ATE278024T1 - Methode zur herstellung von rekombinanten zellen - Google Patents

Methode zur herstellung von rekombinanten zellen

Info

Publication number
ATE278024T1
ATE278024T1 AT99961864T AT99961864T ATE278024T1 AT E278024 T1 ATE278024 T1 AT E278024T1 AT 99961864 T AT99961864 T AT 99961864T AT 99961864 T AT99961864 T AT 99961864T AT E278024 T1 ATE278024 T1 AT E278024T1
Authority
AT
Austria
Prior art keywords
recombinant
cell lines
recombinant cells
producing recombinant
amino acid
Prior art date
Application number
AT99961864T
Other languages
English (en)
Inventor
Jorge L Acevedo
Peter R Rhode
Original Assignee
Sunol Molecular Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sunol Molecular Corp filed Critical Sunol Molecular Corp
Application granted granted Critical
Publication of ATE278024T1 publication Critical patent/ATE278024T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/65—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression using markers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT99961864T 1998-12-03 1999-11-30 Methode zur herstellung von rekombinanten zellen ATE278024T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/204,979 US6156514A (en) 1998-12-03 1998-12-03 Methods for making recombinant cells
PCT/US1999/028255 WO2000032821A1 (en) 1998-12-03 1999-11-30 Methods for making recombinant cells

Publications (1)

Publication Number Publication Date
ATE278024T1 true ATE278024T1 (de) 2004-10-15

Family

ID=22760275

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99961864T ATE278024T1 (de) 1998-12-03 1999-11-30 Methode zur herstellung von rekombinanten zellen

Country Status (12)

Country Link
US (2) US6156514A (de)
EP (1) EP1137808B1 (de)
JP (1) JP2002531103A (de)
CN (1) CN1202261C (de)
AT (1) ATE278024T1 (de)
AU (1) AU770119B2 (de)
CA (1) CA2353575A1 (de)
DE (1) DE69920747T2 (de)
DK (1) DK1137808T3 (de)
ES (1) ES2230908T3 (de)
TW (1) TWI221483B (de)
WO (1) WO2000032821A1 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6852510B2 (en) * 2000-07-03 2005-02-08 Gala Design Inc Host cells containing multiple integrating vectors
US20030224415A1 (en) * 2001-06-29 2003-12-04 Gala Design, Inc. Selection free growth of host cells containing multiple integrating vectors
WO2003064659A1 (en) * 2002-01-11 2003-08-07 Genetica, Inc. Methods and compositions for optimizing recombinant expression
EP1504102A2 (de) * 2002-05-21 2005-02-09 Resistentia Pharmaceuticals AB Chimäre ige-polypeptide und wirtszellen
PL377653A1 (pl) * 2003-01-09 2006-02-06 Genentech, Inc. Oczyszczanie polipeptydów
US20050221429A1 (en) * 2004-01-16 2005-10-06 Cardinal Health Pts, Llc Host cells containing multiple integrating vectors comprising an amplifiable marker
EP1982176A1 (de) * 2006-01-30 2008-10-22 Dako Denmark A/S Quantifizierung antigenspezifischer t-zellen in vollblut mit hoher geschwindigkeit mittels durchflusszytometrie
EP2155782A2 (de) 2007-03-26 2010-02-24 Dako Denmark A/S Mhc-peptid-komplexe und anwendungen davon bei infektionskrankheiten
EP2167537A2 (de) 2007-07-03 2010-03-31 Dako Denmark A/S Zusammengestellte verfahren für die analyse und sortierung von proben
WO2009039854A2 (en) 2007-09-27 2009-04-02 Dako Denmark A/S Mhc multimers in tuberculosis diagnostics, vaccine and therapeutics
US10968269B1 (en) 2008-02-28 2021-04-06 Agilent Technologies, Inc. MHC multimers in borrelia diagnostics and disease
WO2010009735A2 (en) * 2008-07-23 2010-01-28 Dako Denmark A/S Combinatorial analysis and repair
GB0817244D0 (en) 2008-09-20 2008-10-29 Univ Cardiff Use of a protein kinase inhibitor to detect immune cells, such as T cells
US10369204B2 (en) 2008-10-02 2019-08-06 Dako Denmark A/S Molecular vaccines for infectious disease
US11992518B2 (en) 2008-10-02 2024-05-28 Agilent Technologies, Inc. Molecular vaccines for infectious disease
WO2010045659A1 (en) 2008-10-17 2010-04-22 American Gene Technologies International Inc. Safe lentiviral vectors for targeted delivery of multiple therapeutic molecules
JP6890831B2 (ja) 2015-07-08 2021-06-18 アメリカン ジーン テクノロジーズ インターナショナル インコーポレイテッド Ｈｉｖ予備免疫化および免疫療法
US10137144B2 (en) 2016-01-15 2018-11-27 American Gene Technologies International Inc. Methods and compositions for the activation of gamma-delta T-cells
IL297238B2 (en) 2016-01-15 2024-08-01 American Gene Tech Int Inc Methods and preparations for gamma-delta T-cell activation
JP7153332B2 (ja) 2016-02-08 2022-10-14 アメリカン ジーン テクノロジーズ インターナショナル インコーポレイテッド Ｈｉｖワクチン接種および免疫療法
US10767183B2 (en) 2016-03-09 2020-09-08 American Gene Technologies International Inc. Combination vectors and methods for treating cancer
WO2017213697A1 (en) * 2016-06-08 2017-12-14 American Gene Technologies International Inc. Non-integrating viral delivery system and methods related thereto
IL300730A (en) 2016-07-08 2023-04-01 American Gene Tech Int Inc Pre-HIV vaccine and immunotherapy
US11583562B2 (en) 2016-07-21 2023-02-21 American Gene Technologies International Inc. Viral vectors for treating Parkinson's disease
KR102737836B1 (ko) 2017-04-03 2024-12-03 아메리칸 진 테크놀로지스 인터내셔널 인코포레이티드 페닐케톤뇨증을 치료하기 위한 조성물 및 방법
JP2020524996A (ja) 2017-06-16 2020-08-27 アメリカン ジーン テクノロジーズ インターナショナル インコーポレイテッド ヒトガンマデルタｔ細胞を介する腫瘍細胞傷害性の活性化のための方法および組成物
US12258373B2 (en) 2018-12-17 2025-03-25 Immudex Aps Panel comprising Borrelia MHC multimers

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3167442D1 (en) * 1980-07-07 1985-01-10 Nat Res Dev Improvements in or relating to cell lines
US4766067A (en) * 1985-05-31 1988-08-23 President And Fellows Of Harvard College Gene amplification
IL80511A0 (en) * 1985-11-05 1987-02-27 Genetics Inst Multiply amplifiable vectors for high level expression of exogenous dna
AU620326B2 (en) * 1987-02-27 1992-02-20 Dsm Ip Assets B.V. Stable gene amplification in chromosomal dna of prokaryotic microorganisms
US4956288A (en) * 1988-04-22 1990-09-11 Biogen, Inc. Method for producing cells containing stably integrated foreign DNA at a high copy number, the cells produced by this method, and the use of these cells to produce the polypeptides coded for by the foreign DNA
WO1989010959A1 (en) * 1988-05-06 1989-11-16 Codon Supertransformants for high expression rates in eukaryotic cells
EP0555203B1 (de) * 1988-12-08 1995-10-18 Abbott Laboratories Verfahren zur induzierbaren genexpression unter verwendung eines dhfr-gens
DK0587791T3 (da) * 1991-05-31 2004-07-26 Genentech Inc Forstærkelse af ekspression ved hjælp af gentargeting i endogene retroviruslignende sekvenser
US5733761A (en) * 1991-11-05 1998-03-31 Transkaryotic Therapies, Inc. Protein production and protein delivery
US5420019A (en) * 1993-02-02 1995-05-30 Xoma Corporation Stable bactericidal/permeability-increasing protein muteins
JP4098355B2 (ja) * 1993-08-12 2008-06-11 ニューロテック ユーエスエー， インコーポレイテッド 遺伝的に改変された細胞を含む生体適合性免疫隔離カプセル
US5585237A (en) * 1993-10-25 1996-12-17 Creative Biomolecules, Inc. Methods and compositions for high protein production from recombinant DNA
US5631158A (en) * 1993-10-25 1997-05-20 Creative Biomolecules, Inc. Methods and compositions for high protein production from non-native DNA
WO1995017513A1 (en) * 1993-12-23 1995-06-29 Novo Nordisk A/S Retransformation of filamentous fungi
US5776746A (en) * 1996-05-01 1998-07-07 Genitope Corporation Gene amplification methods

Also Published As

Publication number Publication date
EP1137808A4 (de) 2002-10-02
JP2002531103A (ja) 2002-09-24
DK1137808T3 (da) 2005-01-31
CN1202261C (zh) 2005-05-18
EP1137808B1 (de) 2004-09-29
AU770119B2 (en) 2004-02-12
AU1835600A (en) 2000-06-19
DE69920747T2 (de) 2005-10-06
WO2000032821A1 (en) 2000-06-08
DE69920747D1 (de) 2004-11-04
EP1137808A1 (de) 2001-10-04
US6156514A (en) 2000-12-05
US6306605B1 (en) 2001-10-23
ES2230908T3 (es) 2005-05-01
CA2353575A1 (en) 2000-06-08
CN1328605A (zh) 2001-12-26
TWI221483B (en) 2004-10-01

Similar Documents

Publication Publication Date Title
DE69920747D1 (de) Methode zur herstellung von rekombinanten zellen
ATE500331T1 (de) Verfahren zur gleichzeitigen herstellung von multiplen proteinen; vektoren und zellen, die hierfür verwendung finden
AR020735A1 (es) Un procedimiento para la obtencion de un polipeptido glucosilado a partir de celulas eucarioticas
WO2002029083A3 (en) Industrial-scale serum-free production of recombinant proteins in mammalian cells
DE3851289D1 (de) Verfahren zur Züchtung rekombinanter Zellen.
ATE213271T1 (de) Verfahren zur herstellung von rekombinanten proteinen in e. coli mittels hochzelldichte- fermentation
BRPI0411475A (pt) adições de código genético de aminoácido reativo não natural
DE69939901D1 (de) Verfahren und materialien zur herstellung von glucosamin
ATE521695T1 (de) Zirkuläres dna-molekül mit einem konditionalen replikationsursprung, verfahren zur herstellung davon und ihre verwendung in der gentherapie
CY1105772T1 (el) Συνθεσεις και μεθοδοι για βελτιωμενη κυτταρικη καλλιεργεια
ATE457355T1 (de) Verfahren und dna-konstrukte zur produktion von polypeptiden mit hoher ausbeute
ATE111956T1 (de) Co-expression in eukaryontischen zellen.
DE69939548D1 (de) Verfahren zur herstellung von faktor vii
ATE152124T1 (de) Wachstumsfaktor aus parenchymalen lebenszellen, dafür kodierendes gen, verfahren zur herstellung dieses faktors und transformanten
AU8110487A (en) DNA molecules coding for proteins targeted to plant cell walls
PT1025245E (pt) Criacao rapida de linhas celulares estaveis de mamifero produzindo elevados iiveis de proteinas recombinantes
DE69604550D1 (de) Verfahren zur Herstellung von Lithiumionzelle mit deaktivierter Kohlenstoffanode
ATE362544T1 (de) Polypeptide mit alpha-h alpha amino acid amide racemase aktivitität und nukleinsäuren kodierend dafür
DE69425809D1 (de) Methoden zur Herstellung von Protein C
WO2002008417A1 (fr) Procede de production d'une proteine de recombinaison
DE69825580D1 (de) Neurotrophischer faktor nnt-1
DE69933699D1 (de) Verfahren zur produktion rekombinanter proteine in säugetierzellen durch co-expression mit fetuin
DE69939876D1 (de) Methoden zur massenkultivierung von zellen die rekombinantes menschliches erythropoietin produzieren
DE69831242D1 (de) Erhöhte herstellung von sekretierten proteinen durch rekombinante hefezellen
ATE288476T1 (de) Herstellung von proteinen

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1137808

Country of ref document: EP