ATE460479T1 - Antikörper gegen ein den von-willebrand-faktor spezifisch spaltendes enzym und assay-system unter verwendung davon - Google Patents
Antikörper gegen ein den von-willebrand-faktor spezifisch spaltendes enzym und assay-system unter verwendung davonInfo
- Publication number
- ATE460479T1 ATE460479T1 AT03798512T AT03798512T ATE460479T1 AT E460479 T1 ATE460479 T1 AT E460479T1 AT 03798512 T AT03798512 T AT 03798512T AT 03798512 T AT03798512 T AT 03798512T AT E460479 T1 ATE460479 T1 AT E460479T1
- Authority
- AT
- Austria
- Prior art keywords
- adamts
- antibody
- cliping
- antibodies
- assay system
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6489—Metalloendopeptidases (3.4.24)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2002279924 | 2002-09-25 | ||
JP2002377569 | 2002-12-26 | ||
PCT/JP2003/012280 WO2004029242A1 (ja) | 2002-09-25 | 2003-09-25 | フォンビルブランド因子特異的切断酵素に対する抗体及びそれを用いたアッセイ系 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE460479T1 true ATE460479T1 (de) | 2010-03-15 |
Family
ID=32044615
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT03798512T ATE460479T1 (de) | 2002-09-25 | 2003-09-25 | Antikörper gegen ein den von-willebrand-faktor spezifisch spaltendes enzym und assay-system unter verwendung davon |
Country Status (10)
Country | Link |
---|---|
US (1) | US7575872B2 (de) |
EP (2) | EP1544293B1 (de) |
JP (3) | JPWO2004029242A1 (de) |
KR (1) | KR101154550B1 (de) |
CN (1) | CN1701117B (de) |
AT (1) | ATE460479T1 (de) |
AU (2) | AU2003266632A1 (de) |
CA (1) | CA2499926C (de) |
DE (1) | DE60331666D1 (de) |
WO (1) | WO2004029242A1 (de) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003284570A (ja) * | 2001-04-25 | 2003-10-07 | Chemo Sero Therapeut Res Inst | フォンビルブラント因子(vWF)切断酵素 |
WO2004083250A1 (ja) * | 2003-03-17 | 2004-09-30 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | フォンビルブランド因子特異的切断酵素に対する抗体の認識領域からなる構成物 |
US20040185042A1 (en) * | 2003-03-20 | 2004-09-23 | Friedrich Scheiflinger | Immunoadsorption of anti-von Willebrand Factor cleaving protease antibodies |
US8088624B2 (en) | 2003-12-22 | 2012-01-03 | Mitsubishi Kagaku Iatron, Inc. | Method of detecting thrombosis by measuring von Willenbrand factor-cleaving protease |
EP1568782A1 (de) * | 2004-02-25 | 2005-08-31 | Clemens Bockmeyer | Diagnose und Therapie von ADAMTS-13 assoziierten Erkrankungen |
EP1816211A4 (de) * | 2004-11-08 | 2008-11-12 | Mitsubishi Kagaku Iatron Inc | Verfahren zum nachweis von blutplättchenthrombose oder organversagen |
JP5067917B2 (ja) * | 2005-12-28 | 2012-11-07 | アルフレッサファーマ株式会社 | Adamts13の分離精製方法 |
AU2007210643B2 (en) * | 2006-01-31 | 2013-09-19 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | Method for determination of condition of disseminated intravascular coagulation syndrome |
ES2386574T3 (es) | 2006-02-16 | 2012-08-23 | Mitsubishi Chemical Medience Corporation | Procedimiento de detección de afección en paciente con alteración de la consciencia |
JP2008136453A (ja) * | 2006-12-05 | 2008-06-19 | Mitsubishi Kagaku Iatron Inc | フォンビレブランド因子切断酵素の活性阻害因子把握方法 |
WO2009001743A1 (ja) | 2007-06-22 | 2008-12-31 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | 新規adamts-13改変体 |
EP3388529A1 (de) * | 2008-12-05 | 2018-10-17 | Baxalta GmbH | Verfahren zum messen der adamts13-vermittelten in-vivo-spaltung von von-willebrand-faktor und verwendungen davon |
JP2013040912A (ja) * | 2011-08-18 | 2013-02-28 | Miyazakiken Sangyo Shien Zaidan | 成人t細胞白血病診断器具 |
US11597778B2 (en) | 2015-04-07 | 2023-03-07 | The Trustees Of The University Of Pennsylvania | Human monoclonal autoantibodies to ADAMTS13 and uses thereof |
EP3401685B1 (de) | 2016-01-08 | 2021-12-01 | Kyoto University | Diagnoseverfahren und medikament mit adamts13 als hauptbestandteil |
CN106008715B (zh) * | 2016-07-18 | 2019-11-08 | 苏州大学附属第一医院 | 一种抗人血管性血友病因子裂解酶的抑制性单克隆抗体及其应用 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20010049106A1 (en) * | 2000-04-27 | 2001-12-06 | Leonard Buckbinder | ADAMTS polypeptides, nucleic acids encoding them, and uses thereof |
DE10034154A1 (de) * | 2000-07-07 | 2002-01-24 | Inst Polymerforschung Dresden | Multifunktionelle Kopplungsagenzien mit zyklischen Iminoester- und Iminoethergruppen, Verfahren zu deren Herstellung und Verwendung |
US6926894B2 (en) * | 2000-11-22 | 2005-08-09 | Baxter Aktiengesellschaft | Composition exhibiting a von willebrand factor (vWF) protease activity comprising a polypeptide chain with the amino acid sequence AAGGILHLELLV |
JP2002279924A (ja) | 2001-03-19 | 2002-09-27 | Seiko Instruments Inc | 大きな試料の観察・加工を可能とする集束イオンビーム装置 |
JP2003284570A (ja) | 2001-04-25 | 2003-10-07 | Chemo Sero Therapeut Res Inst | フォンビルブラント因子(vWF)切断酵素 |
WO2003016492A2 (en) * | 2001-08-16 | 2003-02-27 | The Regents Of The University Of Michigan | Adamts13 genes and proteins and variants, and uses thereof |
-
2003
- 2003-09-25 DE DE60331666T patent/DE60331666D1/de not_active Expired - Lifetime
- 2003-09-25 JP JP2004539542A patent/JPWO2004029242A1/ja active Pending
- 2003-09-25 EP EP03798512A patent/EP1544293B1/de not_active Expired - Lifetime
- 2003-09-25 CA CA2499926A patent/CA2499926C/en not_active Expired - Lifetime
- 2003-09-25 AT AT03798512T patent/ATE460479T1/de active
- 2003-09-25 US US10/529,009 patent/US7575872B2/en active Active
- 2003-09-25 WO PCT/JP2003/012280 patent/WO2004029242A1/ja active Application Filing
- 2003-09-25 EP EP09163352A patent/EP2157178A1/de not_active Withdrawn
- 2003-09-25 CN CN038253933A patent/CN1701117B/zh not_active Expired - Lifetime
- 2003-09-25 KR KR1020057005108A patent/KR101154550B1/ko active IP Right Grant
- 2003-09-25 AU AU2003266632A patent/AU2003266632A1/en not_active Abandoned
-
2008
- 2008-07-04 AU AU2008202992A patent/AU2008202992B2/en not_active Expired
-
2009
- 2009-07-13 JP JP2009165142A patent/JP2009236925A/ja active Pending
-
2012
- 2012-11-07 JP JP2012245096A patent/JP2013078319A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
US20060251655A1 (en) | 2006-11-09 |
CA2499926C (en) | 2013-06-04 |
DE60331666D1 (de) | 2010-04-22 |
JPWO2004029242A1 (ja) | 2006-01-26 |
KR20050048647A (ko) | 2005-05-24 |
EP1544293B1 (de) | 2010-03-10 |
CN1701117A (zh) | 2005-11-23 |
JP2009236925A (ja) | 2009-10-15 |
EP1544293A1 (de) | 2005-06-22 |
JP2013078319A (ja) | 2013-05-02 |
EP2157178A1 (de) | 2010-02-24 |
CA2499926A1 (en) | 2004-04-08 |
AU2008202992A1 (en) | 2008-07-31 |
EP1544293A4 (de) | 2006-03-15 |
US7575872B2 (en) | 2009-08-18 |
AU2003266632A1 (en) | 2004-04-19 |
AU2008202992B2 (en) | 2012-03-29 |
KR101154550B1 (ko) | 2012-06-08 |
CN1701117B (zh) | 2011-04-20 |
WO2004029242A1 (ja) | 2004-04-08 |
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