ATE341632T1 - Streptomyces avermitilis gen zum regulieren des verhältnisses der b2:b1 avermectinen - Google Patents

Streptomyces avermitilis gen zum regulieren des verhältnisses der b2:b1 avermectinen

Info

Publication number
ATE341632T1
ATE341632T1 AT00944154T AT00944154T ATE341632T1 AT E341632 T1 ATE341632 T1 AT E341632T1 AT 00944154 T AT00944154 T AT 00944154T AT 00944154 T AT00944154 T AT 00944154T AT E341632 T1 ATE341632 T1 AT E341632T1
Authority
AT
Austria
Prior art keywords
avermectins
ratio
streptomyces avermitilis
gene regulating
avermitilis gene
Prior art date
Application number
AT00944154T
Other languages
English (en)
Inventor
Yan Chen
Claes Gustafsson
Anke Krebber
Jeremy Stephen Minshull
Sun Ai Raillard
Kim Jonelle Stutzman-Engwall
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Application granted granted Critical
Publication of ATE341632T1 publication Critical patent/ATE341632T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C12P19/623—Avermectin; Milbemycin; Ivermectin; C-076
AT00944154T 1999-08-12 2000-07-24 Streptomyces avermitilis gen zum regulieren des verhältnisses der b2:b1 avermectinen ATE341632T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US14864599P 1999-08-12 1999-08-12

Publications (1)

Publication Number Publication Date
ATE341632T1 true ATE341632T1 (de) 2006-10-15

Family

ID=22526696

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00944154T ATE341632T1 (de) 1999-08-12 2000-07-24 Streptomyces avermitilis gen zum regulieren des verhältnisses der b2:b1 avermectinen

Country Status (39)

Country Link
US (3) US6632673B1 (de)
EP (1) EP1200606B1 (de)
JP (1) JP3884651B2 (de)
KR (1) KR100489856B1 (de)
CN (1) CN1186446C (de)
AP (1) AP2002002418A0 (de)
AR (1) AR022646A1 (de)
AT (1) ATE341632T1 (de)
AU (1) AU778837B2 (de)
BG (1) BG65902B1 (de)
BR (1) BRPI0013119B8 (de)
CA (1) CA2380872C (de)
CO (1) CO5290295A1 (de)
CY (1) CY1105778T1 (de)
CZ (1) CZ304402B6 (de)
DE (1) DE60031126T2 (de)
DK (1) DK1200606T3 (de)
EA (1) EA200200056A1 (de)
ES (1) ES2272299T3 (de)
GT (1) GT200000136A (de)
HK (1) HK1046710B (de)
HR (1) HRP20020130A2 (de)
HU (1) HU230600B1 (de)
IL (2) IL147563A0 (de)
IS (1) IS6250A (de)
MA (1) MA26813A1 (de)
MX (1) MXPA02001513A (de)
NO (1) NO20020664L (de)
NZ (1) NZ516517A (de)
OA (1) OA11998A (de)
PA (1) PA8499501A1 (de)
PE (1) PE20010690A1 (de)
PL (1) PL203818B1 (de)
PT (1) PT1200606E (de)
SK (1) SK288086B6 (de)
TN (1) TNSN00171A1 (de)
UY (1) UY26286A1 (de)
WO (1) WO2001012821A1 (de)
ZA (1) ZA200201072B (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2380872C (en) * 1999-08-12 2007-11-27 Yan Chen Streptomyces avermitilis gene directing the ratio of b2:b1 avermectins
ATE426659T1 (de) 2002-02-12 2009-04-15 Pfizer Prod Inc Streptomyces avermitilis gen zur regulierung des verhaltnisses der b2:b1 avermectine
US7943160B2 (en) * 2002-05-09 2011-05-17 Scimetrics Limited Corp. Pest control methods
US9493744B2 (en) * 2012-06-20 2016-11-15 Genentech, Inc. Methods for viral inactivation and other adventitious agents

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN167980B (de) * 1987-01-23 1991-01-19 Pfizer
US5525506A (en) 1987-01-23 1996-06-11 Pfizer Inc. Process for production of avermectins and cultures therefor
US5234831A (en) 1987-01-23 1993-08-10 Pfizer Inc Cultures for production of B avermectins
US5238848A (en) 1987-01-23 1993-08-24 Pfizer Inc Cultures for production of avermectins
US5240850A (en) 1987-10-23 1993-08-31 Pfizer Inc. Cultures for production of avermectin aglycones
DE3881147T2 (de) 1987-10-23 1993-09-02 Pfizer Verfahren zur herstellung von aglykonen von avermectin und sie enthaltende kulturen.
US5252474A (en) 1989-03-31 1993-10-12 Merck & Co., Inc. Cloning genes from Streptomyces avermitilis for avermectin biosynthesis and the methods for their use
NZ233116A (en) 1989-03-31 1994-09-27 Merck & Co Inc Cloning genes from steptomyces avermitilis for avermectin biosynthesis
ATE248916T1 (de) 1993-07-30 2003-09-15 Pfizer Gene, die verzweigte-alpha-ketosäure- dehydrogenasekomplexe von streptomyces avermitius kodieren
FI942725A (fi) 1993-12-16 1995-06-17 Pfizer Haaraketjuista alfaketohappodenydrogenaasikompleksia koodaavia geenejä Streptomyces avermitiliksesta
US5605793A (en) 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
US5837458A (en) 1994-02-17 1998-11-17 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
US6117679A (en) 1994-02-17 2000-09-12 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US6335160B1 (en) 1995-02-17 2002-01-01 Maxygen, Inc. Methods and compositions for polypeptide engineering
US6096548A (en) 1996-03-25 2000-08-01 Maxygen, Inc. Method for directing evolution of a virus
WO1998013487A1 (en) 1996-09-27 1998-04-02 Maxygen, Inc. Methods for optimization of gene therapy by recursive sequence shuffling and selection
CA2276064C (en) 1997-01-17 2013-12-17 Maxygen, Inc. Evolution of whole cells and organisms by recursive sequence recombination
AU1449499A (en) 1997-10-31 1999-05-24 Maxygen, Incorporated Modification of virus tropism and host range by viral genome shuffling
EP1053335A1 (de) * 1998-02-13 2000-11-22 Pfizer Products Inc. Streptomyces avermilitis gen zum regulieren des verhältnisses der b2:b1 avermectinen
US6248579B1 (en) * 1998-02-13 2001-06-19 Pfizer Inc Streptomyces avermitilis gene directing the ratio of B2:B1 avermectins
CA2380872C (en) * 1999-08-12 2007-11-27 Yan Chen Streptomyces avermitilis gene directing the ratio of b2:b1 avermectins

Also Published As

Publication number Publication date
CZ304402B6 (cs) 2014-04-16
MA26813A1 (fr) 2004-12-20
NO20020664D0 (no) 2002-02-11
TNSN00171A1 (fr) 2005-11-10
HUP0202487A2 (en) 2002-10-28
MXPA02001513A (es) 2002-07-02
PL203818B1 (pl) 2009-11-30
ES2272299T3 (es) 2007-05-01
AU778837B2 (en) 2004-12-23
BR0013119A (pt) 2002-04-23
BR0013119B1 (pt) 2014-02-25
CA2380872C (en) 2007-11-27
CN1373809A (zh) 2002-10-09
PA8499501A1 (es) 2001-12-14
BG65902B1 (bg) 2010-04-30
CO5290295A1 (es) 2003-06-27
ZA200201072B (en) 2003-04-30
PE20010690A1 (es) 2001-07-06
EA200200056A1 (ru) 2002-06-27
HRP20020130A2 (en) 2003-06-30
JP3884651B2 (ja) 2007-02-21
DE60031126T2 (de) 2007-02-08
SK1392002A3 (en) 2002-12-03
WO2001012821A1 (en) 2001-02-22
AU5838600A (en) 2001-03-13
HU230600B1 (hu) 2017-02-28
KR100489856B1 (ko) 2005-05-17
BRPI0013119B8 (pt) 2021-05-25
CA2380872A1 (en) 2001-02-22
HK1046710A1 (en) 2003-01-24
AR022646A1 (es) 2002-09-04
CZ2002296A3 (cs) 2002-08-14
NZ516517A (en) 2003-10-31
EP1200606A1 (de) 2002-05-02
US20040009560A1 (en) 2004-01-15
DE60031126D1 (de) 2006-11-16
OA11998A (en) 2006-04-18
SK288086B6 (sk) 2013-06-03
UY26286A1 (es) 2001-03-16
JP2003507017A (ja) 2003-02-25
KR20020029379A (ko) 2002-04-18
EP1200606B1 (de) 2006-10-04
IL147563A (en) 2009-06-15
HUP0202487A3 (en) 2004-07-28
US7858340B2 (en) 2010-12-28
US6632673B1 (en) 2003-10-14
IS6250A (is) 2002-01-25
GT200000136A (es) 2002-02-01
PL353874A1 (en) 2003-12-01
PT1200606E (pt) 2006-12-29
NO20020664L (no) 2002-02-11
IL147563A0 (en) 2002-08-14
US20030232415A1 (en) 2003-12-18
HK1046710B (zh) 2005-05-13
DK1200606T3 (da) 2007-01-08
BG106479A (bg) 2002-10-31
CN1186446C (zh) 2005-01-26
CY1105778T1 (el) 2011-02-02
AP2002002418A0 (en) 2002-03-31

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