DE60134588D1 - Verwendung des Cre-ERT2 Fusionsproteins zur konditionalen gezielten DNS-Rekombination in der Maus - Google Patents

Verwendung des Cre-ERT2 Fusionsproteins zur konditionalen gezielten DNS-Rekombination in der Maus

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Publication number
DE60134588D1
DE60134588D1 DE60134588T DE60134588T DE60134588D1 DE 60134588 D1 DE60134588 D1 DE 60134588D1 DE 60134588 T DE60134588 T DE 60134588T DE 60134588 T DE60134588 T DE 60134588T DE 60134588 D1 DE60134588 D1 DE 60134588D1
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organism
mouse
fusion protein
cre
interest
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Expired - Lifetime
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DE60134588T
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English (en)
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Pierre Chambon
Daniel Metzger
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GIE CERBM CT EUROP DE RECH EN
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GIE CERBM CT EUROP DE RECH EN
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
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    • A01K2217/07—Animals genetically altered by homologous recombination
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    • A—HUMAN NECESSITIES
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    • A01K2217/20—Animal model comprising regulated expression system
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    • A01K2217/00—Genetically modified animals
    • A01K2217/20—Animal model comprising regulated expression system
    • A01K2217/203—Animal model comprising inducible/conditional expression system, e.g. hormones, tet
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
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    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
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    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0331—Animal model for proliferative diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2319/00—Fusion polypeptide
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/71—Fusion polypeptide containing domain for protein-protein interaction containing domain for transcriptional activaation, e.g. VP16
    • C07K2319/715—Fusion polypeptide containing domain for protein-protein interaction containing domain for transcriptional activaation, e.g. VP16 containing a domain for ligand dependent transcriptional activation, e.g. containing a steroid receptor domain
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DE60134588T 2000-10-03 2001-09-28 Verwendung des Cre-ERT2 Fusionsproteins zur konditionalen gezielten DNS-Rekombination in der Maus Expired - Lifetime DE60134588D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0012570A FR2814642B1 (fr) 2000-10-03 2000-10-03 Souris transgenique pour la recombinaison ciblee mediee par la cre-er modifiee
US09/853,033 US7112715B2 (en) 2000-10-03 2001-05-11 Transgenic mouse for targeted recombination mediated by modified Cre-ER

Publications (1)

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DE60134588D1 true DE60134588D1 (de) 2008-08-07

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DE60134588T Expired - Lifetime DE60134588D1 (de) 2000-10-03 2001-09-28 Verwendung des Cre-ERT2 Fusionsproteins zur konditionalen gezielten DNS-Rekombination in der Maus

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US (1) US7112715B2 (de)
EP (1) EP1692936B1 (de)
AT (1) ATE398922T1 (de)
DE (1) DE60134588D1 (de)
FR (1) FR2814642B1 (de)

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