ATE371490T1 - Verfahren und system zur herstellung von trockenem pulver mittels sprühtrocknung - Google Patents

Verfahren und system zur herstellung von trockenem pulver mittels sprühtrocknung

Info

Publication number
ATE371490T1
ATE371490T1 AT00945042T AT00945042T ATE371490T1 AT E371490 T1 ATE371490 T1 AT E371490T1 AT 00945042 T AT00945042 T AT 00945042T AT 00945042 T AT00945042 T AT 00945042T AT E371490 T1 ATE371490 T1 AT E371490T1
Authority
AT
Austria
Prior art keywords
conditioning zone
formulation
dry powder
producing dry
spray drying
Prior art date
Application number
AT00945042T
Other languages
German (de)
English (en)
Inventor
David Bennett
Thomas Brewer
Robert Platz
Original Assignee
Nektar Therapeutics
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nektar Therapeutics filed Critical Nektar Therapeutics
Application granted granted Critical
Publication of ATE371490T1 publication Critical patent/ATE371490T1/de

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
    • B01J2/04—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a gaseous medium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D1/00—Evaporating
    • B01D1/16—Evaporating by spraying
    • B01D1/18—Evaporating by spraying to obtain dry solids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Vaporization, Distillation, Condensation, Sublimation, And Cold Traps (AREA)
  • Drying Of Solid Materials (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT00945042T 1999-06-30 2000-06-30 Verfahren und system zur herstellung von trockenem pulver mittels sprühtrocknung ATE371490T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14171999P 1999-06-30 1999-06-30
US14167099P 1999-06-30 1999-06-30

Publications (1)

Publication Number Publication Date
ATE371490T1 true ATE371490T1 (de) 2007-09-15

Family

ID=26839351

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00945042T ATE371490T1 (de) 1999-06-30 2000-06-30 Verfahren und system zur herstellung von trockenem pulver mittels sprühtrocknung

Country Status (11)

Country Link
EP (1) EP1196236B1 (enExample)
JP (2) JP4327394B2 (enExample)
KR (1) KR100667720B1 (enExample)
AT (1) ATE371490T1 (enExample)
AU (1) AU780327B2 (enExample)
CA (1) CA2376937C (enExample)
DE (1) DE60036214T2 (enExample)
HK (1) HK1044130B (enExample)
MX (1) MXPA01013168A (enExample)
TW (1) TW453876B (enExample)
WO (1) WO2001000312A1 (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6956021B1 (en) 1998-08-25 2005-10-18 Advanced Inhalation Research, Inc. Stable spray-dried protein formulations
US6749835B1 (en) 1999-08-25 2004-06-15 Advanced Inhalation Research, Inc. Formulation for spray-drying large porous particles
US7678364B2 (en) 1999-08-25 2010-03-16 Alkermes, Inc. Particles for inhalation having sustained release properties
FI20002217A7 (fi) * 1999-12-30 2001-07-01 Orion Yhtymae Oyj Inhalaatiopartikkelit
US6848197B2 (en) 2001-04-18 2005-02-01 Advanced Inhalation Research, Inc. Control of process humidity to produce large, porous particles
EP1446104B2 (en) 2001-11-01 2011-08-03 Novartis AG Spray drying methods
AU2002352836B2 (en) 2001-11-20 2005-09-29 Alkermes, Inc. Improved particulate compositions for pulmonary delivery
KR20120080243A (ko) 2003-05-28 2012-07-16 노바르티스 아게 아미노산 및/또는 인지질로 부분 또는 완전 코팅된 수불용성 활성제 미립자의 제조를 위한 알코올성 수용액의 분무 건조법
TWI348408B (en) 2004-04-28 2011-09-11 Olympus Corp Laser processing device
US8513204B2 (en) 2004-06-21 2013-08-20 Novartis Ag Compositions comprising amphotericin B, mehods and systems
CN101442989B (zh) 2004-06-21 2013-04-03 诺瓦帝斯公司 包括两性霉素b的组合物
DE102006030166A1 (de) * 2006-06-29 2008-01-10 Boehringer Ingelheim Pharma Gmbh & Co. Kg Tempern
PL220269B1 (pl) * 2008-04-21 2015-09-30 Przedsiębiorstwo Produkcji Farmaceutycznej Hasco Lek Spółka Akcyjna Kompozytowy nośnik leków proszkowych, sposób wytwarzania nośnika leków oraz urządzenie do wytwarzania cząstek nośnika kompozytowego
PT3111927T (pt) 2009-05-29 2020-03-03 Pearl Therapeutics Inc Composições para administração respiratória de agentes ativos e métodos e sistemas associados
US8815258B2 (en) 2009-05-29 2014-08-26 Pearl Therapeutics, Inc. Compositions, methods and systems for respiratory delivery of two or more active agents
EP2330094B1 (en) 2009-12-03 2017-02-08 PURAC Biochem BV Alkali metal cinnamate powder and method for preparation
NZ707160A (en) 2012-12-19 2016-08-26 Wockhardt Ltd A stable aqueous composition comprising human insulin or an analogue or derivative thereof
TR201902687T4 (tr) * 2013-03-15 2019-03-21 Pearl Therapeutics Inc İri parçacıklı kristal malzemelerin koşullandırılması için yöntemler ve sistemler.
PT107567B (pt) * 2014-03-31 2019-02-13 Hovione Farm S A Secador por atomização com atomizador múltiplo, método para o aumento de escala de pós para inalação secos por dispositivo de atomização múltiplo e uso de vários atomizadores num secador por atomização
SI3346990T1 (sl) 2015-09-09 2020-07-31 Vectura Limited Postopek mletja s curkom

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1567348B2 (de) * 1964-10-13 1976-10-14 Nihon Shiryo Kogyo Co., Ltd., Tokushima (Japan) Verfahren zur herstellung eines dextroseproduktes aus staerkehydrolysat
AU6010994A (en) * 1993-11-11 1995-05-29 Hisato Sugawara Time-division three-dimensional projecting method of projecting three-dimensional image and additionally displaying signal
JPH09505516A (ja) * 1993-11-17 1997-06-03 ニロ・ホールディング・アー／エス 凝集塊粉体を製造するための噴霧乾燥方法及び装置
US6051256A (en) * 1994-03-07 2000-04-18 Inhale Therapeutic Systems Dispersible macromolecule compositions and methods for their preparation and use
US6001336A (en) * 1996-12-31 1999-12-14 Inhale Therapeutic Systems Processes for spray drying aqueous suspensions of hydrophobic drugs and compositions thereof
WO1998036888A1 (en) * 1997-02-24 1998-08-27 Superior Micropowders Llc Aerosol method and apparatus, particulate products, and electronic devices made therefrom

Also Published As

Publication number Publication date
WO2001000312A1 (en) 2001-01-04
KR20020015066A (ko) 2002-02-27
AU5903800A (en) 2001-01-31
DE60036214D1 (de) 2007-10-11
DE60036214T2 (de) 2008-05-21
TW453876B (en) 2001-09-11
HK1044130A1 (en) 2002-10-11
CA2376937C (en) 2009-01-06
CA2376937A1 (en) 2001-01-04
JP2009106790A (ja) 2009-05-21
EP1196236B1 (en) 2007-08-29
HK1044130B (en) 2008-03-14
WO2001000312A9 (en) 2002-07-25
KR100667720B1 (ko) 2007-01-15
MXPA01013168A (es) 2002-07-30
JP2003503122A (ja) 2003-01-28
AU780327B2 (en) 2005-03-17
JP4327394B2 (ja) 2009-09-09
EP1196236A1 (en) 2002-04-17

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