SK288086B6 - Polynucleotide molecule comprising mutated nucleotide sequence of Streptomyces avermitilis aveC allele, vector and host cell, method of making strain of S. avermitilis and process for producing avermectins and final composition - Google Patents

Polynucleotide molecule comprising mutated nucleotide sequence of Streptomyces avermitilis aveC allele, vector and host cell, method of making strain of S. avermitilis and process for producing avermectins and final composition Download PDF

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Publication number
SK288086B6
SK288086B6 SK139-2002A SK1392002A SK288086B6 SK 288086 B6 SK288086 B6 SK 288086B6 SK 1392002 A SK1392002 A SK 1392002A SK 288086 B6 SK288086 B6 SK 288086B6
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SK
Slovakia
Prior art keywords
amino acid
seq
avec
avec allele
nucleotide
Prior art date
Application number
SK139-2002A
Other languages
English (en)
Slovak (sk)
Other versions
SK1392002A3 (en
Inventor
Yan Chen
Claes Gustafsson
Anke Krebber
Jeremy Stephen Minshull
Sun Ai Raillard
Kim Jonelle Stutzman-Engwall
Original Assignee
Pfizer Products Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc. filed Critical Pfizer Products Inc.
Publication of SK1392002A3 publication Critical patent/SK1392002A3/sk
Publication of SK288086B6 publication Critical patent/SK288086B6/sk

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C12P19/623—Avermectin; Milbemycin; Ivermectin; C-076

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
SK139-2002A 1999-08-12 2000-07-24 Polynucleotide molecule comprising mutated nucleotide sequence of Streptomyces avermitilis aveC allele, vector and host cell, method of making strain of S. avermitilis and process for producing avermectins and final composition SK288086B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14864599P 1999-08-12 1999-08-12
PCT/IB2000/001017 WO2001012821A1 (en) 1999-08-12 2000-07-24 Streptomyces avermitilis gene directing the ratio of b2:b1 avermectins

Publications (2)

Publication Number Publication Date
SK1392002A3 SK1392002A3 (en) 2002-12-03
SK288086B6 true SK288086B6 (sk) 2013-06-03

Family

ID=22526696

Family Applications (1)

Application Number Title Priority Date Filing Date
SK139-2002A SK288086B6 (sk) 1999-08-12 2000-07-24 Polynucleotide molecule comprising mutated nucleotide sequence of Streptomyces avermitilis aveC allele, vector and host cell, method of making strain of S. avermitilis and process for producing avermectins and final composition

Country Status (39)

Country Link
US (3) US6632673B1 (de)
EP (1) EP1200606B1 (de)
JP (1) JP3884651B2 (de)
KR (1) KR100489856B1 (de)
CN (1) CN1186446C (de)
AP (1) AP2002002418A0 (de)
AR (1) AR022646A1 (de)
AT (1) ATE341632T1 (de)
AU (1) AU778837B2 (de)
BG (1) BG65902B1 (de)
BR (1) BRPI0013119B8 (de)
CA (1) CA2380872C (de)
CO (1) CO5290295A1 (de)
CY (1) CY1105778T1 (de)
CZ (1) CZ304402B6 (de)
DE (1) DE60031126T2 (de)
DK (1) DK1200606T3 (de)
EA (1) EA200200056A1 (de)
ES (1) ES2272299T3 (de)
GT (1) GT200000136A (de)
HK (1) HK1046710B (de)
HR (1) HRP20020130A2 (de)
HU (1) HU230600B1 (de)
IL (2) IL147563A0 (de)
IS (1) IS6250A (de)
MA (1) MA26813A1 (de)
MX (1) MXPA02001513A (de)
NO (1) NO20020664D0 (de)
NZ (1) NZ516517A (de)
OA (1) OA11998A (de)
PA (1) PA8499501A1 (de)
PE (1) PE20010690A1 (de)
PL (1) PL203818B1 (de)
PT (1) PT1200606E (de)
SK (1) SK288086B6 (de)
TN (1) TNSN00171A1 (de)
UY (1) UY26286A1 (de)
WO (1) WO2001012821A1 (de)
ZA (1) ZA200201072B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3884651B2 (ja) * 1999-08-12 2007-02-21 ファイザー・プロダクツ・インク Ｂ２アベルメクチン：ｂ１アベルメクチンの比を指示するストレプトミセス・アベルミティリス遺伝子
RU2293117C2 (ru) * 2002-02-12 2007-02-10 Пфайзер Продактс Инк. Ген streptomyces avermitilis и его применение для изменения соотношения авермектинов b2:b1
US7943160B2 (en) * 2002-05-09 2011-05-17 Scimetrics Limited Corp. Pest control methods
US9493744B2 (en) 2012-06-20 2016-11-15 Genentech, Inc. Methods for viral inactivation and other adventitious agents
KR102657859B1 (ko) 2021-04-07 2024-04-16 윤재식 일체형 내화 소켓

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5525506A (en) 1987-01-23 1996-06-11 Pfizer Inc. Process for production of avermectins and cultures therefor
US5238848A (en) 1987-01-23 1993-08-24 Pfizer Inc Cultures for production of avermectins
IN167980B (de) * 1987-01-23 1991-01-19 Pfizer
US5234831A (en) 1987-01-23 1993-08-10 Pfizer Inc Cultures for production of B avermectins
ES2054822T3 (es) 1987-10-23 1994-08-16 Pfizer Procedimiento para la produccion de agliconas de avermectinas y sus cultivos.
US5240850A (en) 1987-10-23 1993-08-31 Pfizer Inc. Cultures for production of avermectin aglycones
DE69023036T2 (de) 1989-03-31 1996-06-13 Merck & Co Inc Klonierung von Streptomyces avermitilis Genen zur Biosynthese von Avermectin und Verfahren zu ihrer Verwendung.
US5252474A (en) 1989-03-31 1993-10-12 Merck & Co., Inc. Cloning genes from Streptomyces avermitilis for avermectin biosynthesis and the methods for their use
WO1995004150A1 (en) 1993-07-30 1995-02-09 Pfizer Inc. Genes encoding branched-chain alpha-ketoacid dehydrogenase complex from streptomyces avermitilis
FI942725A (fi) 1993-12-16 1995-06-17 Pfizer Haaraketjuista alfaketohappodenydrogenaasikompleksia koodaavia geenejä Streptomyces avermitiliksesta
US5605793A (en) 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
US6335160B1 (en) 1995-02-17 2002-01-01 Maxygen, Inc. Methods and compositions for polypeptide engineering
US5837458A (en) 1994-02-17 1998-11-17 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
US6117679A (en) 1994-02-17 2000-09-12 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US6096548A (en) 1996-03-25 2000-08-01 Maxygen, Inc. Method for directing evolution of a virus
EP0964922A4 (de) 1996-09-27 2000-10-25 Maxygen Inc Verfahren zur optimierung der gentherapie durch widerholtes sequenzmischen und selektion
EP1007732B1 (de) 1997-01-17 2006-07-26 Maxygen, Inc. EVOLUTION Prokaryotischer GANZER ZELLEN DURCH REKURSIVE SEQUENZREKOMBINATION
EP1030861A4 (de) 1997-10-31 2001-09-05 Maxygen Inc Modifizierung des virustropismius und des wirtspektrums durch virale genomdurchmischung
US6248579B1 (en) * 1998-02-13 2001-06-19 Pfizer Inc Streptomyces avermitilis gene directing the ratio of B2:B1 avermectins
BR9907893A (pt) * 1998-02-13 2000-11-14 Pfizer Prod Inc Gene de streptomyces avermitilis que dirige a proporção de avermectinas b2:b1
JP3884651B2 (ja) * 1999-08-12 2007-02-21 ファイザー・プロダクツ・インク Ｂ２アベルメクチン：ｂ１アベルメクチンの比を指示するストレプトミセス・アベルミティリス遺伝子

Also Published As

Publication number Publication date
CN1373809A (zh) 2002-10-09
HUP0202487A3 (en) 2004-07-28
BR0013119B1 (pt) 2014-02-25
BG65902B1 (bg) 2010-04-30
NO20020664L (no) 2002-02-11
UY26286A1 (es) 2001-03-16
AP2002002418A0 (en) 2002-03-31
PL353874A1 (en) 2003-12-01
BRPI0013119B8 (pt) 2021-05-25
US7858340B2 (en) 2010-12-28
BG106479A (bg) 2002-10-31
SK1392002A3 (en) 2002-12-03
ES2272299T3 (es) 2007-05-01
CO5290295A1 (es) 2003-06-27
CN1186446C (zh) 2005-01-26
PA8499501A1 (es) 2001-12-14
MA26813A1 (fr) 2004-12-20
CZ304402B6 (cs) 2014-04-16
CA2380872C (en) 2007-11-27
KR100489856B1 (ko) 2005-05-17
PT1200606E (pt) 2006-12-29
CY1105778T1 (el) 2011-02-02
KR20020029379A (ko) 2002-04-18
ZA200201072B (en) 2003-04-30
OA11998A (en) 2006-04-18
US20040009560A1 (en) 2004-01-15
HUP0202487A2 (en) 2002-10-28
JP3884651B2 (ja) 2007-02-21
EP1200606B1 (de) 2006-10-04
DK1200606T3 (da) 2007-01-08
HK1046710A1 (en) 2003-01-24
PE20010690A1 (es) 2001-07-06
HK1046710B (zh) 2005-05-13
HU230600B1 (hu) 2017-02-28
AU5838600A (en) 2001-03-13
ATE341632T1 (de) 2006-10-15
DE60031126T2 (de) 2007-02-08
EP1200606A1 (de) 2002-05-02
CA2380872A1 (en) 2001-02-22
DE60031126D1 (de) 2006-11-16
JP2003507017A (ja) 2003-02-25
AU778837B2 (en) 2004-12-23
BR0013119A (pt) 2002-04-23
IL147563A0 (en) 2002-08-14
PL203818B1 (pl) 2009-11-30
IS6250A (is) 2002-01-25
US20030232415A1 (en) 2003-12-18
NO20020664D0 (no) 2002-02-11
HRP20020130A2 (en) 2003-06-30
AR022646A1 (es) 2002-09-04
GT200000136A (es) 2002-02-01
EA200200056A1 (ru) 2002-06-27
MXPA02001513A (es) 2002-07-02
US6632673B1 (en) 2003-10-14
IL147563A (en) 2009-06-15
WO2001012821A1 (en) 2001-02-22
CZ2002296A3 (cs) 2002-08-14
TNSN00171A1 (fr) 2005-11-10
NZ516517A (en) 2003-10-31

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SK288086B6 (sk) Polynucleotide molecule comprising mutated nucleotide sequence of Streptomyces avermitilis aveC allele, vector and host cell, method of making strain of S. avermitilis and process for producing avermectins and final composition

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Owner name: PAH USA 15 LLC, NEW YORK, NY, US

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Effective date: 20130703

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MK4A Patent expired

Expiry date: 20200724