ATE278024T1 - Methode zur herstellung von rekombinanten zellen - Google Patents

Methode zur herstellung von rekombinanten zellen

Info

Publication number
ATE278024T1
ATE278024T1 AT99961864T AT99961864T ATE278024T1 AT E278024 T1 ATE278024 T1 AT E278024T1 AT 99961864 T AT99961864 T AT 99961864T AT 99961864 T AT99961864 T AT 99961864T AT E278024 T1 ATE278024 T1 AT E278024T1
Authority
AT
Austria
Prior art keywords
recombinant
cell lines
recombinant cells
producing recombinant
amino acid
Prior art date
Application number
AT99961864T
Other languages
English (en)
Inventor
Jorge L Acevedo
Peter R Rhode
Original Assignee
Sunol Molecular Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sunol Molecular Corp filed Critical Sunol Molecular Corp
Application granted granted Critical
Publication of ATE278024T1 publication Critical patent/ATE278024T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/65—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression using markers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT99961864T 1998-12-03 1999-11-30 Methode zur herstellung von rekombinanten zellen ATE278024T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/204,979 US6156514A (en) 1998-12-03 1998-12-03 Methods for making recombinant cells
PCT/US1999/028255 WO2000032821A1 (en) 1998-12-03 1999-11-30 Methods for making recombinant cells

Publications (1)

Publication Number Publication Date
ATE278024T1 true ATE278024T1 (de) 2004-10-15

Family

ID=22760275

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99961864T ATE278024T1 (de) 1998-12-03 1999-11-30 Methode zur herstellung von rekombinanten zellen

Country Status (12)

Country Link
US (2) US6156514A (de)
EP (1) EP1137808B1 (de)
JP (1) JP2002531103A (de)
CN (1) CN1202261C (de)
AT (1) ATE278024T1 (de)
AU (1) AU770119B2 (de)
CA (1) CA2353575A1 (de)
DE (1) DE69920747T2 (de)
DK (1) DK1137808T3 (de)
ES (1) ES2230908T3 (de)
TW (1) TWI221483B (de)
WO (1) WO2000032821A1 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001271614B2 (en) * 2000-07-03 2007-05-31 Catalent Pharma Solutions, Llc Host cells containing multiple integrating vectors
US20030224415A1 (en) * 2001-06-29 2003-12-04 Gala Design, Inc. Selection free growth of host cells containing multiple integrating vectors
WO2003064659A1 (en) * 2002-01-11 2003-08-07 Genetica, Inc. Methods and compositions for optimizing recombinant expression
WO2003096966A2 (en) * 2002-05-21 2003-11-27 Resistentia Pharmaceuticals Ab Chimeric ige polypeptides and host cells
EP1581644B1 (de) * 2003-01-09 2007-06-06 Genentech, Inc. Reinigung von polypeptiden
US20050221429A1 (en) * 2004-01-16 2005-10-06 Cardinal Health Pts, Llc Host cells containing multiple integrating vectors comprising an amplifiable marker
US20090061478A1 (en) * 2006-01-30 2009-03-05 Lene Have Poulsen High-Speed Quantification of Antigen Specific T-Cells in Whole Blood by Flow Cytometry
WO2008116468A2 (en) 2007-03-26 2008-10-02 Dako Denmark A/S Mhc peptide complexes and uses thereof in infectious diseases
EP3620465B1 (de) 2007-07-03 2025-02-19 Dako Denmark A/S Verbesserte verfahren zur herstellung, markierung und verwendung von mhc-multimeren
US10611818B2 (en) 2007-09-27 2020-04-07 Agilent Technologies, Inc. MHC multimers in tuberculosis diagnostics, vaccine and therapeutics
DK2254592T3 (da) 2008-02-28 2019-09-09 Dako Denmark As MHC-multimerer til Borrelia-diagnostik og sygdom
WO2010009735A2 (en) * 2008-07-23 2010-01-28 Dako Denmark A/S Combinatorial analysis and repair
GB0817244D0 (en) 2008-09-20 2008-10-29 Univ Cardiff Use of a protein kinase inhibitor to detect immune cells, such as T cells
US11992518B2 (en) 2008-10-02 2024-05-28 Agilent Technologies, Inc. Molecular vaccines for infectious disease
WO2010037402A1 (en) 2008-10-02 2010-04-08 Dako Denmark A/S Molecular vaccines for infectious disease
US20100183558A1 (en) 2008-10-17 2010-07-22 Zhennan Lai Safe lentiviral vectors for targeted delivery of multiple therapeutic molecules
EP3319631A4 (de) 2015-07-08 2019-01-09 American Gene Technologies International Inc. Hiv-vorimmunisierung und immuntherapie
CN116064678A (zh) 2016-01-15 2023-05-05 美国基因技术国际有限公司 用于活化γ-δT细胞的方法和组合物
US10137144B2 (en) 2016-01-15 2018-11-27 American Gene Technologies International Inc. Methods and compositions for the activation of gamma-delta T-cells
WO2017139065A1 (en) 2016-02-08 2017-08-17 American Gene Technologies International Inc. Hiv vaccination and immunotherapy
WO2017156311A2 (en) 2016-03-09 2017-09-14 American Gene Technologies International Inc. Combination vectors and methods for treating cancer
EP3468617A4 (de) * 2016-06-08 2020-01-22 American Gene Technologies International Inc. System zur nichtintegralen viralen ausgabe und verfahren im zusammenhang damit
AU2017292582C1 (en) 2016-07-08 2021-11-11 American Gene Technologies International Inc. HIV pre-immunization and immunotherapy
EP3487507A4 (de) 2016-07-21 2020-04-08 American Gene Technologies International, Inc. Virale vektoren zur behandlung der parkinson-krankheit
US11820999B2 (en) 2017-04-03 2023-11-21 American Gene Technologies International Inc. Compositions and methods for treating phenylketonuria
JP2020524996A (ja) 2017-06-16 2020-08-27 アメリカン ジーン テクノロジーズ インターナショナル インコーポレイテッド ヒトガンマデルタｔ細胞を介する腫瘍細胞傷害性の活性化のための方法および組成物
WO2020127222A2 (en) 2018-12-17 2020-06-25 Immudex Aps Panel comprising borrelia mhc multimers

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0043718B1 (de) * 1980-07-07 1984-11-28 National Research Development Corporation Zellinien
US4766067A (en) * 1985-05-31 1988-08-23 President And Fellows Of Harvard College Gene amplification
IL80511A0 (en) * 1985-11-05 1987-02-27 Genetics Inst Multiply amplifiable vectors for high level expression of exogenous dna
WO1988006623A1 (en) * 1987-02-27 1988-09-07 Gist-Brocades N.V. Stable gene amplification in chromosomal dna of prokaryotic microorganisms
US4956288A (en) * 1988-04-22 1990-09-11 Biogen, Inc. Method for producing cells containing stably integrated foreign DNA at a high copy number, the cells produced by this method, and the use of these cells to produce the polypeptides coded for by the foreign DNA
WO1989010959A1 (en) * 1988-05-06 1989-11-16 Codon Supertransformants for high expression rates in eukaryotic cells
EP0555203B1 (de) * 1988-12-08 1995-10-18 Abbott Laboratories Verfahren zur induzierbaren genexpression unter verwendung eines dhfr-gens
ATE263837T1 (de) * 1991-05-31 2004-04-15 Genentech Inc Expressionsteigerung durch gentargeting in endogene retrovirus-ähnliche sequenzen
US5733761A (en) * 1991-11-05 1998-03-31 Transkaryotic Therapies, Inc. Protein production and protein delivery
US5420019A (en) * 1993-02-02 1995-05-30 Xoma Corporation Stable bactericidal/permeability-increasing protein muteins
SG48813A1 (en) * 1993-08-12 1998-05-18 Cytotherapeutics Inc Improved composition and methods for the delivery of biologically active molecules using genetically altered cells contained in biocompatible immunoisolatory capsules
US5585237A (en) * 1993-10-25 1996-12-17 Creative Biomolecules, Inc. Methods and compositions for high protein production from recombinant DNA
US5733782A (en) * 1993-10-25 1998-03-31 Creative Biomolecules, Inc. Methods and compositions for high protein production from non-native DNA
WO1995017513A1 (en) * 1993-12-23 1995-06-29 Novo Nordisk A/S Retransformation of filamentous fungi
US5776746A (en) * 1996-05-01 1998-07-07 Genitope Corporation Gene amplification methods

Also Published As

Publication number Publication date
US6156514A (en) 2000-12-05
DE69920747D1 (de) 2004-11-04
EP1137808A1 (de) 2001-10-04
WO2000032821A1 (en) 2000-06-08
JP2002531103A (ja) 2002-09-24
EP1137808A4 (de) 2002-10-02
ES2230908T3 (es) 2005-05-01
US6306605B1 (en) 2001-10-23
CN1328605A (zh) 2001-12-26
DE69920747T2 (de) 2005-10-06
CN1202261C (zh) 2005-05-18
TWI221483B (en) 2004-10-01
CA2353575A1 (en) 2000-06-08
AU770119B2 (en) 2004-02-12
DK1137808T3 (da) 2005-01-31
AU1835600A (en) 2000-06-19
EP1137808B1 (de) 2004-09-29

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