OA11998A - Streptomyces avermitilis gene directing the ratio of b2:b1 avermectins. - Google Patents

Streptomyces avermitilis gene directing the ratio of b2:b1 avermectins. Download PDF

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Publication number
OA11998A
OA11998A OA1200200025A OA1200200025A OA11998A OA 11998 A OA11998 A OA 11998A OA 1200200025 A OA1200200025 A OA 1200200025A OA 1200200025 A OA1200200025 A OA 1200200025A OA 11998 A OA11998 A OA 11998A
Authority
OA
OAPI
Prior art keywords
leu
ala
val
gly
avec
Prior art date
Application number
OA1200200025A
Other languages
English (en)
Inventor
Yan Chen
Claes Gustafsson
Anke Krebber
Jeremy Stephen Minshull
Sun Ai Raillard
Kim Jonelle Stutzman-Engwall
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of OA11998A publication Critical patent/OA11998A/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C12P19/623—Avermectin; Milbemycin; Ivermectin; C-076

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
OA1200200025A 1999-08-12 2000-07-24 Streptomyces avermitilis gene directing the ratio of b2:b1 avermectins. OA11998A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US14864599P 1999-08-12 1999-08-12

Publications (1)

Publication Number Publication Date
OA11998A true OA11998A (en) 2006-04-18

Family

ID=22526696

Family Applications (1)

Application Number Title Priority Date Filing Date
OA1200200025A OA11998A (en) 1999-08-12 2000-07-24 Streptomyces avermitilis gene directing the ratio of b2:b1 avermectins.

Country Status (39)

Country Link
US (3) US6632673B1 (de)
EP (1) EP1200606B1 (de)
JP (1) JP3884651B2 (de)
KR (1) KR100489856B1 (de)
CN (1) CN1186446C (de)
AP (1) AP2002002418A0 (de)
AR (1) AR022646A1 (de)
AT (1) ATE341632T1 (de)
AU (1) AU778837B2 (de)
BG (1) BG65902B1 (de)
BR (1) BRPI0013119B8 (de)
CA (1) CA2380872C (de)
CO (1) CO5290295A1 (de)
CY (1) CY1105778T1 (de)
CZ (1) CZ304402B6 (de)
DE (1) DE60031126T2 (de)
DK (1) DK1200606T3 (de)
EA (1) EA200200056A1 (de)
ES (1) ES2272299T3 (de)
GT (1) GT200000136A (de)
HK (1) HK1046710B (de)
HR (1) HRP20020130A2 (de)
HU (1) HU230600B1 (de)
IL (2) IL147563A0 (de)
IS (1) IS6250A (de)
MA (1) MA26813A1 (de)
MX (1) MXPA02001513A (de)
NO (1) NO20020664L (de)
NZ (1) NZ516517A (de)
OA (1) OA11998A (de)
PA (1) PA8499501A1 (de)
PE (1) PE20010690A1 (de)
PL (1) PL203818B1 (de)
PT (1) PT1200606E (de)
SK (1) SK288086B6 (de)
TN (1) TNSN00171A1 (de)
UY (1) UY26286A1 (de)
WO (1) WO2001012821A1 (de)
ZA (1) ZA200201072B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1200606B1 (de) * 1999-08-12 2006-10-04 Pfizer Products Inc. Streptomyces avermitilis gen zum regulieren des verhältnisses der b2:b1 avermectinen
ATE530645T1 (de) * 2002-02-12 2011-11-15 Pfizer Prod Inc Streptomyces avermitilis gen zur regulierung des verhältnisses der b2:b1 avermectine
US7943160B2 (en) * 2002-05-09 2011-05-17 Scimetrics Limited Corp. Pest control methods
US9493744B2 (en) * 2012-06-20 2016-11-15 Genentech, Inc. Methods for viral inactivation and other adventitious agents
KR102657859B1 (ko) 2021-04-07 2024-04-16 윤재식 일체형 내화 소켓

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN167980B (de) * 1987-01-23 1991-01-19 Pfizer
US5234831A (en) 1987-01-23 1993-08-10 Pfizer Inc Cultures for production of B avermectins
US5238848A (en) 1987-01-23 1993-08-24 Pfizer Inc Cultures for production of avermectins
US5525506A (en) 1987-01-23 1996-06-11 Pfizer Inc. Process for production of avermectins and cultures therefor
US5240850A (en) 1987-10-23 1993-08-31 Pfizer Inc. Cultures for production of avermectin aglycones
ES2054822T3 (es) 1987-10-23 1994-08-16 Pfizer Procedimiento para la produccion de agliconas de avermectinas y sus cultivos.
ES2079436T3 (es) 1989-03-31 1996-01-16 Merck & Co Inc Clonacion de genes de streptomyces avermitilis para biosintesis de avermectinas y procedimientos para su uso.
US5252474A (en) 1989-03-31 1993-10-12 Merck & Co., Inc. Cloning genes from Streptomyces avermitilis for avermectin biosynthesis and the methods for their use
DK0711349T3 (da) 1993-07-30 2003-11-24 Pfizer Gener, der koder for forgrenet alfaketosyredehydrogenasekompleks fra Streptomyces avermitilis
FI942725A (fi) 1993-12-16 1995-06-17 Pfizer Haaraketjuista alfaketohappodenydrogenaasikompleksia koodaavia geenejä Streptomyces avermitiliksesta
US5837458A (en) 1994-02-17 1998-11-17 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
US6335160B1 (en) 1995-02-17 2002-01-01 Maxygen, Inc. Methods and compositions for polypeptide engineering
US5605793A (en) 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
US6117679A (en) 1994-02-17 2000-09-12 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US6096548A (en) 1996-03-25 2000-08-01 Maxygen, Inc. Method for directing evolution of a virus
JP2001504325A (ja) 1996-09-27 2001-04-03 マキシジェン，インコーポレイテッド 回帰的配列シャフリングおよび選択による遺伝子治療の最適化のための方法
EP2261373A3 (de) 1997-01-17 2011-12-14 Codexis Mayflower Holdings, LLC Evolution prokaryotischer ganzer Zellen durch rekursive Sequenzrekombination
US6596539B1 (en) 1997-10-31 2003-07-22 Maxygen, Inc. Modification of virus tropism and host range by viral genome shuffling
US6248579B1 (en) * 1998-02-13 2001-06-19 Pfizer Inc Streptomyces avermitilis gene directing the ratio of B2:B1 avermectins
EP1053335A1 (de) * 1998-02-13 2000-11-22 Pfizer Products Inc. Streptomyces avermilitis gen zum regulieren des verhältnisses der b2:b1 avermectinen
EP1200606B1 (de) * 1999-08-12 2006-10-04 Pfizer Products Inc. Streptomyces avermitilis gen zum regulieren des verhältnisses der b2:b1 avermectinen

Also Published As

Publication number Publication date
PE20010690A1 (es) 2001-07-06
UY26286A1 (es) 2001-03-16
IL147563A0 (en) 2002-08-14
CA2380872A1 (en) 2001-02-22
CZ304402B6 (cs) 2014-04-16
EP1200606B1 (de) 2006-10-04
HU230600B1 (hu) 2017-02-28
ATE341632T1 (de) 2006-10-15
US20030232415A1 (en) 2003-12-18
CO5290295A1 (es) 2003-06-27
NO20020664D0 (no) 2002-02-11
AU5838600A (en) 2001-03-13
AP2002002418A0 (en) 2002-03-31
US20040009560A1 (en) 2004-01-15
ES2272299T3 (es) 2007-05-01
PT1200606E (pt) 2006-12-29
HRP20020130A2 (en) 2003-06-30
SK288086B6 (sk) 2013-06-03
TNSN00171A1 (fr) 2005-11-10
CY1105778T1 (el) 2011-02-02
NO20020664L (no) 2002-02-11
GT200000136A (es) 2002-02-01
BG65902B1 (bg) 2010-04-30
DE60031126D1 (de) 2006-11-16
MA26813A1 (fr) 2004-12-20
KR100489856B1 (ko) 2005-05-17
AU778837B2 (en) 2004-12-23
BR0013119A (pt) 2002-04-23
JP3884651B2 (ja) 2007-02-21
HK1046710B (zh) 2005-05-13
BG106479A (bg) 2002-10-31
CN1186446C (zh) 2005-01-26
NZ516517A (en) 2003-10-31
KR20020029379A (ko) 2002-04-18
BRPI0013119B8 (pt) 2021-05-25
SK1392002A3 (en) 2002-12-03
HUP0202487A2 (en) 2002-10-28
EP1200606A1 (de) 2002-05-02
MXPA02001513A (es) 2002-07-02
CN1373809A (zh) 2002-10-09
JP2003507017A (ja) 2003-02-25
PL353874A1 (en) 2003-12-01
PL203818B1 (pl) 2009-11-30
PA8499501A1 (es) 2001-12-14
DK1200606T3 (da) 2007-01-08
HK1046710A1 (en) 2003-01-24
ZA200201072B (en) 2003-04-30
IS6250A (is) 2002-01-25
HUP0202487A3 (en) 2004-07-28
US7858340B2 (en) 2010-12-28
DE60031126T2 (de) 2007-02-08
CA2380872C (en) 2007-11-27
US6632673B1 (en) 2003-10-14
CZ2002296A3 (cs) 2002-08-14
IL147563A (en) 2009-06-15
EA200200056A1 (ru) 2002-06-27
BR0013119B1 (pt) 2014-02-25
AR022646A1 (es) 2002-09-04
WO2001012821A1 (en) 2001-02-22

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