AU566928B2 - Ultrasound contrast agent containing microparticles and gas micro-bubbles - Google Patents

Ultrasound contrast agent containing microparticles and gas micro-bubbles

Info

Publication number
AU566928B2
AU566928B2 AU26805/84A AU2680584A AU566928B2 AU 566928 B2 AU566928 B2 AU 566928B2 AU 26805/84 A AU26805/84 A AU 26805/84A AU 2680584 A AU2680584 A AU 2680584A AU 566928 B2 AU566928 B2 AU 566928B2
Authority
AU
Australia
Prior art keywords
bubbles
contrast agent
agent containing
containing microparticles
ultrasound contrast
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU26805/84A
Other versions
AU2680584A (en
Inventor
Jurgen Hilmann
Lothar Lange
Ingfried Zimmermann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Publication of AU2680584A publication Critical patent/AU2680584A/en
Application granted granted Critical
Publication of AU566928B2 publication Critical patent/AU566928B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
    • A61B2090/3925—Markers, e.g. radio-opaque or breast lesions markers ultrasonic

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Radiology & Medical Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Acoustics & Sound (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Cosmetics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Fire-Detection Mechanisms (AREA)
  • Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Manufacturing Of Micro-Capsules (AREA)

Abstract

1. Contrast medium containing microparticles and gas bubbles for ultrasound diagnostics, characterised in that it contains microparticles of a solid surface-active substance, optionally in combination with microparticles of a non-surface-active solid, in a liquid carrier.
AU26805/84A 1983-04-15 1984-04-13 Ultrasound contrast agent containing microparticles and gas micro-bubbles Ceased AU566928B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3313946 1983-04-15
DE3313946A DE3313946A1 (en) 1983-04-15 1983-04-15 MICROPARTICLES AND GAS BUBBLES CONTAINING ULTRASONIC CONTRASTING AGENTS

Publications (2)

Publication Number Publication Date
AU2680584A AU2680584A (en) 1984-10-18
AU566928B2 true AU566928B2 (en) 1987-11-05

Family

ID=6196665

Family Applications (1)

Application Number Title Priority Date Filing Date
AU26805/84A Ceased AU566928B2 (en) 1983-04-15 1984-04-13 Ultrasound contrast agent containing microparticles and gas micro-bubbles

Country Status (12)

Country Link
EP (1) EP0122624B1 (en)
JP (1) JPS59205328A (en)
AT (1) ATE36958T1 (en)
AU (1) AU566928B2 (en)
CA (1) CA1239092A (en)
DE (2) DE3313946A1 (en)
DK (1) DK165171C (en)
FI (1) FI81264C (en)
IE (1) IE57272B1 (en)
NO (1) NO161356C (en)
NZ (1) NZ207853A (en)
ZA (1) ZA842801B (en)

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DE3834705A1 (en) 1988-10-07 1990-04-12 Schering Ag ULTRASONIC CONTRASTING AGENTS FROM GAS BUBBLES AND MICROPARTICLES CONTAINING FATTY ACID
DE3313947A1 (en) * 1983-04-15 1984-10-18 Schering AG, 1000 Berlin und 4709 Bergkamen MICROPARTICLES AND GAS BUBBLES CONTAINING ULTRASONIC CONTRASTING AGENTS
US5141738A (en) * 1983-04-15 1992-08-25 Schering Aktiengesellschaft Ultrasonic contrast medium comprising gas bubbles and solid lipophilic surfactant-containing microparticles and use thereof
DK151366C (en) * 1984-12-05 1988-05-16 Tytex As Panty AND PROCEDURE FOR MANUFACTURING THEREOF
DE3637926C1 (en) * 1986-11-05 1987-11-26 Schering Ag Ultrasonic manometry in a liquid using microbubbles
DE3741201A1 (en) * 1987-12-02 1989-06-15 Schering Ag ULTRASONIC PROCESS AND METHOD FOR IMPLEMENTING IT
DE3741199A1 (en) * 1987-12-02 1989-08-17 Schering Ag USE OF ULTRASONIC CONTRASTING AGENTS FOR ULTRASONIC LITHOTRIPSY
DE3803971C2 (en) * 1988-02-05 1997-09-18 Schering Ag Ultrasound contrast media
DE3803972A1 (en) * 1988-02-05 1989-08-10 Schering Ag Ultrasound contrast media
JP2907911B2 (en) * 1988-02-05 1999-06-21 シエーリング アクチエンゲゼルシヤフト Ultrasound contrast agent, method for producing the same, and diagnostic or therapeutic preparation comprising the ultrasound contrast agent
US5425366A (en) * 1988-02-05 1995-06-20 Schering Aktiengesellschaft Ultrasonic contrast agents for color Doppler imaging
US5922304A (en) * 1989-12-22 1999-07-13 Imarx Pharmaceutical Corp. Gaseous precursor filled microspheres as magnetic resonance imaging contrast agents
US5445813A (en) 1992-11-02 1995-08-29 Bracco International B.V. Stable microbubble suspensions as enhancement agents for ultrasound echography
US6613306B1 (en) 1990-04-02 2003-09-02 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US6989141B2 (en) 1990-05-18 2006-01-24 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
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US5578292A (en) 1991-11-20 1996-11-26 Bracco International B.V. Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof
US7083778B2 (en) 1991-05-03 2006-08-01 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
USRE39146E1 (en) 1990-04-02 2006-06-27 Bracco International B.V. Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof
US5205287A (en) * 1990-04-26 1993-04-27 Hoechst Aktiengesellschaft Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents
US5190982A (en) * 1990-04-26 1993-03-02 Hoechst Aktiengesellschaft Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents
US5137928A (en) * 1990-04-26 1992-08-11 Hoechst Aktiengesellschaft Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents
AU636481B2 (en) * 1990-05-18 1993-04-29 Bracco International B.V. Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography
US5147631A (en) * 1991-04-30 1992-09-15 Du Pont Merck Pharmaceutical Company Porous inorganic ultrasound contrast agents
ES2103947T5 (en) † 1991-06-03 2001-05-16 Nycomed Imaging As IMPROVEMENTS INTRODUCED IN OR RELATED TO CONTRAST AGENTS.
WO1993000933A1 (en) * 1991-07-05 1993-01-21 University Of Rochester Ultrasmall non-aggregated porous particles entrapping gas-bubbles
IE80926B1 (en) * 1991-07-05 1999-06-30 Nycomed Imaging As Improvements in or relating to contrast agents
JPH0521183U (en) * 1991-09-02 1993-03-19 サンデン株式会社 Rotating swash plate compressor
GB9200387D0 (en) * 1992-01-09 1992-02-26 Nycomed As Improvements in or relating to contrast agents
GB9200388D0 (en) * 1992-01-09 1992-02-26 Nycomed As Improvements in or relating to contrast agents
GB9200391D0 (en) * 1992-01-09 1992-02-26 Nycomed As Improvements in or relating to contrast agents
IL104084A (en) 1992-01-24 1996-09-12 Bracco Int Bv Long-lasting aqueous suspensions of pressure-resistant gas-filled microvesicles their preparation and contrast agents consisting of them
PL182223B1 (en) 1993-12-15 2001-11-30 Bracco Research Sa Usg contrast medium
DE4406474A1 (en) * 1994-02-23 1995-08-24 Schering Ag Gas-containing microparticles, agents containing them, their use in ultrasound diagnostics, and methods for producing the particles and agents
DE19510690A1 (en) 1995-03-14 1996-09-19 Schering Ag Polymeric nano- and / or microparticles, processes for their production, and use in medical diagnostics and therapy
DE19543077C2 (en) * 1995-11-13 1997-10-16 Schering Ag Use of gas-containing metal complexes as ultrasound contrast agent
DE19602930A1 (en) * 1996-01-18 1997-07-24 Schering Ag Porous matrices made of low molecular weight substances for the generation of stable gas bubble suspensions, their use as ultrasound contrast agents and processes for their production
DE19813174A1 (en) * 1998-03-25 1999-05-27 Schering Ag Gas-filled microparticles, used for administering biologically active substances
WO2000021578A1 (en) 1998-10-12 2000-04-20 Mallinckrodt Inc. Novel ultrasound contrast agents
US6254852B1 (en) 1999-07-16 2001-07-03 Dupont Pharmaceuticals Company Porous inorganic targeted ultrasound contrast agents
EP2286843A3 (en) 2000-06-02 2011-08-03 Bracco Suisse SA Compounds for targeting endothelial cells
AU2002253454A1 (en) 2001-04-06 2002-10-21 Bracco Research S.A. Method for improved measurement of local physical parameters in afluid-filled cavity
WO2003047439A2 (en) 2001-12-03 2003-06-12 Ekos Corporation Catheter with multiple ultrasound radiating members
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US7794693B2 (en) 2002-03-01 2010-09-14 Bracco International B.V. Targeting vector-phospholipid conjugates
US7211240B2 (en) 2002-03-01 2007-05-01 Bracco International B.V. Multivalent constructs for therapeutic and diagnostic applications
US7261876B2 (en) 2002-03-01 2007-08-28 Bracco International Bv Multivalent constructs for therapeutic and diagnostic applications
EP1587944A4 (en) 2002-03-01 2007-03-21 Dyax Corp Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy
US8623822B2 (en) 2002-03-01 2014-01-07 Bracco Suisse Sa KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
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US7842377B2 (en) 2003-08-08 2010-11-30 Boston Scientific Scimed, Inc. Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient
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US9011473B2 (en) 2005-09-07 2015-04-21 Ulthera, Inc. Dissection handpiece and method for reducing the appearance of cellulite
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US8101197B2 (en) 2005-12-19 2012-01-24 Stryker Corporation Forming coils
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US10182833B2 (en) 2007-01-08 2019-01-22 Ekos Corporation Power parameters for ultrasonic catheter
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KR101595795B1 (en) 2014-03-19 2016-02-22 (주)아이엠지티 Dual-Purpose PAT/Ultrasound Contrast Agent with Nanoparticles Including Drug and Method for Preparing the Same
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EP0052575A2 (en) * 1980-11-17 1982-05-26 Schering Aktiengesellschaft Composition generating microbubbles
AU8916382A (en) * 1981-10-16 1983-04-21 Schering Aktiengesellschaft Contrast medium for ultrasonic diagnosis

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US4265251A (en) * 1979-06-28 1981-05-05 Rasor Associates, Inc. Method of determining pressure within liquid containing vessel

Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
EP0052575A2 (en) * 1980-11-17 1982-05-26 Schering Aktiengesellschaft Composition generating microbubbles
AU8916382A (en) * 1981-10-16 1983-04-21 Schering Aktiengesellschaft Contrast medium for ultrasonic diagnosis
EP0077752A2 (en) * 1981-10-16 1983-04-27 Schering Aktiengesellschaft Liquid mixture for absorbing and stabilizing gas bubbles to be used as contrast agent in ultrasonic diagnosis and process for its preparation

Also Published As

Publication number Publication date
DE3313946A1 (en) 1984-10-18
FI81264B (en) 1990-06-29
NO841489L (en) 1984-10-16
FI81264C (en) 1990-10-10
DK165171B (en) 1992-10-19
CA1239092A (en) 1988-07-12
JPS59205328A (en) 1984-11-20
ATE36958T1 (en) 1988-09-15
IE57272B1 (en) 1992-07-01
DE3473828D1 (en) 1988-10-13
EP0122624A3 (en) 1986-11-20
DK78984A (en) 1984-10-16
AU2680584A (en) 1984-10-18
NZ207853A (en) 1988-01-08
EP0122624A2 (en) 1984-10-24
IE840835L (en) 1984-10-15
FI841462A (en) 1984-10-16
FI841462A0 (en) 1984-04-12
NO161356C (en) 1989-08-09
EP0122624B1 (en) 1988-09-07
DK165171C (en) 1993-03-01
DK78984D0 (en) 1984-02-20
JPH0425934B2 (en) 1992-05-06
ZA842801B (en) 1984-11-28
NO161356B (en) 1989-05-02

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Legal Events

Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired