EP1206477A4 - Klonierung des streptomyces avermitilis genes zur glycosylierung von avermectin aglyconen - Google Patents

Klonierung des streptomyces avermitilis genes zur glycosylierung von avermectin aglyconen

Info

Publication number
EP1206477A4
EP1206477A4 EP00950713A EP00950713A EP1206477A4 EP 1206477 A4 EP1206477 A4 EP 1206477A4 EP 00950713 A EP00950713 A EP 00950713A EP 00950713 A EP00950713 A EP 00950713A EP 1206477 A4 EP1206477 A4 EP 1206477A4
Authority
EP
European Patent Office
Prior art keywords
glycosylation
cloning
streptomyces avermitilis
avermectin aglycones
avermitilis genes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00950713A
Other languages
English (en)
French (fr)
Other versions
EP1206477A1 (de
Inventor
Douglas J Macneil
James Occi
Keith M Gewain
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP1206477A1 publication Critical patent/EP1206477A1/de
Publication of EP1206477A4 publication Critical patent/EP1206477A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP00950713A 1999-07-30 2000-07-26 Klonierung des streptomyces avermitilis genes zur glycosylierung von avermectin aglyconen Withdrawn EP1206477A4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14669999P 1999-07-30 1999-07-30
US146699P 1999-07-30
PCT/US2000/020331 WO2001009155A1 (en) 1999-07-30 2000-07-26 Cloning of the streptomyces avermitilis genes for glycosylation of avermectin aglycones

Publications (2)

Publication Number Publication Date
EP1206477A1 EP1206477A1 (de) 2002-05-22
EP1206477A4 true EP1206477A4 (de) 2004-11-24

Family

ID=22518585

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00950713A Withdrawn EP1206477A4 (de) 1999-07-30 2000-07-26 Klonierung des streptomyces avermitilis genes zur glycosylierung von avermectin aglyconen

Country Status (4)

Country Link
EP (1) EP1206477A4 (de)
JP (1) JP2003506022A (de)
CA (1) CA2380639A1 (de)
WO (1) WO2001009155A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000245457A (ja) 1999-02-24 2000-09-12 Kitasato Inst:The エバーメクチンアグリコン合成酵素遺伝子
US20030171562A1 (en) * 2001-04-26 2003-09-11 Farnet Chris M. Genes and proteins for the biosynthesis of polyketides
EP1524318A1 (de) * 2001-04-26 2005-04-20 Ecopia Biosciences Inc. Gene und Proteine für Polyketide Biosynthese
US7630836B2 (en) * 2001-05-30 2009-12-08 The Kitasato Institute Polynucleotides
EP1477563A3 (de) * 2003-05-16 2004-11-24 Wyeth Klonierung von Streptomyces cyaneogriseus subsp.noncyanogenus Genen zur Biosynthese von Antibiotika und Verfahren zu ihrer Verwendung

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0391594A2 (de) * 1989-03-31 1990-10-10 Merck & Co. Inc. Klonierung von Streptomyces avermitilis Genen zur Biosynthese von Avermectin und Verfahren zu ihrer Verwendung

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997008323A1 (en) * 1995-08-30 1997-03-06 Novartis Ag Staurosporin biosynthesis gene clusters

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0391594A2 (de) * 1989-03-31 1990-10-10 Merck & Co. Inc. Klonierung von Streptomyces avermitilis Genen zur Biosynthese von Avermectin und Verfahren zu ihrer Verwendung

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL 10 February 1999 (1999-02-10), "Streptomyces cyanogenus landomycin biosynthetic gene cluster, complete sequence", XP002298610, Database accession no. AF080235 *
MACNEIL D J ET AL: "ANALYSIS OF STREPTOMYCES AVERMITILIS GENES REQUIRED FOR AVERMECTIN BIOSYNTHESIS UTILIZING A NOVEL INTEGRATION VECTOR", GENE, ELSEVIER BIOMEDICAL PRESS. AMSTERDAM, NL, vol. 111, no. 1, 1992, pages 61 - 68, XP001180832, ISSN: 0378-1119 *
OCCI J L ET AL: "CLONING AND SEQUENCING A 5.2 KB REGION FROM STREPTOMYCES-AVERMITILIS INVOLVED IN GLYCOSYLATION OF AVERMECTIN", ABSTRACTS OF THE ANNUAL MEETING OF THE AMERICAN SOCIETY FOR MICROBIOLOGY, vol. 90, 1990, 90TH ANNUAL MEETING OF THE AMERICAN SOCIETY FOR MICROBIOLOGY 1990, ANAHEIM, CALIFORNIA, USA, MAY 13-, pages 268, XP008036043, ISSN: 0094-8519 *
SCHULMAN M D ET AL: "PURIFICATION AND IDENTIFICATION OF D-TDP-OLEANDROSE THE PRECURSOR OF THE OLEANDROSE UNITS OF THE AVERMECTINS", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 265, no. 28, 1990, pages 16965 - 16970, XP002298197, ISSN: 0021-9258 *
See also references of WO0109155A1 *

Also Published As

Publication number Publication date
WO2001009155A1 (en) 2001-02-08
JP2003506022A (ja) 2003-02-18
CA2380639A1 (en) 2001-02-08
EP1206477A1 (de) 2002-05-22

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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A4 Supplementary search report drawn up and despatched

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Ipc: 7C 12N 9/00 J

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