ATE420864T1 - Verfahren zur chiralen inversion von (s)-(+)- und (r)-(-)-10,11-dihydro-10-hydroxy-5h-dibenz/b, f/azepin-5-carbonsäureamid und optisch angereicherten mischungen davon - Google Patents

Verfahren zur chiralen inversion von (s)-(+)- und (r)-(-)-10,11-dihydro-10-hydroxy-5h-dibenz/b, f/azepin-5-carbonsäureamid und optisch angereicherten mischungen davon

Info

Publication number
ATE420864T1
ATE420864T1 AT05759707T AT05759707T ATE420864T1 AT E420864 T1 ATE420864 T1 AT E420864T1 AT 05759707 T AT05759707 T AT 05759707T AT 05759707 T AT05759707 T AT 05759707T AT E420864 T1 ATE420864 T1 AT E420864T1
Authority
AT
Austria
Prior art keywords
dibenz
azepine
dihydro
hydroxy
acid amide
Prior art date
Application number
AT05759707T
Other languages
German (de)
English (en)
Inventor
David Learmonth
Guenter Weingaertner
Matthias Kraemer
Original Assignee
Bial Portela & Ca Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bial Portela & Ca Sa filed Critical Bial Portela & Ca Sa
Application granted granted Critical
Publication of ATE420864T1 publication Critical patent/ATE420864T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT05759707T 2004-07-13 2005-07-13 Verfahren zur chiralen inversion von (s)-(+)- und (r)-(-)-10,11-dihydro-10-hydroxy-5h-dibenz/b, f/azepin-5-carbonsäureamid und optisch angereicherten mischungen davon ATE420864T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB0415664A GB2416167A (en) 2004-07-13 2004-07-13 Chiral inversion and esterification of (S)- and (R)-10-hydroxy-dibenzazepine carboxamides

Publications (1)

Publication Number Publication Date
ATE420864T1 true ATE420864T1 (de) 2009-01-15

Family

ID=32893499

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05759707T ATE420864T1 (de) 2004-07-13 2005-07-13 Verfahren zur chiralen inversion von (s)-(+)- und (r)-(-)-10,11-dihydro-10-hydroxy-5h-dibenz/b, f/azepin-5-carbonsäureamid und optisch angereicherten mischungen davon

Country Status (20)

Country Link
US (1) US7999100B2 (https=)
EP (1) EP1789395B8 (https=)
JP (1) JP2008506676A (https=)
CN (1) CN100582095C (https=)
AR (1) AR050170A1 (https=)
AT (1) ATE420864T1 (https=)
AU (1) AU2005261497A1 (https=)
BR (1) BRPI0513383A (https=)
CA (1) CA2574002C (https=)
DE (1) DE602005012405D1 (https=)
DK (1) DK1789395T3 (https=)
ES (1) ES2320155T3 (https=)
GB (1) GB2416167A (https=)
HR (1) HRP20090212T1 (https=)
MX (1) MX2007000575A (https=)
PL (1) PL1789395T3 (https=)
PT (1) PT103308B (https=)
RU (1) RU2382772C2 (https=)
SI (1) SI1789395T1 (https=)
WO (1) WO2006005951A1 (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0515690D0 (en) 2005-07-29 2005-09-07 Portela & Ca Sa Asymmetric catalytic reduction
GB2437078A (en) * 2006-04-11 2007-10-17 Portela & Ca Sa 10-Acyloxy-5H-dibenzo[b,f]azepine-5-carboxamides & their asymmetric hydrogenation to the chiral 10,11-dihydro derivatives
GB0700773D0 (en) 2007-01-15 2007-02-21 Portela & Ca Sa Drug therapies
US8372431B2 (en) 2007-10-26 2013-02-12 Bial-Portela & C.A., S.A. Pharmaceutical composition comprising licarbazepine acetate
WO2010113179A2 (en) * 2009-04-02 2010-10-07 Glenmark Generics Limited A process for the purification of eslicarbazepine acetate
UA106384C2 (ru) 2009-07-27 2014-08-26 БИАЛ-ПОРТЕЛА энд КА., С.А. ПРИМЕНЕНИЕ ПРОИЗВОДНЫХ 5H-ДИБЕНЗ/б,ф/АЗЕПИН-5-КАРБОКСАМИДА ДЛЯ ЛЕЧЕНИЯ ФИБРОМИАЛГИИ
WO2011045648A2 (en) * 2009-10-12 2011-04-21 Matrix Laboratories Limited Process for preparing (s)-(-)-10-acetoxy-10,11-dihydro-5h-dibenz[b,f]azepine-5-carboxamide and its esters thereof
WO2011091131A2 (en) * 2010-01-23 2011-07-28 Dr. Reddy's Laboratories Ltd. Eslicarbazepine acetate and its polymorphs
WO2011117885A1 (en) * 2010-03-23 2011-09-29 Intas Pharmaceuticals Limited Process for preparation of enantiomers of licarbazepine
US9346760B2 (en) 2011-03-08 2016-05-24 Jubilant Life Sciences Limited Process for the preparation of (S)-(+)- or (R)-(-)-10-hydroxy dihydrodibenz[B,F]azepines by enantioselective reduction of 10,11-dihydro-10-OXO-5H-dibenz[B,F]azepines and polymorphs thereof
WO2012156987A2 (en) * 2011-05-19 2012-11-22 Glenmark Generics Limited A novel process for the preparation of eslicarbazepine
WO2013008194A2 (en) 2011-07-13 2013-01-17 Ranbaxy Laboratories Limited Process for the preparation and purification of eslicarbazepine acetate and intermediates thereof
US20150232426A1 (en) 2012-09-26 2015-08-20 Ranbaxy Laboratories Limited Process for the preparation of oxcarbazepine and its use as intermediate in the preparation of eslicarbazepine acetate
EP3064490A1 (en) 2015-03-06 2016-09-07 F.I.S.- Fabbrica Italiana Sintetici S.p.A. Improved process for the preparation of eslicarbazepine and eslicarbazepine acetate

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT101732B (pt) * 1995-06-30 1997-12-31 Portela & Ca Sa Novas di-hidrodibenzo<b,f>azepinas substituidas processo para a sua preparacao composicoes farmaceuticas que as contem e utilizacao dos novos compostos na preparacao de composicoes farmaceuticas empregues em doencas do sistema nervoso
PT101876B (pt) * 1996-05-27 1999-09-30 Portela & Ca Sa Novos derivados de 10,11-di-hidro-10-oxo-5h-dibenzo(b,f)azepina-5-carboxamida
GB0111566D0 (en) * 2001-05-11 2001-07-04 Portela & Ca Sa Method for preparation of (s)-(+)-and (r)-(-)-10,11-dihydro-10-hydroxy-5h-dibenz/b,f/azephine-5-carboxamide

Also Published As

Publication number Publication date
CN101023061A (zh) 2007-08-22
GB2416167A (en) 2006-01-18
CA2574002C (en) 2014-02-04
PL1789395T3 (pl) 2009-06-30
RU2382772C2 (ru) 2010-02-27
EP1789395B1 (en) 2009-01-14
AU2005261497A1 (en) 2006-01-19
PT103308A (pt) 2007-01-31
GB0415664D0 (en) 2004-08-18
ES2320155T3 (es) 2009-05-19
WO2006005951A1 (en) 2006-01-19
US7999100B2 (en) 2011-08-16
US20080293934A1 (en) 2008-11-27
BRPI0513383A (pt) 2008-05-06
EP1789395B8 (en) 2009-08-12
EP1789395A1 (en) 2007-05-30
PT103308B (pt) 2008-06-11
SI1789395T1 (sl) 2009-06-30
DK1789395T3 (da) 2009-04-20
HRP20090212T1 (hr) 2009-09-30
JP2008506676A (ja) 2008-03-06
DE602005012405D1 (de) 2009-03-05
AR050170A1 (es) 2006-10-04
CA2574002A1 (en) 2006-01-19
MX2007000575A (es) 2007-03-30
RU2007105228A (ru) 2008-08-20
CN100582095C (zh) 2010-01-20

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