ATE398922T1 - Verwendung des cre-ert2 fusionsproteins zur konditionalen gezielten dns-rekombination in der maus - Google Patents
Verwendung des cre-ert2 fusionsproteins zur konditionalen gezielten dns-rekombination in der mausInfo
- Publication number
- ATE398922T1 ATE398922T1 AT06101289T AT06101289T ATE398922T1 AT E398922 T1 ATE398922 T1 AT E398922T1 AT 06101289 T AT06101289 T AT 06101289T AT 06101289 T AT06101289 T AT 06101289T AT E398922 T1 ATE398922 T1 AT E398922T1
- Authority
- AT
- Austria
- Prior art keywords
- organism
- mouse
- fusion protein
- cre
- interest
- Prior art date
Links
- 108020001507 fusion proteins Proteins 0.000 title abstract 2
- 238000012270 DNA recombination Methods 0.000 title 1
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 2
- 102000018120 Recombinases Human genes 0.000 abstract 2
- 108010091086 Recombinases Proteins 0.000 abstract 2
- 102100038595 Estrogen receptor Human genes 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 101710200251 Recombinase cre Proteins 0.000 abstract 1
- 229940046836 anti-estrogen Drugs 0.000 abstract 1
- 230000001833 anti-estrogenic effect Effects 0.000 abstract 1
- 230000008827 biological function Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940011871 estrogen Drugs 0.000 abstract 1
- 239000000262 estrogen Substances 0.000 abstract 1
- 239000000328 estrogen antagonist Substances 0.000 abstract 1
- 102000037865 fusion proteins Human genes 0.000 abstract 1
- 108020001756 ligand binding domains Proteins 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000002703 mutagenesis Methods 0.000 abstract 1
- 231100000350 mutagenesis Toxicity 0.000 abstract 1
- 108091008589 nuclear estrogen receptors Proteins 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0276—Knock-out vertebrates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4741—Keratin; Cytokeratin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70567—Nuclear receptors, e.g. retinoic acid receptor [RAR], RXR, nuclear orphan receptors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
- C07K14/721—Steroid/thyroid hormone superfamily, e.g. GR, EcR, androgen receptor, oestrogen receptor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8121—Serpins
- C07K14/8125—Alpha-1-antitrypsin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/20—Animal model comprising regulated expression system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/20—Animal model comprising regulated expression system
- A01K2217/203—Animal model comprising inducible/conditional expression system, e.g. hormones, tet
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0331—Animal model for proliferative diseases
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/035—Animal model for multifactorial diseases
- A01K2267/0362—Animal model for lipid/glucose metabolism, e.g. obesity, type-2 diabetes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/71—Fusion polypeptide containing domain for protein-protein interaction containing domain for transcriptional activaation, e.g. VP16
- C07K2319/715—Fusion polypeptide containing domain for protein-protein interaction containing domain for transcriptional activaation, e.g. VP16 containing a domain for ligand dependent transcriptional activation, e.g. containing a steroid receptor domain
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
- C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Toxicology (AREA)
- Plant Pathology (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Environmental Sciences (AREA)
- Animal Husbandry (AREA)
- High Energy & Nuclear Physics (AREA)
- Biodiversity & Conservation Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Endocrinology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0012570A FR2814642B1 (fr) | 2000-10-03 | 2000-10-03 | Souris transgenique pour la recombinaison ciblee mediee par la cre-er modifiee |
US09/853,033 US7112715B2 (en) | 2000-10-03 | 2001-05-11 | Transgenic mouse for targeted recombination mediated by modified Cre-ER |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE398922T1 true ATE398922T1 (de) | 2008-07-15 |
Family
ID=8854918
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT06101289T ATE398922T1 (de) | 2000-10-03 | 2001-09-28 | Verwendung des cre-ert2 fusionsproteins zur konditionalen gezielten dns-rekombination in der maus |
Country Status (5)
Country | Link |
---|---|
US (1) | US7112715B2 (de) |
EP (1) | EP1692936B1 (de) |
AT (1) | ATE398922T1 (de) |
DE (1) | DE60134588D1 (de) |
FR (1) | FR2814642B1 (de) |
Families Citing this family (101)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8673589B2 (en) | 2002-05-29 | 2014-03-18 | Regeneron Pharmaceuticals, Inc. | Inducible eukaryotic expression system |
JP4817657B2 (ja) * | 2002-05-29 | 2011-11-16 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 誘導性の真核生物発現システム |
US20080307537A1 (en) * | 2005-03-31 | 2008-12-11 | Dana-Farber Cancer Institute, Inc. | Compositions and Methods for the Identification, Assessment, Prevention, and Therapy of Neurological Diseases, Disorders and Conditions |
WO2007045903A2 (en) * | 2005-10-21 | 2007-04-26 | Medical Research Council | Methods of analysing cell behaviour |
US20100190187A1 (en) * | 2006-02-15 | 2010-07-29 | The Regents Of The University Of Michigan Office Of Technology Transfer | Screening Assays for Antagonists and Analyses of Cardiac Hypertrophy |
EP1942192A1 (de) * | 2007-01-08 | 2008-07-09 | Heinrich-Pette-Institut für experimentelle Virologie und Immunologie | Verwendung einer massgeschneiderten Recombinase für die Behandlung einer retroviralen Erkrankung |
US8173792B2 (en) | 2007-02-09 | 2012-05-08 | The Board Of Trustees Of The Leland Stanford Junior University | Method for regulating protein function in cells using synthetic small molecules |
WO2008103475A1 (en) * | 2007-02-20 | 2008-08-28 | Anaptysbio, Inc. | Somatic hypermutation systems |
US20090165150A1 (en) * | 2007-12-21 | 2009-06-25 | Yinghui Zhou | Directed complementation with removable gene of interest |
US8530636B2 (en) * | 2008-05-07 | 2013-09-10 | The Board Of Trustees Of The Leland Stanford Junior University | Method for regulating protein function in cells in vivo using synthetic small molecules |
EP2389391B1 (de) | 2009-01-22 | 2014-03-12 | Centre National De La Recherche Scientifique CNRS | Verfahren zur zeitweiligen steuerung der biologischen aktivität von proteinen in wirbeltieren, und anwendungen davon |
EP2414507B1 (de) | 2009-04-03 | 2014-07-02 | Medical Research Council | Mutanten von aktivierungsinduzierter cytidin-deaminase (aid) und verwendungsverfahren |
AU2010313456A1 (en) | 2009-10-30 | 2012-05-17 | Ntf Therapeutics, Inc. | Improved neurturin molecules |
WO2011057254A2 (en) | 2009-11-09 | 2011-05-12 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Simian adenoviral vector-based vaccines |
US20130164271A1 (en) | 2010-05-27 | 2013-06-27 | Max-Planck-Gesellschaft Zur Foederug Der Wissensch E.V. | Tailored recombinase for recombining asymmetric target sites in a plurality of retrovirus strains |
DK2597945T3 (da) | 2010-07-26 | 2020-09-21 | Trianni Inc | Transgene dyr og fremgangsmåder til anvendelse deraf |
WO2012021730A2 (en) | 2010-08-11 | 2012-02-16 | Genvec, Inc. | Respiratory syncytial virus (rsv) vaccine |
WO2012083297A2 (en) | 2010-12-17 | 2012-06-21 | Genvec, Inc. | Adenoviral vectors with modified hexon regions |
WO2012088041A1 (en) | 2010-12-20 | 2012-06-28 | Genvec, Inc. | Adenoviral vector-based dengue fever vaccine |
US9580476B2 (en) | 2011-10-05 | 2017-02-28 | Genvec, Inc. | Adenoviral vector-based respiratory syncytial virus (RSV) vaccine |
WO2013116591A1 (en) | 2012-02-02 | 2013-08-08 | Genvec, Inc. | Adenoviral vector-based malaria vaccine |
NZ628126A (en) | 2012-02-16 | 2016-10-28 | Atyr Pharma Inc | Histidyl-trna synthetases for treating autoimmune and inflammatory diseases |
WO2013130393A1 (en) | 2012-02-28 | 2013-09-06 | Cornell University | Aav-directed persistent expression of an anti-nicotine antibody gene for smoking cessation |
SG11201406414WA (en) | 2012-04-11 | 2014-11-27 | Us Health | Chimeric antigen receptors targeting b-cell maturation antigen |
EP2855511B1 (de) | 2012-05-29 | 2019-07-24 | GenVec, Inc. | Impfstoff gegen das herpes-simplex virus |
AU2013352067A1 (en) | 2012-11-28 | 2015-06-04 | Abwiz Bio, Inc. | Preparation of gene-specific templates for the use in single primer amplification |
US9510569B2 (en) | 2013-03-13 | 2016-12-06 | Regeneron Pharmaceuticals, Inc. | Genetically modified mouse with an inducible Acvr1 gene with a mutant R206H exon 5 that has ectopic bone formation |
DK2992017T3 (da) | 2013-05-02 | 2021-01-25 | Anaptysbio Inc | Antistoffer rettet mod programmeret død-1 (pd-1) |
US20160355573A1 (en) | 2013-09-05 | 2016-12-08 | Cornell University | Gene therapy for alzheimer's and other neurodegenerative diseases and conditions |
US10087224B2 (en) | 2013-11-01 | 2018-10-02 | Cornell University | Gene therapy for Alzheimer's and other neurodegenerative diseases and conditions |
CA2936366A1 (en) | 2014-01-10 | 2015-07-16 | Anaptysbio, Inc. | Antibodies directed against interleukin-33 (il-33) |
US10106583B2 (en) | 2014-03-07 | 2018-10-23 | Cornell University | Materials and methods for producing cleaved, HIV-1 envelope glycoprotein trimers |
AU2015270912B9 (en) | 2014-06-02 | 2021-01-21 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Chimeric antigen receptors targeting CD-19 |
EP2993229A1 (de) | 2014-09-02 | 2016-03-09 | Heinrich-Pette-Institut Leibniz-Institut für experimentelle Virologie-Stiftung bürgerlichen Rechts - | Verträgliche und hochspezifische massgeschneiderte Rekombinase zur Rekombination asymmetrischer Zielorte in mehreren Retrovirenstämmen |
EP3224381B1 (de) | 2014-11-25 | 2019-09-04 | The Brigham and Women's Hospital, Inc. | Verfahren zur identifizierung von personen mit einer prädisposition für eine kardiometabolische krankheit oder davon betroffenen personen |
US10683552B2 (en) | 2014-11-25 | 2020-06-16 | Presidents And Fellows Of Harvard College | Clonal haematopoiesis |
MA41463A (fr) | 2015-02-03 | 2017-12-12 | Anaptysbio Inc | Anticorps dirigés contre le gène d'activation 3 des lymphocytes (lag-3) |
US10946094B2 (en) | 2015-02-24 | 2021-03-16 | Cornell University | Adenoassociated viral mediated persistant anti-VEGF therapy for ovarian cancer |
MA41867A (fr) | 2015-04-01 | 2018-02-06 | Anaptysbio Inc | Anticorps dirigés contre l'immunoglobuline de cellule t et protéine 3 de mucine (tim-3) |
US10293059B2 (en) | 2015-04-09 | 2019-05-21 | Cornell University | Gene therapy to prevent reactions to allergens |
CN107847590B (zh) | 2015-04-15 | 2022-07-26 | 安奈普泰斯生物有限公司 | 针对白细胞介素36受体(il-36r)的抗体 |
WO2016183297A1 (en) | 2015-05-12 | 2016-11-17 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Aav isolate and fusion protein comprising nerve growth factor signal peptide and parathyroid hormone |
CA2987103A1 (en) | 2015-05-28 | 2016-12-01 | Cornell University | Adeno-associated virus mediated delivery of c1ei as a therapy for angioedema |
WO2017180587A2 (en) | 2016-04-11 | 2017-10-19 | Obsidian Therapeutics, Inc. | Regulated biocircuit systems |
US11155624B2 (en) | 2016-11-01 | 2021-10-26 | Anaptysbio, Inc. | Antibodies directed against programmed death-1 (PD-1) |
WO2018085469A2 (en) | 2016-11-01 | 2018-05-11 | Anaptysbio, Inc. | Antibodies directed against t cell immunoglobulin and mucin protein 3 (tim-3) |
MX2019008208A (es) | 2017-01-09 | 2019-12-11 | Tesaro Inc | Métodos para tratar el cáncer con anticuerpos anti-tim-3. |
KR102606252B1 (ko) | 2017-01-09 | 2023-11-23 | 테사로, 인코포레이티드 | 항-pd-1 항체로 암을 치료하는 방법 |
CA3060514A1 (en) | 2017-04-20 | 2018-10-25 | Atyr Pharma, Inc. | Compositions and methods for treating lung inflammation |
WO2018231759A1 (en) | 2017-06-12 | 2018-12-20 | Obsidian Therapeutics, Inc. | Pde5 compositions and methods for immunotherapy |
HRP20220615T1 (hr) | 2017-06-30 | 2022-06-24 | Inscripta, Inc. | Postupci, moduli, instrumenti i sustavi za automatiziranu obradu stanica |
US10869465B2 (en) * | 2017-08-10 | 2020-12-22 | Osaka University | Transgenic mouse model of retinal vascular disease, method of making, and method of using |
US10738327B2 (en) | 2017-08-28 | 2020-08-11 | Inscripta, Inc. | Electroporation cuvettes for automation |
US10443074B2 (en) | 2017-09-30 | 2019-10-15 | Inscripta, Inc. | Modification of cells by introduction of exogenous material |
KR20200105494A (ko) | 2017-12-29 | 2020-09-07 | 코넬 유니버시티 | 호산구성 장애에 대한 유전자 요법 |
EP3775159A4 (de) | 2018-03-29 | 2022-01-19 | Inscripta, Inc. | Automatisierte steuerung von zellwachstumsgeschwindigkeiten für induktion und transformation |
WO2019200004A1 (en) | 2018-04-13 | 2019-10-17 | Inscripta, Inc. | Automated cell processing instruments comprising reagent cartridges |
WO2019209926A1 (en) | 2018-04-24 | 2019-10-31 | Inscripta, Inc. | Automated instrumentation for production of peptide libraries |
US10526598B2 (en) | 2018-04-24 | 2020-01-07 | Inscripta, Inc. | Methods for identifying T-cell receptor antigens |
US10858761B2 (en) | 2018-04-24 | 2020-12-08 | Inscripta, Inc. | Nucleic acid-guided editing of exogenous polynucleotides in heterologous cells |
US11821009B2 (en) | 2018-05-15 | 2023-11-21 | Cornell University | Genetic modification of the AAV capsid resulting in altered tropism and enhanced vector delivery |
AU2019284762A1 (en) | 2018-06-13 | 2020-11-19 | Regeneron Pharmaceuticals, Inc. | A rodent model of fibrodysplasia ossificans progressiva |
EA202190358A1 (ru) | 2018-07-31 | 2021-05-04 | Корнелл Юниверсити | Способы генной терапии для контроля функции органов |
US10532324B1 (en) | 2018-08-14 | 2020-01-14 | Inscripta, Inc. | Instruments, modules, and methods for improved detection of edited sequences in live cells |
IL292273B2 (en) | 2018-08-14 | 2023-10-01 | Inscripta Inc | Devices, modules and methods for improved detection of edited sequences in living cells |
US11142740B2 (en) | 2018-08-14 | 2021-10-12 | Inscripta, Inc. | Detection of nuclease edited sequences in automated modules and instruments |
CA3108892A1 (en) | 2018-08-30 | 2020-04-23 | Inscripta, Inc. | Improved detection of nuclease edited sequences in automated modules and instruments |
WO2020104648A2 (en) | 2018-11-22 | 2020-05-28 | Fundació Institut De Recerca Biomèdica (Irb Barcelona) | TGFβ INHIBITOR AND PRODRUGS |
EP3969037A4 (de) | 2019-05-16 | 2024-01-17 | Univ Boston | Regulierte synthetische genexpressionssysteme |
AU2020286444A1 (en) | 2019-06-05 | 2021-12-23 | Anaptysbio, Inc. | PD-1 agonist and method of using same |
WO2020247815A1 (en) * | 2019-06-06 | 2020-12-10 | Cornell University | Transgenic rodent model for lung fibrosis and uses thereof |
CN114008070A (zh) | 2019-06-21 | 2022-02-01 | 因思科瑞普特公司 | 导致大肠杆菌赖氨酸产量增加的全基因组合理设计的突变 |
US10927385B2 (en) | 2019-06-25 | 2021-02-23 | Inscripta, Inc. | Increased nucleic-acid guided cell editing in yeast |
JP2022538886A (ja) | 2019-07-01 | 2022-09-06 | トリアニ・インコーポレイテッド | トランスジェニック哺乳動物およびその使用法 |
CA3144958A1 (en) | 2019-07-01 | 2021-01-07 | Trianni, Inc. | Transgenic mammals and methods of use thereof |
WO2021022208A1 (en) | 2019-08-01 | 2021-02-04 | Kaplitt Michael G | Targeted gene therapy to treat neurological diseases |
US20220332780A1 (en) | 2019-09-10 | 2022-10-20 | Obsidian Therapeutics, Inc. | Ca2-il15 fusion proteins for tunable regulation |
WO2021076794A1 (en) | 2019-10-15 | 2021-04-22 | Cornell University | Methods for modulating level of expression from gene therapy expression cassette |
JP2023500793A (ja) | 2019-10-16 | 2023-01-11 | コーネル・ユニバーシティー | アルツハイマー病に対する遺伝子治療方法 |
WO2021091945A1 (en) | 2019-11-05 | 2021-05-14 | Janssen Biotech, Inc. | Bcma-targeted car-t cell therapy of multiple myeloma |
US10689669B1 (en) | 2020-01-11 | 2020-06-23 | Inscripta, Inc. | Automated multi-module cell processing methods, instruments, and systems |
WO2021150701A1 (en) | 2020-01-21 | 2021-07-29 | Bolt Biotherapeutics, Inc. | Anti-pd-l1 antibodies |
US20230069055A1 (en) | 2020-01-21 | 2023-03-02 | Bolt Biotherapeutics, Inc | Anti-pd-l1 antibodies |
US20210332388A1 (en) | 2020-04-24 | 2021-10-28 | Inscripta, Inc. | Compositions, methods, modules and instruments for automated nucleic acid-guided nuclease editing in mammalian cells |
WO2021222894A1 (en) | 2020-05-01 | 2021-11-04 | Bolt Biotherapeutics, Inc. | Anti-dectin-2 antibodies |
CN111705080A (zh) * | 2020-05-14 | 2020-09-25 | 广州市第八人民医院 | Hbv非人动物模型的构建方法及其应用 |
US11787841B2 (en) | 2020-05-19 | 2023-10-17 | Inscripta, Inc. | Rationally-designed mutations to the thrA gene for enhanced lysine production in E. coli |
WO2022026829A1 (en) | 2020-07-30 | 2022-02-03 | Anaptysbio, Inc. | Anti-interleukin 36 receptor (il-36r) therapy for skin toxicity |
WO2022026832A1 (en) | 2020-07-30 | 2022-02-03 | Anaptysbio, Inc. | Anti-interleukin 36 receptor (il-36r) therapy for ichthyosis |
US20230391872A1 (en) | 2020-10-23 | 2023-12-07 | Anaptysbio, Inc. | B and t lymphocyte attenuator (btla) modulators and method of using same |
WO2022116086A1 (en) | 2020-12-03 | 2022-06-09 | Janssen Biotech, Inc. | Bcma-targeted car-t cell therapy for multiple myeloma |
AU2022268937A1 (en) | 2021-05-05 | 2023-10-26 | Trianni, Inc. | Transgenic rodents expressing chimeric equine-rodent antibodies and methods of use thereof |
WO2023077343A1 (en) | 2021-11-04 | 2023-05-11 | Janssen Biotech, Inc. | Bcma-targeted car-t cell therapy for multiple myeloma |
CA3237341A1 (en) | 2021-11-04 | 2023-05-11 | Nanjing Legend Biotech Co., Ltd. | Bcma-targeted car-t cell therapy for multiple myeloma |
CA3235395A1 (en) | 2021-11-10 | 2023-05-19 | Peter Burrows | Transgenic mammals and methods of use thereof |
WO2023137460A1 (en) | 2022-01-14 | 2023-07-20 | Saccharo, Inc. | De-n-acetylated polysialic acid (dpsa) binding agent and method of using same |
WO2023164727A1 (en) | 2022-02-28 | 2023-08-31 | University Of Iowa Research Foundation | A-fabp antibodies for diagnosis and treatment of obesity-associated diseases |
WO2023164695A2 (en) | 2022-02-28 | 2023-08-31 | Janssen Biotech, Inc. | Bcma-targeted car-t cell therapy for multiple myeloma |
WO2023212611A1 (en) | 2022-04-27 | 2023-11-02 | Anaptysbio, Inc. | B and t lymphocyte attenuator (btla) modulators and method of using same |
WO2023239609A1 (en) | 2022-06-06 | 2023-12-14 | Cornell University | Promoting nutrient absorption through the colon |
WO2024102760A2 (en) | 2022-11-07 | 2024-05-16 | Anaptysbio, Inc. | Cd 122 binding agents and method of using same |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1992006104A1 (en) | 1990-09-28 | 1992-04-16 | The Dana-Farber Cancer Institute | Adipocyte-specific dna sequences and use for the production of transgenic animals exhibiting altered fat metabolism |
AU683227B2 (en) | 1992-08-26 | 1997-11-06 | Bioscience 2002 Llc | Tetracycline repressor-mediated binary regulation system for control of gene expression in transgenic animals |
EP0659045A4 (de) * | 1993-05-18 | 1997-02-26 | Inst Nat Sante Rech Med | Gentechnologisch hergestellte mäuse, die veränderungen in den genen enthalten, welche retinoinsäure-rezeptor proteine kodieren. |
US5866755A (en) | 1993-06-14 | 1999-02-02 | Basf Aktiengellschaft | Animals transgenic for a tetracycline-regulated transcriptional inhibitor |
EP0632054A1 (de) * | 1993-06-28 | 1995-01-04 | European Molecular Biology Laboratory | Regulation stellenspezifischer Rekombination mittels stellungsspezifischer Rekombinase/Kernrezeptor-Fusionsproteine |
EP0739412B1 (de) | 1993-12-23 | 2002-02-27 | Infigen, Inc. | EMBRYONALE STAMMZELLEN von Huftieren ALS KERNDONATOREN UND KERNTRANSFERTECHNIKEN ZUR HERSTELLUNG CHIMÄRER UND TRANSGENER TIERE |
FR2723315B1 (fr) | 1994-08-02 | 1996-10-25 | Cird Galderma | Procede et composition pour stimuler la differenciation des cellules preadipocytaires et traitements therapeutiques associes |
EP0804546A4 (de) | 1995-01-20 | 2000-09-20 | Human Genome Sciences Inc | Menschliche, prostata-spezifische reduktase |
GB9517780D0 (en) | 1995-08-31 | 1995-11-01 | Roslin Inst Edinburgh | Biological manipulation |
GB9517779D0 (en) | 1995-08-31 | 1995-11-01 | Roslin Inst Edinburgh | Biological manipulation |
JPH11511472A (ja) | 1995-09-18 | 1999-10-05 | リガンド・ファーマシューティカルズ・インコーポレイテッド | Rxrアゴニストを用いたniddmの治療 |
FR2745008A1 (fr) * | 1996-02-20 | 1997-08-22 | Ass Pour Le Dev De La Rech En | Recepteur nucleaire de glucocorticoides modifie, fragments d'adn codant pour ledit recepteur et procedes dans lesquels ils sont mis en oeuvre |
US6093873A (en) * | 1996-08-19 | 2000-07-25 | Institut National De La Sante Et De La Recherche Medicale | Genetically engineered mice containing alterations in the gene encoding RXR |
US5945577A (en) | 1997-01-10 | 1999-08-31 | University Of Massachusetts As Represented By Its Amherst Campus | Cloning using donor nuclei from proliferating somatic cells |
BR9811657A (pt) | 1997-07-03 | 2000-09-05 | Univ Massachusetts Public Inst | Clonagem usando-se núcleos doadores oriundos de células diferenciadas não-carentes de soro |
SE9703663D0 (sv) * | 1997-10-08 | 1997-10-08 | Pharmacia & Upjohn Ab | Beta recombinase |
JP4206154B2 (ja) * | 1997-11-13 | 2009-01-07 | 大日本住友製薬株式会社 | 変異型loxP配列とその応用 |
US6331659B1 (en) | 1998-01-21 | 2001-12-18 | University Of Hawaii | Cumulus cells as nuclear donors |
CA2362970A1 (en) | 1999-02-19 | 2000-08-24 | Octagene Gmbh | Hormone-hormone receptor complexes and nucleic acid constructs and their use in gene therapy |
-
2000
- 2000-10-03 FR FR0012570A patent/FR2814642B1/fr not_active Expired - Fee Related
-
2001
- 2001-05-11 US US09/853,033 patent/US7112715B2/en not_active Expired - Lifetime
- 2001-09-28 DE DE60134588T patent/DE60134588D1/de not_active Expired - Lifetime
- 2001-09-28 EP EP06101289A patent/EP1692936B1/de not_active Expired - Lifetime
- 2001-09-28 AT AT06101289T patent/ATE398922T1/de not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP1692936B1 (de) | 2008-06-25 |
FR2814642B1 (fr) | 2005-07-01 |
US7112715B2 (en) | 2006-09-26 |
EP1692936A1 (de) | 2006-08-23 |
US20020100068A1 (en) | 2002-07-25 |
FR2814642A1 (fr) | 2002-04-05 |
DE60134588D1 (de) | 2008-08-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE398922T1 (de) | Verwendung des cre-ert2 fusionsproteins zur konditionalen gezielten dns-rekombination in der maus | |
ATE318900T1 (de) | Ef-1-alpha transkriptionsregulatorische dna aus hamster | |
ATE443074T1 (de) | Zubereitungen und methoden zur verwendung in rekombinatorischem klonen von nukleinsäuren | |
WO1999057128A8 (en) | Optimization of pest resistance genes using dna shuffling | |
WO2002029032A3 (en) | Whole cell engineering by mutagenizing a substantial portion of a starting genome, combining mutations, and optionally repeating | |
MXPA05014215A (es) | Mapeo de genoma de elementos funcionales de adn y proteinas celulares. | |
ATE456577T1 (de) | T1r1-geschmacksrezeptoren und diese verschlüsselnde gene | |
ATE480383T1 (de) | Zusammensetzungen und verfahren zur verbesserung der aufwärmrate von pet unter verwendung von aktivkohle | |
ATE535615T1 (de) | Chemisch modifizierte nukleinsäuren und methode zur kopplung von nukleinsäuren an einen festen träger | |
DE60207978T2 (de) | Biochip mit Kohlenstoff-Nanoröhrchen sowie Verfahren zur Trennung von Proben unter Verwendung dieses Biochips | |
DE69838483D1 (de) | Thymidinkinase mutanten und fusionproteine mit thymidinkinase und guanylatekinase aktivitäten | |
DE69738254D1 (de) | Methode zur bereitstellung von dna sequenzen | |
WO2006018650A3 (en) | Method of in vitro polypeptide selection using the arc dna binding domain fused to the polypeptide to be selected | |
WO2001090340A3 (en) | Assembly of large viral genomes and chromosomes from subclones | |
WO2002028175A3 (en) | Transgenic mouse for targeted recombination mediated by modified cre-er | |
Heller et al. | Ctenosciara alexanderkoenigi sp. n.(Diptera: Sciaridae), an exotic invader in Germany? | |
DE69928250D1 (de) | Analytisches verfahren unter verwendung von multipelviren-markierung | |
ATE441728T1 (de) | Mit cmv-resistenz assoziierter molekularer marker und verwendung davon | |
ATE319819T1 (de) | Humane hirn-spezifische carboxypeptidase b | |
ATE455562T1 (de) | Endothelzellspezifität zeigende promotoren und verfahren zu deren verwendung | |
TR200003695T2 (tr) | Anjiyostatin bağlayıcı protein. | |
DE60036645D1 (de) | Methoden zur identifizierung evolutionär signifikanter änderungen in polynukleotid- und polypeptidsequenzen in domestizierten pflanzen und tieren | |
DE69733082D1 (de) | Verfahren zur identifizierung von mutanten und molekülen | |
ATE269905T1 (de) | Verfahren zur herstellung von proteinen in wirtszellen unter verwendung von chaperoninen | |
DE69532161D1 (de) | Vektoren zum einschaeuse von dns in mykobakterien und verwendung dieser bakterien als impfstoffe |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |