ATE44384T1 - Methode zur selektiven methylierung von erythromycin a-derivaten. - Google Patents

Methode zur selektiven methylierung von erythromycin a-derivaten.

Info

Publication number
ATE44384T1
ATE44384T1 AT85301997T AT85301997T ATE44384T1 AT E44384 T1 ATE44384 T1 AT E44384T1 AT 85301997 T AT85301997 T AT 85301997T AT 85301997 T AT85301997 T AT 85301997T AT E44384 T1 ATE44384 T1 AT E44384T1
Authority
AT
Austria
Prior art keywords
erythromycin
derivatives
selective methylation
methylation
selective
Prior art date
Application number
AT85301997T
Other languages
English (en)
Inventor
Yoshiaki Watanabe
Shigeo Morimoto
Masami Goi
Morihiro Mitsukuchi
Takashi Adachi
Jozi Nakagami
Toshifumi Asaka
Tadashi Eguchi
Kaoru Sota
Original Assignee
Taisho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=13375748&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE44384(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Taisho Pharmaceutical Co Ltd filed Critical Taisho Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ATE44384T1 publication Critical patent/ATE44384T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT85301997T 1984-04-06 1985-03-22 Methode zur selektiven methylierung von erythromycin a-derivaten. ATE44384T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP59068509A JPS60214796A (ja) 1984-04-06 1984-04-06 ６−０−メチルエリスロマイシン類の製法
EP85301997A EP0158467B1 (de) 1984-04-06 1985-03-22 Methode zur selektiven Methylierung von Erythromycin A-Derivaten

Publications (1)

Publication Number Publication Date
ATE44384T1 true ATE44384T1 (de) 1989-07-15

Family

ID=13375748

Family Applications (1)

Application Number Title Priority Date Filing Date
AT85301997T ATE44384T1 (de) 1984-04-06 1985-03-22 Methode zur selektiven methylierung von erythromycin a-derivaten.

Country Status (17)

Country Link
US (1) US4672109A (de)
EP (1) EP0158467B1 (de)
JP (1) JPS60214796A (de)
KR (1) KR910007572B1 (de)
AR (1) AR240833A1 (de)
AT (1) ATE44384T1 (de)
AU (1) AU567803B2 (de)
CA (1) CA1225637A (de)
DE (1) DE3571323D1 (de)
DK (1) DK172481B1 (de)
ES (1) ES541898A0 (de)
FI (1) FI77250C (de)
GE (1) GEP19960318B (de)
HK (1) HK99694A (de)
PT (1) PT80237B (de)
SU (1) SU1577700A3 (de)
ZA (1) ZA852349B (de)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61103890A (ja) * 1984-10-26 1986-05-22 Taisho Pharmaceut Co Ltd ６−０−メチルエリスロマイシンａ誘導体
GB8506380D0 (en) * 1985-03-12 1985-04-11 Beecham Group Plc Chemical compounds
NO860901L (no) 1985-03-12 1986-09-15 Beecham Group Plc Fremgangsmaate for fremstilling av farmasoeytisk aktive erytromycinderivater.
US4670549A (en) * 1985-03-18 1987-06-02 Taisho Pharmaceutical Co., Ltd. Method for selective methylation of erythromycin a derivatives
US4833236A (en) * 1986-05-02 1989-05-23 Taisho Pharmaceutical Co., Ltd. Erythromycin derivatives
DE3782994T2 (de) * 1986-09-18 1993-04-08 Taisho Pharmaceutical Co Ltd Erythromycin-a-derivate und verfahren zu ihrer herstellung.
KR960000434B1 (ko) * 1986-12-17 1996-01-06 다이쇼 세이야꾸 가부시끼가이샤 에리스로마이신 a유도체 및 그의 제조 방법
JP2751385B2 (ja) * 1988-05-19 1998-05-18 大正製薬株式会社 エリスロマイシンａオキシム及びその塩の製造方法
US5302705A (en) * 1989-10-07 1994-04-12 Taisho Pharmaceutical Co., Ltd. 6-O-methylerythromycin a oxime derivatives
US5872229A (en) * 1995-11-21 1999-02-16 Abbott Laboratories Process for 6-O-alkylation of erythromycin derivatives
US5756473A (en) * 1995-11-21 1998-05-26 Abbott Laboratories 6-O-methyl erythromycin D and process for making
US5719272A (en) * 1996-04-02 1998-02-17 Abbott Laboratories 2'-protected 3'-dimethylamine, 9-etheroxime erythromycin A derivatives
US5808017A (en) * 1996-04-10 1998-09-15 Abbott Laboratories Process for preparing erythromycin A oxime
ATE272646T1 (de) * 1996-07-29 2004-08-15 Abbott Lab Herstellung von kristallinen form ii von clarithromycin
US5858986A (en) * 1996-07-29 1999-01-12 Abbott Laboratories Crystal form I of clarithromycin
US5945405A (en) * 1997-01-17 1999-08-31 Abbott Laboratories Crystal form O of clarithromycin
US5864023A (en) * 1997-02-13 1999-01-26 Abbott Laboratories 3'-N'oxide, 3'-n-dimethylamine, 9-oxime erythromycin a derivatives
US5929219A (en) * 1997-09-10 1999-07-27 Abbott Laboratories 9-hydrazone and 9-azine erythromycin derivatives and a process of making the same
US5852180A (en) * 1997-11-17 1998-12-22 Abbott Laboratories Chemical synthesis of 6-O-alkyl erythromycin A
US5932710A (en) 1997-12-01 1999-08-03 Abbott Laboratories Process for preparing 6-O-alkyl-9-oxime erythromycin B
IL135792A0 (en) * 1997-12-01 2001-05-20 Abbott Lab 6-o-alkyl derivatives of erythronolide b
IL124084A0 (en) * 1998-04-14 1999-04-11 Chemagis Ltd Erythromycin a derivatives and methods for the preparation thereof
IL125372A0 (en) * 1998-07-15 1999-03-12 Chemagis Ltd Erythromycin derivatives and methods for the preparation thereof
KR100283990B1 (ko) * 1998-12-29 2001-03-02 민경윤 에리스로마이신 a 유도체 및 그의 제조방법
SI20150A (sl) * 1999-02-19 2000-08-31 Lek, Tovarna Farmacevtskih In Direktno stisljivi matriks za nadzorovano sproščanje celodnevne doze klaritromicina
US6437106B1 (en) 1999-06-24 2002-08-20 Abbott Laboratories Process for preparing 6-o-substituted erythromycin derivatives
KR20010008496A (ko) * 1999-07-01 2001-02-05 유충식 6-오-메틸 에리트로마이신의 제조방법
US6627743B1 (en) 1999-12-03 2003-09-30 Abbott Laboratories 6-O-methylerythromycin A crystal form III
EP1254146B1 (de) * 1999-12-16 2005-08-24 Teva Pharmaceutical Industries Ltd. Verfahren zur herstllung von clarithromycin polymorphen und polymorph iv
PT1280535E (pt) 2000-01-11 2005-04-29 Teva Pharma Processos para a preparacao de polimorfos de claritromicina
US6544555B2 (en) 2000-02-24 2003-04-08 Advancis Pharmaceutical Corp. Antibiotic product, use and formulation thereof
US6565882B2 (en) 2000-02-24 2003-05-20 Advancis Pharmaceutical Corp Antibiotic composition with inhibitor
CA2401571A1 (en) 2000-02-29 2001-09-07 Ilya Avrutov Processes for preparing clarithromycin and clarithromycin intermediate, essentially oxime-free clarithromycin, and pharmaceutical composition comprising the same
BR0109194A (pt) * 2000-03-15 2003-02-11 Hanmi Pharm Ind Co Ltd Método para preparar claritromicina em cristais da forma ii
DE60102232T2 (de) 2000-05-15 2005-02-24 Ranbaxy Laboratories, Ltd. Kosteneffektive methode zur selektiven methylierung von erythromycin a-derivaten
AU2001280000A1 (en) 2000-08-23 2002-03-04 Jaweed Mukarram, Siddiqui Mohammed Process for preparation of anhydrous azithromycin
US6541014B2 (en) 2000-10-13 2003-04-01 Advancis Pharmaceutical Corp. Antiviral product, use and formulation thereof
US20020068078A1 (en) 2000-10-13 2002-06-06 Rudnic Edward M. Antifungal product, use and formulation thereof
WO2003082241A2 (en) * 2002-04-03 2003-10-09 Ranbaxy Laboratories Limited Clarithromycin formulations having improved bioavailability
US6843854B2 (en) 2002-05-31 2005-01-18 Purdue Research Foundation Method and apparatus for separating a component from a mixture
ES2221807B1 (es) * 2003-06-24 2005-12-16 Ercros Industrial, S.A. Un procedimiento para la obtencion de claritromicina.
WO2005009364A2 (en) 2003-07-21 2005-02-03 Advancis Pharmaceutical Corporation Antibiotic product, use and formulation thereof
EP1648407A4 (de) 2003-07-21 2011-08-31 Middlebrook Pharmaceuticals Inc Antibiotisches produkt, seine verwendung und formulierung
JP2006528189A (ja) 2003-07-21 2006-12-14 アドバンシス ファーマスーティカル コーポレイション 抗生物質産物、その使用法および製剤
EP1653925A1 (de) 2003-08-11 2006-05-10 Advancis Pharmaceutical Corporation Robustes pellet
JP2007502294A (ja) 2003-08-12 2007-02-08 アドバンシス ファーマスーティカル コーポレイション 抗生物質製剤、その使用法及び作成方法
EP1658034A4 (de) 2003-08-29 2011-06-22 Middlebrook Pharmaceuticals Inc Antibiotisches produkt, seine verwendung und formulierung
CA2538064C (en) 2003-09-15 2013-12-17 Advancis Pharmaceutical Corporation Antibiotic product, use and formulation thereof
WO2006014427A1 (en) 2004-07-02 2006-02-09 Advancis Pharmaceutical Corporation Tablet for pulsed delivery
US20060111560A1 (en) * 2004-11-01 2006-05-25 Glenmark Pharmaceuticals Limited Process for the preparation of crystalline form II of clarithromycin
US8357394B2 (en) 2005-12-08 2013-01-22 Shionogi Inc. Compositions and methods for improved efficacy of penicillin-type antibiotics
US8778924B2 (en) 2006-12-04 2014-07-15 Shionogi Inc. Modified release amoxicillin products
CN103193840A (zh) 2006-05-01 2013-07-10 大正制药株式会社 大环内酯衍生物
US8299052B2 (en) * 2006-05-05 2012-10-30 Shionogi Inc. Pharmaceutical compositions and methods for improved bacterial eradication
WO2009023191A2 (en) * 2007-08-09 2009-02-19 Teva Pharmaceutical Industries Ltd. An improved process for the preparation of clarithromycin

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1100504A (en) * 1967-08-16 1968-01-24 Pliva Pharm & Chem Works Erythromycin oxime and 9-amino-3-o-cladinosyl-5-o-desosaminyl-6,11,12-trihydroxy-2,4,6,8,10,12-hexamethylpentadecane-13-olide
US4166901A (en) * 1978-01-03 1979-09-04 Pfizer Inc. 4"-Deoxy-4"-arylglyoxamido- and aroylthioformamido derivatives of oleandomycin and its esters
FR2473525A1 (fr) * 1980-01-11 1981-07-17 Roussel Uclaf Nouvelles oximes derivees de l'erythromycine, leur procede de preparation et leur application comme medicaments
US4331803A (en) * 1980-06-04 1982-05-25 Taisho Pharmaceutical Co., Ltd. Novel erythromycin compounds
JPS5896095A (ja) * 1981-11-30 1983-06-07 Taisho Pharmaceut Co Ltd １１−ｏ−アルキルエリスロマイシンａ誘導体
JPS5896097A (ja) * 1981-12-01 1983-06-07 Taisho Pharmaceut Co Ltd エリスロマイシンｂ誘導体
JPS5896098A (ja) * 1981-12-03 1983-06-07 Taisho Pharmaceut Co Ltd エリスロマイシンａ誘導体
US4382085A (en) * 1982-03-01 1983-05-03 Pfizer Inc. 4"-Epi erythromycin A and derivatives thereof as useful antibacterial agents
IL75908A0 (en) * 1984-08-31 1985-12-31 Abbott Lab Macrolide alkylation process

Also Published As

Publication number Publication date
DK172481B1 (da) 1998-11-23
DE3571323D1 (en) 1989-08-10
CA1225637A (en) 1987-08-18
DK152385A (da) 1985-10-07
DK152385D0 (da) 1985-04-03
ES8602839A1 (es) 1985-12-01
PT80237A (en) 1985-05-01
GEP19960318B (en) 1996-06-24
KR910007572B1 (ko) 1991-09-28
FI851376A0 (fi) 1985-04-04
SU1577700A3 (ru) 1990-07-07
FI77250B (fi) 1988-10-31
EP0158467A2 (de) 1985-10-16
ES541898A0 (es) 1985-12-01
FI77250C (fi) 1989-02-10
JPS60214796A (ja) 1985-10-28
EP0158467B1 (de) 1989-07-05
US4672109A (en) 1987-06-09
JPH053475B2 (de) 1993-01-14
KR850007434A (ko) 1985-12-04
PT80237B (pt) 1987-06-17
EP0158467A3 (en) 1986-03-19
ZA852349B (en) 1985-11-27
AR240833A1 (es) 1991-02-28
HK99694A (en) 1994-09-23
AU4037885A (en) 1985-10-10
AU567803B2 (en) 1987-12-03
FI851376L (fi) 1985-10-07

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Legal Events

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EELA Cancelled due to lapse of time