ATE443767T1 - Kostengünstige herstellung von peptiden - Google Patents
Kostengünstige herstellung von peptidenInfo
- Publication number
- ATE443767T1 ATE443767T1 AT03726398T AT03726398T ATE443767T1 AT E443767 T1 ATE443767 T1 AT E443767T1 AT 03726398 T AT03726398 T AT 03726398T AT 03726398 T AT03726398 T AT 03726398T AT E443767 T1 ATE443767 T1 AT E443767T1
- Authority
- AT
- Austria
- Prior art keywords
- peptides
- multimers
- subject invention
- amps
- subject
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 8
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 7
- 102000044503 Antimicrobial Peptides Human genes 0.000 abstract 5
- 108700042778 Antimicrobial Peptides Proteins 0.000 abstract 5
- 102000037865 fusion proteins Human genes 0.000 abstract 2
- 108020001507 fusion proteins Proteins 0.000 abstract 2
- 239000000178 monomer Substances 0.000 abstract 2
- 241000589540 Pseudomonas fluorescens Species 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4723—Cationic antimicrobial peptides, e.g. defensins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/35—Fusion polypeptide containing a fusion for enhanced stability/folding during expression, e.g. fusions with chaperones or thioredoxin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Analytical Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37464402P | 2002-04-22 | 2002-04-22 | |
| PCT/US2003/012407 WO2003089455A2 (en) | 2002-04-22 | 2003-04-22 | Low-cost production of peptides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE443767T1 true ATE443767T1 (de) | 2009-10-15 |
Family
ID=29251215
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03726398T ATE443767T1 (de) | 2002-04-22 | 2003-04-22 | Kostengünstige herstellung von peptiden |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US7595173B2 (de) |
| EP (1) | EP1501935B1 (de) |
| JP (1) | JP4472998B2 (de) |
| KR (1) | KR20050016362A (de) |
| CN (1) | CN100489114C (de) |
| AT (1) | ATE443767T1 (de) |
| AU (1) | AU2003228637B2 (de) |
| CA (1) | CA2482995C (de) |
| DE (1) | DE60329382D1 (de) |
| IN (1) | IN2004CH02621A (de) |
| WO (1) | WO2003089455A2 (de) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9453251B2 (en) | 2002-10-08 | 2016-09-27 | Pfenex Inc. | Expression of mammalian proteins in Pseudomonas fluorescens |
| WO2005052151A1 (en) | 2003-11-19 | 2005-06-09 | Dow Global Technologies Inc. | Improved protein expression systems |
| US7985564B2 (en) | 2003-11-21 | 2011-07-26 | Pfenex, Inc. | Expression systems with sec-system secretion |
| CN101151272A (zh) * | 2003-12-01 | 2008-03-26 | 陶氏环球技术公司 | 在假单胞菌中生产重组二十面体病毒样颗粒 |
| BRPI0506917A (pt) * | 2004-01-16 | 2007-06-05 | Dow Global Technologies Inc | expressão de proteìnas de mamìferos em pseudomonas fluorescens |
| JP2007528727A (ja) | 2004-02-27 | 2007-10-18 | ザ ダウ ケミカル カンパニー | 植物細胞における高効率ペプチド生産 |
| EP2412816B1 (de) | 2004-07-26 | 2014-12-03 | Pfenex Inc. | Verfahren zur verbesserten Proteinexpression durch Strain-Engineering |
| US20080280781A1 (en) * | 2005-01-16 | 2008-11-13 | Georgia Tech Research Corporation | Methods and Compositions for Increasing Membrane Permeability |
| EP2468869B1 (de) | 2007-01-31 | 2015-03-18 | Pfenex Inc. | Bakterielle Leader-Sequenzen für erhöhte Expression |
| EP2615172A1 (de) | 2007-04-27 | 2013-07-17 | Pfenex Inc. | Schnellscreeningverfahren für Bakterienwirte zur Identifizierung bestimmter Stämme mit verbessertem Ertrag und/oder verbesserter Qualität bei der Expression heterologer Proteine |
| US9580719B2 (en) | 2007-04-27 | 2017-02-28 | Pfenex, Inc. | Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins |
| WO2009076196A1 (en) | 2007-12-07 | 2009-06-18 | Dow Global Technologies Inc. | High copy number self-replicating plasmids in pseudomonas |
| WO2009094634A1 (en) | 2008-01-24 | 2009-07-30 | Esperance Pharmaceuticals | Lytic domain fusion constructs and methods of making and using same |
| GB0815484D0 (en) | 2008-08-26 | 2008-10-01 | Univ Leuven Kath | Antibacterial agents |
| MX2011012109A (es) * | 2009-05-15 | 2012-01-27 | Basf Se | Composiciones farmaceuticas que contienen peptidos antimicoticos. |
| WO2010139736A2 (de) * | 2009-06-03 | 2010-12-09 | Basf Se | Rekombinante herstellung von peptiden |
| EP2446028B1 (de) | 2009-06-26 | 2018-04-04 | Lysando Aktiengesellschaft | Antimikrobielle wirkstoffe |
| PL2445515T3 (pl) | 2009-06-26 | 2016-10-31 | Środki przeciwdrobnoustrojowe | |
| EP3401410B1 (de) | 2010-06-26 | 2020-12-30 | Virdia, Inc. | Verfahren zur herstellung von zuckermischungen |
| US8609621B2 (en) | 2010-11-15 | 2013-12-17 | E I Du Pont De Nemours And Company | Acid-cleavable linkers exhibiting altered rates of acid hydrolysis |
| KR102195193B1 (ko) | 2012-03-09 | 2020-12-28 | 베스타론 코포레이션 | 독성 펩타이드 제조, 식물에서의 펩타이드 발현 및 시스테인 농후 펩타이드의 조합 |
| US11692016B2 (en) | 2012-03-09 | 2023-07-04 | Vestaron Corporation | High gene expression yeast strain |
| US9492563B2 (en) | 2012-10-30 | 2016-11-15 | Esperance Pharmaceuticals, Inc. | Antibody/drug conjugates and methods of use |
| KR101830792B1 (ko) * | 2016-01-27 | 2018-02-21 | 건국대학교 산학협력단 | 항균 펩타이드를 포함하는 불용성 융합단백질 및 이를 이용한 항균 펩타이드의 제조 방법 |
| CN110267527A (zh) | 2016-10-21 | 2019-09-20 | 韦斯塔隆公司 | 可切割肽及包含可切割肽的杀昆虫和杀线虫蛋白 |
| JP2019002696A (ja) * | 2017-06-12 | 2019-01-10 | 日本電子株式会社 | 質量分析データ処理装置、質量分析システム及び質量分析データ処理方法 |
| WO2020206056A1 (en) | 2019-04-04 | 2020-10-08 | Greenvenus Llc | Peptides and methods of plant protection |
| CN110305890A (zh) * | 2019-07-02 | 2019-10-08 | 河南城建学院 | 一种新型5种抗菌肽串联表达重组工程菌构建方法及其应用 |
| US20250042946A1 (en) | 2021-12-08 | 2025-02-06 | Oakgrove Bio Llc | Biological Production of Histidine-Rich Peptides |
| CN115083176B (zh) * | 2022-06-28 | 2024-05-10 | 浙江大学 | 一种基于多任务并行控制的网联自动车群串联排列实现方法 |
| CN120882737A (zh) * | 2023-02-23 | 2025-10-31 | 微肽技术有限公司 | 控制植物病原体的抗真菌肽 |
| CN116333051A (zh) * | 2023-03-09 | 2023-06-27 | 天津科技大学 | 一种抗菌肽改造体om19r原核表达制备方法及应用 |
| WO2025093952A1 (en) * | 2023-10-30 | 2025-05-08 | Ramakrishna Reddy Isanaka | Peptide with anti-inflammatory and anti-microbial activity |
Family Cites Families (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2274344A (en) * | 1939-01-06 | 1942-02-24 | Kraft Cheese Company | Package and method of making the same |
| GB1549167A (en) * | 1975-04-11 | 1979-08-01 | Takeda Chemical Industries Ltd | Method for producing aminoglycosidec anitibiotics |
| US5206154A (en) * | 1985-01-28 | 1993-04-27 | Xoma Corporation | Method of producing cecropins by microbiological techniques |
| US5861478A (en) * | 1987-07-06 | 1999-01-19 | Helix Biomedix, Inc. | Lytic peptides |
| ATE127838T1 (de) * | 1987-07-06 | 1995-09-15 | Univ Louisiana State | Inhibierung von eukaryotischen pathogenen und neoplasmen mit lytischen peptiden. |
| CA1327311C (en) * | 1987-07-06 | 1994-03-01 | Jesse M. Jaynes | Therapeutic antimicrobial polypeptides, their use and methods for preparation |
| US6132775A (en) * | 1987-08-11 | 2000-10-17 | New York University | Therapeutic uses of biologically active bactericidal/permeability-increasing protein fragments |
| US5128130A (en) * | 1988-01-22 | 1992-07-07 | Mycogen Corporation | Hybrid Bacillus thuringiensis gene, plasmid and transformed Pseudomonas fluorescens |
| US5055294A (en) * | 1988-03-03 | 1991-10-08 | Mycogen Corporation | Chimeric bacillus thuringiensis crystal protein gene comprising hd-73 and berliner 1715 toxin genes, transformed and expressed in pseudomonas fluorescens |
| US4853334A (en) * | 1988-04-27 | 1989-08-01 | Microlife Technics, Inc. | Method for the degradation of volatile chlorinated aliphatic hydrocarbons using pseudomonas fluorescens |
| JP2854872B2 (ja) | 1989-02-02 | 1999-02-10 | マルハ株式会社 | カブトガニ血球膜由来抗菌性ペプタイドをリガンドとする不溶性担体 |
| EP1004595B1 (de) | 1989-04-10 | 2003-06-18 | Helix BioMedix, Inc. | Lytsche und proliferative Peptide und deren Verwendung als Pharmaka und Phytopharmaka |
| US5627262A (en) * | 1989-07-05 | 1997-05-06 | The Board Of Regents Of The University Of Oklahoma | Method and composition for the treatment of septic shock |
| US5169760A (en) * | 1989-07-27 | 1992-12-08 | Mycogen Corporation | Method, vectors, and host cells for the control of expression of heterologous genes from lac operated promoters |
| ATE118788T1 (de) * | 1990-06-15 | 1995-03-15 | Hoechst Schering Agrevo Gmbh | Antifungisches polypeptid, verfahren zu seiner herstellung. |
| JPH07108232B2 (ja) * | 1990-10-09 | 1995-11-22 | エム・ディ・リサーチ株式会社 | ペプチド又は蛋白質の製造方法 |
| JP3523252B2 (ja) * | 1990-11-21 | 2004-04-26 | ホウテン ファーマシューティカルズ インコーポレイテッド | 等モル多種オリゴマー混合物、特にオリゴペプチド混合物の合成 |
| US5348742A (en) * | 1991-05-24 | 1994-09-20 | Ciba-Geigy Corporation | Anti-pathogenic bacterial strains of Pseudomonas fluorescens |
| GB9115669D0 (en) | 1991-07-19 | 1991-09-04 | Sandoz Ltd | Improvements in or relating to organic compounds |
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| US5593866A (en) * | 1992-08-21 | 1997-01-14 | The University Of British Columbia | Cationic peptides and method for production |
| US5789377A (en) * | 1992-08-21 | 1998-08-04 | University Of British Columbia | Treatment of endotoxin-associated disorders with cationic peptides |
| US5496547A (en) * | 1994-01-24 | 1996-03-05 | Ciba-Geigy Corporation | Pseudomonas biocontrol strains |
| US5527883A (en) * | 1994-05-06 | 1996-06-18 | Mycogen Corporation | Delta-endotoxin expression in pseudomonas fluorescens |
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| US5985617A (en) * | 1997-02-18 | 1999-11-16 | Liao; James C. | Microorganisms and methods for overproduction of DAHP by cloned PPS gene |
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| US5944306A (en) * | 1995-11-07 | 1999-08-31 | Fuji Photo Film Co., Ltd. | Package of thermal recording sheets and magazine |
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| EP0866804B1 (de) * | 1995-12-16 | 2001-09-19 | Planton GmbH, | Gegen bakterien, mycota und viren wirksame vertebraten proteine und dessen kosmetische zubereitungen |
| AUPN861496A0 (en) | 1996-03-13 | 1996-04-04 | Commonwealth Scientific And Industrial Research Organisation | Lytic peptides |
| US5851802A (en) * | 1996-03-22 | 1998-12-22 | Xoma Corporation | Methods for recombinant microbial production of fusion proteins and BPI-derived peptides |
| DK0848064T3 (da) * | 1996-12-13 | 2002-02-04 | Hoechst Ag | Nyt antibiotikum, feglymycin, fremgangsmåde til dets fremstilling og anvendelse |
| AU6035398A (en) | 1997-01-31 | 1998-08-25 | Incyte Pharmaceuticals, Inc. | Human c5a-like receptor |
| KR100263583B1 (ko) * | 1997-05-28 | 2000-08-01 | 박종헌 | 항균 펩타이드의 대량 제조방법 및 그에 유용한 플라즈미드 벡타 |
| FR2766191B1 (fr) * | 1997-07-21 | 2000-11-10 | Ifremer | Peptides anti-microbiens de crustaces |
| WO1999048912A1 (en) | 1998-03-25 | 1999-09-30 | Korea Advanced Institute Of Science And Technology | A novel antimicrobial peptide isolated from parasilurus asotus and its uses |
| KR100319529B1 (ko) * | 1998-06-09 | 2002-01-09 | 김일웅 | 펩타이드 항생물질의 대량 생산 방법 및 그에 유용한 유전자 구조물 |
| US20020107174A1 (en) * | 1998-07-02 | 2002-08-08 | Erik J. Paus | Composition comprising endotoxin neutralizing protein and derivatives and uses thereof |
| EP1131448A2 (de) * | 1998-11-20 | 2001-09-12 | Micrologix Biotech, Inc. | Herstellung von kationischen antimikrobienpeptiden als fusionsproteinen |
| WO2000034312A1 (en) | 1998-12-10 | 2000-06-15 | Samyang Genex Corporation | Method of separating basic peptide or basic protein |
| US6242219B1 (en) * | 1999-03-18 | 2001-06-05 | Xoma (Us) Llc | Methods for recombinant peptide production |
| WO2003068948A1 (en) | 2002-02-13 | 2003-08-21 | Dow Global Technologies Inc. | Over-expression of extremozyme genes in pseudomonads and closely related bacteria |
-
2003
- 2003-04-22 DE DE60329382T patent/DE60329382D1/de not_active Expired - Lifetime
- 2003-04-22 AU AU2003228637A patent/AU2003228637B2/en not_active Expired
- 2003-04-22 CA CA2482995A patent/CA2482995C/en not_active Expired - Lifetime
- 2003-04-22 AT AT03726398T patent/ATE443767T1/de not_active IP Right Cessation
- 2003-04-22 CN CNB038145413A patent/CN100489114C/zh not_active Expired - Lifetime
- 2003-04-22 KR KR20047017047A patent/KR20050016362A/ko not_active Ceased
- 2003-04-22 WO PCT/US2003/012407 patent/WO2003089455A2/en not_active Ceased
- 2003-04-22 EP EP03726398A patent/EP1501935B1/de not_active Expired - Lifetime
- 2003-04-22 JP JP2003586175A patent/JP4472998B2/ja not_active Expired - Lifetime
-
2004
- 2004-10-22 US US10/971,444 patent/US7595173B2/en not_active Expired - Lifetime
- 2004-11-22 IN IN2621CH2004 patent/IN2004CH02621A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2003228637B2 (en) | 2010-08-05 |
| DE60329382D1 (de) | 2009-11-05 |
| IN2004CH02621A (en) | 2007-03-02 |
| US7595173B2 (en) | 2009-09-29 |
| CA2482995A1 (en) | 2003-10-30 |
| EP1501935A4 (de) | 2007-05-23 |
| JP2006504400A (ja) | 2006-02-09 |
| CA2482995C (en) | 2013-01-29 |
| US20050227321A1 (en) | 2005-10-13 |
| CN1662657A (zh) | 2005-08-31 |
| CN100489114C (zh) | 2009-05-20 |
| AU2003228637A1 (en) | 2003-11-03 |
| KR20050016362A (ko) | 2005-02-21 |
| WO2003089455A3 (en) | 2004-05-27 |
| WO2003089455A2 (en) | 2003-10-30 |
| JP4472998B2 (ja) | 2010-06-02 |
| EP1501935B1 (de) | 2009-09-23 |
| EP1501935A2 (de) | 2005-02-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |