IS6250A - Streptomyces avermitilis gen sem stýra hlutfallinu á B2:B1 avermektínum - Google Patents

Streptomyces avermitilis gen sem stýra hlutfallinu á B2:B1 avermektínum

Info

Publication number
IS6250A
IS6250A IS6250A IS6250A IS6250A IS 6250 A IS6250 A IS 6250A IS 6250 A IS6250 A IS 6250A IS 6250 A IS6250 A IS 6250A IS 6250 A IS6250 A IS 6250A
Authority
IS
Iceland
Prior art keywords
avermectins
ratio
control
streptomyces avermitilis
avermitilis genes
Prior art date
Application number
IS6250A
Other languages
English (en)
Inventor
Jonelle Stutzman-Engwall Kim
Chen Yan
Gustafsson Claes
Krebber Anke
Stephen Minshull Jeremy
Ai Raillard Sun
Original Assignee
Pfizer Products Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc. filed Critical Pfizer Products Inc.
Publication of IS6250A publication Critical patent/IS6250A/is

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52Genes encoding for enzymes or proenzymes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88Lyases (4.)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/44Preparation of O-glycosides, e.g. glucosides
    • C12P19/60Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C12P19/623Avermectin; Milbemycin; Ivermectin; C-076

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
IS6250A 1999-08-12 2002-01-25 Streptomyces avermitilis gen sem stýra hlutfallinu á B2:B1 avermektínum IS6250A (is)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14864599P 1999-08-12 1999-08-12
PCT/IB2000/001017 WO2001012821A1 (en) 1999-08-12 2000-07-24 Streptomyces avermitilis gene directing the ratio of b2:b1 avermectins

Publications (1)

Publication Number Publication Date
IS6250A true IS6250A (is) 2002-01-25

Family

ID=22526696

Family Applications (1)

Application Number Title Priority Date Filing Date
IS6250A IS6250A (is) 1999-08-12 2002-01-25 Streptomyces avermitilis gen sem stýra hlutfallinu á B2:B1 avermektínum

Country Status (39)

Country Link
US (3) US6632673B1 (is)
EP (1) EP1200606B1 (is)
JP (1) JP3884651B2 (is)
KR (1) KR100489856B1 (is)
CN (1) CN1186446C (is)
AP (1) AP2002002418A0 (is)
AR (1) AR022646A1 (is)
AT (1) ATE341632T1 (is)
AU (1) AU778837B2 (is)
BG (1) BG65902B1 (is)
BR (1) BRPI0013119B8 (is)
CA (1) CA2380872C (is)
CO (1) CO5290295A1 (is)
CY (1) CY1105778T1 (is)
CZ (1) CZ304402B6 (is)
DE (1) DE60031126T2 (is)
DK (1) DK1200606T3 (is)
EA (1) EA200200056A1 (is)
ES (1) ES2272299T3 (is)
GT (1) GT200000136A (is)
HK (1) HK1046710B (is)
HR (1) HRP20020130A2 (is)
HU (1) HU230600B1 (is)
IL (2) IL147563A0 (is)
IS (1) IS6250A (is)
MA (1) MA26813A1 (is)
MX (1) MXPA02001513A (is)
NO (1) NO20020664L (is)
NZ (1) NZ516517A (is)
OA (1) OA11998A (is)
PA (1) PA8499501A1 (is)
PE (1) PE20010690A1 (is)
PL (1) PL203818B1 (is)
PT (1) PT1200606E (is)
SK (1) SK288086B6 (is)
TN (1) TNSN00171A1 (is)
UY (1) UY26286A1 (is)
WO (1) WO2001012821A1 (is)
ZA (1) ZA200201072B (is)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100489856B1 (ko) * 1999-08-12 2005-05-17 화이자 프로덕츠 인코포레이티드 B2:b1 아베르멕틴의 비율을 제어하는 스트렙토마이세스아베르미틸리스 유전자
BRPI0307620B8 (pt) * 2002-02-12 2016-09-13 Pah Usa 15 Llc moléculas de polinucleotídeo codificando variantes de avec, métodos para produzir uma cepa recombinante de streptomyces avermitilis, bem como as referidas células recombinantes e composição de avermectinas
US7943160B2 (en) * 2002-05-09 2011-05-17 Scimetrics Limited Corp. Pest control methods
US9493744B2 (en) * 2012-06-20 2016-11-15 Genentech, Inc. Methods for viral inactivation and other adventitious agents
KR102657859B1 (ko) 2021-04-07 2024-04-16 윤재식 일체형 내화 소켓

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5234831A (en) 1987-01-23 1993-08-10 Pfizer Inc Cultures for production of B avermectins
US5525506A (en) 1987-01-23 1996-06-11 Pfizer Inc. Process for production of avermectins and cultures therefor
US5238848A (en) 1987-01-23 1993-08-24 Pfizer Inc Cultures for production of avermectins
IN167980B (is) * 1987-01-23 1991-01-19 Pfizer
US5240850A (en) 1987-10-23 1993-08-31 Pfizer Inc. Cultures for production of avermectin aglycones
ATE89604T1 (de) 1987-10-23 1993-06-15 Pfizer Verfahren zur herstellung von aglykonen von avermectin und sie enthaltende kulturen.
DE69023036T2 (de) 1989-03-31 1996-06-13 Merck & Co Inc Klonierung von Streptomyces avermitilis Genen zur Biosynthese von Avermectin und Verfahren zu ihrer Verwendung.
US5252474A (en) 1989-03-31 1993-10-12 Merck & Co., Inc. Cloning genes from Streptomyces avermitilis for avermectin biosynthesis and the methods for their use
WO1995004150A1 (en) 1993-07-30 1995-02-09 Pfizer Inc. Genes encoding branched-chain alpha-ketoacid dehydrogenase complex from streptomyces avermitilis
FI942725A (fi) 1993-12-16 1995-06-17 Pfizer Haaraketjuista alfaketohappodenydrogenaasikompleksia koodaavia geenejä Streptomyces avermitiliksesta
US6117679A (en) 1994-02-17 2000-09-12 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US5837458A (en) 1994-02-17 1998-11-17 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
US6335160B1 (en) 1995-02-17 2002-01-01 Maxygen, Inc. Methods and compositions for polypeptide engineering
US5605793A (en) 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
US6096548A (en) 1996-03-25 2000-08-01 Maxygen, Inc. Method for directing evolution of a virus
JP2001504325A (ja) 1996-09-27 2001-04-03 マキシジェン,インコーポレイテッド 回帰的配列シャフリングおよび選択による遺伝子治療の最適化のための方法
WO1998031837A1 (en) 1997-01-17 1998-07-23 Maxygen, Inc. Evolution of whole cells and organisms by recursive sequence recombination
EP1690868A1 (en) 1997-10-31 2006-08-16 Maxygen, Inc. Modification of virus tropism and host range by viral genome shuffling
NZ518657A (en) * 1998-02-13 2003-10-31 Pfizer Prod Inc Streptomyces hygroscopicus directing the ratio of B2:B1 avermectins
US6248579B1 (en) * 1998-02-13 2001-06-19 Pfizer Inc Streptomyces avermitilis gene directing the ratio of B2:B1 avermectins
KR100489856B1 (ko) * 1999-08-12 2005-05-17 화이자 프로덕츠 인코포레이티드 B2:b1 아베르멕틴의 비율을 제어하는 스트렙토마이세스아베르미틸리스 유전자

Also Published As

Publication number Publication date
ES2272299T3 (es) 2007-05-01
BG65902B1 (bg) 2010-04-30
CZ2002296A3 (cs) 2002-08-14
EP1200606A1 (en) 2002-05-02
KR100489856B1 (ko) 2005-05-17
AR022646A1 (es) 2002-09-04
MA26813A1 (fr) 2004-12-20
HU230600B1 (hu) 2017-02-28
HRP20020130A2 (en) 2003-06-30
CO5290295A1 (es) 2003-06-27
IL147563A0 (en) 2002-08-14
SK288086B6 (sk) 2013-06-03
CZ304402B6 (cs) 2014-04-16
US20040009560A1 (en) 2004-01-15
TNSN00171A1 (fr) 2005-11-10
AP2002002418A0 (en) 2002-03-31
US20030232415A1 (en) 2003-12-18
PL203818B1 (pl) 2009-11-30
CN1186446C (zh) 2005-01-26
OA11998A (en) 2006-04-18
DK1200606T3 (da) 2007-01-08
CY1105778T1 (el) 2011-02-02
CA2380872C (en) 2007-11-27
BRPI0013119B8 (pt) 2021-05-25
AU778837B2 (en) 2004-12-23
BR0013119A (pt) 2002-04-23
JP2003507017A (ja) 2003-02-25
NO20020664D0 (no) 2002-02-11
HK1046710A1 (en) 2003-01-24
HK1046710B (zh) 2005-05-13
UY26286A1 (es) 2001-03-16
HUP0202487A2 (en) 2002-10-28
BR0013119B1 (pt) 2014-02-25
JP3884651B2 (ja) 2007-02-21
US7858340B2 (en) 2010-12-28
DE60031126T2 (de) 2007-02-08
GT200000136A (es) 2002-02-01
PT1200606E (pt) 2006-12-29
DE60031126D1 (de) 2006-11-16
CA2380872A1 (en) 2001-02-22
IL147563A (en) 2009-06-15
US6632673B1 (en) 2003-10-14
ATE341632T1 (de) 2006-10-15
WO2001012821A1 (en) 2001-02-22
EA200200056A1 (ru) 2002-06-27
CN1373809A (zh) 2002-10-09
SK1392002A3 (en) 2002-12-03
PL353874A1 (en) 2003-12-01
AU5838600A (en) 2001-03-13
EP1200606B1 (en) 2006-10-04
NO20020664L (no) 2002-02-11
KR20020029379A (ko) 2002-04-18
NZ516517A (en) 2003-10-31
BG106479A (bg) 2002-10-31
ZA200201072B (en) 2003-04-30
HUP0202487A3 (en) 2004-07-28
PE20010690A1 (es) 2001-07-06
PA8499501A1 (es) 2001-12-14
MXPA02001513A (es) 2002-07-02

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