ATE36958T1 - Mikropartikel und gasblaeschen enthaltendes ultraschallkontrastmittel. - Google Patents

Mikropartikel und gasblaeschen enthaltendes ultraschallkontrastmittel.

Info

Publication number
ATE36958T1
ATE36958T1 AT84104210T AT84104210T ATE36958T1 AT E36958 T1 ATE36958 T1 AT E36958T1 AT 84104210 T AT84104210 T AT 84104210T AT 84104210 T AT84104210 T AT 84104210T AT E36958 T1 ATE36958 T1 AT E36958T1
Authority
AT
Austria
Prior art keywords
gas bubbles
contrast agent
agent containing
containing microparticles
ultrasound contrast
Prior art date
Application number
AT84104210T
Other languages
German (de)
English (en)
Inventor
Juergen Hilmann
Lothar Dr Lange
Ingfried Dr Zimmermann
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Application granted granted Critical
Publication of ATE36958T1 publication Critical patent/ATE36958T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
    • A61B2090/3925—Markers, e.g. radio-opaque or breast lesions markers ultrasonic

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Acoustics & Sound (AREA)
  • Public Health (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Cosmetics (AREA)
  • Fire-Detection Mechanisms (AREA)
  • Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
AT84104210T 1983-04-15 1984-04-13 Mikropartikel und gasblaeschen enthaltendes ultraschallkontrastmittel. ATE36958T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3313946A DE3313946A1 (de) 1983-04-15 1983-04-15 Mikropartikel und gasblaeschen enthaltende ultraschall-kontrastmittel
EP84104210A EP0122624B1 (de) 1983-04-15 1984-04-13 Mikropartikel und Gasbläschen enthaltendes Ultraschallkontrastmittel

Publications (1)

Publication Number Publication Date
ATE36958T1 true ATE36958T1 (de) 1988-09-15

Family

ID=6196665

Family Applications (1)

Application Number Title Priority Date Filing Date
AT84104210T ATE36958T1 (de) 1983-04-15 1984-04-13 Mikropartikel und gasblaeschen enthaltendes ultraschallkontrastmittel.

Country Status (12)

Country Link
EP (1) EP0122624B1 (cg-RX-API-DMAC10.html)
JP (1) JPS59205328A (cg-RX-API-DMAC10.html)
AT (1) ATE36958T1 (cg-RX-API-DMAC10.html)
AU (1) AU566928B2 (cg-RX-API-DMAC10.html)
CA (1) CA1239092A (cg-RX-API-DMAC10.html)
DE (2) DE3313946A1 (cg-RX-API-DMAC10.html)
DK (1) DK165171C (cg-RX-API-DMAC10.html)
FI (1) FI81264C (cg-RX-API-DMAC10.html)
IE (1) IE57272B1 (cg-RX-API-DMAC10.html)
NO (1) NO161356C (cg-RX-API-DMAC10.html)
NZ (1) NZ207853A (cg-RX-API-DMAC10.html)
ZA (1) ZA842801B (cg-RX-API-DMAC10.html)

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DE3834705A1 (de) 1988-10-07 1990-04-12 Schering Ag Ultraschallkontrastmittel aus gasblaeschen und fettsaeure enthaltenden mikropartikeln
US5141738A (en) * 1983-04-15 1992-08-25 Schering Aktiengesellschaft Ultrasonic contrast medium comprising gas bubbles and solid lipophilic surfactant-containing microparticles and use thereof
DE3313947A1 (de) * 1983-04-15 1984-10-18 Schering AG, 1000 Berlin und 4709 Bergkamen Mikropartikel und gasblaeschen enthaltende ultraschall-kontrastmittel
DK151366C (da) * 1984-12-05 1988-05-16 Tytex As Trusse samt fremgangsmaade til fremstilling heraf
DE3637926C1 (de) * 1986-11-05 1987-11-26 Schering Ag Ultraschall-Manometrieverfahren in einer Fluessigkeit mittels Mikroblaeschen
DE3741201A1 (de) * 1987-12-02 1989-06-15 Schering Ag Ultraschallarbeitsverfahren und mittel zu dessen durchfuehrung
DE3741199A1 (de) * 1987-12-02 1989-08-17 Schering Ag Verwendung von ultraschallkontrastmitteln fuer die ultraschall-lithotripsie
EP0327490A1 (de) * 1988-02-05 1989-08-09 Schering Aktiengesellschaft Ultraschallkontrastmittel, Verfahren zu deren Herstellung und deren Verwendung als Diagnostika und Therapeutika
DE3803972A1 (de) * 1988-02-05 1989-08-10 Schering Ag Ultraschallkontrastmittel
DE3803971C2 (de) * 1988-02-05 1997-09-18 Schering Ag Ultraschallkontrastmittel
US5425366A (en) * 1988-02-05 1995-06-20 Schering Aktiengesellschaft Ultrasonic contrast agents for color Doppler imaging
US5922304A (en) * 1989-12-22 1999-07-13 Imarx Pharmaceutical Corp. Gaseous precursor filled microspheres as magnetic resonance imaging contrast agents
US6613306B1 (en) 1990-04-02 2003-09-02 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
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US7083778B2 (en) 1991-05-03 2006-08-01 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
USRE39146E1 (en) 1990-04-02 2006-06-27 Bracco International B.V. Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof
US5578292A (en) 1991-11-20 1996-11-26 Bracco International B.V. Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof
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US5445813A (en) 1992-11-02 1995-08-29 Bracco International B.V. Stable microbubble suspensions as enhancement agents for ultrasound echography
US5137928A (en) * 1990-04-26 1992-08-11 Hoechst Aktiengesellschaft Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents
US5190982A (en) * 1990-04-26 1993-03-02 Hoechst Aktiengesellschaft Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents
US5205287A (en) * 1990-04-26 1993-04-27 Hoechst Aktiengesellschaft Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents
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US5147631A (en) * 1991-04-30 1992-09-15 Du Pont Merck Pharmaceutical Company Porous inorganic ultrasound contrast agents
HK1006946A1 (en) † 1991-06-03 1999-03-26 Nycomed Imaging As Improvements in or relating to contrast agents
JPH06511481A (ja) * 1991-07-05 1994-12-22 ユニバーシティ オブ ロチェスター 気泡を取り込む超微小非凝集多孔質粒子
JPH06510758A (ja) * 1991-07-05 1994-12-01 ニユコメド・イメージング・アクシエセルカペト 造影剤におけるまたは造影剤に関する改良
JPH0521183U (ja) * 1991-09-02 1993-03-19 サンデン株式会社 回転斜板式圧縮機
GB9200391D0 (en) * 1992-01-09 1992-02-26 Nycomed As Improvements in or relating to contrast agents
GB9200387D0 (en) * 1992-01-09 1992-02-26 Nycomed As Improvements in or relating to contrast agents
GB9200388D0 (en) * 1992-01-09 1992-02-26 Nycomed As Improvements in or relating to contrast agents
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CA2154867C (en) * 1993-12-15 2007-05-29 Feng Yan Gas mixtures useful as ultrasound contrast media
DE4406474A1 (de) * 1994-02-23 1995-08-24 Schering Ag Gas enthaltende Mikropartikel, diese enthaltende Mittel, deren Verwendung in der Ultraschalldiagnostik, sowie Verfahren zur Herstellung der Partikel und Mittel
DE19510690A1 (de) * 1995-03-14 1996-09-19 Schering Ag Polymere Nano- und/oder Mikropartikel, Verfahren zu deren Herstellung, sowie Verwendung in medizinischen Diagnostik und Therapie
DE19543077C2 (de) * 1995-11-13 1997-10-16 Schering Ag Verwendung von gashaltigen Metallkomplexen als Ultraschallkontrastmittel
DE19602930A1 (de) * 1996-01-18 1997-07-24 Schering Ag Poröse Matrices aus niedermolekularen Substanzen zur Genierung stabiler Gasblasensuspensionen, deren Verwendung als Ultraschallkontrastmittel sowie Verfahren zu deren Herstellung
DE19813174A1 (de) * 1998-03-25 1999-05-27 Schering Ag Mikropartikel aus Polymeren und mindestens einer gerüstbildenden Komponente und ihre Herstellung und Verwendung in der Ultraschalldiagnostik und zur ultraschallinduzierten Wirkstofffreisetzung
JP2002527410A (ja) 1998-10-12 2002-08-27 マリンクロッド・インコーポレイテッド 新規超音波造影剤
US6254852B1 (en) 1999-07-16 2001-07-03 Dupont Pharmaceuticals Company Porous inorganic targeted ultrasound contrast agents
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EP1387637B1 (en) 2001-04-06 2007-10-31 Bracco Research S.A. Apparatus for measuring local physical parameters in a fluid filled cavity
ATE520362T1 (de) 2001-12-03 2011-09-15 Ekos Corp Katheter mit mehreren ultraschall-abstrahlenden teilen
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US7794693B2 (en) 2002-03-01 2010-09-14 Bracco International B.V. Targeting vector-phospholipid conjugates
US8623822B2 (en) 2002-03-01 2014-01-07 Bracco Suisse Sa KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
US7211240B2 (en) 2002-03-01 2007-05-01 Bracco International B.V. Multivalent constructs for therapeutic and diagnostic applications
US20050100963A1 (en) 2002-03-01 2005-05-12 Dyax Corporation KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
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CA1170569A (en) * 1980-11-17 1984-07-10 Julia S. Rasor Microbubble precursors and methods for their production and use
DE3141641A1 (de) * 1981-10-16 1983-04-28 Schering Ag, 1000 Berlin Und 4619 Bergkamen Ultraschall-kontrastmittel und dessen herstellung

Also Published As

Publication number Publication date
AU2680584A (en) 1984-10-18
JPH0425934B2 (cg-RX-API-DMAC10.html) 1992-05-06
ZA842801B (en) 1984-11-28
FI841462L (fi) 1984-10-16
EP0122624A3 (en) 1986-11-20
NO161356C (no) 1989-08-09
DK78984A (da) 1984-10-16
NO161356B (no) 1989-05-02
DK78984D0 (da) 1984-02-20
EP0122624B1 (de) 1988-09-07
NO841489L (no) 1984-10-16
DK165171C (da) 1993-03-01
CA1239092A (en) 1988-07-12
FI81264B (fi) 1990-06-29
EP0122624A2 (de) 1984-10-24
NZ207853A (en) 1988-01-08
IE57272B1 (en) 1992-07-01
DE3313946A1 (de) 1984-10-18
DK165171B (da) 1992-10-19
DE3473828D1 (en) 1988-10-13
FI81264C (fi) 1990-10-10
AU566928B2 (en) 1987-11-05
JPS59205328A (ja) 1984-11-20
FI841462A0 (fi) 1984-04-12
IE840835L (en) 1984-10-15

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