ATE374827T1 - Überexpression von gewünschten proteinen in eukaryotischen zellen mittels überexpression von cyclin d1 - Google Patents

Überexpression von gewünschten proteinen in eukaryotischen zellen mittels überexpression von cyclin d1

Info

Publication number
ATE374827T1
ATE374827T1 AT99942098T AT99942098T ATE374827T1 AT E374827 T1 ATE374827 T1 AT E374827T1 AT 99942098 T AT99942098 T AT 99942098T AT 99942098 T AT99942098 T AT 99942098T AT E374827 T1 ATE374827 T1 AT E374827T1
Authority
AT
Austria
Prior art keywords
protein
interest
cyclin
overexpression
nucleic acid
Prior art date
Application number
AT99942098T
Other languages
English (en)
Inventor
Shaw-Fen Hu
Jean Gudas
David Brankow
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Application granted granted Critical
Publication of ATE374827T1 publication Critical patent/ATE374827T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4738—Cell cycle regulated proteins, e.g. cyclin, CDC, INK-CCR
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
AT99942098T 1998-08-11 1999-08-11 Überexpression von gewünschten proteinen in eukaryotischen zellen mittels überexpression von cyclin d1 ATE374827T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9608698P 1998-08-11 1998-08-11
US09/371,309 US6210924B1 (en) 1998-08-11 1999-08-10 Overexpressing cyclin D 1 in a eukaryotic cell line

Publications (1)

Publication Number Publication Date
ATE374827T1 true ATE374827T1 (de) 2007-10-15

Family

ID=22255220

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99942098T ATE374827T1 (de) 1998-08-11 1999-08-11 Überexpression von gewünschten proteinen in eukaryotischen zellen mittels überexpression von cyclin d1

Country Status (15)

Country Link
US (1) US6210924B1 (de)
EP (1) EP1105507B1 (de)
JP (1) JP4562915B2 (de)
KR (1) KR100502701B1 (de)
CN (1) CN1151263C (de)
AT (1) ATE374827T1 (de)
AU (1) AU747640B2 (de)
CA (1) CA2338820C (de)
CY (1) CY1106987T1 (de)
DE (1) DE69937243T2 (de)
DK (1) DK1105507T3 (de)
ES (1) ES2291038T3 (de)
HU (1) HU230247B1 (de)
PT (1) PT1105507E (de)
WO (1) WO2000009714A1 (de)

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MY146381A (en) 2004-12-22 2012-08-15 Amgen Inc Compositions and methods relating relating to anti-igf-1 receptor antibodies
EP1739179A1 (de) * 2005-06-30 2007-01-03 Octapharma AG Serumfreie stabile Transfektion und Produktion von rekombinanten humanen Proteinen in humanen Zelllinien
TW200736277A (en) 2005-11-14 2007-10-01 Amgen Inc RANKL antibody-PTH/PTHrP chimeric molecules
KR20090074040A (ko) 2006-09-13 2009-07-03 아보트 러보러터리즈 세포 배양의 개선
EP2500416A1 (de) 2006-09-13 2012-09-19 Abbott Laboratories Verbesserungen an Zellkulturen
AU2008214386B2 (en) * 2007-02-02 2013-09-19 Amgen Inc Hepcidin and hepcidin antibodies
US7982016B2 (en) 2007-09-10 2011-07-19 Amgen Inc. Antigen binding proteins capable of binding thymic stromal lymphopoietin
JO3382B1 (ar) 2008-12-23 2019-03-13 Amgen Inc أجسام مضادة ترتبط مع مستقبل cgrp بشري
WO2011063348A1 (en) 2009-11-23 2011-05-26 Amgen Inc. Monomeric antibody fc
EP2591121B1 (de) * 2010-07-05 2018-01-24 Lonza Ltd Produktionszelllinie
CA2825894C (en) 2011-02-02 2021-11-30 Amgen Inc. Prognosis of cancer using a circulating biomarker
EP2847219A1 (de) 2012-05-07 2015-03-18 Amgen Inc. Anti-erythropoietin-antikörper
WO2014004549A2 (en) 2012-06-27 2014-01-03 Amgen Inc. Anti-mesothelin binding proteins
AU2014318017B2 (en) 2013-09-05 2020-02-06 Amgen Inc. Fc-containing molecules exhibiting predictable, consistent, and reproducible glycoform profiles
US10435464B1 (en) 2014-09-05 2019-10-08 Coherus Biosciences, Inc. Methods for making recombinant proteins
TW201620938A (zh) 2014-09-15 2016-06-16 安美基公司 雙特異性抗cgrp受體/pac1受體抗原結合蛋白質及其用途
JP6749898B2 (ja) 2014-10-15 2020-09-02 アムジエン・インコーポレーテツド 宿主細胞における異種由来遺伝子の発現を改善するためのプロモーター及び調節エレメント
CN111018987B (zh) 2014-12-05 2023-11-21 鸿运华宁（杭州）生物医药有限公司 一种能与人内皮素受体特异性结合的抗体及其应用
US10358497B2 (en) 2015-09-29 2019-07-23 Amgen Inc. Methods of treating cardiovascular disease with an ASGR inhibitor
US11098310B2 (en) 2016-01-27 2021-08-24 Just-Evotec Biologics, Inc. Expression from transposon-based vectors and uses
ES2823173T3 (es) 2016-01-27 2021-05-06 Just Biotherapeutics Inc Promotor híbrido y usos del mismo
US11261462B2 (en) 2016-01-27 2022-03-01 Just-Evotec Biologics, Inc. Inducible expression from transposon-based vectors and uses
TWI826351B (zh) 2016-05-31 2023-12-21 大陸商鴻運華寧（杭州）生物醫藥有限公司 Ｒ抗體,其藥物組合物及其應用
EP3576789A4 (de) 2017-02-01 2020-11-25 Centrymed Pharmaceuticals Inc. Monomere menschliche igg1-fc- und bispezifische antikörper
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CN110357959B (zh) 2018-04-10 2023-02-28 鸿运华宁（杭州）生物医药有限公司 Gcgr抗体及其与glp-1的融合蛋白质，以及其药物组合物和应用
MA52490A (fr) 2018-05-01 2021-03-10 Amgen Inc Anticorps présentant des profils de glycane modulés
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Also Published As

Publication number Publication date
CY1106987T1 (el) 2012-09-26
JP2003524378A (ja) 2003-08-19
US6210924B1 (en) 2001-04-03
PT1105507E (pt) 2007-12-07
HUP0103485A2 (hu) 2002-01-28
ES2291038T3 (es) 2008-02-16
EP1105507A1 (de) 2001-06-13
KR20020013462A (ko) 2002-02-20
KR100502701B1 (ko) 2005-07-22
AU747640B2 (en) 2002-05-16
CA2338820A1 (en) 2000-02-24
DE69937243T2 (de) 2008-07-03
CN1151263C (zh) 2004-05-26
HUP0103485A3 (en) 2010-01-28
CN1322253A (zh) 2001-11-14
DK1105507T3 (da) 2007-11-05
HU230247B1 (hu) 2015-11-30
AU5554699A (en) 2000-03-06
EP1105507B1 (de) 2007-10-03
JP4562915B2 (ja) 2010-10-13
CA2338820C (en) 2005-10-18
WO2000009714A1 (en) 2000-02-24
WO2000009714A9 (en) 2000-05-18
DE69937243D1 (de) 2007-11-15

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