-24 2007-11-01 Erasmus Universiteit Rotterdam Determining the replicative history of lymphocytes
US20080050724A1 (en) * 2006-08-24 2008-02-28 Microfluidic Systems, Inc. Method of detecting one or more limited copy targets
WO2008026927A2 (en) * 2006-08-30 2008-03-06 Academisch Medisch Centrum Process for displaying t- and b-cell receptor repertoires
WO2008046056A1 (en) * 2006-10-13 2008-04-17 Welldoc Communications, Inc. Reduction of nonspecific binding in nucleic acid assays and nucleic acid synthesis reactions
AU2008255569A1 (en) * 2007-06-01 2008-12-04 Monoquant Pty Ltd A method for DNA breakpoint analysis
US20160068905A1 (en) 2007-11-26 2016-03-10 Immunid Method for Studying V(D)J Combinatory Diversity
EP2062982A1 (de) * 2007-11-26 2009-05-27 ImmunID Verfahren zur Untersuchung der kombinatorischen Diversität von V(D)J.
US8592150B2 (en) 2007-12-05 2013-11-26 Complete Genomics, Inc. Methods and compositions for long fragment read sequencing
US9012148B2 (en) * 2008-04-16 2015-04-21 Jian Han Method for evaluating and comparing immunorepertoires
EP2806037B1 (de) 2008-05-13 2016-09-21 Gen-Probe Incorporated Inaktivierbare Target-Capture-Oligomere zur Verwendung bei der selektiven Hybridisierung und beim Fangen von Zielnukleinsäuresequenzen
US9394567B2 (en) 2008-11-07 2016-07-19 Adaptive Biotechnologies Corporation Detection and quantification of sample contamination in immune repertoire analysis
US8628927B2 (en) 2008-11-07 2014-01-14 Sequenta, Inc. Monitoring health and disease status using clonotype profiles
ES2781754T3 (es) 2008-11-07 2020-09-07 Adaptive Biotechnologies Corp Métodos para supervisar las condiciones por análisis de secuencia
US9365901B2 (en) 2008-11-07 2016-06-14 Adaptive Biotechnologies Corp. Monitoring immunoglobulin heavy chain evolution in B-cell acute lymphoblastic leukemia
US9528160B2 (en) 2008-11-07 2016-12-27 Adaptive Biotechnolgies Corp. Rare clonotypes and uses thereof
US8691510B2 (en) 2008-11-07 2014-04-08 Sequenta, Inc. Sequence analysis of complex amplicons
US8748103B2 (en) 2008-11-07 2014-06-10 Sequenta, Inc. Monitoring health and disease status using clonotype profiles
US9506119B2 (en) 2008-11-07 2016-11-29 Adaptive Biotechnologies Corp. Method of sequence determination using sequence tags
US20100124741A1 (en) * 2008-11-18 2010-05-20 Quest Disgnostics Investments Incorporated METHODS FOR DETECTING IgH/BCL-1 CHROMOSOMAL TRANSLOCATION
US8367330B2 (en) 2008-12-22 2013-02-05 Quest Diagnostics Investments Incorporated Methods for detecting TCR-gamma gene rearrangement
DK2387627T3 (en) 2009-01-15 2016-07-04 Adaptive Biotechnologies Corp Adaptive immunity profiling and methods for producing monoclonal antibodies
US9524369B2 (en) 2009-06-15 2016-12-20 Complete Genomics, Inc. Processing and analysis of complex nucleic acid sequence data
KR20120044941A (ko) 2009-06-25 2012-05-08 프레드 헛친슨 켄서 리서치 센터 적응 면역의 측정방법
US9043160B1 (en) 2009-11-09 2015-05-26 Sequenta, Inc. Method of determining clonotypes and clonotype profiles
EE201000013A (et) * 2010-01-29 2011-10-17 Selfdiagnostics O� Meetod ja kiirtesti seade sihtm„rk-molekuli proovimaterjalist detekteerimiseks
JP2011223940A (ja) * 2010-04-21 2011-11-10 Asahi Breweries Ltd 偽陰性を排除するｐｃｒ検査方法およびそれに使用するプライマー
EP2567226B1 (de) * 2010-05-06 2016-08-10 Adaptive Biotechnologies Corporation Überwachung von gesundheits- und krankheitsstatus mithilfe von klonotyp-profilen
US11022573B2 (en) * 2010-08-31 2021-06-01 Canon U.S.A., Inc. Positive controls
JP6159252B2 (ja) * 2010-08-31 2017-07-05 キヤノン ユー．エス． ライフ サイエンシズ， インコーポレイテッドＣａｎｏｎ Ｕ．Ｓ． Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ， Ｉｎｃ． 熱較正
WO2012097374A1 (en) 2011-01-14 2012-07-19 Cb Biotechnologies, Inc. Immunodiversity assessment method and its use
WO2012158967A1 (en) * 2011-05-17 2012-11-22 Dxterity Diagnostics Incorporated Methods and compositions for detecting target nucleic acids
EP2744916A4 (de) 2011-07-13 2015-06-17 Primeradx Inc Multimodale verfahren zur simultanen erkennung und quantifizierung mehrerer nukleinsäuren in einer probe
US10385475B2 (en) 2011-09-12 2019-08-20 Adaptive Biotechnologies Corp. Random array sequencing of low-complexity libraries
EP2768982A4 (de) 2011-10-21 2015-06-03 Adaptive Biotechnologies Corp Quantifizierung von adaptiven immunzellgenomen in einer komplexen mischung von zellen
EP3492604B1 (de) 2011-11-04 2021-01-06 Gen-Probe Incorporated Molekulartestreagenzien und -verfahren
EP3388535B1 (de) 2011-12-09 2021-03-24 Adaptive Biotechnologies Corporation Diagnose von lymphoid-malignomen und nachweis von minimaler resterkrankung
US9499865B2 (en) 2011-12-13 2016-11-22 Adaptive Biotechnologies Corp. Detection and measurement of tissue-infiltrating lymphocytes
GB201203720D0 (en) * 2012-03-02 2012-04-18 Babraham Inst Method of identifying VDJ recombination products
EP2823060B1 (de) 2012-03-05 2018-02-14 Adaptive Biotechnologies Corporation Festlegung von gepaarten immunrezeptorketten aus frequenzabgestimmten untereinheiten
CN102605070A (zh) * 2012-03-19 2012-07-25 中国人民解放军第二军医大学 淋巴细胞基因重排克隆性检测试剂盒及其检测方法
AU2013259544B9 (en) 2012-05-08 2017-09-28 Adaptive Biotechnologies Corporation Compositions and method for measuring and calibrating amplification bias in multiplexed PCR reactions
US20160002731A1 (en) 2012-10-01 2016-01-07 Adaptive Biotechnologies Corporation Immunocompetence assessment by adaptive immune receptor diversity and clonality characterization
ES2748204T3 (es) 2013-02-22 2020-03-13 Adaptive Biotechnologies Corp Procedimiento para seleccionar clonotipos raros
US9816088B2 (en) 2013-03-15 2017-11-14 Abvitro Llc Single cell bar-coding for antibody discovery
CA2914367A1 (en) * 2013-06-07 2014-12-11 Athena Diagnostics, Inc. Molecular barcoding for multiplex sequencing
US9708657B2 (en) 2013-07-01 2017-07-18 Adaptive Biotechnologies Corp. Method for generating clonotype profiles using sequence tags
WO2015063121A1 (en) * 2013-10-29 2015-05-07 Region Syddanmark Method for analyzing body fluid samples
WO2015066530A1 (en) * 2013-10-31 2015-05-07 Atherotech, Inc. Methods for nucleic acid amplification
WO2015075939A1 (ja) 2013-11-21 2015-05-28 Ｒｅｐｅｒｔｏｉｒｅ Ｇｅｎｅｓｉｓ株式会社 Ｔ細胞受容体およびｂ細胞受容体レパトアの解析システムならびにその治療および診断への利用
WO2015134787A2 (en) 2014-03-05 2015-09-11 Adaptive Biotechnologies Corporation Methods using randomer-containing synthetic molecules
US10066265B2 (en) 2014-04-01 2018-09-04 Adaptive Biotechnologies Corp. Determining antigen-specific t-cells
US11390921B2 (en) 2014-04-01 2022-07-19 Adaptive Biotechnologies Corporation Determining WT-1 specific T cells and WT-1 specific T cell receptors (TCRs)
EP3126524B1 (de) * 2014-04-04 2020-07-22 Affymetrix, Inc. Verbesserte zusammensetzungen und verfahren für molekularinversionsprobenassays
ES2777529T3 (es) 2014-04-17 2020-08-05 Adaptive Biotechnologies Corp Cuantificación de genomas de células inmunitarias adaptativas en una mezcla compleja de células
US10202640B2 (en) 2014-05-07 2019-02-12 The Board Of Trustees Of The Leland Stanford Junior University Single cell analysis of T cells using high-throughput multiplex amplification and deep sequencing
CA2961210A1 (en) 2014-09-15 2016-03-24 Abvitro, Inc. High-throughput nucleotide library sequencing
CA2966201A1 (en) 2014-10-29 2016-05-06 Adaptive Biotechnologies Corp. Highly-multiplexed simultaneous detection of nucleic acids encoding paired adaptive immune receptor heterodimers from many samples
EP3018214B1 (de) 2014-11-05 2017-12-13 Fundacion de Investigacion Hospital 12 de Octubre Verfahren zur Quantifizierung des Niveaus minimaler Resterkrankung bei einer Person
US10246701B2 (en) 2014-11-14 2019-04-02 Adaptive Biotechnologies Corp. Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture
EP3498866A1 (de) 2014-11-25 2019-06-19 Adaptive Biotechnologies Corp. Charakterisierung von adaptiver immunreaktion auf impfungen oder infektionen unter verwendung von immunrepertoiresequenzierung
AU2016222788B2 (en) 2015-02-24 2022-03-31 Adaptive Biotechnologies Corp. Methods for diagnosing infectious disease and determining HLA status using immune repertoire sequencing
WO2016161273A1 (en) 2015-04-01 2016-10-06 Adaptive Biotechnologies Corp. Method of identifying human compatible t cell receptors specific for an antigenic target
WO2016196229A1 (en) 2015-06-01 2016-12-08 Cellular Research, Inc. Methods for rna quantification
ES2924487T3 (es) * 2016-01-29 2022-10-07 Hoffmann La Roche Un adaptador de conformación en Y novedoso para secuenciación de ácidos nucleicos y procedimiento de uso
US11459619B2 (en) 2016-02-08 2022-10-04 The Johns Hopkins University Handheld nucleic acid-based assay for rapid identification
US20170226593A1 (en) * 2016-02-08 2017-08-10 The Johns Hopkins University Handheld nucleic acid-based assay for rapid identification
BR112018016240A2 (pt) * 2016-02-11 2019-01-02 Htg Molecular Diagnostics Inc método de sequência alvo direta que utiliza proteção da nuclease
WO2017165614A1 (en) * 2016-03-23 2017-09-28 The Methodist Hospital System Pre-transplant tcr clonality assessment to predict post-liver transplant survival
US20170275680A1 (en) * 2016-03-24 2017-09-28 Paul Chi Hang Li Methods and Apparatus for Nanoparticle-assisted Nucleic Acid Amplification, Hybridization and Microarray Analysis
SG11201808493QA (en) * 2016-03-29 2018-10-30 Univ Rice William M Surface-based detection of nucleic acid in a convection flow fluidic device
WO2017174572A1 (en) * 2016-04-04 2017-10-12 F. Hoffmann-La Roche Ag Nucleic acid sample preparation methods
CN106191262A (zh) * 2016-07-18 2016-12-07 南开大学 一种分析Igκ基因二次重排中间产物的方法及试剂盒
US20180037942A1 (en) * 2016-08-03 2018-02-08 Cellular Research, Inc. Enzyme-independent molecular indexing
US10428325B1 (en) 2016-09-21 2019-10-01 Adaptive Biotechnologies Corporation Identification of antigen-specific B cell receptors
CN106701954A (zh) * 2017-01-09 2017-05-24 浙江大学 一种用于检测肝癌的引物组及检测方法
US10822662B2 (en) 2017-03-06 2020-11-03 Karkinos Precision Oncology LLC Diagnostic methods for identifying T-cell lymphoma and leukemia by high-throughput TCR-β sequencing
CN108823306A (zh) * 2017-05-03 2018-11-16 杭州赫玛生物科技有限公司 检测白血病细胞的系统和方法
WO2019074972A1 (en) * 2017-10-10 2019-04-18 Memorial Sloan Kettering Cancer Center SYSTEM AND METHODS FOR PRIMER EXTRACTION AND CLONALITY DETECTION
US11254980B1 (en) 2017-11-29 2022-02-22 Adaptive Biotechnologies Corporation Methods of profiling targeted polynucleotides while mitigating sequencing depth requirements
CH714402A1 (fr) * 2017-12-04 2019-06-14 Fond Luc Montagnier Procédé de détection de la présence d'un élément biochimique.
CN111492068A (zh) 2017-12-19 2020-08-04 贝克顿迪金森公司 与寡核苷酸相关联的颗粒
EP3802870A4 (de) * 2018-06-11 2022-03-23 Monoquant PTY LTD Amplifikationsverfahren und primer dafür
CN110656161B (zh) * 2018-06-28 2022-12-13 苏州云泰生物医药科技有限公司 用于检测人免疫球蛋白基因重排的毛细管电泳试剂盒及其使用方法
EP3824103A1 (de) * 2018-07-18 2021-05-26 Life Technologies Corporation Zusammensetzungen und verfahren zur sequenzierung des immunrepertoires
WO2020146740A1 (en) 2019-01-10 2020-07-16 Iovance Biotherapeutics, Inc. System and methods for monitoring adoptive cell therapy clonality and persistence
WO2020150356A1 (en) 2019-01-16 2020-07-23 Becton, Dickinson And Company Polymerase chain reaction normalization through primer titration
WO2023076832A1 (en) * 2021-10-25 2023-05-04 Singular Genomics Systems, Inc. Manipulating and detecting biological samples
CN113957128A (zh) * 2021-12-21 2022-01-21 迈杰转化医学研究(苏州)有限公司 一种核酸完整性评估试剂盒及评估方法
WO2024182219A1 (en) 2023-02-27 2024-09-06 Adaptive Biotechnologies Corp. Therapeutic t cell receptors targeting kras g12d
CN117363722A (zh) * 2023-12-07 2024-01-09 北京旌准医疗科技有限公司 一种用于检测igk和igl基因的引物组合及其应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2781438B2 (ja) * 1988-10-20 1998-07-30 モーリィ，アリグザンダー，アラン 白血病及びリンパ腫におけるモノクローナリテイーの診断法
IT1244983B (it) * 1991-04-29 1994-09-13 Raggio Italgene Spa Procedimento per rivelare sequenze di acidi nucleici e kit per la sua utilizzazione.
US5472693A (en) * 1993-02-16 1995-12-05 The Dow Chemical Company Family of anti-carcinoembryonic antigen chimeric antibodies
FR2724182B1 (fr) * 1994-09-02 1996-12-13 Pasteur Institut Obtention d'un anticorps monoclonal recombinant a partir d'un anticorps monoclonal humain anti-rhesus d, sa production en cellules d'insecte, et ses utilisations
US20020150891A1 (en) * 1994-09-19 2002-10-17 Leroy E. Hood Diagnostic and therapeutic compositions and methods which utilize the t cell receptor beta gene region
US6087096A (en) 1995-11-13 2000-07-11 Dau; Peter C. Method of intrafamily fragment analysis of the T cell receptor α and β chain CDR3 regions
AU776049B2 (en) * 1998-10-09 2004-08-26 United Kingdom Research And Innovation Method for generating diversity
WO2000028086A1 (en) * 1998-11-06 2000-05-18 Ivs Technologies Llc Methods and compositions for diagnostic assays
DK1218542T3 (da) 1999-09-13 2004-08-02 Nugen Technologies Inc Fremgangsmåder og sammensætninger til lineær isotermisk amplifikation af polynukleotidsekvenser
JP2004506414A (ja) * 2000-06-28 2004-03-04 アセンデイア　アクチエボラグ Ｄｎａ／ｒｎａ組み込み媒体およびその使用法

Also Published As

Publication number Publication date
WO2004033728A3 (en) 2004-08-12
AU2003300565A1 (en) 2004-05-04
CA2501863A1 (en) 2004-04-22
ES2354068T3 (es) 2011-03-09
US10280462B2 (en) 2019-05-07
EP2418287A3 (de) 2012-07-04
EP1549764A2 (de) 2005-07-06
EP1549764B1 (de) 2010-10-06
HK1171794A1 (en) 2013-04-05
US20200172973A1 (en) 2020-06-04
US20150099646A1 (en) 2015-04-09
DK2418287T3 (da) 2013-12-16
EP2418287B1 (de) 2013-09-18
JP4708029B2 (ja) 2011-06-22
EP2460889B1 (de) 2013-11-20
EP2460889A2 (de) 2012-06-06
CN1965089A (zh) 2007-05-16
EP2460889A3 (de) 2012-07-04
DK1549764T3 (da) 2011-01-24
HK1167436A1 (en) 2012-11-30
ES2442791T3 (es) 2014-02-13
WO2004033728A2 (en) 2004-04-22
EP2418287A2 (de) 2012-02-15
DE60334471D1 (de) 2010-11-18
US8859748B2 (en) 2014-10-14
JP2006501842A (ja) 2006-01-19
US20060234234A1 (en) 2006-10-19
ES2438782T3 (es) 2014-01-20

Similar Documents

Publication Publication Date Title
DE60334471D1 (de) Primer für nukleinsäureamplifikation in pcr-basierten klonalitätsstudien
ATE137269T1 (de) Verbessertes verfahren zur amplifikation von nuklein säurezielsequenz, einsetzbar für die polymerase und ligasekettenreaktion
EP2272952B8 (de) Thermostabiler oder thermoactiver DNA-polymerase mit abgeschwächter 3'-5' Exonukleaseaktivität
ATE207543T1 (de) Isotherme amplifikation von nukleinsäuren durch strangverdrängung
NZ244071A (en) Oligonucleotide probe composition and kit for detecting hepatitis c
DE69834056D1 (de) De novo oder "universaler" sequenzierungs-array
DK0550696T3 (da) Oprenset termostabilt nukleinsyre-polymeraseenzym fra Thermosipho africanus
ATE518004T1 (de) Standardisiertes und optimiertes quantitatives reverse-transkriptase echtzeit- polymerasekettenreaktion verfahren zum nachweis von minimalen resterkrankungen bei leukämie
ES2151002T3 (es) Deteccion del treponema pallidum y haemophilus ducreyi.
AU650055B2 (en) Nucleotide sequences useful as type-specific probes, PCR primers and LCR probes for the amplification and detection of human papilloma virus, and related kits and methods
ATE345400T1 (de) Primern zum nachweis von hiv-1
ATE478961T1 (de) Methode zur amplifizierung von hla klasse i allelen
ES2286212T3 (es) Secuencias suprimidas especificamente del genoma de mycobacterium tuberculosis, y su uso en el diagnostico y como vacunas.
AU2003234932A1 (en) Nucleic acid amplification primers for detecting cytokeratins and examination method with the use of the primers
DE69425386D1 (de) Nukleotidsonden
Gasser et al. Screening for nucleotide variations in ribosomal DNA arrays of Oesophagostomum bifurcum by polymerase chain reaction‐coupled single‐strand conformation polymorphism
DE69231608D1 (de) Verfahren und mittel für die analyse von genetischem polymorphismus des angiotensin-umwandlungs-enzyms i
SE9002060D0 (sv) A method of detecting an infection caused by a specific type of virus, primers, probes and a test kit
KR920019935A (ko) 쭈쭈가무시균의 종 특이 dna염기서열 및 이를 이용한 쭈쭈가무시병의 진단방법
RU93013954A (ru) Способ обнаружения вируса иммунодефицита

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1549764

Country of ref document: EP