ATE374607T1 - Zusammensetzung enthaltend stickstoffoxid- donatoren und methode zur behandlung analer krankheiten - Google Patents

Zusammensetzung enthaltend stickstoffoxid- donatoren und methode zur behandlung analer krankheiten

Info

Publication number
ATE374607T1
ATE374607T1 AT00202372T AT00202372T ATE374607T1 AT E374607 T1 ATE374607 T1 AT E374607T1 AT 00202372 T AT00202372 T AT 00202372T AT 00202372 T AT00202372 T AT 00202372T AT E374607 T1 ATE374607 T1 AT E374607T1
Authority
AT
Austria
Prior art keywords
composition containing
nitrogen oxide
containing nitrogen
treating anal
anal diseases
Prior art date
Application number
AT00202372T
Other languages
English (en)
Inventor
Stephen R Gorfine
Original Assignee
Strakan Int Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26940977&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE374607(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US08/250,555 external-priority patent/US5504117A/en
Application filed by Strakan Int Ltd filed Critical Strakan Int Ltd
Application granted granted Critical
Publication of ATE374607T1 publication Critical patent/ATE374607T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/14Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Emergency Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Steroid Compounds (AREA)
AT00202372T 1994-05-27 1995-04-10 Zusammensetzung enthaltend stickstoffoxid- donatoren und methode zur behandlung analer krankheiten ATE374607T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/250,555 US5504117A (en) 1994-05-27 1994-05-27 Pharmacologic preparation for the treatment of anal disorders
US37108895A 1995-01-10 1995-01-10

Publications (1)

Publication Number Publication Date
ATE374607T1 true ATE374607T1 (de) 2007-10-15

Family

ID=26940977

Family Applications (2)

Application Number Title Priority Date Filing Date
AT00202372T ATE374607T1 (de) 1994-05-27 1995-04-10 Zusammensetzung enthaltend stickstoffoxid- donatoren und methode zur behandlung analer krankheiten
AT95916264T ATE196082T1 (de) 1994-05-27 1995-04-10 Stickstoffoxyd abgebendes präparat zur behandlung von analen erkrankungen

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT95916264T ATE196082T1 (de) 1994-05-27 1995-04-10 Stickstoffoxyd abgebendes präparat zur behandlung von analen erkrankungen

Country Status (15)

Country Link
US (4) US5693676A (de)
EP (2) EP1051972B1 (de)
JP (3) JP3211892B2 (de)
KR (1) KR100386525B1 (de)
CN (1) CN1107499C (de)
AT (2) ATE374607T1 (de)
AU (1) AU2282395A (de)
CA (1) CA2168247C (de)
DE (3) DE719145T1 (de)
DK (2) DK0719145T3 (de)
ES (2) ES2092460T3 (de)
GR (2) GR960300077T1 (de)
IL (1) IL113448A (de)
PT (2) PT719145E (de)
WO (1) WO1995032715A1 (de)

Families Citing this family (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE374607T1 (de) * 1994-05-27 2007-10-15 Strakan Int Ltd Zusammensetzung enthaltend stickstoffoxid- donatoren und methode zur behandlung analer krankheiten
US20050137191A1 (en) * 1996-06-04 2005-06-23 Thatcher Gregory R. Nitrate esters and their use for mitigating cellular damage
US7115661B1 (en) * 1999-12-29 2006-10-03 Queen's University At Kingston Methods and compositions for mitigating pain
US8048875B1 (en) 1997-02-24 2011-11-01 S.L.A. Pharma Ag Topical pharmaceutical composition comprising a cholinergic agent or a calcium channel blocker
WO1998036733A2 (en) 1997-02-24 1998-08-27 Michael Albert Kamm Topical pharmaceutical composition comprising a cholinergic agent or a calcium channel blocker
ID20270A (id) * 1997-05-18 1998-11-19 Adel Abdel Wadood Gomaa Prof D Preparat topikal yang baru untuk pengobatan ketidak-fungsian penis
US6159944A (en) * 1998-02-27 2000-12-12 Synchroneuron, Llc Method for treating painful conditions of the anal region and compositions therefor
IT1303793B1 (it) * 1998-11-27 2001-02-23 Promefarm S R L "composizione farmaceutica comprendente un composto organico donatoredi ossido nitrico (no)"
US6627632B2 (en) * 1998-12-14 2003-09-30 Cellegy Pharmaceuticals, Inc. Compositions and methods for the treatment of anorectal disorders
US6395736B1 (en) * 1998-12-14 2002-05-28 Cellegy Pharmaceuticals, Inc. Compositions and methods for the treatment of anorectal disorders
US6391869B1 (en) * 1998-12-14 2002-05-21 Cellergy Pharmaceuticals, Inc. Compositions and methods for the treatment of anorectal disorders
US6077227A (en) * 1998-12-28 2000-06-20 Medtronic, Inc. Method for manufacture and implant of an implantable blood vessel cuff
ES2151454B1 (es) * 1999-05-06 2001-07-01 Szlec Christopher Dura Pomada para el tratamiento de la fisura anal cronica y otros procesos inflamatorios del ano.
DE19945484A1 (de) * 1999-09-22 2001-04-05 Kolb Bachofen Victoria NO-freisetzende topisch applizierbare Zusammensetzung
WO2001043735A1 (en) * 1999-12-15 2001-06-21 Cellegy Pharmaceuticals, Inc. Nitroglycerin ointment for treatment of pain associated with anal disease
US20020006435A1 (en) * 2000-01-27 2002-01-17 Samuels Paul J. Transdermal anesthetic and vasodilator composition and methods for topical administration
AUPQ577700A0 (en) * 2000-02-22 2000-03-16 K. King & Co Pty Limited Method of treatment of anorectal disorders
HUP0002628A2 (en) * 2000-07-14 2002-06-29 Keri Pharma Kft Pharmaceutical combinations for treating diabetes
AU8484901A (en) * 2000-08-11 2002-02-25 David R Whitlock Compositions including ammonia oxidizing bacteria to increase production of nitric oxide and nitric oxide precursors and methods of using same
JP4563679B2 (ja) * 2001-12-06 2010-10-13 デューク ユニバーシティ 形成外科における組織弁壊死の予防
US6833139B1 (en) 2002-01-09 2004-12-21 Ferndale Laboratories, Inc. Composition and method for the treatment of anorectal disorders
US20050244382A9 (en) * 2002-01-11 2005-11-03 Whitlock David R Compositions including ammonia oxidizing bacteria and methods of using same
US20040018237A1 (en) * 2002-05-31 2004-01-29 Perricone Nicholas V. Topical drug delivery using phosphatidylcholine
US20060078580A1 (en) * 2004-10-08 2006-04-13 Mediquest Therapeutics, Inc. Organo-gel formulations for therapeutic applications
US7740875B2 (en) * 2004-10-08 2010-06-22 Mediquest Therapeutics, Inc. Organo-gel formulations for therapeutic applications
JP2008520694A (ja) * 2004-11-17 2008-06-19 リンジー・バークソン 非治癒性及び治癒遅延性の創傷及び潰瘍の治癒を促進させる組成物及び方法
US7731993B2 (en) * 2004-11-17 2010-06-08 Lindsey Berkson Composition for treating a dermal anomaly
US20060105027A1 (en) * 2004-11-17 2006-05-18 Lindsey Berkson Method for treating skin ulcers
WO2006085127A1 (en) * 2005-02-08 2006-08-17 Antibe Therapeutics, Inc. Topical compositions
WO2006084913A2 (en) * 2005-02-11 2006-08-17 Nolabs Ab Device for treatment of rectal disorders, and manufacturing process for the same, involving nitric oxide
EP1888510A4 (de) 2005-05-27 2013-01-16 Univ North Carolina Stickoxidfreisetzende partikel für stickoxidtherapeutika und biomedizinische anwendungen
US20080194471A1 (en) * 2005-08-10 2008-08-14 Otkrytoe Aktsyonernoe Obshchestvo "Polema" Compositions and Methods for Treating Wounds
US7507842B2 (en) 2005-08-12 2009-03-24 Radiorx, Inc. Cyclic nitro compounds, pharmaceutical compositions thereof and uses thereof
AU2012203798B2 (en) * 2005-08-12 2013-11-07 Northrop Grumman Systems Corporation O-nitro compounds, pharmaceutical compositons thereof and uses thereof
US20070135380A1 (en) * 2005-08-12 2007-06-14 Radiorx, Inc. O-nitro compounds, pharmaceutical compositions thereof and uses thereof
CA2643364C (en) 2006-03-09 2017-06-06 Salix Pharmaceuticals, Inc. Rifaximin anti-rectal dysfunction preparation
US20080193385A1 (en) * 2007-02-08 2008-08-14 Todd Maibach Compositions and methods for treating neuropathy
JP2011525116A (ja) * 2008-06-24 2011-09-15 マイクロファーマ・リミテッド 一酸化窒素デバイス、ならびに創傷の治癒、皮膚障害および微生物感染症の治療の方法
US11684624B2 (en) 2009-06-24 2023-06-27 Strategic Science & Technologies, Llc Treatment of erectile dysfunction and other indications
US9463158B2 (en) 2009-06-24 2016-10-11 Strategic Science & Technologies, Llc Treatment of erectile dysfunction and other indications
US12138268B2 (en) 2009-06-24 2024-11-12 Strategic Science & Technologies, Llc Treatment of erectile dysfunction and other indications
BR112012003804B1 (pt) 2009-08-21 2019-02-19 Novan, Inc. Curativo para ferimentos, método para formar um curativo para ferimentos, e, kit de curativo para ferimento
BR112012003792B1 (pt) 2009-08-21 2020-05-19 Novan Inc composição tópica, e, uso da composição tópica
US9023890B2 (en) * 2009-12-02 2015-05-05 The Charlotte-Mecklenburg Hospital Authority Nitrate esters and their use for the treatment of muscle and muscle related diseases
US8471041B2 (en) 2010-02-09 2013-06-25 Alliant Techsystems Inc. Methods of synthesizing and isolating N-(bromoacetyl)-3,3-dinitroazetidine and a composition including the same
US8591876B2 (en) 2010-12-15 2013-11-26 Novan, Inc. Methods of decreasing sebum production in the skin
ES2695173T3 (es) 2011-02-28 2019-01-02 Novan Inc Partículas de sílice modificadas con S-nitrosotiol que liberan óxido nítrico y procedimientos de fabricación de las mismas
US8668937B2 (en) 2011-03-17 2014-03-11 Transdermal Biotechnology, Inc. Topical nitric oxide systems and methods of use thereof
US9452117B2 (en) 2011-06-01 2016-09-27 The Charlotte-Mecklenburg Hospital Authority Nitrate esters and their use for the treatment of muscle and muscle related diseases
US8664247B2 (en) 2011-08-26 2014-03-04 Radiorx, Inc. Acyclic organonitro compounds for use in treating cancer
CA2850723C (en) 2011-10-07 2019-07-09 Radiorx, Inc. Organonitro thioether compounds and medical uses thereof
US20140308260A1 (en) 2011-10-07 2014-10-16 Radiorx, Inc. Methods and compositions comprising a nitrite-reductase promoter for treatment of medical disorders and preservation of blood products
DE102012009570A1 (de) * 2012-05-09 2013-11-14 Naum Goldstein Komposition für nasale Anwendung
US8871254B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Systems and methods for treatment of acne vulgaris and other conditions with a topical nitric oxide delivery system
US8871261B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Cancer treatments and compositions for use thereof
US8871257B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Prevention and treatment of cardiovascular diseases using systems and methods for transdermal nitric oxide delivery
US8871262B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Compositions and methods for treatment of osteoporosis and other indications
US8871256B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Methods and systems for treatment of inflammatory diseases with nitric oxide
US8871258B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Treatment and prevention of learning and memory disorders
US8871255B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Treatment of skin and soft tissue infection with nitric oxide
US8871260B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Methods and compositions for muscular and neuromuscular diseases
US8871259B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Techniques and systems for treatment of neuropathic pain and other indications
US9314422B2 (en) 2013-03-13 2016-04-19 Transdermal Biotechnology, Inc. Peptide systems and methods for metabolic conditions
US9724419B2 (en) 2013-03-13 2017-08-08 Transdermal Biotechnology, Inc. Peptide systems and methods for metabolic conditions
US9314417B2 (en) 2013-03-13 2016-04-19 Transdermal Biotechnology, Inc. Treatment of skin, including aging skin, to improve appearance
US20140271731A1 (en) 2013-03-13 2014-09-18 Transdermal Biotechnology, Inc. Cardiovascular disease treatment and prevention
US9295636B2 (en) 2013-03-13 2016-03-29 Transdermal Biotechnology, Inc. Wound healing using topical systems and methods
US9320706B2 (en) 2013-03-13 2016-04-26 Transdermal Biotechnology, Inc. Immune modulation using peptides and other compositions
US9339457B2 (en) 2013-03-13 2016-05-17 Transdermal Biotechnology, Inc. Cardiovascular disease treatment and prevention
US9241899B2 (en) 2013-03-13 2016-01-26 Transdermal Biotechnology, Inc. Topical systems and methods for treating sexual dysfunction
US9393265B2 (en) 2013-03-13 2016-07-19 Transdermal Biotechnology, Inc. Wound healing using topical systems and methods
US9750787B2 (en) 2013-03-13 2017-09-05 Transdermal Biotechnology, Inc. Memory or learning improvement using peptide and other compositions
US9314433B2 (en) 2013-03-13 2016-04-19 Transdermal Biotechnology, Inc. Methods and systems for treating or preventing cancer
US9295637B2 (en) 2013-03-13 2016-03-29 Transdermal Biotechnology, Inc. Compositions and methods for affecting mood states
US9393264B2 (en) 2013-03-13 2016-07-19 Transdermal Biotechnology, Inc. Immune modulation using peptides and other compositions
US20140271937A1 (en) 2013-03-13 2014-09-18 Transdermal Biotechnology, Inc. Brain and neural treatments comprising peptides and other compositions
US9314423B2 (en) 2013-03-13 2016-04-19 Transdermal Biotechnology, Inc. Hair treatment systems and methods using peptides and other compositions
US9320758B2 (en) 2013-03-13 2016-04-26 Transdermal Biotechnology, Inc. Brain and neural treatments comprising peptides and other compositions
US9295647B2 (en) 2013-03-13 2016-03-29 Transdermal Biotechnology, Inc. Systems and methods for delivery of peptides
US9849160B2 (en) 2013-03-13 2017-12-26 Transdermal Biotechnology, Inc. Methods and systems for treating or preventing cancer
US9387159B2 (en) 2013-03-13 2016-07-12 Transdermal Biotechnology, Inc. Treatment of skin, including aging skin, to improve appearance
US20140271938A1 (en) 2013-03-13 2014-09-18 Transdermal Biotechnology, Inc. Systems and methods for delivery of peptides
US9687520B2 (en) 2013-03-13 2017-06-27 Transdermal Biotechnology, Inc. Memory or learning improvement using peptide and other compositions
US20160081915A1 (en) * 2013-03-15 2016-03-24 Strategic Science & Technologies, Llc Transdermal formulations of fluticasone
KR20230165365A (ko) 2014-04-15 2023-12-05 에이오바이오미 엘엘씨 암모니아-산화 니트로소모나스 유트로파 균주 d23
US11225640B2 (en) 2014-04-15 2022-01-18 Aobiome Llc Ammonia oxidizing bacteria for treatment of psoriasis
US10342778B1 (en) 2015-10-20 2019-07-09 Epicentrx, Inc. Treatment of brain metastases using organonitro compound combination therapy
US9987270B1 (en) 2015-10-29 2018-06-05 Epicentrix, Inc. Treatment of gliomas using organonitro compound combination therapy
SG11201805942UA (en) 2016-01-11 2018-08-30 Epicentrx Inc Compositions and methods for intravenous administration of 2-bromo-1-(3,3-dinitroazetidin-1-yl)ethanone
EA201990949A1 (ru) 2016-10-14 2019-10-31 Сульфоксиалкильные органические нитросоединения и родственные соединения и фармацевтические композиции для применения в медицине
IL311727A (en) 2017-07-07 2024-05-01 Epicentrx Inc Preparations for intravenous administration of medical substances
TW201927292A (zh) 2017-12-13 2019-07-16 大陸商上海小午醫藥科技有限公司 一種用於預防或治療與egfr被抑制相關疾病的方法
WO2019164593A2 (en) 2018-01-08 2019-08-29 Epicentrx, Inc. Methods and compositions utilizing rrx-001 combination therapy for radioprotection
AU2019254237B2 (en) 2018-04-16 2025-01-30 Onquality Pharmaceuticals China Ltd. Method for preventing or treating side effects of cancer therapy
RU2733080C1 (ru) 2019-12-13 2020-09-29 Александр Евгеньевич Баранников Фармакологическая композиция для лечения проктологических заболеваний (варианты).
US12070440B2 (en) 2022-06-27 2024-08-27 Permeatus, Inc. Topical formulations of nitroglycerin
US20240285572A1 (en) * 2023-02-27 2024-08-29 Opticgon Llc Compositions comprising nitric oxide-releasing compounds for treating choroidal vascular diseases and methods of their use
US12036398B1 (en) * 2023-12-22 2024-07-16 Pelvic Rehabilitation Medicine Treatment of neuromuscular dysfunction

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE304730C (de)
US814408A (en) * 1905-02-28 1906-03-06 Frederick Albert Steele Toilet article.
US2840080A (en) * 1956-12-18 1958-06-24 Millard J Clark Hygienic pad
US3419571A (en) 1966-04-06 1968-12-31 Warner Lambert Pharmaceutical Method for relieving coronary insufficiency
US4118480A (en) * 1973-02-09 1978-10-03 Charles V. Stoelker Pharmaceutical preparation for treating hemorrhoids and anal fissures
GB1548022A (en) * 1976-10-06 1979-07-04 Wyeth John & Brother Ltd Pharmaceutial dosage forms
ZA771135B (en) * 1977-02-25 1978-05-30 J Prinsloo Mediese preparaat
JPS5562012A (en) * 1978-11-06 1980-05-10 Teijin Ltd Slow-releasing preparation
US4842854A (en) * 1979-05-29 1989-06-27 Vsesojuzny Kardiologichesky Nauchny Tsentr Akademii Meditsinskiki Nauk Ssr Antianginal plate for treating ischemic heart disease
US4226849A (en) * 1979-06-14 1980-10-07 Forest Laboratories Inc. Sustained release therapeutic compositions
CA1163561A (en) * 1979-11-06 1984-03-13 Cyril Boroda Preparation containing nitroglycerine and optionally other medicaments and preparation thereof
US4657906A (en) 1982-06-05 1987-04-14 Smith Kline & French Laboratories Ltd. Heterocyclic compounds having inotropic activity
US4608249A (en) 1982-11-02 1986-08-26 Nitto Electric Industrial Co., Ltd. Hydrophilic therapeutic material
US4514384A (en) * 1983-03-14 1985-04-30 Gallina Damian J Hemorrhoid treatment method
JPS59184135A (ja) 1983-04-04 1984-10-19 Teijin Ltd グリセリンピログルタミン酸エステル類を含有する医薬品組成物
JPS6267017A (ja) 1985-09-19 1987-03-26 Sanwa Kagaku Kenkyusho:Kk 被膜形成型揮散性薬物含有軟膏剤
US4683242A (en) 1985-10-28 1987-07-28 A. H. Robins Company, Incorporated Transdermal treatment for pain and inflammation with 2-amino-3-aroylbenzeneacetic acids, salts and esters
US4764381A (en) 1985-12-06 1988-08-16 Key Pharmaceuticals, Inc. Percutaneous penetration enhancer of oleic acid and 2-ethyl-1, 3-hexanediol
HU199678B (en) * 1988-07-08 1990-03-28 Egyt Gyogyszervegyeszeti Gyar Process for producing aerosols containing nitroglicerol
US5183663A (en) * 1989-06-07 1993-02-02 Hercules Incorporated Treating skin lesions
US5059603A (en) * 1989-06-12 1991-10-22 Centuries Laboratories, Inc. Method and composition for treating impotence
US5085650A (en) * 1989-10-20 1992-02-04 Giglio Frank A Gynecological urethral suppository
JPH0692317B2 (ja) 1990-08-06 1994-11-16 龍也 橋岡 肛門用外用薬剤
DE4038203A1 (de) 1990-11-30 1992-06-04 Kali Chemie Pharma Gmbh Pharmazeutische spray-zubereitungen mit coronaraktiven wirkstoffen
US5508045A (en) 1992-10-09 1996-04-16 The Regents Of The University Of California Method and agents for control and management of labor during pregnancy
US5439938A (en) * 1993-04-07 1995-08-08 The Johns Hopkins University Treatments for male sexual dysfunction
US5595970A (en) * 1993-07-16 1997-01-21 Schering Aktiengesellschaft Treatment of climacteric disorders with nitric oxide synthase substrates and/or donors
WO1995006466A1 (en) * 1993-09-01 1995-03-09 Koren Laboratories Pty. Limited Treatment of anorectal disorders
AU708694C (en) 1993-09-01 2002-12-19 Cellegy Australia Pty Ltd Treatment of anorectal disorders
AUPM424794A0 (en) 1994-03-04 1994-03-31 Koren Laboratories Pty Ltd Treatment of anorectal disorders
ATE374607T1 (de) * 1994-05-27 2007-10-15 Strakan Int Ltd Zusammensetzung enthaltend stickstoffoxid- donatoren und methode zur behandlung analer krankheiten
US5504117A (en) * 1994-05-27 1996-04-02 Neptune Pharmaceutical Corporation Pharmacologic preparation for the treatment of anal disorders
US5595753A (en) * 1995-04-14 1997-01-21 President And Fellows Of Harvard College Topical formulations and methods for treating hemorrhoidal pain and sphincter and smooth muscle spasm in the gastrointestinal tract
US5827889A (en) * 1996-04-23 1998-10-27 Robert Cunico Anal fissure treatment preparation and method
WO1998036733A2 (en) 1997-02-24 1998-08-27 Michael Albert Kamm Topical pharmaceutical composition comprising a cholinergic agent or a calcium channel blocker
IT1297886B1 (it) 1997-02-28 1999-12-20 Carmine Antropoli Nifedipina per uso topico

Also Published As

Publication number Publication date
JP2001026550A (ja) 2001-01-30
DE69535607D1 (de) 2007-11-15
GR3035001T3 (en) 2001-03-30
CN1131392A (zh) 1996-09-18
DK0719145T3 (da) 2001-01-02
IL113448A (en) 2000-11-21
US20010025057A1 (en) 2001-09-27
HK1032545A1 (en) 2001-07-27
PT1051972E (pt) 2007-12-07
WO1995032715A1 (en) 1995-12-07
CA2168247C (en) 2000-12-12
JP3866906B2 (ja) 2007-01-10
US20050075391A1 (en) 2005-04-07
DE69518729D1 (de) 2000-10-12
MX9600386A (es) 1998-06-30
CA2168247A1 (en) 1995-12-07
JPH09504037A (ja) 1997-04-22
EP0719145A4 (de) 1999-01-20
ES2292402T3 (es) 2008-03-16
KR100386525B1 (ko) 2003-08-25
IL113448A0 (en) 1995-07-31
DE69518729T2 (de) 2001-05-31
ES2092460T3 (es) 2001-02-01
CN1107499C (zh) 2003-05-07
DE69535607T2 (de) 2008-07-10
DK1051972T3 (da) 2008-01-28
US20020161042A1 (en) 2002-10-31
US7189761B2 (en) 2007-03-13
JP2003073302A (ja) 2003-03-12
ATE196082T1 (de) 2000-09-15
US5693676A (en) 1997-12-02
EP0719145B1 (de) 2000-09-06
ES2092460T1 (es) 1996-12-01
DE719145T1 (de) 1997-02-13
AU2282395A (en) 1995-12-21
GR960300077T1 (en) 1997-01-31
JP3211892B2 (ja) 2001-09-25
PT719145E (pt) 2001-01-31
EP0719145A1 (de) 1996-07-03
EP1051972A1 (de) 2000-11-15
EP1051972B1 (de) 2007-10-03

Similar Documents

Publication Publication Date Title
ATE374607T1 (de) Zusammensetzung enthaltend stickstoffoxid- donatoren und methode zur behandlung analer krankheiten
ES2163090T3 (es) Uso de toxina botulinica para tratar la cefalea tensional.
ATE109471T1 (de) Antibakterielle mittel.
ATE136030T1 (de) Azaheterocyclylmethyl-chromane als wirkstoffe zur behandlung von erkrankungen des zentralnervensystems
ATE86501T1 (de) Produkt, praeparat und methode zum bekaempfen der allergien.
DE69435284D1 (de) Behandlung neuromuskulärer Erkrankungen und Zustände mit verschiedenem Botulin-Serotyp
ATE184792T1 (de) 2-bromomelatonin zur behandlung von schlafstörungen
ATE99932T1 (de) Verwendung von pyrrolicloncarbonsaeurealkylestern zur herstellung eines arzneimittels zur behandlung von ichtyosis.
DE3781182D1 (de) Tamoxifen zur topischen verwendung.
FI950909A0 (fi) Rasvahappojohdannaisia
ATE136896T1 (de) Piperidylmethyl substituierte chromanderivate als wirkstoffe zur behandlung von erkrankungen des zentralnervensystems
ATE69949T1 (de) Liposomen mit inhalativen allergenen zur behandlung von allergien, verfahren zu ihrer herstellung und diese enthaltende arzneimittel.
ATE271896T1 (de) Salbe enthaltend mometason-furoat und salicylsäure zur topischen behandlung von psoriasis
FI952203L (fi) Sykloheksaanijohdannaiset, menetelmä niiden valmistamiseksi ja yhdisteiden käyttö sairauksien hoitamiseksi
FI950649A7 (fi) Substituoidut sykloheksanoliesterit, niiden käyttö sairauksien hoitamiseksi ja farmaseuttiset valmisteet
ATE285778T1 (de) Topische verabreichung von bestimmten azapriranen zur vorbeugung oder behandlung von hautzuständen, die mit hautzellhyperproliferation und/oder immunologisch vermittelten krankheiten verbunden sind
ATE49964T1 (de) Benzodioxepane, verfahren zur herstellung und verwendung als heilmittel.
RU96101270A (ru) Способ лечения аллергодерматозов у детей

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1051972

Country of ref document: EP