DK152385A - Fremgangsmaade til selektiv methylering af erythromycin-a derivater - Google Patents

Fremgangsmaade til selektiv methylering af erythromycin-a derivater Download PDF

Info

Publication number
DK152385A
DK152385A DK152385A DK152385A DK152385A DK 152385 A DK152385 A DK 152385A DK 152385 A DK152385 A DK 152385A DK 152385 A DK152385 A DK 152385A DK 152385 A DK152385 A DK 152385A
Authority
DK
Denmark
Prior art keywords
erythromycin
derivatives
procedure
selective methylation
methylation
Prior art date
Application number
DK152385A
Other languages
English (en)
Other versions
DK172481B1 (da
DK152385D0 (da
Inventor
Yoshiaki Watanabe
Shigeo Morimoto
Masami Goi
Takashi Adachi
Jozi Nakagami
Morihiro Mitsukuchi
Toshifumi Asaka
Tadashi Eguchi
Kaoru Sota
Original Assignee
Taisho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=13375748&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK152385(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Taisho Pharmaceutical Co Ltd filed Critical Taisho Pharmaceutical Co Ltd
Publication of DK152385D0 publication Critical patent/DK152385D0/da
Publication of DK152385A publication Critical patent/DK152385A/da
Application granted granted Critical
Publication of DK172481B1 publication Critical patent/DK172481B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK198501523A 1984-04-06 1985-04-03 Fremgangsmåde til selektiv methylering af erythromycin A-derivater DK172481B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP59068509A JPS60214796A (ja) 1984-04-06 1984-04-06 ６−０−メチルエリスロマイシン類の製法
JP6850984 1984-04-06

Publications (3)

Publication Number Publication Date
DK152385D0 DK152385D0 (da) 1985-04-03
DK152385A true DK152385A (da) 1985-10-07
DK172481B1 DK172481B1 (da) 1998-11-23

Family

ID=13375748

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198501523A DK172481B1 (da) 1984-04-06 1985-04-03 Fremgangsmåde til selektiv methylering af erythromycin A-derivater

Country Status (17)

Country Link
US (1) US4672109A (da)
EP (1) EP0158467B1 (da)
JP (1) JPS60214796A (da)
KR (1) KR910007572B1 (da)
AR (1) AR240833A1 (da)
AT (1) ATE44384T1 (da)
AU (1) AU567803B2 (da)
CA (1) CA1225637A (da)
DE (1) DE3571323D1 (da)
DK (1) DK172481B1 (da)
ES (1) ES8602839A1 (da)
FI (1) FI77250C (da)
GE (1) GEP19960318B (da)
HK (1) HK99694A (da)
PT (1) PT80237B (da)
SU (1) SU1577700A3 (da)
ZA (1) ZA852349B (da)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61103890A (ja) * 1984-10-26 1986-05-22 Taisho Pharmaceut Co Ltd ６−０−メチルエリスロマイシンａ誘導体
GB8506380D0 (en) * 1985-03-12 1985-04-11 Beecham Group Plc Chemical compounds
GR860655B (en) 1985-03-12 1986-07-11 Beecham Group Plc Chemical compounds
US4670549A (en) * 1985-03-18 1987-06-02 Taisho Pharmaceutical Co., Ltd. Method for selective methylation of erythromycin a derivatives
US4833236A (en) * 1986-05-02 1989-05-23 Taisho Pharmaceutical Co., Ltd. Erythromycin derivatives
DE3782994T2 (de) * 1986-09-18 1993-04-08 Taisho Pharmaceutical Co Ltd Erythromycin-a-derivate und verfahren zu ihrer herstellung.
KR960000434B1 (ko) * 1986-12-17 1996-01-06 다이쇼 세이야꾸 가부시끼가이샤 에리스로마이신 a유도체 및 그의 제조 방법
JP2751385B2 (ja) * 1988-05-19 1998-05-18 大正製薬株式会社 エリスロマイシンａオキシム及びその塩の製造方法
US5302705A (en) * 1989-10-07 1994-04-12 Taisho Pharmaceutical Co., Ltd. 6-O-methylerythromycin a oxime derivatives
US5872229A (en) * 1995-11-21 1999-02-16 Abbott Laboratories Process for 6-O-alkylation of erythromycin derivatives
US5756473A (en) * 1995-11-21 1998-05-26 Abbott Laboratories 6-O-methyl erythromycin D and process for making
US5719272A (en) * 1996-04-02 1998-02-17 Abbott Laboratories 2'-protected 3'-dimethylamine, 9-etheroxime erythromycin A derivatives
US5808017A (en) * 1996-04-10 1998-09-15 Abbott Laboratories Process for preparing erythromycin A oxime
US5858986A (en) * 1996-07-29 1999-01-12 Abbott Laboratories Crystal form I of clarithromycin
DE29724846U1 (de) * 1996-07-29 2004-12-16 Abbott Laboratories, Abbott Park Herstellung von kristalliner Form II von Clarithromycin
US5945405A (en) 1997-01-17 1999-08-31 Abbott Laboratories Crystal form O of clarithromycin
US5864023A (en) * 1997-02-13 1999-01-26 Abbott Laboratories 3'-N'oxide, 3'-n-dimethylamine, 9-oxime erythromycin a derivatives
US5929219A (en) * 1997-09-10 1999-07-27 Abbott Laboratories 9-hydrazone and 9-azine erythromycin derivatives and a process of making the same
US5852180A (en) * 1997-11-17 1998-12-22 Abbott Laboratories Chemical synthesis of 6-O-alkyl erythromycin A
IL135792A0 (en) * 1997-12-01 2001-05-20 Abbott Lab 6-o-alkyl derivatives of erythronolide b
US5932710A (en) * 1997-12-01 1999-08-03 Abbott Laboratories Process for preparing 6-O-alkyl-9-oxime erythromycin B
IL124084A0 (en) * 1998-04-14 1999-04-11 Chemagis Ltd Erythromycin a derivatives and methods for the preparation thereof
IL125372A0 (en) * 1998-07-15 1999-03-12 Chemagis Ltd Erythromycin derivatives and methods for the preparation thereof
KR100283990B1 (ko) * 1998-12-29 2001-03-02 민경윤 에리스로마이신 a 유도체 및 그의 제조방법
SI20150A (sl) * 1999-02-19 2000-08-31 Lek, Tovarna Farmacevtskih In Direktno stisljivi matriks za nadzorovano sproščanje celodnevne doze klaritromicina
US6437106B1 (en) 1999-06-24 2002-08-20 Abbott Laboratories Process for preparing 6-o-substituted erythromycin derivatives
KR20010008496A (ko) * 1999-07-01 2001-02-05 유충식 6-오-메틸 에리트로마이신의 제조방법
US6627743B1 (en) 1999-12-03 2003-09-30 Abbott Laboratories 6-O-methylerythromycin A crystal form III
YU45602A (sh) * 1999-12-16 2005-06-10 Teva Pharmaceutical Industries Ltd. Postupci za dobijanje polimorfa klaritromicina i novi polimorf iv
ATE288758T1 (de) 2000-01-11 2005-02-15 Teva Pharma Verfahren zur herstellung von polymorphen des clarithromycins
US6544555B2 (en) 2000-02-24 2003-04-08 Advancis Pharmaceutical Corp. Antibiotic product, use and formulation thereof
US6565882B2 (en) 2000-02-24 2003-05-20 Advancis Pharmaceutical Corp Antibiotic composition with inhibitor
AU2578701A (en) 2000-02-29 2001-09-12 Teva Pharma Processes for preparing clarithromycin and clarithromycin intermediate, essentially oxime-free clarithromycin, and pharmaceutical composition comprising the same
RU2230748C2 (ru) * 2000-03-15 2004-06-20 Ханми Фарм. Ко., Лтд. Способ получения кларитромицина в виде кристаллов формы ii
US6900296B2 (en) 2000-05-15 2005-05-31 Ranbaxy Laboratories Limited Cost effective method for selective methylation of erythromycin A derivatives
WO2002015842A2 (en) 2000-08-23 2002-02-28 Wockhardt Limited Process for preparation of anhydrous azithromycin
US20020068078A1 (en) 2000-10-13 2002-06-06 Rudnic Edward M. Antifungal product, use and formulation thereof
US6541014B2 (en) 2000-10-13 2003-04-01 Advancis Pharmaceutical Corp. Antiviral product, use and formulation thereof
AU2003214506A1 (en) * 2002-04-03 2003-10-13 Ranbaxy Laboratories Limited Clarithromycin formulations having improved bioavailability
US6843854B2 (en) 2002-05-31 2005-01-18 Purdue Research Foundation Method and apparatus for separating a component from a mixture
ES2221807B1 (es) * 2003-06-24 2005-12-16 Ercros Industrial, S.A. Un procedimiento para la obtencion de claritromicina.
US8425936B2 (en) 2003-07-21 2013-04-23 Shionogi Inc. Antibiotic product, use and formulation thereof
EP1648407A4 (en) 2003-07-21 2011-08-31 Middlebrook Pharmaceuticals Inc ANTIBIOTIC PRODUCT, CORRESPONDING USE AND FORMULATION
JP2006528189A (ja) 2003-07-21 2006-12-14 アドバンシス ファーマスーティカル コーポレイション 抗生物質産物、その使用法および製剤
AU2004264939A1 (en) 2003-08-11 2005-02-24 Middlebrook Pharmaceuticals, Inc. Robust pellet
US8062672B2 (en) 2003-08-12 2011-11-22 Shionogi Inc. Antibiotic product, use and formulation thereof
WO2005023184A2 (en) 2003-08-29 2005-03-17 Advancis Pharmaceuticals Corporation Antibiotic product, use and formulation thereof
US8460710B2 (en) 2003-09-15 2013-06-11 Shionogi, Inc. Antibiotic product, use and formulation thereof
WO2006014427A1 (en) 2004-07-02 2006-02-09 Advancis Pharmaceutical Corporation Tablet for pulsed delivery
US20060111560A1 (en) * 2004-11-01 2006-05-25 Glenmark Pharmaceuticals Limited Process for the preparation of crystalline form II of clarithromycin
US8778924B2 (en) 2006-12-04 2014-07-15 Shionogi Inc. Modified release amoxicillin products
US8357394B2 (en) 2005-12-08 2013-01-22 Shionogi Inc. Compositions and methods for improved efficacy of penicillin-type antibiotics
EP2077271A4 (en) 2006-05-01 2010-09-15 Taisho Pharmaceutical Co Ltd MACROLIDE DERIVATIVE
US8299052B2 (en) * 2006-05-05 2012-10-30 Shionogi Inc. Pharmaceutical compositions and methods for improved bacterial eradication
WO2009023191A2 (en) * 2007-08-09 2009-02-19 Teva Pharmaceutical Industries Ltd. An improved process for the preparation of clarithromycin

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1100504A (en) * 1967-08-16 1968-01-24 Pliva Pharm & Chem Works Erythromycin oxime and 9-amino-3-o-cladinosyl-5-o-desosaminyl-6,11,12-trihydroxy-2,4,6,8,10,12-hexamethylpentadecane-13-olide
US4166901A (en) * 1978-01-03 1979-09-04 Pfizer Inc. 4"-Deoxy-4"-arylglyoxamido- and aroylthioformamido derivatives of oleandomycin and its esters
FR2473525A1 (fr) * 1980-01-11 1981-07-17 Roussel Uclaf Nouvelles oximes derivees de l'erythromycine, leur procede de preparation et leur application comme medicaments
US4331803A (en) * 1980-06-04 1982-05-25 Taisho Pharmaceutical Co., Ltd. Novel erythromycin compounds
JPS5896095A (ja) * 1981-11-30 1983-06-07 Taisho Pharmaceut Co Ltd １１−ｏ−アルキルエリスロマイシンａ誘導体
JPS5896097A (ja) * 1981-12-01 1983-06-07 Taisho Pharmaceut Co Ltd エリスロマイシンｂ誘導体
JPS5896098A (ja) * 1981-12-03 1983-06-07 Taisho Pharmaceut Co Ltd エリスロマイシンａ誘導体
US4382085A (en) * 1982-03-01 1983-05-03 Pfizer Inc. 4"-Epi erythromycin A and derivatives thereof as useful antibacterial agents
IL75908A0 (en) * 1984-08-31 1985-12-31 Abbott Lab Macrolide alkylation process

Also Published As

Publication number Publication date
ES541898A0 (es) 1985-12-01
DE3571323D1 (en) 1989-08-10
SU1577700A3 (ru) 1990-07-07
ATE44384T1 (de) 1989-07-15
EP0158467A2 (en) 1985-10-16
AR240833A1 (es) 1991-02-28
US4672109A (en) 1987-06-09
FI77250B (fi) 1988-10-31
JPS60214796A (ja) 1985-10-28
ES8602839A1 (es) 1985-12-01
CA1225637A (en) 1987-08-18
FI851376A0 (fi) 1985-04-04
FI77250C (fi) 1989-02-10
AU4037885A (en) 1985-10-10
JPH053475B2 (da) 1993-01-14
AU567803B2 (en) 1987-12-03
PT80237B (pt) 1987-06-17
GEP19960318B (en) 1996-06-24
EP0158467B1 (en) 1989-07-05
EP0158467A3 (en) 1986-03-19
KR850007434A (ko) 1985-12-04
PT80237A (en) 1985-05-01
ZA852349B (en) 1985-11-27
DK172481B1 (da) 1998-11-23
DK152385D0 (da) 1985-04-03
HK99694A (en) 1994-09-23
KR910007572B1 (ko) 1991-09-28
FI851376L (fi) 1985-10-07

Similar Documents

Publication Publication Date Title
DK152385D0 (da) Fremgangsmaade til selektiv methylering af erythromycin-a derivater
DK121586A (da) Fremgangsmaade til selektiv methylering af erythromycinderivater
DK76286D0 (da) Derivater af humant alfa1-antitrypsin og fremgangsmaade til fremstilling deraf
DK343682A (da) Fremgangsmaade til fremstilling af thiazolidinylalkylen-piperazin-derivater
DK155984A (da) Fremgangsmaade til fremstilling af thiadiazolderivater
DK165984C (da) Fremgangsmaade til fremstilling af sphingosinderivater
DK350883D0 (da) Fremgangsmade til fremstilling af mycaminosyltylonolid og beslaegtede macrolidderivater og mellemprodukter herved
DK140584D0 (da) Fremgangsmaade til fremstilling af carbapenemderivater
DK312584D0 (da) Fremgangsmaade til fremstilling af quinonderivater
DK454085A (da) Monotertiaeralkylderivater af toluendiamin
DK531085A (da) Fremgangsmaade til fremstilling af hydroquinonderivater
DK516286D0 (da) Fremgangsmaade til fremstilling af oxazolderivater
DK38493A (da) Fremgangsmaade til fremstilling af alkoxymethylether- og alkoxymethylesterderivater af glyceroler
DK343782A (da) Fremgangsmaade til fremstilling af spirothiazolidinyl-piperazin-derivater
DK343386D0 (da) Fremgangsmaade til fremstilling af 2-cyanamino-pyrimidin-derivater
DK44985D0 (da) Apparat til afskaering af stykker af forudbestemt laengde
DK382886A (da) Fremgangsmaade til fremstilling af hormonfaktorderivater
DK158224C (da) Fremgangsmaade til fremstilling af indolderivater
DK270585A (da) Fremgangsmaade til fremstilling af aminderivater
DK450285D0 (da) Fremgangsmaade til fremstilling af pyrazolonderivater
DK493384D0 (da) Fremgangsmaade til fremstilling af bis-dioxopiperazin-derivater
DK291785A (da) Fremgangsmaade til fremstilling af iminderivater
DK75985D0 (da) Fremgangsmaade til fremstilling af et ethendiaminderivat
DK64085A (da) Fremgangsmaade til fremstilling af imidazolderivater
DK348886D0 (da) Fremgangsmaade til fremstilling af benzenderivater

Legal Events

Date Code Title Description
PBP Patent lapsed
PUP Patent expired