ATE374827T1 - Überexpression von gewünschten proteinen in eukaryotischen zellen mittels überexpression von cyclin d1 - Google Patents
Überexpression von gewünschten proteinen in eukaryotischen zellen mittels überexpression von cyclin d1Info
- Publication number
- ATE374827T1 ATE374827T1 AT99942098T AT99942098T ATE374827T1 AT E374827 T1 ATE374827 T1 AT E374827T1 AT 99942098 T AT99942098 T AT 99942098T AT 99942098 T AT99942098 T AT 99942098T AT E374827 T1 ATE374827 T1 AT E374827T1
- Authority
- AT
- Austria
- Prior art keywords
- protein
- interest
- cyclin
- overexpression
- nucleic acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4738—Cell cycle regulated proteins, e.g. cyclin, CDC, INK-CCR
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US9608698P | 1998-08-11 | 1998-08-11 | |
US09/371,309 US6210924B1 (en) | 1998-08-11 | 1999-08-10 | Overexpressing cyclin D 1 in a eukaryotic cell line |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE374827T1 true ATE374827T1 (de) | 2007-10-15 |
Family
ID=22255220
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT99942098T ATE374827T1 (de) | 1998-08-11 | 1999-08-11 | Überexpression von gewünschten proteinen in eukaryotischen zellen mittels überexpression von cyclin d1 |
Country Status (15)
Country | Link |
---|---|
US (1) | US6210924B1 (de) |
EP (1) | EP1105507B1 (de) |
JP (1) | JP4562915B2 (de) |
KR (1) | KR100502701B1 (de) |
CN (1) | CN1151263C (de) |
AT (1) | ATE374827T1 (de) |
AU (1) | AU747640B2 (de) |
CA (1) | CA2338820C (de) |
CY (1) | CY1106987T1 (de) |
DE (1) | DE69937243T2 (de) |
DK (1) | DK1105507T3 (de) |
ES (1) | ES2291038T3 (de) |
HU (1) | HU230247B1 (de) |
PT (1) | PT1105507E (de) |
WO (1) | WO2000009714A1 (de) |
Families Citing this family (43)
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US20020090646A1 (en) * | 2000-05-03 | 2002-07-11 | Amgen Inc. | Calcitonin-related molecules |
ATE464068T1 (de) | 2001-06-26 | 2010-04-15 | Amgen Fremont Inc | Antikörper gegen opgl |
AU2002316384A1 (en) * | 2001-06-26 | 2003-03-03 | Photomed Technologies, Inc. | Multiple wavelength illuminator |
KR100427299B1 (ko) * | 2001-08-10 | 2004-04-14 | 한국생명공학연구원 | 인체 골 재흡수 억제인자(hOPG)를 생산하는 재조합플라스미드 pGHOPG(KCTC 1019BP) |
JP4761710B2 (ja) | 2002-04-05 | 2011-08-31 | アムジェン インコーポレイテッド | 選択的opgl経路インヒビターとしてのヒト抗opgl中和抗体 |
EA033750B1 (ru) | 2002-09-06 | 2019-11-21 | Amgen Inc | Изолированная молекула нуклеиновой кислоты, кодирующая антитело человека к рецептору интерлейкина-1, и ее применение |
MY146381A (en) | 2004-12-22 | 2012-08-15 | Amgen Inc | Compositions and methods relating relating to anti-igf-1 receptor antibodies |
EP1739179A1 (de) * | 2005-06-30 | 2007-01-03 | Octapharma AG | Serumfreie stabile Transfektion und Produktion von rekombinanten humanen Proteinen in humanen Zelllinien |
PE20070684A1 (es) | 2005-11-14 | 2007-08-06 | Amgen Inc | MOLECULAS QUIMERICAS DE ANTICUERPO RANKL-PTH/PTHrP |
BRPI0716762A2 (pt) | 2006-09-13 | 2013-09-24 | Abbott Lab | melhorias da cultura celular |
EP2500416A1 (de) | 2006-09-13 | 2012-09-19 | Abbott Laboratories | Verbesserungen an Zellkulturen |
PE20130588A1 (es) * | 2007-02-02 | 2013-05-21 | Amgen Inc | Hepcidina, antagonistas de la hepcidina y metodos de uso |
US7982016B2 (en) | 2007-09-10 | 2011-07-19 | Amgen Inc. | Antigen binding proteins capable of binding thymic stromal lymphopoietin |
JO3382B1 (ar) | 2008-12-23 | 2019-03-13 | Amgen Inc | أجسام مضادة ترتبط مع مستقبل cgrp بشري |
ES2688978T3 (es) | 2009-11-23 | 2018-11-07 | Amgen Inc. | Anticuerpo monomérico Fc |
US8962277B2 (en) * | 2010-07-05 | 2015-02-24 | Univeristät für Bodenkultur Wien | Production cell line |
WO2012106556A2 (en) | 2011-02-02 | 2012-08-09 | Amgen Inc. | Methods and compositons relating to inhibition of igf-1r |
US9441039B2 (en) | 2012-05-07 | 2016-09-13 | Amgen Inc. | Anti-erythropoietin antibodies |
US20140004121A1 (en) | 2012-06-27 | 2014-01-02 | Amgen Inc. | Anti-mesothelin binding proteins |
US11427627B2 (en) | 2013-09-05 | 2022-08-30 | Amgen Inc. | Fc-containing molecules exhibiting predictable, consistent, and reproducible glycoform profiles |
US10435464B1 (en) | 2014-09-05 | 2019-10-08 | Coherus Biosciences, Inc. | Methods for making recombinant proteins |
MX2017003247A (es) | 2014-09-15 | 2017-11-30 | Amgen Inc | Proteina de union a antigenos, bi-especificos del receptor anti-cgrp/receptor pac1 y usos de las mismas. |
AU2015332577B2 (en) | 2014-10-15 | 2021-12-23 | Amgen Inc. | Promoter and regulatory elements for improved expression of heterologous genes in host cells |
CN105669863B (zh) | 2014-12-05 | 2019-09-13 | 鸿运华宁(杭州)生物医药有限公司 | 一种能与人内皮素受体特异性结合的抗体及其应用 |
WO2017058944A1 (en) | 2015-09-29 | 2017-04-06 | Amgen Inc. | Asgr inhibitors |
US11028410B2 (en) | 2016-01-27 | 2021-06-08 | Just-Evotec Biologics, Inc. | Hybrid promoter and uses thereof |
US11261462B2 (en) | 2016-01-27 | 2022-03-01 | Just-Evotec Biologics, Inc. | Inducible expression from transposon-based vectors and uses |
US11098310B2 (en) | 2016-01-27 | 2021-08-24 | Just-Evotec Biologics, Inc. | Expression from transposon-based vectors and uses |
TWI826351B (zh) | 2016-05-31 | 2023-12-21 | 大陸商鴻運華寧(杭州)生物醫藥有限公司 | R抗體,其藥物組合物及其應用 |
CN110234355B (zh) | 2017-02-01 | 2021-11-09 | 浙江时迈药业有限公司 | 单体人IgG1 Fc和双特异性抗体 |
CN117003874A (zh) | 2018-03-20 | 2023-11-07 | 鸿运华宁(杭州)生物医药有限公司 | Gipr抗体及其与glp-1的融合蛋白质,以及其药物组合物和应用 |
CN110357959B (zh) | 2018-04-10 | 2023-02-28 | 鸿运华宁(杭州)生物医药有限公司 | Gcgr抗体及其与glp-1的融合蛋白质,以及其药物组合物和应用 |
EP3788076A1 (de) | 2018-05-01 | 2021-03-10 | Amgen Inc. | Antikörper mit modulierten glycanprofilen |
CN110655577A (zh) | 2018-06-13 | 2020-01-07 | 鸿运华宁(杭州)生物医药有限公司 | APJ抗体及其与Elabela的融合蛋白质,以及其药物组合物和应用 |
EP3980464A1 (de) | 2019-06-07 | 2022-04-13 | Amgen Inc. | Bispezifische bindungskonstrukte mit selektiv spaltbaren linkern |
CN112239507A (zh) | 2019-07-17 | 2021-01-19 | 鸿运华宁(杭州)生物医药有限公司 | ETA抗体与TGF-β Trap的融合蛋白质,以及其药物组合物和应用 |
CN112521501A (zh) | 2019-09-18 | 2021-03-19 | 鸿运华宁(杭州)生物医药有限公司 | Gipr抗体及其与glp-1的融合蛋白质,以及其药物组合物和应用 |
CA3184351A1 (en) | 2020-06-04 | 2021-12-09 | Amgen Inc. | Bispecific binding constructs |
AU2021393456A1 (en) | 2020-12-03 | 2023-06-29 | Amgen Inc. | Immunoglobuline constructs with multiple binding domains |
CN115141276A (zh) | 2021-03-31 | 2022-10-04 | 鸿运华宁(杭州)生物医药有限公司 | 一种能与人内皮素受体特异性结合的抗体及其在糖尿病肾病和慢性肾病治疗中的应用 |
AU2022287014A1 (en) | 2021-06-04 | 2023-12-07 | Amgen Inc. | T cell engager molecules and uses thereof |
CN113698466B (zh) * | 2021-07-30 | 2023-07-14 | 山东农业大学 | Ccnd1在制备禽反转录病毒生产增强剂中的应用 |
WO2024092033A1 (en) | 2022-10-26 | 2024-05-02 | Amgen Inc. | Multispecific molecules for clearance of immunoglobulins in the treatment of autoantibody-induced diseases |
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US4703008A (en) | 1983-12-13 | 1987-10-27 | Kiren-Amgen, Inc. | DNA sequences encoding erythropoietin |
IL79176A (en) | 1985-06-20 | 1992-06-21 | Kirin Amgen Inc | Process for the recovery of erythropoietin from a fluid |
US5013718A (en) | 1986-11-21 | 1991-05-07 | Amgen, Inc. | Method for treating iron overload using EPO |
WO1991005867A1 (en) | 1989-10-13 | 1991-05-02 | Amgen Inc. | Erythropoietin isoforms |
JPH06117187A (ja) | 1992-10-08 | 1994-04-26 | Iseki Tory Tech Inc | シールド掘削機 |
US5514571A (en) | 1993-08-05 | 1996-05-07 | University Technologies International Inc. | Cyclin D1 negative regulatory activity |
US5521066A (en) | 1993-09-13 | 1996-05-28 | Bristol-Myers Squibb Company | Periplasmic membrane-bound system for detecting protein-protein interactions |
WO1995016774A1 (en) | 1993-12-17 | 1995-06-22 | Spinal Cord Society | Method for inducing dna synthesis in neurons |
US6309853B1 (en) | 1994-08-17 | 2001-10-30 | The Rockfeller University | Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof |
AU6028396A (en) | 1995-06-07 | 1996-12-30 | Amgen, Inc. | Ob protein compositions and method |
CA2229450A1 (en) | 1995-08-17 | 1997-02-27 | Amgen Inc. | Methods of reducing or maintaining reduced levels of blood lipids using ob protein compositions |
NZ511617A (en) | 1995-11-22 | 2003-08-29 | Amgen Inc | DNA encoding OB protein and uses thereof |
US6369027B1 (en) | 1995-12-22 | 2002-04-09 | Amgen Inc. | Osteoprotegerin |
GB9608143D0 (en) * | 1996-04-19 | 1996-06-26 | Ver Nl Kanker Inst | Assay |
-
1999
- 1999-08-10 US US09/371,309 patent/US6210924B1/en not_active Expired - Lifetime
- 1999-08-11 DK DK99942098T patent/DK1105507T3/da active
- 1999-08-11 WO PCT/US1999/018213 patent/WO2000009714A1/en active IP Right Grant
- 1999-08-11 CA CA002338820A patent/CA2338820C/en not_active Expired - Lifetime
- 1999-08-11 DE DE69937243T patent/DE69937243T2/de not_active Expired - Lifetime
- 1999-08-11 JP JP2000565148A patent/JP4562915B2/ja not_active Expired - Lifetime
- 1999-08-11 KR KR10-2001-7001843A patent/KR100502701B1/ko not_active IP Right Cessation
- 1999-08-11 HU HU0103485A patent/HU230247B1/hu unknown
- 1999-08-11 ES ES99942098T patent/ES2291038T3/es not_active Expired - Lifetime
- 1999-08-11 AU AU55546/99A patent/AU747640B2/en not_active Expired
- 1999-08-11 PT PT99942098T patent/PT1105507E/pt unknown
- 1999-08-11 AT AT99942098T patent/ATE374827T1/de active
- 1999-08-11 EP EP99942098A patent/EP1105507B1/de not_active Expired - Lifetime
- 1999-08-11 CN CNB998118990A patent/CN1151263C/zh not_active Expired - Lifetime
-
2007
- 2007-11-08 CY CY20071101438T patent/CY1106987T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
US6210924B1 (en) | 2001-04-03 |
EP1105507B1 (de) | 2007-10-03 |
CA2338820C (en) | 2005-10-18 |
DE69937243T2 (de) | 2008-07-03 |
CY1106987T1 (el) | 2012-09-26 |
JP4562915B2 (ja) | 2010-10-13 |
CN1322253A (zh) | 2001-11-14 |
AU5554699A (en) | 2000-03-06 |
ES2291038T3 (es) | 2008-02-16 |
JP2003524378A (ja) | 2003-08-19 |
HUP0103485A2 (hu) | 2002-01-28 |
PT1105507E (pt) | 2007-12-07 |
WO2000009714A9 (en) | 2000-05-18 |
AU747640B2 (en) | 2002-05-16 |
WO2000009714A1 (en) | 2000-02-24 |
DE69937243D1 (de) | 2007-11-15 |
KR20020013462A (ko) | 2002-02-20 |
HUP0103485A3 (en) | 2010-01-28 |
DK1105507T3 (da) | 2007-11-05 |
KR100502701B1 (ko) | 2005-07-22 |
CA2338820A1 (en) | 2000-02-24 |
EP1105507A1 (de) | 2001-06-13 |
HU230247B1 (hu) | 2015-11-30 |
CN1151263C (zh) | 2004-05-26 |
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