ATE423194T1 - Von-willebrand-faktor (vwf) spaltendes protease- polypeptid, für das polypeptid codierende nukleinsäure und verwendung des polypeptids - Google Patents

Von-willebrand-faktor (vwf) spaltendes protease- polypeptid, für das polypeptid codierende nukleinsäure und verwendung des polypeptids

Info

Publication number
ATE423194T1
ATE423194T1 AT01997546T AT01997546T ATE423194T1 AT E423194 T1 ATE423194 T1 AT E423194T1 AT 01997546 T AT01997546 T AT 01997546T AT 01997546 T AT01997546 T AT 01997546T AT E423194 T1 ATE423194 T1 AT E423194T1
Authority
AT
Austria
Prior art keywords
polypeptide
vwf
cliving
nucleic acid
von willebrand
Prior art date
Application number
AT01997546T
Other languages
English (en)
Inventor
Bernhard Laemmle
Helena Schaller-Gerritsen
Miha Furlan
Peter Turecek
Hans-Peter Schwarz
Friedrich Scheiflinger
Gerhard Antoine
Randolf Kerschbaumer
Luigina Tagliavacca
Klaus Zimmermann
Dirk Voelkel
Original Assignee
Baxter Innovations Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27110398&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE423194(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Baxter Innovations Gmbh filed Critical Baxter Innovations Gmbh
Application granted granted Critical
Publication of ATE423194T1 publication Critical patent/ATE423194T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6402—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals
    • C12N9/6405—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals not being snakes
    • C12N9/6416—Metalloendopeptidases (3.4.24)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/24—Metalloendopeptidases (3.4.24)
    • C12Y304/24087—ADAMTS13 endopeptidase (3.4.24.87)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Chemical Or Physical Treatment Of Fibers (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT01997546T 2000-11-22 2001-11-20 Von-willebrand-faktor (vwf) spaltendes protease- polypeptid, für das polypeptid codierende nukleinsäure und verwendung des polypeptids ATE423194T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72125400A 2000-11-22 2000-11-22
US09/833,328 US6926894B2 (en) 2000-11-22 2001-04-12 Composition exhibiting a von willebrand factor (vWF) protease activity comprising a polypeptide chain with the amino acid sequence AAGGILHLELLV

Publications (1)

Publication Number Publication Date
ATE423194T1 true ATE423194T1 (de) 2009-03-15

Family

ID=27110398

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01997546T ATE423194T1 (de) 2000-11-22 2001-11-20 Von-willebrand-faktor (vwf) spaltendes protease- polypeptid, für das polypeptid codierende nukleinsäure und verwendung des polypeptids

Country Status (15)

Country Link
US (7) US6926894B2 (de)
EP (1) EP1346034B1 (de)
AT (1) ATE423194T1 (de)
AU (1) AU2002218306A1 (de)
CZ (1) CZ305602B6 (de)
DE (1) DE60137710D1 (de)
DK (1) DK1346034T3 (de)
ES (1) ES2322126T3 (de)
HU (1) HU227996B1 (de)
NZ (1) NZ526616A (de)
PT (1) PT1346034E (de)
RU (1) RU2003118441A (de)
SI (1) SI1346034T1 (de)
SK (1) SK288119B6 (de)
WO (1) WO2002042441A2 (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6926894B2 (en) 2000-11-22 2005-08-09 Baxter Aktiengesellschaft Composition exhibiting a von willebrand factor (vWF) protease activity comprising a polypeptide chain with the amino acid sequence AAGGILHLELLV
JP2003284570A (ja) 2001-04-25 2003-10-07 Chemo Sero Therapeut Res Inst フォンビルブラント因子（ｖＷＦ）切断酵素
US7037658B2 (en) * 2001-08-16 2006-05-02 Regents Of University Of Michigan Methods and compositions for detecting variant ADAMTS13 genes
DE20213920U1 (de) 2002-07-03 2003-01-16 Böhm, Martina, 60439 Frankfurt Diagnostikum zum Nachweis der den von Willebrand-Faktorspaltenden Aktivität von ADAMTS13
ATE460479T1 (de) * 2002-09-25 2010-03-15 Chemo Sero Therapeut Res Inst Antikörper gegen ein den von-willebrand-faktor spezifisch spaltendes enzym und assay-system unter verwendung davon
AU2012203101B2 (en) * 2002-09-25 2014-10-02 Km Biologics Co., Ltd. Antibody against enzyme specifically cleaving von villebrand factor and assay system using the same
US20040185042A1 (en) * 2003-03-20 2004-09-23 Friedrich Scheiflinger Immunoadsorption of anti-von Willebrand Factor cleaving protease antibodies
US7763430B2 (en) * 2003-04-22 2010-07-27 Baxter International Inc. Diagnostic assay for anti-von Willebrand Factor cleaving protease (ADAMTS13) antibodies
CN1898567A (zh) 2003-12-22 2007-01-17 株式会社三菱化学药得论 通过测定冯维勒布兰德因子分解酶检测血栓症的方法
EP1568782A1 (de) * 2004-02-25 2005-08-31 Clemens Bockmeyer Diagnose und Therapie von ADAMTS-13 assoziierten Erkrankungen
US20080138837A1 (en) * 2004-07-19 2008-06-12 Robert Greenfield Methods and kits for detecting and measuring ADAMTS13/FXI complexes
US7270976B2 (en) * 2004-07-19 2007-09-18 American Diagnostica, Inc. Methods for measuring ADAMTS13 activity and protein on platelets and in plasma
ATE468536T1 (de) * 2004-07-19 2010-06-15 American Diagnostica Inc Verfahren zur messung von adamts13-aktivität auf der blutplättchenoberfläche.
CA2606351C (en) * 2005-06-17 2016-12-13 Baxter International Inc. Adamts13-comprising compositions having thrombolytic activity
US7893616B2 (en) * 2006-02-27 2011-02-22 Ohio State University Process to determine enzyme activity
FR2918375B1 (fr) 2007-07-05 2009-10-16 Lab Francais Du Fractionnement Utilisation d'un support de chromatographie pour reduire la quantite d'adamts13 dans une solution derivee du plasma
AU2008345231B2 (en) 2007-12-27 2014-09-11 Takeda Pharmaceutical Company Limited Cell culture processes
US8313926B2 (en) 2009-07-31 2012-11-20 Baxter International Inc. Methods for expressing ADAMTS proteins in cell culture medium supplemented with zinc
US8945895B2 (en) 2009-07-31 2015-02-03 Baxter International Inc. Methods of purifying recombinant ADAMTS13 and other proteins and compositions thereof
BR112012006283B1 (pt) * 2009-09-21 2022-03-15 Takeda Pharmaceutical Company Limited Formulação de adamts13 estabilizada, método para fabricar uma formulação de adamts13 estabilizada, kit, e, usos de adamts13
PL3626736T3 (pl) 2010-07-08 2025-10-13 Takeda Pharmaceutical Company Limited Sposób wytwarzania rekombinowanego vwf o dużej masie cząsteczkowej w hodowli komórkowej
AU2011343813B2 (en) 2010-12-15 2015-05-21 Takeda Pharmaceutical Company Limited Eluate collection using conductivity gradient
ES2554231T3 (es) 2011-05-19 2015-12-17 Baxalta Incorporated Detección de complejos de ADAMTS13-anticuerpo en circulación
KR102006151B1 (ko) 2012-11-27 2019-10-10 삼성디스플레이 주식회사 터치를 인식하고 전기 촉각 자극을 제공하는 표시 장치 및 그 구동 방법
AU2013203062C1 (en) 2013-03-15 2018-06-28 Takeda Pharmaceutical Company Limited Subcutaneous administration of adamts13
US10639307B2 (en) * 2015-05-15 2020-05-05 Children's Medical Center Corporation Methods relating to the diagnosis and treatment of preeclampsia comprising administration of ADAMTS13 polypeptides
EP3493830B1 (de) 2016-08-04 2025-12-03 Takeda Pharmaceutical Company Limited Verwendung von adamts13 zur behandlung, linderung und/oder prävention einer vaso-okklusiven krise bei sichelzellanämie, akuter lungenläsion und/oder akutem atemstresssyndrom
FR3069156B1 (fr) * 2017-07-21 2019-08-09 Universite de Bordeaux Clusterine pour son utilisation dans le traitement des micro-angiopathies thrombotiques
EP4037704B1 (de) 2019-10-04 2025-12-03 The Children's Medical Center Corporation Adamts13-behandlung zum verbessern des überlebens von transplantaten
EP4127158A2 (de) 2020-04-02 2023-02-08 Takeda Pharmaceutical Company Limited Adamts13-variante, zusammensetzungen und verwendungen davon
CN115835904A (zh) 2020-05-22 2023-03-21 武田药品工业有限公司 用于治疗和诊断冠状病毒疾病并发症的adamts13组合物和方法
CN119604763A (zh) * 2022-01-26 2025-03-11 艾德克斯实验室公司 用于区分进展性慢性肾脏疾病与稳定性慢性肾脏疾病的方法和组合物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6068838A (en) * 1996-04-29 2000-05-30 Baxter Aktiengesellschaft Purified multimerase
AT406867B (de) * 1997-02-27 2000-10-25 Immuno Ag Verfahren zur gewinnung von hochreinem vwf oder faktor viii/vwf-komplex
US20010049106A1 (en) 2000-04-27 2001-12-06 Leonard Buckbinder ADAMTS polypeptides, nucleic acids encoding them, and uses thereof
US6926894B2 (en) 2000-11-22 2005-08-09 Baxter Aktiengesellschaft Composition exhibiting a von willebrand factor (vWF) protease activity comprising a polypeptide chain with the amino acid sequence AAGGILHLELLV
US7070532B2 (en) * 2003-08-26 2006-07-04 General Motors Corporation Planetary transmission having a rotating-type torque-transmitting mechanism with a stationary piston

Also Published As

Publication number Publication date
HUP0400588A2 (hu) 2004-06-28
SK288119B6 (sk) 2013-09-03
WO2002042441A3 (en) 2002-08-08
US20080176312A1 (en) 2008-07-24
SK8022003A3 (en) 2004-04-06
EP1346034B1 (de) 2009-02-18
US20140335071A1 (en) 2014-11-13
US9309506B2 (en) 2016-04-12
US7910094B2 (en) 2011-03-22
AU2002218306A1 (en) 2002-06-03
US8703429B2 (en) 2014-04-22
EP1346034A2 (de) 2003-09-24
ES2322126T3 (es) 2009-06-17
SI1346034T1 (sl) 2009-08-31
US8703426B2 (en) 2014-04-22
US7501117B2 (en) 2009-03-10
US20090203110A1 (en) 2009-08-13
DE60137710D1 (de) 2009-04-02
US20170065686A1 (en) 2017-03-09
PT1346034E (pt) 2009-05-05
WO2002042441A2 (en) 2002-05-30
HUP0400588A3 (en) 2006-01-30
CZ20031718A3 (cs) 2004-07-14
US20020136713A1 (en) 2002-09-26
US20090017467A1 (en) 2009-01-15
HU227996B1 (hu) 2012-08-28
CZ305602B6 (cs) 2016-01-06
DK1346034T3 (da) 2009-05-11
US20050266528A1 (en) 2005-12-01
NZ526616A (en) 2005-04-29
US6926894B2 (en) 2005-08-09
RU2003118441A (ru) 2004-12-10

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