CN100582095C - (S)-(+)-和(R)-(-)-10,11-二氢-10-羟基-5H-二苯并/b,f/氮杂䓬-5-甲酰胺及其光学富集的混合物的手性反转方法 - Google Patents

(S)-(+)-和(R)-(-)-10,11-二氢-10-羟基-5H-二苯并/b,f/氮杂䓬-5-甲酰胺及其光学富集的混合物的手性反转方法 Download PDF

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Publication number
CN100582095C
CN100582095C CN200580030684A CN200580030684A CN100582095C CN 100582095 C CN100582095 C CN 100582095C CN 200580030684 A CN200580030684 A CN 200580030684A CN 200580030684 A CN200580030684 A CN 200580030684A CN 100582095 C CN100582095 C CN 100582095C
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China
Prior art keywords
dihydro
dibenzo
aza
carboxamide
carbon atoms
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Expired - Fee Related
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Chinese (zh)
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CN101023061A (zh
Inventor
戴维·亚历山大·利尔茅斯
京特·魏因格特纳
马蒂亚斯·克雷默
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Bial Portela and Cia SA
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Bial Portela and Cia SA
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN200580030684A 2004-07-13 2005-07-13 (S)-(+)-和(R)-(-)-10,11-二氢-10-羟基-5H-二苯并/b,f/氮杂䓬-5-甲酰胺及其光学富集的混合物的手性反转方法 Expired - Fee Related CN100582095C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0415664A GB2416167A (en) 2004-07-13 2004-07-13 Chiral inversion and esterification of (S)- and (R)-10-hydroxy-dibenzazepine carboxamides
GB0415664.2 2004-07-13

Publications (2)

Publication Number Publication Date
CN101023061A CN101023061A (zh) 2007-08-22
CN100582095C true CN100582095C (zh) 2010-01-20

Family

ID=32893499

Family Applications (1)

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CN200580030684A Expired - Fee Related CN100582095C (zh) 2004-07-13 2005-07-13 (S)-(+)-和(R)-(-)-10,11-二氢-10-羟基-5H-二苯并/b,f/氮杂䓬-5-甲酰胺及其光学富集的混合物的手性反转方法

Country Status (20)

Country Link
US (1) US7999100B2 (https=)
EP (1) EP1789395B8 (https=)
JP (1) JP2008506676A (https=)
CN (1) CN100582095C (https=)
AR (1) AR050170A1 (https=)
AT (1) ATE420864T1 (https=)
AU (1) AU2005261497A1 (https=)
BR (1) BRPI0513383A (https=)
CA (1) CA2574002C (https=)
DE (1) DE602005012405D1 (https=)
DK (1) DK1789395T3 (https=)
ES (1) ES2320155T3 (https=)
GB (1) GB2416167A (https=)
HR (1) HRP20090212T1 (https=)
MX (1) MX2007000575A (https=)
PL (1) PL1789395T3 (https=)
PT (1) PT103308B (https=)
RU (1) RU2382772C2 (https=)
SI (1) SI1789395T1 (https=)
WO (1) WO2006005951A1 (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0515690D0 (en) 2005-07-29 2005-09-07 Portela & Ca Sa Asymmetric catalytic reduction
GB2437078A (en) * 2006-04-11 2007-10-17 Portela & Ca Sa 10-Acyloxy-5H-dibenzo[b,f]azepine-5-carboxamides & their asymmetric hydrogenation to the chiral 10,11-dihydro derivatives
GB0700773D0 (en) 2007-01-15 2007-02-21 Portela & Ca Sa Drug therapies
US8372431B2 (en) 2007-10-26 2013-02-12 Bial-Portela & C.A., S.A. Pharmaceutical composition comprising licarbazepine acetate
WO2010113179A2 (en) * 2009-04-02 2010-10-07 Glenmark Generics Limited A process for the purification of eslicarbazepine acetate
UA106384C2 (ru) 2009-07-27 2014-08-26 БИАЛ-ПОРТЕЛА энд КА., С.А. ПРИМЕНЕНИЕ ПРОИЗВОДНЫХ 5H-ДИБЕНЗ/б,ф/АЗЕПИН-5-КАРБОКСАМИДА ДЛЯ ЛЕЧЕНИЯ ФИБРОМИАЛГИИ
WO2011045648A2 (en) * 2009-10-12 2011-04-21 Matrix Laboratories Limited Process for preparing (s)-(-)-10-acetoxy-10,11-dihydro-5h-dibenz[b,f]azepine-5-carboxamide and its esters thereof
WO2011091131A2 (en) * 2010-01-23 2011-07-28 Dr. Reddy's Laboratories Ltd. Eslicarbazepine acetate and its polymorphs
WO2011117885A1 (en) * 2010-03-23 2011-09-29 Intas Pharmaceuticals Limited Process for preparation of enantiomers of licarbazepine
US9346760B2 (en) 2011-03-08 2016-05-24 Jubilant Life Sciences Limited Process for the preparation of (S)-(+)- or (R)-(-)-10-hydroxy dihydrodibenz[B,F]azepines by enantioselective reduction of 10,11-dihydro-10-OXO-5H-dibenz[B,F]azepines and polymorphs thereof
WO2012156987A2 (en) * 2011-05-19 2012-11-22 Glenmark Generics Limited A novel process for the preparation of eslicarbazepine
WO2013008194A2 (en) 2011-07-13 2013-01-17 Ranbaxy Laboratories Limited Process for the preparation and purification of eslicarbazepine acetate and intermediates thereof
US20150232426A1 (en) 2012-09-26 2015-08-20 Ranbaxy Laboratories Limited Process for the preparation of oxcarbazepine and its use as intermediate in the preparation of eslicarbazepine acetate
EP3064490A1 (en) 2015-03-06 2016-09-07 F.I.S.- Fabbrica Italiana Sintetici S.p.A. Improved process for the preparation of eslicarbazepine and eslicarbazepine acetate

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002092572A1 (en) * 2001-05-11 2002-11-21 Portela & Ca Sa Method for preparation of (s)-(+)- and (r)-(-)-10,11-dihydro-10-hydroxy-5h-dibenz/b,f/azepine-5-carboxamide

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT101732B (pt) * 1995-06-30 1997-12-31 Portela & Ca Sa Novas di-hidrodibenzo<b,f>azepinas substituidas processo para a sua preparacao composicoes farmaceuticas que as contem e utilizacao dos novos compostos na preparacao de composicoes farmaceuticas empregues em doencas do sistema nervoso
PT101876B (pt) * 1996-05-27 1999-09-30 Portela & Ca Sa Novos derivados de 10,11-di-hidro-10-oxo-5h-dibenzo(b,f)azepina-5-carboxamida

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002092572A1 (en) * 2001-05-11 2002-11-21 Portela & Ca Sa Method for preparation of (s)-(+)- and (r)-(-)-10,11-dihydro-10-hydroxy-5h-dibenz/b,f/azepine-5-carboxamide

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Synthesis and structure-activity relationship of 2-(aminoalkyl)-3,3a,8,12b-tetrahydro-2H-dibenzocyclohepta[1,2-b]furanderivatives: a novel series of 5-HT receptor antagonists. CID J ET AL.Bioorganic & Medicinal Chemistry Letters,Vol.14 No.11. 2004 *
The use of diethyl azodicarboxylate and triphenylphosphineinsynthesis and transformation of natural products. Mitsunobu.synthesis. 1981 *

Also Published As

Publication number Publication date
CN101023061A (zh) 2007-08-22
GB2416167A (en) 2006-01-18
CA2574002C (en) 2014-02-04
PL1789395T3 (pl) 2009-06-30
RU2382772C2 (ru) 2010-02-27
EP1789395B1 (en) 2009-01-14
AU2005261497A1 (en) 2006-01-19
PT103308A (pt) 2007-01-31
GB0415664D0 (en) 2004-08-18
ES2320155T3 (es) 2009-05-19
WO2006005951A1 (en) 2006-01-19
US7999100B2 (en) 2011-08-16
US20080293934A1 (en) 2008-11-27
ATE420864T1 (de) 2009-01-15
BRPI0513383A (pt) 2008-05-06
EP1789395B8 (en) 2009-08-12
EP1789395A1 (en) 2007-05-30
PT103308B (pt) 2008-06-11
SI1789395T1 (sl) 2009-06-30
DK1789395T3 (da) 2009-04-20
HRP20090212T1 (hr) 2009-09-30
JP2008506676A (ja) 2008-03-06
DE602005012405D1 (de) 2009-03-05
AR050170A1 (es) 2006-10-04
CA2574002A1 (en) 2006-01-19
MX2007000575A (es) 2007-03-30
RU2007105228A (ru) 2008-08-20

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