ATE278024T1 - Methode zur herstellung von rekombinanten zellen - Google Patents
Methode zur herstellung von rekombinanten zellenInfo
- Publication number
- ATE278024T1 ATE278024T1 AT99961864T AT99961864T ATE278024T1 AT E278024 T1 ATE278024 T1 AT E278024T1 AT 99961864 T AT99961864 T AT 99961864T AT 99961864 T AT99961864 T AT 99961864T AT E278024 T1 ATE278024 T1 AT E278024T1
- Authority
- AT
- Austria
- Prior art keywords
- recombinant
- cell lines
- recombinant cells
- producing recombinant
- amino acid
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 2
- 210000004027 cell Anatomy 0.000 abstract 2
- 210000004962 mammalian cell Anatomy 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 abstract 1
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 abstract 1
- 238000011031 large-scale manufacturing process Methods 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/65—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression using markers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/204,979 US6156514A (en) | 1998-12-03 | 1998-12-03 | Methods for making recombinant cells |
| PCT/US1999/028255 WO2000032821A1 (en) | 1998-12-03 | 1999-11-30 | Methods for making recombinant cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE278024T1 true ATE278024T1 (de) | 2004-10-15 |
Family
ID=22760275
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99961864T ATE278024T1 (de) | 1998-12-03 | 1999-11-30 | Methode zur herstellung von rekombinanten zellen |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US6156514A (de) |
| EP (1) | EP1137808B1 (de) |
| JP (1) | JP2002531103A (de) |
| CN (1) | CN1202261C (de) |
| AT (1) | ATE278024T1 (de) |
| AU (1) | AU770119B2 (de) |
| CA (1) | CA2353575A1 (de) |
| DE (1) | DE69920747T2 (de) |
| DK (1) | DK1137808T3 (de) |
| ES (1) | ES2230908T3 (de) |
| TW (1) | TWI221483B (de) |
| WO (1) | WO2000032821A1 (de) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6852510B2 (en) * | 2000-07-03 | 2005-02-08 | Gala Design Inc | Host cells containing multiple integrating vectors |
| US20030224415A1 (en) * | 2001-06-29 | 2003-12-04 | Gala Design, Inc. | Selection free growth of host cells containing multiple integrating vectors |
| WO2003064659A1 (en) * | 2002-01-11 | 2003-08-07 | Genetica, Inc. | Methods and compositions for optimizing recombinant expression |
| EP1504102A2 (de) * | 2002-05-21 | 2005-02-09 | Resistentia Pharmaceuticals AB | Chimäre ige-polypeptide und wirtszellen |
| JP2006517415A (ja) * | 2003-01-09 | 2006-07-27 | ジェネンテック・インコーポレーテッド | ポリペプチドの精製 |
| US20050221429A1 (en) * | 2004-01-16 | 2005-10-06 | Cardinal Health Pts, Llc | Host cells containing multiple integrating vectors comprising an amplifiable marker |
| EP1982176A1 (de) * | 2006-01-30 | 2008-10-22 | Dako Denmark A/S | Quantifizierung antigenspezifischer t-zellen in vollblut mit hoher geschwindigkeit mittels durchflusszytometrie |
| EP2155782A2 (de) | 2007-03-26 | 2010-02-24 | Dako Denmark A/S | Mhc-peptid-komplexe und anwendungen davon bei infektionskrankheiten |
| EP3620465B1 (de) | 2007-07-03 | 2025-02-19 | Dako Denmark A/S | Verbesserte verfahren zur herstellung, markierung und verwendung von mhc-multimeren |
| US10611818B2 (en) | 2007-09-27 | 2020-04-07 | Agilent Technologies, Inc. | MHC multimers in tuberculosis diagnostics, vaccine and therapeutics |
| DK2254592T3 (da) | 2008-02-28 | 2019-09-09 | Dako Denmark As | MHC-multimerer til Borrelia-diagnostik og sygdom |
| WO2010009735A2 (en) * | 2008-07-23 | 2010-01-28 | Dako Denmark A/S | Combinatorial analysis and repair |
| GB0817244D0 (en) | 2008-09-20 | 2008-10-29 | Univ Cardiff | Use of a protein kinase inhibitor to detect immune cells, such as T cells |
| US11992518B2 (en) | 2008-10-02 | 2024-05-28 | Agilent Technologies, Inc. | Molecular vaccines for infectious disease |
| US10369204B2 (en) | 2008-10-02 | 2019-08-06 | Dako Denmark A/S | Molecular vaccines for infectious disease |
| US20100183558A1 (en) | 2008-10-17 | 2010-07-22 | Zhennan Lai | Safe lentiviral vectors for targeted delivery of multiple therapeutic molecules |
| WO2017007994A1 (en) | 2015-07-08 | 2017-01-12 | American Gene Technologies International Inc. | Hiv pre-immunization and immunotherapy |
| US10137144B2 (en) | 2016-01-15 | 2018-11-27 | American Gene Technologies International Inc. | Methods and compositions for the activation of gamma-delta T-cells |
| CN116064678A (zh) | 2016-01-15 | 2023-05-05 | 美国基因技术国际有限公司 | 用于活化γ-δT细胞的方法和组合物 |
| US10888613B2 (en) | 2016-02-08 | 2021-01-12 | American Gene Technologies International Inc. | Method of producing cells resistant to HIV infection |
| WO2017156311A2 (en) | 2016-03-09 | 2017-09-14 | American Gene Technologies International Inc. | Combination vectors and methods for treating cancer |
| JP7173548B2 (ja) | 2016-06-08 | 2022-11-16 | アメリカン ジーン テクノロジーズ インターナショナル インコーポレイテッド | 非組み込みウイルス送達系およびその関連方法 |
| IL300730A (en) | 2016-07-08 | 2023-04-01 | American Gene Tech Int Inc | Pre-HIV vaccine and immunotherapy |
| US11583562B2 (en) | 2016-07-21 | 2023-02-21 | American Gene Technologies International Inc. | Viral vectors for treating Parkinson's disease |
| WO2018187231A2 (en) | 2017-04-03 | 2018-10-11 | American Gene Technologies International Inc. | Compositions and methods for treating phenylketonuria |
| EP3898666A2 (de) | 2018-12-17 | 2021-10-27 | Immudex ApS | Panel mit borrelia-mhc-multimeren |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0043718B1 (de) * | 1980-07-07 | 1984-11-28 | National Research Development Corporation | Zellinien |
| US4766067A (en) * | 1985-05-31 | 1988-08-23 | President And Fellows Of Harvard College | Gene amplification |
| IL80511A0 (en) * | 1985-11-05 | 1987-02-27 | Genetics Inst | Multiply amplifiable vectors for high level expression of exogenous dna |
| RU2091487C1 (ru) * | 1987-02-27 | 1997-09-27 | Гист-Брокейдс Н.В. | Способ получения штамма bacillus, содержащего две копии последовательности днк, кодирующей фермент с гидролазной активностью |
| US4956288A (en) * | 1988-04-22 | 1990-09-11 | Biogen, Inc. | Method for producing cells containing stably integrated foreign DNA at a high copy number, the cells produced by this method, and the use of these cells to produce the polypeptides coded for by the foreign DNA |
| WO1989010959A1 (en) * | 1988-05-06 | 1989-11-16 | Codon | Supertransformants for high expression rates in eukaryotic cells |
| AU4741090A (en) * | 1988-12-08 | 1990-06-26 | Damon Biotech Inc. | Expression induction method employing mutant dhfr gene |
| JP3449418B2 (ja) * | 1991-05-31 | 2003-09-22 | ジェネンテック・インコーポレーテッド | 内因性レトロウイルス様配列内への遺伝子標的化による発現の増大 |
| US5733761A (en) * | 1991-11-05 | 1998-03-31 | Transkaryotic Therapies, Inc. | Protein production and protein delivery |
| US5420019A (en) * | 1993-02-02 | 1995-05-30 | Xoma Corporation | Stable bactericidal/permeability-increasing protein muteins |
| DE69430824T2 (de) * | 1993-08-12 | 2003-01-23 | Neurotech S.A., Evry | Biokompatible immunoisolatorische Kapseln, die genetisch veränderte Zellen enthalten |
| US5585237A (en) * | 1993-10-25 | 1996-12-17 | Creative Biomolecules, Inc. | Methods and compositions for high protein production from recombinant DNA |
| US5733782A (en) * | 1993-10-25 | 1998-03-31 | Creative Biomolecules, Inc. | Methods and compositions for high protein production from non-native DNA |
| WO1995017513A1 (en) * | 1993-12-23 | 1995-06-29 | Novo Nordisk A/S | Retransformation of filamentous fungi |
| US5776746A (en) * | 1996-05-01 | 1998-07-07 | Genitope Corporation | Gene amplification methods |
-
1998
- 1998-12-03 US US09/204,979 patent/US6156514A/en not_active Expired - Lifetime
-
1999
- 1999-11-30 CA CA002353575A patent/CA2353575A1/en not_active Abandoned
- 1999-11-30 DE DE69920747T patent/DE69920747T2/de not_active Expired - Lifetime
- 1999-11-30 DK DK99961864T patent/DK1137808T3/da active
- 1999-11-30 EP EP99961864A patent/EP1137808B1/de not_active Expired - Lifetime
- 1999-11-30 ES ES99961864T patent/ES2230908T3/es not_active Expired - Lifetime
- 1999-11-30 CN CNB998138738A patent/CN1202261C/zh not_active Expired - Lifetime
- 1999-11-30 AT AT99961864T patent/ATE278024T1/de active
- 1999-11-30 AU AU18356/00A patent/AU770119B2/en not_active Expired
- 1999-11-30 JP JP2000585452A patent/JP2002531103A/ja active Pending
- 1999-11-30 WO PCT/US1999/028255 patent/WO2000032821A1/en not_active Ceased
- 1999-12-01 TW TW088120940A patent/TWI221483B/zh not_active IP Right Cessation
-
2000
- 2000-02-01 US US09/496,311 patent/US6306605B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US6306605B1 (en) | 2001-10-23 |
| ES2230908T3 (es) | 2005-05-01 |
| EP1137808A4 (de) | 2002-10-02 |
| US6156514A (en) | 2000-12-05 |
| DE69920747T2 (de) | 2005-10-06 |
| CN1328605A (zh) | 2001-12-26 |
| CA2353575A1 (en) | 2000-06-08 |
| TWI221483B (en) | 2004-10-01 |
| DE69920747D1 (de) | 2004-11-04 |
| EP1137808B1 (de) | 2004-09-29 |
| CN1202261C (zh) | 2005-05-18 |
| JP2002531103A (ja) | 2002-09-24 |
| AU1835600A (en) | 2000-06-19 |
| EP1137808A1 (de) | 2001-10-04 |
| WO2000032821A1 (en) | 2000-06-08 |
| AU770119B2 (en) | 2004-02-12 |
| DK1137808T3 (da) | 2005-01-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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