ATE438113T1 - Thermocyclervorrichtung mit linsenvorrichtung für biologische tests - Google Patents

Thermocyclervorrichtung mit linsenvorrichtung für biologische tests

Info

Publication number
ATE438113T1
ATE438113T1 AT03753075T AT03753075T ATE438113T1 AT E438113 T1 ATE438113 T1 AT E438113T1 AT 03753075 T AT03753075 T AT 03753075T AT 03753075 T AT03753075 T AT 03753075T AT E438113 T1 ATE438113 T1 AT E438113T1
Authority
AT
Austria
Prior art keywords
biological samples
lens
sample
light
heated cover
Prior art date
Application number
AT03753075T
Other languages
English (en)
Inventor
Donald Sandell
Steven J Boege
Eugene F Young
Original Assignee
Applera Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=29418728&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE438113(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Applera Corp filed Critical Applera Corp
Application granted granted Critical
Publication of ATE438113T1 publication Critical patent/ATE438113T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/251—Colorimeters; Construction thereof
    • G01N21/253—Colorimeters; Construction thereof for batch operation, i.e. multisample apparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/046—Function or devices integrated in the closure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0654—Lenses; Optical fibres
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0829—Multi-well plates; Microtitration plates
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B3/00—Simple or compound lenses
    • G02B3/0006—Arrays
    • G02B3/0037—Arrays characterized by the distribution or form of lenses
    • G02B3/0056—Arrays characterized by the distribution or form of lenses arranged along two different directions in a plane, e.g. honeycomb arrangement of lenses
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B3/00—Simple or compound lenses
    • G02B3/02—Simple or compound lenses with non-spherical faces
    • G02B3/08—Simple or compound lenses with non-spherical faces with discontinuous faces, e.g. Fresnel lens
AT03753075T 2002-05-16 2003-05-15 Thermocyclervorrichtung mit linsenvorrichtung für biologische tests ATE438113T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/146,066 US6982166B2 (en) 2002-05-16 2002-05-16 Lens assembly for biological testing
PCT/US2003/015586 WO2003098282A1 (en) 2002-05-16 2003-05-15 Lens assembly for biological testing

Publications (1)

Publication Number Publication Date
ATE438113T1 true ATE438113T1 (de) 2009-08-15

Family

ID=29418728

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03753075T ATE438113T1 (de) 2002-05-16 2003-05-15 Thermocyclervorrichtung mit linsenvorrichtung für biologische tests

Country Status (7)

Country Link
US (4) US6982166B2 (de)
EP (3) EP1509789B8 (de)
JP (3) JP4447450B2 (de)
AT (1) ATE438113T1 (de)
AU (1) AU2003248531A1 (de)
DE (2) DE60328598D1 (de)
WO (1) WO2003098282A1 (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9157860B2 (en) 2002-05-16 2015-10-13 Applied Biosystems, Llc Achromatic lens array
US6982166B2 (en) 2002-05-16 2006-01-03 Applera Corporation Lens assembly for biological testing
US8676383B2 (en) * 2002-12-23 2014-03-18 Applied Biosystems, Llc Device for carrying out chemical or biological reactions
US7295316B2 (en) * 2004-01-14 2007-11-13 Applera Corporation Fluorescent detector with automatic changing filters
KR100817702B1 (ko) * 2005-08-05 2008-03-27 산요덴키가부시키가이샤 반응 검출 장치
JP2007046904A (ja) * 2005-08-05 2007-02-22 Sanyo Electric Co Ltd 反応検出装置
US8232091B2 (en) * 2006-05-17 2012-07-31 California Institute Of Technology Thermal cycling system
US7820428B2 (en) * 2006-06-29 2010-10-26 General Electric Company Portable light generation and detection system
WO2008151832A1 (en) * 2007-06-15 2008-12-18 Eppendorf Ag Optically accessible cover
US9370324B2 (en) 2008-11-05 2016-06-21 Fresenius Medical Care Holdings, Inc. Hemodialysis patient data acquisition, management and analysis system
DE212010000039U1 (de) * 2009-04-03 2012-02-02 Helixis, Inc. Geräte zum erhitzen biologischer proben
WO2011031377A1 (en) * 2009-09-09 2011-03-17 Helixis, Inc. Optical system for multiple reactions
EP2311909A1 (de) * 2009-10-16 2011-04-20 Nanoresins AG Hybrid-Partikel von Polymeren und Nanopartikeln
DE102010016382B4 (de) * 2010-04-09 2022-06-02 Leica Microsystems Cms Gmbh Fluoreszenzmikroskop und Verfahren zur Durchführung von Multipositionierungen in einer Screening-Applikation
US9194792B2 (en) 2010-09-07 2015-11-24 Fresenius Medical Care Holdings, Inc. Blood chamber for an optical blood monitoring system
US8743354B2 (en) 2010-09-07 2014-06-03 Fresenius Medical Care Holdings, Inc. Shrouded sensor clip assembly and blood chamber for an optical blood monitoring system
US9173988B2 (en) 2010-11-17 2015-11-03 Fresenius Medical Care Holdings, Inc. Sensor clip assembly for an optical monitoring system
AU2011329788B2 (en) 2010-11-17 2015-09-03 Fresenius Medical Care Holdings, Inc. Sensor clip assembly for an optical monitoring system
USD725261S1 (en) 2012-02-24 2015-03-24 Fresenius Medical Care Holdings, Inc. Blood flow chamber
WO2013151622A1 (en) 2012-04-03 2013-10-10 Illumina, Inc. Integrated optoelectronic read head and fluidic cartridge useful for nucleic acid sequencing
US9546771B2 (en) 2013-08-26 2017-01-17 GE Lighting Solutions, LLC Packed pillow optic array
EP3194934B1 (de) 2014-08-08 2024-03-06 Quantum-Si Incorporated Integrierte vorrichtung zur verwendung mit einer externen lichtquelle zur sondierung, detektion und analyse von molekülen mittels lumineszenzlebensdauermessungen
USD799031S1 (en) 2015-09-09 2017-10-03 Fresenius Medical Care Holdings, Inc. Blood flow chamber with directional arrow
KR101749598B1 (ko) * 2016-04-19 2017-06-22 (주)유티아이 노출패턴이 구현된 카메라 윈도우의 제조방법 및 그에 의해 제조된 노출패턴이 구현된 카메라 윈도우
US10450603B2 (en) 2016-09-12 2019-10-22 Delta Electronics Int'l (Singapore) Pte Ltd Fluorescence detection device
SG10201609334WA (en) 2016-11-08 2018-06-28 Delta Electronics Intl Singapore Pte Ltd Multi-Channel Fluorescence Detection Device
CN108375043B (zh) * 2016-11-24 2021-02-23 法雷奥照明湖北技术中心有限公司 光束调整装置、光学组件与照明和/或信号指示装置
SG10201801853WA (en) 2018-03-02 2019-10-30 Delta Electronics Int’L Singapore Pte Ltd Portable multi-color fluorescence detection device
WO2020066981A1 (ja) * 2018-09-25 2020-04-02 Ｓｃｉｖａｘ株式会社 回折光学素子およびこれを用いたドットプロジェクタ等の光学系装置
CN113454776A (zh) 2019-04-30 2021-09-28 惠普发展公司，有限责任合伙企业 模块化和平铺式光学传感器
TWI722785B (zh) 2020-01-31 2021-03-21 台達電子工業股份有限公司 光學校正工具
CN113707038A (zh) * 2020-05-22 2021-11-26 北京芯海视界三维科技有限公司 发光模组、显示模组、显示屏及显示器
WO2022140213A1 (en) * 2020-12-23 2022-06-30 Materials And Machines Corporation Of Amercia Limited well thermal cycling device
WO2023158993A2 (en) * 2022-02-15 2023-08-24 Pleno, Inc. Multiscale lens systems and methods for imaging well plates and including event-based detection

Family Cites Families (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5096807A (en) * 1985-03-06 1992-03-17 Murex Corporation Imaging immunoassay detection system with background compensation and its use
JP2666907B2 (ja) * 1986-03-05 1997-10-22 オリンパス光学工業株式会社 液晶レンズ
JP2658203B2 (ja) * 1988-06-29 1997-09-30 オムロン株式会社 マルチ・ビーム光源，ならびにそれを利用したマルチ・ビームプロジェクタおよび形状認識装置
JPH077135B2 (ja) 1989-02-09 1995-01-30 松下電器産業株式会社 光導波路および光波長変換素子および短波長レーザ光源の製造方法
JPH02280707A (ja) 1989-04-24 1990-11-16 Matsushita Seiko Co Ltd 厨芥処理装置付コンロ台
NL8901077A (nl) * 1989-04-28 1990-11-16 Koninkl Philips Electronics Nv Optische belichtingsstelsel en projectie-apparaat voorzien van een dergelijk stelsel.
JPH0678978B2 (ja) * 1990-05-25 1994-10-05 スズキ株式会社 凝集パターン検出装置
US5734496A (en) * 1991-06-03 1998-03-31 Her Majesty The Queen In Right Of New Zealand Lens system
US5370842A (en) * 1991-11-29 1994-12-06 Canon Kabushiki Kaisha Sample measuring device and sample measuring system
US5315375A (en) 1992-02-11 1994-05-24 Acrogen, Inc. Sensitive light detection system
US5745153A (en) * 1992-12-07 1998-04-28 Eastman Kodak Company Optical means for using diode laser arrays in laser multibeam printers and recorders
US5961926A (en) * 1993-09-27 1999-10-05 Packard Instrument Co., Inc. Microplate assembly and method of preparing samples for analysis in a microplate assembly
ATE198511T1 (de) 1994-04-29 2001-01-15 Perkin Elmer Corp Verfahren und vorrichtung zur echtzeiterfassung der produkte von nukleinsäureamplifikation
US5972716A (en) 1994-04-29 1999-10-26 The Perkin-Elmer Corporation Fluorescence monitoring device with textured optical tube and method for reducing background fluorescence
GB9418981D0 (en) * 1994-09-21 1994-11-09 Univ Glasgow Apparatus and method for carrying out analysis of samples
US6330017B1 (en) * 1994-10-12 2001-12-11 Ricoh Co., Ltd. Light emitting diode array head including focusing lenses
JP3561891B2 (ja) * 1995-08-25 2004-09-02 株式会社三菱化学ヤトロン マイクロプレート遮光手段及び発光測定装置
FI954512A0 (fi) * 1995-09-22 1995-09-22 Labsystems Oy Plattbaerare
US5759494A (en) * 1995-10-05 1998-06-02 Corning Incorporated Microplates which prevent optical cross-talk between wells
US5675349A (en) * 1996-02-12 1997-10-07 Boeing North American, Inc. Durable, lightweight, radar lens antenna
AU706862B2 (en) 1996-04-03 1999-06-24 Applied Biosystems, Llc Device and method for multiple analyte detection
US5914760A (en) * 1996-06-21 1999-06-22 Casio Computer Co., Ltd. Surface light source device and liquid crystal display device using the same
DE19635942A1 (de) 1996-09-05 1998-03-12 Vitaly Dr Lissotschenko Optisches Strahlformungssystem
US5780857A (en) * 1996-10-04 1998-07-14 Wallac Oy Apparatus for imaging biochemical samples on substrates
US5774214A (en) * 1996-12-12 1998-06-30 Photometrics, Ltd. Multi-mode imaging apparatus for radiation-emitting or absorbing samples
US6063338A (en) * 1997-06-02 2000-05-16 Aurora Biosciences Corporation Low background multi-well plates and platforms for spectroscopic measurements
US6008892A (en) * 1997-05-23 1999-12-28 Molecular Dynamics, Inc. Optical substrate for enhanced detectability of fluorescence
GB2326229A (en) * 1997-06-13 1998-12-16 Robert Jeffrey Geddes Carr Detecting and analysing submicron particles
DE19725050C2 (de) * 1997-06-13 1999-06-24 Fraunhofer Ges Forschung Anordnung zur Detektion biochemischer oder chemischer Substanzen mittels Fluoreszenzlichtanregung und Verfahren zu deren Herstellung
AU8102998A (en) * 1997-07-04 1999-01-25 Scan Vision Screen Aps Rear projection screen
US6258326B1 (en) * 1997-09-20 2001-07-10 Ljl Biosystems, Inc. Sample holders with reference fiducials
JP3472092B2 (ja) 1997-07-28 2003-12-02 キヤノン株式会社 回折光学素子及びそれを用いた光学系
DE19748211A1 (de) * 1997-10-31 1999-05-06 Zeiss Carl Fa Optisches Array-System und Reader für Mikrotiterplatten
JPH11202105A (ja) * 1998-01-20 1999-07-30 Nikon Corp マイクロレンズアレイおよびその製造方法
US6381072B1 (en) * 1998-01-23 2002-04-30 Proxemics Lenslet array systems and methods
JP3746894B2 (ja) * 1998-02-05 2006-02-15 ペンタックス株式会社 色消しレンズ系
US6198577B1 (en) * 1998-03-10 2001-03-06 Glaxo Wellcome, Inc. Doubly telecentric lens and imaging system for multiwell plates
US6388788B1 (en) 1998-03-16 2002-05-14 Praelux, Inc. Method and apparatus for screening chemical compounds
IL138496A0 (en) * 1998-03-16 2001-10-31 Praelux Inc Confocal microscopy imaging system
US6027695A (en) * 1998-04-01 2000-02-22 Dupont Pharmaceuticals Company Apparatus for holding small volumes of liquids
US6024920A (en) * 1998-04-21 2000-02-15 Bio-Rad Laboratories, Inc. Microplate scanning read head
GB9810350D0 (en) * 1998-05-14 1998-07-15 Ciba Geigy Ag Organic compounds
US6818437B1 (en) * 1998-05-16 2004-11-16 Applera Corporation Instrument for monitoring polymerase chain reaction of DNA
AU759974B2 (en) 1998-05-16 2003-05-01 Applied Biosystems, Llc Instrument for monitoring polymerase chain reaction of DNA
JP2000004871A (ja) * 1998-06-29 2000-01-11 Olympus Optical Co Ltd 培養容器、及び培養容器内の試料を観察する顕微鏡
JP2000074837A (ja) * 1998-08-31 2000-03-14 Fuji Photo Film Co Ltd 撮影装置
DE19846928A1 (de) * 1998-10-12 2000-04-13 Zeiss Carl Fa Abbildungssystem mit einem Zylinderlinsenarray
US6159368A (en) 1998-10-29 2000-12-12 The Perkin-Elmer Corporation Multi-well microfiltration apparatus
EP1057177A1 (de) * 1998-12-21 2000-12-06 Koninklijke Philips Electronics N.V. Optische abtastvorrichtung
US6130745A (en) * 1999-01-07 2000-10-10 Biometric Imaging, Inc. Optical autofocus for use with microtiter plates
GB9906929D0 (en) * 1999-03-26 1999-05-19 Univ Glasgow Assay system
DE19919092A1 (de) 1999-04-27 2000-11-02 Zeiss Carl Jena Gmbh Anordnung zur optischen Auswertung eines Gegenstandsarrays
JP3815969B2 (ja) * 1999-05-12 2006-08-30 アクララ バイオサイエンシーズ， インコーポレイテッド 微量流体デバイスにおける多重方式蛍光検出
US6272939B1 (en) 1999-10-15 2001-08-14 Applera Corporation System and method for filling a substrate with a liquid sample
JP4846152B2 (ja) 1999-11-12 2011-12-28 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー 低発熱光源を有する蛍光測定器
US6235495B1 (en) 1999-11-12 2001-05-22 Oxis International, Inc. Methods for the quantitation of oxidized glutathione
JP4870256B2 (ja) * 1999-11-29 2012-02-08 Ｓａｂｉｃイノベーティブプラスチックスジャパン合同会社 熱可塑性樹脂組成物及びその成形品
JP2001166254A (ja) * 1999-12-10 2001-06-22 Koyo Seiko Co Ltd 光スポット群形成装置
US6563581B1 (en) 2000-07-14 2003-05-13 Applera Corporation Scanning system and method for scanning a plurality of samples
US6377403B1 (en) * 2000-09-07 2002-04-23 David C. Smith Short pulse laser protection fly's eye lens
US7027932B2 (en) * 2001-03-21 2006-04-11 Olympus Optical Co., Ltd. Biochemical examination method
US6514750B2 (en) * 2001-07-03 2003-02-04 Pe Corporation (Ny) PCR sample handling device
US6750457B2 (en) 2001-08-29 2004-06-15 Becton Dickinson And Company System for high throughput analysis
US6942836B2 (en) * 2001-10-16 2005-09-13 Applera Corporation System for filling substrate chambers with liquid
US6982166B2 (en) * 2002-05-16 2006-01-03 Applera Corporation Lens assembly for biological testing
JP2009222506A (ja) 2008-03-14 2009-10-01 Shimada Phys & Chem Ind Co Ltd ドップラーソーダーシステム

Also Published As

Publication number Publication date
EP1509789B8 (de) 2009-09-16
US7407798B2 (en) 2008-08-05
US20030215938A1 (en) 2003-11-20
EP2053429A1 (de) 2009-04-29
WO2003098282A1 (en) 2003-11-27
US20060008897A1 (en) 2006-01-12
JP2008058311A (ja) 2008-03-13
EP2302420A1 (de) 2011-03-30
JP4447450B2 (ja) 2010-04-07
US20050170495A1 (en) 2005-08-04
EP2302420B1 (de) 2014-07-09
US6982166B2 (en) 2006-01-03
EP2053429B1 (de) 2016-06-29
JP2009216711A (ja) 2009-09-24
JP2005525579A (ja) 2005-08-25
DE60328598D1 (de) 2009-09-10
DE20321717U1 (de) 2009-03-19
EP1509789B1 (de) 2009-07-29
EP1509789A1 (de) 2005-03-02
US20130052723A1 (en) 2013-02-28
AU2003248531A1 (en) 2003-12-02
US9310301B2 (en) 2016-04-12

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